WO2007095256A3 - Methods of promoting cardiac cell proliferation - Google Patents

Methods of promoting cardiac cell proliferation Download PDF

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Publication number
WO2007095256A3
WO2007095256A3 PCT/US2007/003842 US2007003842W WO2007095256A3 WO 2007095256 A3 WO2007095256 A3 WO 2007095256A3 US 2007003842 W US2007003842 W US 2007003842W WO 2007095256 A3 WO2007095256 A3 WO 2007095256A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
cell proliferation
cardiac cell
promoting cardiac
promoting
Prior art date
Application number
PCT/US2007/003842
Other languages
French (fr)
Other versions
WO2007095256A2 (en
Inventor
C M Amy Chen
Lisa-Anne Whittemore
Original Assignee
Hydra Biosciences Inc
C M Amy Chen
Lisa-Anne Whittemore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hydra Biosciences Inc, C M Amy Chen, Lisa-Anne Whittemore filed Critical Hydra Biosciences Inc
Publication of WO2007095256A2 publication Critical patent/WO2007095256A2/en
Publication of WO2007095256A3 publication Critical patent/WO2007095256A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

Abstract

The present invention provides compositions and methods for promoting cardiac cell proliferation.
PCT/US2007/003842 2006-02-10 2007-02-12 Methods of promoting cardiac cell proliferation WO2007095256A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77201906P 2006-02-10 2006-02-10
US60/772,019 2006-02-10

Publications (2)

Publication Number Publication Date
WO2007095256A2 WO2007095256A2 (en) 2007-08-23
WO2007095256A3 true WO2007095256A3 (en) 2007-10-11

Family

ID=38267645

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/003842 WO2007095256A2 (en) 2006-02-10 2007-02-12 Methods of promoting cardiac cell proliferation

Country Status (1)

Country Link
WO (1) WO2007095256A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018232352A1 (en) * 2017-06-16 2018-12-20 The Regents Of The University Of California In utero prevention of congenital heart disease by metabolic intervention

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005118782A2 (en) * 2004-04-16 2005-12-15 Hydra Biosciences, Inc. Methods of promoting cardiac cell proliferation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005118782A2 (en) * 2004-04-16 2005-12-15 Hydra Biosciences, Inc. Methods of promoting cardiac cell proliferation

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BARILLAS RODRIGO ET AL: "Improved tolerance to ischemia in hypertrophied hearts by inhibition of glycogen synthase kinase-3", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 110, no. 17 Suppl S, 7 November 2004 (2004-11-07), pages 357, XP009087342, ISSN: 0009-7322 *
ENGEL F B ET AL: "p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, PLAINVIEW, NY, US, vol. 19, 3 May 2005 (2005-05-03), pages 1175 - 1187, XP003009395, ISSN: 0890-9369 *
KERKELA RISTO ET AL: "Glycogen synthase kinase 3-beta regulates cardiomyocyte proliferation duringcardiac development", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 114, no. 18 Suppl S, 12 November 2006 (2006-11-12), pages 195, XP009087358, ISSN: 0009-7322 *
MEIJER LAURENT ET AL: "GSK-3-selective inhibitors derived from Tyrian purple indirubins.", CHEMISTRY & BIOLOGY DEC 2003, vol. 10, no. 12, December 2003 (2003-12-01), pages 1255 - 1266, XP002444147, ISSN: 1074-5521 *
PRUNIER CÉLINE ET AL: "Wnt signaling: physiology and pathology", GROWTH FACTORS, HARWOOD ACADEMIC PUBLISHERS GMBH, XX, vol. 22, no. 3, September 2004 (2004-09-01), pages 141 - 150, XP009087390, ISSN: 0897-7194 *
RING DAVID B ET AL: "Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo", DIABETES, NEW YORK, NY, US, vol. 52, no. 3, March 2003 (2003-03-01), pages 588 - 595, XP002305100, ISSN: 0012-1797 *
SATO N ET AL: "MAINTENANCE OF PLURIPOTENCY IN HUMAN AND MOUSE EMBRYONIC STEM CELLS THROUGH ACTIVATION OF WNT SIGNALING BY A PHARMACOLOGICAL GSK-3-SPECIFIC INHIBITOR", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 10, no. 1, 21 December 2003 (2003-12-21), pages 55 - 63, XP002380572, ISSN: 1078-8956 *
TAMAMORI-ADACHI MIMI ET AL: "Critical role of cyclin D1 nuclear import in cardiomyocyte proliferation.", CIRCULATION RESEARCH 10 JAN 2003, vol. 92, no. 1, 10 January 2003 (2003-01-10), pages e12 - e19, XP002444836, ISSN: 1524-4571 *
TATEISHI ET AL: "Human cardiac stem cells exhibit mesenchymal features and are maintained through Akt/GSK-3beta signaling", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 352, no. 3, 12 December 2006 (2006-12-12), pages 635 - 641, XP005725086, ISSN: 0006-291X *
TSENG ET AL: "The GSK-3 Inhibitor BIO Promotes Proliferation in Mammalian Cardiomyocytes", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 13, no. 9, September 2006 (2006-09-01), pages 957 - 963, XP005657324, ISSN: 1074-5521 *

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Publication number Publication date
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