MX2010001712A - Derivados de indol 5-amino-4,6-disustituido e indolina 5-amino-4,6-disustituida como moduladores de canales de potasio. - Google Patents

Derivados de indol 5-amino-4,6-disustituido e indolina 5-amino-4,6-disustituida como moduladores de canales de potasio.

Info

Publication number
MX2010001712A
MX2010001712A MX2010001712A MX2010001712A MX2010001712A MX 2010001712 A MX2010001712 A MX 2010001712A MX 2010001712 A MX2010001712 A MX 2010001712A MX 2010001712 A MX2010001712 A MX 2010001712A MX 2010001712 A MX2010001712 A MX 2010001712A
Authority
MX
Mexico
Prior art keywords
amino
disubstituted
potassium channel
channel modulators
derivatives
Prior art date
Application number
MX2010001712A
Other languages
English (en)
Inventor
Jean-Michel Vernier
Huanming Chen
Jianlan Song
Original Assignee
Valeant Pharmaceuticals Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valeant Pharmaceuticals Int filed Critical Valeant Pharmaceuticals Int
Publication of MX2010001712A publication Critical patent/MX2010001712A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Esta invención provee compuestos de la fórmula l (ver fórmula l) en donde la línea discontinua representa un doble enlace opcional; en donde R1 es fenilo, naftilo, piridilo, pirimidilo, pirrolilo, imidazolilo, pirazilo, furilo, tienilo, oxazolilo, isoxazolilo, tiazolilo o isotiazolilo, opcionalmente sustituido, y otros sustituyentes se definen aquí; dichos compuestos son moduladores de canales de potasio.
MX2010001712A 2007-08-13 2008-08-12 Derivados de indol 5-amino-4,6-disustituido e indolina 5-amino-4,6-disustituida como moduladores de canales de potasio. MX2010001712A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96452607P 2007-08-13 2007-08-13
US12/189,709 US7786146B2 (en) 2007-08-13 2008-08-11 Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
PCT/US2008/072926 WO2009023677A1 (en) 2007-08-13 2008-08-12 Derivatives of 5-amino-4, 6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators

Publications (1)

Publication Number Publication Date
MX2010001712A true MX2010001712A (es) 2010-07-28

Family

ID=40029251

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010001712A MX2010001712A (es) 2007-08-13 2008-08-12 Derivados de indol 5-amino-4,6-disustituido e indolina 5-amino-4,6-disustituida como moduladores de canales de potasio.

Country Status (16)

Country Link
US (2) US7786146B2 (es)
EP (1) EP2190534B1 (es)
JP (1) JP2010536771A (es)
KR (1) KR20100075436A (es)
CN (1) CN101795727A (es)
AU (1) AU2008286919B2 (es)
BR (1) BRPI0815210A2 (es)
CA (1) CA2696012C (es)
ES (1) ES2531335T3 (es)
HU (1) HUE025928T2 (es)
MX (1) MX2010001712A (es)
PL (1) PL2190534T3 (es)
RU (1) RU2483060C2 (es)
SG (1) SG183725A1 (es)
TW (1) TW200927096A (es)
WO (1) WO2009023677A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
US8563566B2 (en) * 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
CN102241608A (zh) * 2011-05-12 2011-11-16 天津市汉康医药生物技术有限公司 瑞替加滨化合物及其组合物
EP2844247A4 (en) * 2012-04-20 2015-11-25 Anderson Gaweco ROR MODULATORS AND ITS USES
CN103508960B (zh) * 2012-06-29 2017-12-12 江苏先声药业有限公司 苯并杂环衍生物
CN107098844B (zh) * 2017-05-17 2019-07-30 许昌学院 一种c-5位硝基取代的酰基吲哚啉类化合物的合成方法
CN112010808B (zh) * 2019-05-31 2021-11-30 上海挚盟医药科技有限公司 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用
CN114539120A (zh) * 2022-03-09 2022-05-27 台州学院 一种吲哚类钾离子通道激动剂的制备方法

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Also Published As

Publication number Publication date
US7786146B2 (en) 2010-08-31
AU2008286919B2 (en) 2014-05-29
CA2696012A1 (en) 2009-02-19
SG183725A1 (en) 2012-09-27
JP2010536771A (ja) 2010-12-02
ES2531335T3 (es) 2015-03-13
US8211918B2 (en) 2012-07-03
US20090137635A1 (en) 2009-05-28
CA2696012C (en) 2017-10-31
PL2190534T3 (pl) 2015-11-30
RU2483060C2 (ru) 2013-05-27
EP2190534A1 (en) 2010-06-02
AU2008286919A1 (en) 2009-02-19
US20110118318A1 (en) 2011-05-19
EP2190534B1 (en) 2015-02-18
KR20100075436A (ko) 2010-07-02
HUE025928T2 (en) 2016-05-30
BRPI0815210A2 (pt) 2015-03-31
RU2010109388A (ru) 2011-09-20
WO2009023677A1 (en) 2009-02-19
CN101795727A (zh) 2010-08-04
TW200927096A (en) 2009-07-01

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