WO2010014739A3 - Heterocyclic modulators of tgr5 - Google Patents

Heterocyclic modulators of tgr5 Download PDF

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Publication number
WO2010014739A3
WO2010014739A3 PCT/US2009/052142 US2009052142W WO2010014739A3 WO 2010014739 A3 WO2010014739 A3 WO 2010014739A3 US 2009052142 W US2009052142 W US 2009052142W WO 2010014739 A3 WO2010014739 A3 WO 2010014739A3
Authority
WO
WIPO (PCT)
Prior art keywords
tgr5
heterocyclic modulators
modulators
heterocyclic
cardiovascular
Prior art date
Application number
PCT/US2009/052142
Other languages
French (fr)
Other versions
WO2010014739A2 (en
Inventor
Nicholas D. Smith
Joseph E. Payne
Timothy Z. Hoffman
Original Assignee
Kalypsys, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kalypsys, Inc. filed Critical Kalypsys, Inc.
Publication of WO2010014739A2 publication Critical patent/WO2010014739A2/en
Publication of WO2010014739A3 publication Critical patent/WO2010014739A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed herein are compounds useful as modulators of TGR5 and methods for the treatment or prevention of metabolic, cardiovascular, and inflammatory diseases.
PCT/US2009/052142 2008-07-29 2009-07-29 Heterocyclic modulators of tgr5 WO2010014739A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8456508P 2008-07-29 2008-07-29
US61/084,565 2008-07-29

Publications (2)

Publication Number Publication Date
WO2010014739A2 WO2010014739A2 (en) 2010-02-04
WO2010014739A3 true WO2010014739A3 (en) 2010-05-14

Family

ID=41610946

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/052142 WO2010014739A2 (en) 2008-07-29 2009-07-29 Heterocyclic modulators of tgr5

Country Status (1)

Country Link
WO (1) WO2010014739A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013102929A1 (en) 2011-12-26 2013-07-11 Cadila Healthcare Limited Novel compounds for treatment of diabetes, obesity or related disorders
DK3119397T3 (en) 2014-03-19 2022-03-28 Infinity Pharmaceuticals Inc Heterocyclic compounds for use in the treatment of PI3K-gamma-mediated disorders
KR20180058741A (en) 2015-09-14 2018-06-01 인피니티 파마슈티칼스, 인코포레이티드 Solid form of isoquinolines, a process for their preparation, compositions comprising them and methods for using them
IL291985A (en) 2019-10-07 2022-06-01 Kallyope Inc Gpr119 agonists
MX2022014505A (en) 2020-05-19 2022-12-13 Kallyope Inc Ampk activators.
EP4172162A1 (en) 2020-06-26 2023-05-03 Kallyope, Inc. Ampk activators

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4207324A (en) * 1978-05-15 1980-06-10 Takeda Chemical Industries, Ltd. 1,2-Di-Substituted-4-haloimidazole-5-acetic acid derivatives and their use
EP0434038A1 (en) * 1989-12-22 1991-06-26 Takeda Chemical Industries, Ltd. Fused imidazole derivatives, their production and use
EP0537937A2 (en) * 1991-10-07 1993-04-21 Merck & Co. Inc. Substituted pyrazino 2,3-D pyrimidinones as angiotensin II antagonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4207324A (en) * 1978-05-15 1980-06-10 Takeda Chemical Industries, Ltd. 1,2-Di-Substituted-4-haloimidazole-5-acetic acid derivatives and their use
EP0434038A1 (en) * 1989-12-22 1991-06-26 Takeda Chemical Industries, Ltd. Fused imidazole derivatives, their production and use
EP0537937A2 (en) * 1991-10-07 1993-04-21 Merck & Co. Inc. Substituted pyrazino 2,3-D pyrimidinones as angiotensin II antagonists

Also Published As

Publication number Publication date
WO2010014739A2 (en) 2010-02-04

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