SG187504A1 - Treatment and prophylaxis of amyloidosis - Google Patents

Treatment and prophylaxis of amyloidosis Download PDF

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Publication number
SG187504A1
SG187504A1 SG2013004692A SG2013004692A SG187504A1 SG 187504 A1 SG187504 A1 SG 187504A1 SG 2013004692 A SG2013004692 A SG 2013004692A SG 2013004692 A SG2013004692 A SG 2013004692A SG 187504 A1 SG187504 A1 SG 187504A1
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SG
Singapore
Prior art keywords
seq
antibody
antigen
chain variable
variable region
Prior art date
Application number
SG2013004692A
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English (en)
Inventor
Dale B Schenk
Peter A Seubert
Jonathan Wall
Jose Saldanha
Original Assignee
Univ Tennessee Res Foundation
Elan Pharm Inc
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Publication date
Application filed by Univ Tennessee Res Foundation, Elan Pharm Inc filed Critical Univ Tennessee Res Foundation
Publication of SG187504A1 publication Critical patent/SG187504A1/en

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
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    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
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    • A61K51/1018—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from animals or humans
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K—PEPTIDES
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

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  • Medicinal Chemistry (AREA)
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  • Veterinary Medicine (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
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  • Oncology (AREA)
  • Biophysics (AREA)
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  • Rheumatology (AREA)
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  • Optics & Photonics (AREA)
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  • Mycology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Radiology & Medical Imaging (AREA)
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SG2013004692A 2007-12-28 2008-12-29 Treatment and prophylaxis of amyloidosis SG187504A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US754407P 2007-12-28 2007-12-28
US9593208P 2008-09-10 2008-09-10

Publications (1)

Publication Number Publication Date
SG187504A1 true SG187504A1 (en) 2013-02-28

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ID=40825109

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Application Number Title Priority Date Filing Date
SG2013004692A SG187504A1 (en) 2007-12-28 2008-12-29 Treatment and prophylaxis of amyloidosis
SG2012096137A SG186689A1 (en) 2007-12-28 2008-12-29 Treatment and prophylaxis of amyloidosis

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Application Number Title Priority Date Filing Date
SG2012096137A SG186689A1 (en) 2007-12-28 2008-12-29 Treatment and prophylaxis of amyloidosis

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Country Link
US (13) US8791243B2 (enExample)
EP (3) EP2237803B1 (enExample)
JP (3) JP5730020B2 (enExample)
KR (1) KR101603076B1 (enExample)
CN (1) CN102016059B (enExample)
AU (1) AU2008345022B2 (enExample)
BR (1) BRPI0821949B1 (enExample)
CA (1) CA2710984C (enExample)
CO (1) CO6341486A2 (enExample)
DK (1) DK2237803T3 (enExample)
EA (2) EA036059B1 (enExample)
ES (1) ES2544679T3 (enExample)
HU (1) HUE025560T2 (enExample)
IL (2) IL206641B (enExample)
MX (1) MX384227B (enExample)
NO (1) NO20101036L (enExample)
NZ (1) NZ586875A (enExample)
PL (1) PL2237803T3 (enExample)
PT (1) PT2237803E (enExample)
SG (2) SG187504A1 (enExample)
WO (1) WO2009086539A2 (enExample)

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