WO2009111676A3 - Boron-containing small molecules as anti-inflammatory agents - Google Patents
Boron-containing small molecules as anti-inflammatory agents Download PDFInfo
- Publication number
- WO2009111676A3 WO2009111676A3 PCT/US2009/036250 US2009036250W WO2009111676A3 WO 2009111676 A3 WO2009111676 A3 WO 2009111676A3 US 2009036250 W US2009036250 W US 2009036250W WO 2009111676 A3 WO2009111676 A3 WO 2009111676A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- boron
- small molecules
- inflammatory agents
- containing small
- inflammatory
- Prior art date
Links
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 title 1
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 229910052796 boron Inorganic materials 0.000 title 1
- 150000003384 small molecules Chemical class 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2010140803/04A RU2547441C2 (en) | 2008-03-06 | 2009-03-05 | Boron-containing small molecules as anti-inflammatory agents |
JP2010549900A JP5745279B2 (en) | 2008-01-09 | 2009-03-05 | Boron-containing small molecules as anti-inflammatory agents |
KR1020107022132A KR101672511B1 (en) | 2008-03-06 | 2009-03-05 | Boron-containing small molecules as anti-inflammatory agents |
AU2009221793A AU2009221793B2 (en) | 2008-03-06 | 2009-03-05 | Boron-containing small molecules as anti-inflammatory agents |
BRPI0908565A BRPI0908565A2 (en) | 2008-03-06 | 2009-03-05 | compound, pharmaceutical formulation, methods for reducing the release of a cytokine or chemokine, treating a condition in an animal and inhibiting a phosphodiesterase |
NZ58795509A NZ587955A (en) | 2008-03-06 | 2009-03-05 | Boron-containing small molecules as anti-inflammatory agents |
CA 2718170 CA2718170A1 (en) | 2008-03-06 | 2009-03-05 | Boron-containing small molecules as anti-inflammatory agents |
KR1020157014083A KR20150065941A (en) | 2008-03-06 | 2009-03-05 | Boron-containing small molecules as anti-inflammatory agents |
MX2010009765A MX2010009765A (en) | 2008-03-06 | 2009-03-05 | Boron-containing small molecules as anti-inflammatory agents. |
EP09700012A EP2187893A4 (en) | 2008-03-06 | 2009-03-05 | Boron-containing small molecules as anti-inflammatory agents |
CN2009801162797A CN102014927A (en) | 2008-03-06 | 2009-03-05 | Boron-containing small molecules as anti-inflammatory agents |
IL207955A IL207955A (en) | 2008-03-06 | 2010-09-02 | Boron-containing small molecules as anti-inflammatory agents |
Applications Claiming Priority (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3437108P | 2008-03-06 | 2008-03-06 | |
US61/034,371 | 2008-03-06 | ||
US5263708P | 2008-05-12 | 2008-05-12 | |
US61/052,637 | 2008-05-12 | ||
US9440608P | 2008-09-04 | 2008-09-04 | |
US61/094,406 | 2008-09-04 | ||
US10599008P | 2008-10-16 | 2008-10-16 | |
US61/105,990 | 2008-10-16 | ||
US11090308P | 2008-11-03 | 2008-11-03 | |
US61/110,903 | 2008-11-03 | ||
US14370009P | 2009-01-09 | 2009-01-09 | |
US61/143,700 | 2009-01-09 | ||
US14873109P | 2009-01-30 | 2009-01-30 | |
US61/148,731 | 2009-01-30 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2009111676A2 WO2009111676A2 (en) | 2009-09-11 |
WO2009111676A3 true WO2009111676A3 (en) | 2010-04-01 |
WO2009111676A8 WO2009111676A8 (en) | 2010-09-30 |
Family
ID=41056660
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/036250 WO2009111676A2 (en) | 2008-01-09 | 2009-03-05 | Boron-containing small molecules as anti-inflammatory agents |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP2187893A4 (en) |
WO (1) | WO2009111676A2 (en) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ560448A (en) | 2005-02-16 | 2009-08-28 | Anacor Pharmaceuticals Inc | Boron-containing small molecules |
CN106008571A (en) | 2005-12-30 | 2016-10-12 | 安纳考尔医药公司 | Boron-containing small molecules |
SI2719388T1 (en) | 2006-02-16 | 2019-06-28 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-inflammatory agents |
US8039450B2 (en) | 2008-03-06 | 2011-10-18 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-inflammatory agents |
WO2010027975A1 (en) | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
WO2010028005A1 (en) | 2008-09-04 | 2010-03-11 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
US9493489B2 (en) | 2008-10-15 | 2016-11-15 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agents |
EA201190034A1 (en) | 2008-12-17 | 2012-02-28 | Анакор Фармасьютикалс, Инк. | (S) -3-Aminomethyl-7- (3-dihydroxypropoxy) -3 H -benzo [c] [1,2] oxaborol-1- |
EP2458995A1 (en) | 2009-07-28 | 2012-06-06 | Anacor Pharmaceuticals, Inc. | Trisubstituted boron-containing molecules |
WO2011019618A1 (en) | 2009-08-14 | 2011-02-17 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
MX2012002031A (en) | 2009-08-19 | 2012-07-04 | Anacor Pharmaceuticals Inc | Boron-containing small molecules as antiprotozoal agents. |
US9346834B2 (en) | 2009-10-20 | 2016-05-24 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antiprotozoal agents |
WO2011060196A1 (en) | 2009-11-11 | 2011-05-19 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
