SG43249A1 - Novel pyrido[3,2-e]pyrazinones with anti-asmatic action and processes for their manufacture - Google Patents
Novel pyrido[3,2-e]pyrazinones with anti-asmatic action and processes for their manufactureInfo
- Publication number
- SG43249A1 SG43249A1 SG1996006425A SG1996006425A SG43249A1 SG 43249 A1 SG43249 A1 SG 43249A1 SG 1996006425 A SG1996006425 A SG 1996006425A SG 1996006425 A SG1996006425 A SG 1996006425A SG 43249 A1 SG43249 A1 SG 43249A1
- Authority
- SG
- Singapore
- Prior art keywords
- asmatic
- pyrazinones
- manufacture
- processes
- action
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19510965A DE19510965A1 (de) | 1995-03-24 | 1995-03-24 | Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
SG43249A1 true SG43249A1 (en) | 1997-10-17 |
Family
ID=7757727
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG1996006425A SG43249A1 (en) | 1995-03-24 | 1996-03-21 | Novel pyrido[3,2-e]pyrazinones with anti-asmatic action and processes for their manufacture |
Country Status (30)
Country | Link |
---|---|
US (1) | US5723463A (tr) |
EP (1) | EP0736532B1 (tr) |
JP (1) | JP4124280B2 (tr) |
KR (1) | KR100401395B1 (tr) |
CN (1) | CN1058968C (tr) |
AR (1) | AR002039A1 (tr) |
AT (1) | ATE217624T1 (tr) |
AU (1) | AU697908B2 (tr) |
BR (1) | BR9601093A (tr) |
CA (1) | CA2172472C (tr) |
CZ (1) | CZ290784B6 (tr) |
DE (2) | DE19510965A1 (tr) |
DK (1) | DK0736532T3 (tr) |
ES (1) | ES2174989T3 (tr) |
HR (1) | HRP960129B1 (tr) |
HU (1) | HUP9600731A3 (tr) |
IL (1) | IL117621A (tr) |
MX (1) | MX9601069A (tr) |
NO (1) | NO307091B1 (tr) |
NZ (1) | NZ286232A (tr) |
PL (1) | PL184800B1 (tr) |
PT (1) | PT736532E (tr) |
RU (1) | RU2143433C1 (tr) |
SG (1) | SG43249A1 (tr) |
SI (1) | SI0736532T1 (tr) |
SK (1) | SK36596A3 (tr) |
TR (1) | TR199600217A2 (tr) |
TW (1) | TW426682B (tr) |
UA (1) | UA45319C2 (tr) |
ZA (1) | ZA962270B (tr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010101603A (ko) * | 1999-01-20 | 2001-11-14 | 노왈드 | 이미다조[1,5-a]-피리도[3,2-e]-피라지논의 약제로서의용도 |
DE19961302A1 (de) * | 1999-12-18 | 2001-06-21 | Dresden Arzneimittel | Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen |
MXPA02001830A (es) | 1999-08-21 | 2002-08-12 | Byk Gulden Lomberg Chem Fab | Combinacion sinergica de inhibidores de pde y agonista de beta 2 adrenoceptor. |
DE10012373A1 (de) * | 2000-03-14 | 2001-09-20 | Dresden Arzneimittel | Verwendung von Pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erektiler Dysfunktion |
US6465465B1 (en) | 2000-03-14 | 2002-10-15 | Arzneimittelwerk Dresden Gmbh | Process for the treatment of erectile dysfunction and product therefor |
EA200501548A1 (ru) | 2003-04-01 | 2006-02-24 | Апплайд Резеч Системз Арс Холдинг Н.В. | Ингибиторы фосфодиэстераз при бесплодии |
GB0420722D0 (en) * | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
TWI417095B (zh) * | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
TW200817400A (en) * | 2006-05-30 | 2008-04-16 | Elbion Ag | Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them |
ES2536906T3 (es) | 2006-12-13 | 2015-05-29 | Aska Pharmaceutical Co., Ltd. | Derivado de quinoxalina |
TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
PT2203439E (pt) | 2007-09-14 | 2011-02-11 | Ortho Mcneil Janssen Pharm | 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridinil-2'- onas 1',3'-dissubstituídas |
WO2009033702A1 (en) | 2007-09-14 | 2009-03-19 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones |
TW200927731A (en) * | 2007-09-14 | 2009-07-01 | Ortho Mcneil Janssen Pharm | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
EP2220083B1 (en) * | 2007-11-14 | 2017-07-19 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
EP2227472A1 (en) * | 2007-11-30 | 2010-09-15 | Elbion Gmbh | Aryl and heteroaryl fused imidazo (1,5-a) pyrazines as inhibitors of phosphodiesterase 10 |
CN101918408A (zh) | 2007-11-30 | 2010-12-15 | 惠氏有限责任公司 | 作为磷酸二酯酶10的抑制剂的芳基和杂芳基稠合的咪唑并[1,5-a]吡嗪 |
EP2344470B1 (en) | 2008-09-02 | 2013-11-06 | Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
AU2009304293B2 (en) | 2008-10-16 | 2012-04-26 | Addex Pharma S.A. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
CN102232074B (zh) | 2008-11-28 | 2014-12-03 | 奥梅-杨森制药有限公司 | 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物 |
CA2760741C (en) | 2009-05-12 | 2018-05-01 | Addex Pharma S.A. | 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
ES2409006T3 (es) | 2009-05-12 | 2013-06-24 | Janssen Pharmaceuticals Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de los receptores mGluR2 |
