SG176963A1 - Refolding proteins using a chemically controlled redox state - Google Patents

Refolding proteins using a chemically controlled redox state Download PDF

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Publication number
SG176963A1
SG176963A1 SG2011095411A SG2011095411A SG176963A1 SG 176963 A1 SG176963 A1 SG 176963A1 SG 2011095411 A SG2011095411 A SG 2011095411A SG 2011095411 A SG2011095411 A SG 2011095411A SG 176963 A1 SG176963 A1 SG 176963A1
Authority
SG
Singapore
Prior art keywords
protein
thiol
refold
buffer
pair
Prior art date
Application number
SG2011095411A
Other languages
English (en)
Inventor
Joseph Edward Shultz
Roger Hart
Iii Ronald Nixon Keener
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42710673&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG176963(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG176963A1 publication Critical patent/SG176963A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SG2011095411A 2009-06-22 2010-06-21 Refolding proteins using a chemically controlled redox state SG176963A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21925709P 2009-06-22 2009-06-22
PCT/US2010/039390 WO2011005488A1 (en) 2009-06-22 2010-06-21 Refolding proteins using a chemically controlled redox state

Publications (1)

Publication Number Publication Date
SG176963A1 true SG176963A1 (en) 2012-02-28

Family

ID=42710673

Family Applications (1)

Application Number Title Priority Date Filing Date
SG2011095411A SG176963A1 (en) 2009-06-22 2010-06-21 Refolding proteins using a chemically controlled redox state

Country Status (15)

Country Link
US (5) US8952138B2 (https=)
EP (2) EP3366692A1 (https=)
JP (2) JP5808323B2 (https=)
KR (1) KR101741859B1 (https=)
CN (1) CN102482321B (https=)
AU (1) AU2010270986B2 (https=)
BR (1) BRPI1011940B8 (https=)
CA (1) CA2765881C (https=)
CL (1) CL2011003278A1 (https=)
EA (1) EA020621B1 (https=)
IL (1) IL216954A (https=)
MX (1) MX2011013898A (https=)
SG (1) SG176963A1 (https=)
WO (1) WO2011005488A1 (https=)
ZA (1) ZA201200512B (https=)

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KR102579850B1 (ko) * 2016-07-22 2023-09-18 암젠 인크 Fc-함유 단백질의 정제 방법
CN108276470A (zh) * 2017-01-06 2018-07-13 深圳市新产业生物医学工程股份有限公司 细胞裂解液、提取胞内蛋白的方法、制备弓形虫抗原的方法和试剂盒
CN110494120B (zh) * 2017-04-10 2023-07-18 花王株式会社 去除角栓的方法
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ES3040791T3 (en) 2020-12-18 2025-11-05 Richter Gedeon Nyrt Methods for the purification of refolded fc-peptide fusion protein
CN115894604B (zh) * 2022-12-16 2024-01-23 康日百奥生物科技(苏州)有限公司 重组蛋白澄清纯化方法

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Also Published As

Publication number Publication date
US20100324269A1 (en) 2010-12-23
CA2765881C (en) 2016-08-02
KR20120052939A (ko) 2012-05-24
US20150329586A1 (en) 2015-11-19
EA201270015A1 (ru) 2012-05-30
BRPI1011940B8 (pt) 2021-08-03
ZA201200512B (en) 2012-11-28
IL216954A (en) 2016-09-29
WO2011005488A1 (en) 2011-01-13
AU2010270986A1 (en) 2012-01-19
US20170145049A1 (en) 2017-05-25
IL216954A0 (en) 2012-02-29
CA2765881A1 (en) 2011-01-13
JP6026608B2 (ja) 2016-11-16
CL2011003278A1 (es) 2012-11-09
US20190055281A1 (en) 2019-02-21
US12269843B2 (en) 2025-04-08
EP2445923B1 (en) 2018-09-05
BRPI1011940B1 (pt) 2021-07-20
US8952138B2 (en) 2015-02-10
KR101741859B1 (ko) 2017-06-15
JP2016028065A (ja) 2016-02-25
US9856287B2 (en) 2018-01-02
EP3366692A1 (en) 2018-08-29
CN102482321A (zh) 2012-05-30
EA020621B1 (ru) 2014-12-30
AU2010270986B2 (en) 2014-05-22
EP2445923A1 (en) 2012-05-02
BRPI1011940A2 (pt) 2016-11-22
JP5808323B2 (ja) 2015-11-10
JP2012530782A (ja) 2012-12-06
MX2011013898A (es) 2012-05-22
CN102482321B (zh) 2015-06-17
US20150315232A1 (en) 2015-11-05

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