WO2011063293A1 (en) * | 2009-11-20 | 2011-05-26 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as antihelminth agents |
WO2011094450A1 (en) * | 2010-01-27 | 2011-08-04 | Anacor Pharmaceuticals, Inc | Boron-containing small molecules |
WO2011116348A1 (en) | 2010-03-19 | 2011-09-22 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules as anti-protozoal agent |
ES2898695T3 (en) | 2010-09-07 | 2022-03-08 | Anacor Pharmaceuticals Inc | Benzoxaborole derivatives for the treatment of bacterial infections |
ME02588B (en) | 2011-08-19 | 2017-06-20 | Glaxo Group Ltd | Benzofuran compounds for the treatment of hepatitis c virus infections |
US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
US8669207B1 (en) | 2013-01-30 | 2014-03-11 | Dow Agrosciences, Llc. | Compounds and compositions |
US9585396B2 (en) | 2013-01-30 | 2017-03-07 | Agrofresh Inc. | Volatile applications against pathogens |
PL2950644T3 (en) | 2013-01-30 | 2017-10-31 | Agrofresh Inc | Use of benzoxaboroles as volatile antimicrobial agents on meats, plants, or plant parts |
US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
EP3164404B1 (en) | 2014-07-01 | 2019-04-03 | Daiichi Sankyo Company, Limited | Tricyclic benzoxaboroles as antibacterial agents |
WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
PT3383363T (en) | 2015-11-30 | 2021-03-03 | Anacor Pharmaceuticals Inc | Topical pharmaceutical formulations for treating inflammatory-related conditions |
CA3015662A1 (en) | 2016-03-07 | 2017-09-14 | Agrofresh Inc. | Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops |
US11447506B2 (en) | 2016-05-09 | 2022-09-20 | Anacor Pharmaceuticals, Inc. | Crystal forms of crisaborole in free form and preparation method and use thereof |
WO2017203514A1 (en) * | 2016-05-26 | 2017-11-30 | Perrigo Api Ltd | Polymorphs of crisaborole and production processes therefor |
EP3609504A4 (en) | 2017-03-01 | 2021-03-03 | Anacor Pharmaceuticals, Inc. | Novel oxaborole analogs and uses thereof |
WO2018207216A1 (en) * | 2017-05-12 | 2018-11-15 | Biophore India Pharmaceuticals Pvt. Ltd. | Novel process for the preparation of 4-[(1-hydroxy-1,3-dihydro-2,1-benzoxaborol-5-yl) oxy] benzonitrile (crisaborole) |
US10865217B2 (en) | 2017-05-23 | 2020-12-15 | Msn Laboratories Private Limited, R & D Center | Process for the preparation of 5-(4-cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole and polymorphs thereof |
US11834466B2 (en) | 2017-11-30 | 2023-12-05 | 5Metis, Inc. | Benzoxaborole compounds and formulations thereof |
CA3148168A1 (en) | 2018-08-18 | 2020-02-27 | Chun Yu Liu | Solid forms of substituted benzoxaborole and compositions thereof |
BR112021005870B1 (en) | 2018-10-05 | 2024-01-09 | Pfizer Inc | PDE4 INHIBITORS CONTAINING BORON |
US20220185815A1 (en) | 2019-03-06 | 2022-06-16 | Daiichi Sankyo Company, Limited | Pyrrolopyrazole derivative |
CN112174989B (en) * | 2019-07-02 | 2023-06-20 | 江西同和药业股份有限公司 | Preparation method of clenbuterol |
EP4204012A1 (en) | 2020-08-31 | 2023-07-05 | Pfizer Inc. | Methods of protecting rna |
WO2024038089A1 (en) * | 2022-08-18 | 2024-02-22 | Mitodicure Gmbh | Use of a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance |
CN116239498B (en) * | 2023-05-11 | 2023-07-21 | 北京元延医药科技股份有限公司 | Method for preparing clenbuterol intermediate |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6800845B2 (en) * | 2000-02-22 | 2004-10-05 | Ricoh Company, Ltd. | Multi-beam scanning device, multi-beam scanning method, light source device, and image forming apparatus |
US20060222671A1 (en) * | 2005-03-30 | 2006-10-05 | Astion Development A/S | Dermatological compositions and salts for the treatment of dermatological diseases |
US20070293457A1 (en) * | 2006-02-16 | 2007-12-20 | Baker Stephen J | Boron-containing small molecules as anti-inflammatory agents |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ560448A (en) * | 2005-02-16 | 2009-08-28 | Anacor Pharmaceuticals Inc | Boron-containing small molecules |
-
2009
- 2009-03-05 WO PCT/US2009/036250 patent/WO2009111676A2/en active Application Filing
- 2009-03-05 EP EP09700012A patent/EP2187893A4/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6800845B2 (en) * | 2000-02-22 | 2004-10-05 | Ricoh Company, Ltd. | Multi-beam scanning device, multi-beam scanning method, light source device, and image forming apparatus |
US20060222671A1 (en) * | 2005-03-30 | 2006-10-05 | Astion Development A/S | Dermatological compositions and salts for the treatment of dermatological diseases |
US20070293457A1 (en) * | 2006-02-16 | 2007-12-20 | Baker Stephen J | Boron-containing small molecules as anti-inflammatory agents |
Non-Patent Citations (1)
Title |
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See also references of EP2187893A4 * |
Also Published As
Publication number | Publication date |
---|---|
WO2009111676A8 (en) | 2010-09-30 |
WO2009111676A2 (en) | 2009-09-11 |
EP2187893A2 (en) | 2010-05-26 |
EP2187893A4 (en) | 2012-02-22 |
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