SG183725A1 - Derivatives of 5-amino-4, 6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators - Google Patents

Derivatives of 5-amino-4, 6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators Download PDF

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Publication number
SG183725A1
SG183725A1 SG2012059937A SG2012059937A SG183725A1 SG 183725 A1 SG183725 A1 SG 183725A1 SG 2012059937 A SG2012059937 A SG 2012059937A SG 2012059937 A SG2012059937 A SG 2012059937A SG 183725 A1 SG183725 A1 SG 183725A1
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Singapore
Prior art keywords
compound
formula
dimethyl
alkyl
pharmaceutically acceptable
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SG2012059937A
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English (en)
Inventor
Jean-Michel Vernier
Huanming Chen
Jianlan Song
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Valeant Pharmaceuticals International Inc
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Application filed by Valeant Pharmaceuticals International Inc filed Critical Valeant Pharmaceuticals International Inc
Publication of SG183725A1 publication Critical patent/SG183725A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
SG2012059937A 2007-08-13 2008-08-12 Derivatives of 5-amino-4, 6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators SG183725A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96452607P 2007-08-13 2007-08-13
US12/189,709 US7786146B2 (en) 2007-08-13 2008-08-11 Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators

Publications (1)

Publication Number Publication Date
SG183725A1 true SG183725A1 (en) 2012-09-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
SG2012059937A SG183725A1 (en) 2007-08-13 2008-08-12 Derivatives of 5-amino-4, 6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators

Country Status (16)

Country Link
US (2) US7786146B2 (enExample)
EP (1) EP2190534B1 (enExample)
JP (1) JP2010536771A (enExample)
KR (1) KR20100075436A (enExample)
CN (1) CN101795727A (enExample)
AU (1) AU2008286919B2 (enExample)
BR (1) BRPI0815210A2 (enExample)
CA (1) CA2696012C (enExample)
ES (1) ES2531335T3 (enExample)
HU (1) HUE025928T2 (enExample)
MX (1) MX2010001712A (enExample)
PL (1) PL2190534T3 (enExample)
RU (1) RU2483060C2 (enExample)
SG (1) SG183725A1 (enExample)
TW (1) TW200927096A (enExample)
WO (1) WO2009023677A1 (enExample)

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US8563566B2 (en) * 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
CN102241608A (zh) * 2011-05-12 2011-11-16 天津市汉康医药生物技术有限公司 瑞替加滨化合物及其组合物
US9321750B2 (en) * 2012-04-20 2016-04-26 Innov17 Llc ROR modulators and their uses
CN103508960B (zh) * 2012-06-29 2017-12-12 江苏先声药业有限公司 苯并杂环衍生物
CN107098844B (zh) * 2017-05-17 2019-07-30 许昌学院 一种c-5位硝基取代的酰基吲哚啉类化合物的合成方法
CN112010808B (zh) * 2019-05-31 2021-11-30 上海挚盟医药科技有限公司 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用
CN114539120A (zh) * 2022-03-09 2022-05-27 台州学院 一种吲哚类钾离子通道激动剂的制备方法
TW202604508A (zh) * 2024-05-03 2026-02-01 加拿大商再諾製藥公司 氮雜吲哚及氮雜吲哚啉化合物及其用途
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Also Published As

Publication number Publication date
CA2696012A1 (en) 2009-02-19
TW200927096A (en) 2009-07-01
MX2010001712A (es) 2010-07-28
JP2010536771A (ja) 2010-12-02
US8211918B2 (en) 2012-07-03
RU2483060C2 (ru) 2013-05-27
AU2008286919A1 (en) 2009-02-19
HUE025928T2 (en) 2016-05-30
PL2190534T3 (pl) 2015-11-30
AU2008286919B2 (en) 2014-05-29
WO2009023677A1 (en) 2009-02-19
RU2010109388A (ru) 2011-09-20
EP2190534A1 (en) 2010-06-02
US20110118318A1 (en) 2011-05-19
BRPI0815210A2 (pt) 2015-03-31
CA2696012C (en) 2017-10-31
ES2531335T3 (es) 2015-03-13
EP2190534B1 (en) 2015-02-18
US20090137635A1 (en) 2009-05-28
KR20100075436A (ko) 2010-07-02
CN101795727A (zh) 2010-08-04
US7786146B2 (en) 2010-08-31

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