CA2765881C - Refolding proteins using a chemically controlled redox state - Google Patents
Refolding proteins using a chemically controlled redox state Download PDFInfo
- Publication number
- CA2765881C CA2765881C CA2765881A CA2765881A CA2765881C CA 2765881 C CA2765881 C CA 2765881C CA 2765881 A CA2765881 A CA 2765881A CA 2765881 A CA2765881 A CA 2765881A CA 2765881 C CA2765881 C CA 2765881C
- Authority
- CA
- Canada
- Prior art keywords
- protein
- thiol
- refold
- pair
- buffer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21925709P | 2009-06-22 | 2009-06-22 | |
| US61/219,257 | 2009-06-22 | ||
| PCT/US2010/039390 WO2011005488A1 (en) | 2009-06-22 | 2010-06-21 | Refolding proteins using a chemically controlled redox state |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2765881A1 CA2765881A1 (en) | 2011-01-13 |
| CA2765881C true CA2765881C (en) | 2016-08-02 |
Family
ID=42710673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2765881A Active CA2765881C (en) | 2009-06-22 | 2010-06-21 | Refolding proteins using a chemically controlled redox state |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US8952138B2 (https=) |
| EP (2) | EP3366692A1 (https=) |
| JP (2) | JP5808323B2 (https=) |
| KR (1) | KR101741859B1 (https=) |
| CN (1) | CN102482321B (https=) |
| AU (1) | AU2010270986B2 (https=) |
| BR (1) | BRPI1011940B8 (https=) |
| CA (1) | CA2765881C (https=) |
| CL (1) | CL2011003278A1 (https=) |
| EA (1) | EA020621B1 (https=) |
| IL (1) | IL216954A (https=) |
| MX (1) | MX2011013898A (https=) |
| SG (1) | SG176963A1 (https=) |
| WO (1) | WO2011005488A1 (https=) |
| ZA (1) | ZA201200512B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3366692A1 (en) | 2009-06-22 | 2018-08-29 | Amgen, Inc | Refolding proteins using a chemically controlled redox state |
| AU2010266093B2 (en) | 2009-06-25 | 2013-06-27 | Amgen Inc. | Capture purification processes for proteins expressed in a non-mammalian system |
| EP2417982A1 (en) * | 2010-07-30 | 2012-02-15 | Ferring B.V. | Stabilization of gonadotropins |
| US20150376228A1 (en) * | 2013-02-22 | 2015-12-31 | Biogenomics Limited | Process for high efficiency refolding of recombinant proteins |
| WO2017019776A1 (en) * | 2015-07-27 | 2017-02-02 | Purdue Research Foundation | Tandem folding methods to improve protein folding yield |
| EP3344651B1 (en) | 2015-09-02 | 2022-03-02 | Merck Sharp & Dohme Corp. | A process for obtaining insulin with correctly formed disulfide bonds |
| KR102579850B1 (ko) * | 2016-07-22 | 2023-09-18 | 암젠 인크 | Fc-함유 단백질의 정제 방법 |
| CN108276470A (zh) * | 2017-01-06 | 2018-07-13 | 深圳市新产业生物医学工程股份有限公司 | 细胞裂解液、提取胞内蛋白的方法、制备弓形虫抗原的方法和试剂盒 |
| CN110494120B (zh) * | 2017-04-10 | 2023-07-18 | 花王株式会社 | 去除角栓的方法 |
| WO2019183334A1 (en) | 2018-03-21 | 2019-09-26 | Waters Technologies Corporation | Non-antibody high-affinity-based sample preparation, sorbents, devices and methods |
| EP4083058A3 (en) * | 2018-11-07 | 2023-01-11 | Applied Molecular Transport Inc. | Delivery constructs for transcytosis and related methods |
| ES3040791T3 (en) | 2020-12-18 | 2025-11-05 | Richter Gedeon Nyrt | Methods for the purification of refolded fc-peptide fusion protein |
| CN115894604B (zh) * | 2022-12-16 | 2024-01-23 | 康日百奥生物科技(苏州)有限公司 | 重组蛋白澄清纯化方法 |
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-
2010
- 2010-06-21 EP EP18167168.6A patent/EP3366692A1/en active Pending
- 2010-06-21 US US12/820,087 patent/US8952138B2/en active Active
- 2010-06-21 BR BRPI1011940A patent/BRPI1011940B8/pt active IP Right Grant
- 2010-06-21 KR KR1020127001716A patent/KR101741859B1/ko active Active
- 2010-06-21 AU AU2010270986A patent/AU2010270986B2/en active Active
- 2010-06-21 SG SG2011095411A patent/SG176963A1/en unknown
- 2010-06-21 CA CA2765881A patent/CA2765881C/en active Active
- 2010-06-21 WO PCT/US2010/039390 patent/WO2011005488A1/en not_active Ceased
- 2010-06-21 EP EP10747092.4A patent/EP2445923B1/en active Active
- 2010-06-21 CN CN201080028756.7A patent/CN102482321B/zh active Active
- 2010-06-21 MX MX2011013898A patent/MX2011013898A/es active IP Right Grant
- 2010-06-21 JP JP2012517634A patent/JP5808323B2/ja active Active
- 2010-06-21 EA EA201270015A patent/EA020621B1/ru not_active IP Right Cessation
-
2011
- 2011-12-13 IL IL216954A patent/IL216954A/en active IP Right Grant
- 2011-12-22 CL CL2011003278A patent/CL2011003278A1/es unknown
-
2012
- 2012-01-20 ZA ZA2012/00512A patent/ZA201200512B/en unknown
-
2015
- 2015-01-30 US US14/611,037 patent/US20150315232A1/en not_active Abandoned
- 2015-07-07 US US14/793,590 patent/US20150329586A1/en not_active Abandoned
- 2015-09-07 JP JP2015175422A patent/JP6026608B2/ja active Active
-
2017
- 2017-02-01 US US15/422,327 patent/US9856287B2/en active Active
-
2018
- 2018-02-06 US US15/889,559 patent/US12269843B2/en active Active
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