CA2815002C (en) | 2010-11-08 | 2019-10-22 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
JP5852665B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
CN103298810B (zh) | 2010-11-08 | 2016-03-16 | 杨森制药公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
KR20200036063A (ko) | 2014-01-21 | 2020-04-06 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
JP6629740B2 (ja) | 2014-01-21 | 2020-01-15 | ヤンセン ファーマシューティカ エヌ.ベー. | 代謝型グルタミン酸作動性受容体サブタイプ2の正のアロステリック調節因子またはオルトステリックアゴニストを含む組み合わせ、およびそれらの使用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5166344A (en) * | 1989-05-31 | 1992-11-24 | Berlex Laboratories, Inc. | Process for the preparation of imidazoquinoxalinones |
US5055465A (en) * | 1989-05-31 | 1991-10-08 | Berlex Laboratories, Inc. | Imidazoquinoxalinones, their aza analogs and process for their preparation |
US5153196A (en) * | 1991-06-05 | 1992-10-06 | Eli Lilly And Company | Excitatory amino acid receptor antagonists and methods for the use thereof |
AU657986B2 (en) * | 1991-06-14 | 1995-03-30 | Pharmacia & Upjohn Company | Imidazo(1,5-a)quinoxalines |
US5182386A (en) * | 1991-08-27 | 1993-01-26 | Neurogen Corporation | Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands |
DE4228095A1 (de) * | 1992-08-24 | 1994-03-03 | Asta Medica Ag | Neue 4,5-Dihydro-4-oxo-pyrrolo[1,2-a]chinoxaline und entsprechende Aza-analoga und Verfahren zu deren Herstellung |
JP3252484B2 (ja) * | 1992-10-20 | 2002-02-04 | 東レ株式会社 | 4,5−ジヒドロ[1,2,4]トリアゾロ[4,3−a]キノキサリン誘導体の製造方法 |
JP3252483B2 (ja) * | 1992-10-20 | 2002-02-04 | 東レ株式会社 | 3環性トリアゾロ誘導体の製造方法 |
DE4329970A1 (de) * | 1993-03-31 | 1994-10-06 | Basf Ag | Neue Imidazolo-chinoxalinone, ihre Hestellung und Verwendung |
FR2704547B1 (fr) * | 1993-04-30 | 1995-06-09 | Adir | Nouveaux composés pyrrolopyraziniques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
DE69401583T2 (de) * | 1993-05-06 | 1997-06-12 | Novonordisk As | [1,2,4-TRIAZOLO[4,3-a]CHINOXALINVERBINDUNGEN DEREN HERSTELLUNG UND VERWENDUNG |
CA2112290C (en) * | 1993-12-23 | 2004-06-01 | John R. Francis | A clock recovery circuit for serial digital video |
JP3240462B2 (ja) * | 1996-05-24 | 2001-12-17 | 株式会社ケンウッド | 光ディスク装置の光ピックアップサーボ装置 |
-
1995
- 1995-03-24 DE DE19510965A patent/DE19510965A1/de not_active Withdrawn
-
1996
- 1996-02-29 UA UA96020799A patent/UA45319C2/uk unknown
- 1996-03-04 TW TW085102634A patent/TW426682B/zh not_active IP Right Cessation
- 1996-03-12 SI SI9630473T patent/SI0736532T1/xx unknown
- 1996-03-12 DE DE59609201T patent/DE59609201D1/de not_active Expired - Fee Related
- 1996-03-12 AT AT96103855T patent/ATE217624T1/de not_active IP Right Cessation
- 1996-03-12 ES ES96103855T patent/ES2174989T3/es not_active Expired - Lifetime
- 1996-03-12 EP EP96103855A patent/EP0736532B1/de not_active Expired - Lifetime
- 1996-03-12 PT PT96103855T patent/PT736532E/pt unknown
- 1996-03-12 DK DK96103855T patent/DK0736532T3/da active
- 1996-03-12 CZ CZ1996747A patent/CZ290784B6/cs not_active IP Right Cessation
- 1996-03-19 SK SK365-96A patent/SK36596A3/sk unknown
- 1996-03-20 TR TR96/00217A patent/TR199600217A2/tr unknown
- 1996-03-20 ZA ZA962270A patent/ZA962270B/xx unknown
- 1996-03-20 HR HR960129A patent/HRP960129B1/xx not_active IP Right Cessation
- 1996-03-21 NZ NZ286232A patent/NZ286232A/en unknown
- 1996-03-21 SG SG1996006425A patent/SG43249A1/en unknown
- 1996-03-22 IL IL11762196A patent/IL117621A/xx not_active IP Right Cessation
- 1996-03-22 PL PL96313434A patent/PL184800B1/pl unknown
- 1996-03-22 MX MX9601069A patent/MX9601069A/es not_active IP Right Cessation
- 1996-03-22 CN CN96103169A patent/CN1058968C/zh not_active Expired - Fee Related
- 1996-03-22 AU AU48257/96A patent/AU697908B2/en not_active Ceased
- 1996-03-22 JP JP06671296A patent/JP4124280B2/ja not_active Expired - Fee Related
- 1996-03-22 NO NO961173A patent/NO307091B1/no not_active IP Right Cessation
- 1996-03-22 HU HU9600731A patent/HUP9600731A3/hu unknown
- 1996-03-22 CA CA002172472A patent/CA2172472C/en not_active Expired - Fee Related
- 1996-03-22 AR ARP960101871A patent/AR002039A1/es not_active Application Discontinuation
- 1996-03-22 BR BR9601093A patent/BR9601093A/pt not_active Application Discontinuation
- 1996-03-22 KR KR1019960007810A patent/KR100401395B1/ko not_active IP Right Cessation
- 1996-03-25 US US08/621,315 patent/US5723463A/en not_active Expired - Lifetime
- 1996-03-25 RU RU96105827/04A patent/RU2143433C1/ru not_active IP Right Cessation
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