SG163620A1 - Crystalline forms of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5- trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide - Google Patents

Crystalline forms of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5- trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide

Info

Publication number
SG163620A1
SG163620A1 SG201005165-4A SG2010051654A SG163620A1 SG 163620 A1 SG163620 A1 SG 163620A1 SG 2010051654 A SG2010051654 A SG 2010051654A SG 163620 A1 SG163620 A1 SG 163620A1
Authority
SG
Singapore
Prior art keywords
methyl
ylamino
benzamide
imidazol
pyrimidin
Prior art date
Application number
SG201005165-4A
Other languages
English (en)
Inventor
Paul W Manley
Wen-Chung Shieh
Paul Allen Sutton
Piotr H Karpinski
Raeann Wu
Stephanie Monnier
Joerg Brozio
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37451227&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG163620(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SG163620A1 publication Critical patent/SG163620A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
SG201005165-4A 2005-07-20 2006-07-18 Crystalline forms of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5- trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide SG163620A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70140505P 2005-07-20 2005-07-20
US71621405P 2005-09-12 2005-09-12

Publications (1)

Publication Number Publication Date
SG163620A1 true SG163620A1 (en) 2010-08-30

Family

ID=37451227

Family Applications (1)

Application Number Title Priority Date Filing Date
SG201005165-4A SG163620A1 (en) 2005-07-20 2006-07-18 Crystalline forms of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5- trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide

Country Status (43)

Country Link
US (4) US8343984B2 (hr)
EP (5) EP2535337B1 (hr)
JP (3) JP5289948B2 (hr)
KR (3) KR101651288B1 (hr)
CN (2) CN103804356A (hr)
AR (1) AR054846A1 (hr)
AU (2) AU2006276204A1 (hr)
BR (1) BRPI0613615B1 (hr)
CA (1) CA2614334C (hr)
CR (1) CR9657A (hr)
CU (1) CU23916B1 (hr)
CY (2) CY1113076T1 (hr)
DK (2) DK1912973T3 (hr)
EA (2) EA013464B1 (hr)
EC (1) ECSP088119A (hr)
ES (3) ES2386974T3 (hr)
GE (1) GEP20115302B (hr)
GT (1) GT200600315A (hr)
HK (1) HK1116783A1 (hr)
HN (1) HN2008000311A (hr)
HR (2) HRP20120573T1 (hr)
HU (1) HUE031791T2 (hr)
IL (2) IL188189A0 (hr)
JO (1) JO3308B1 (hr)
LT (1) LT2284167T (hr)
MA (1) MA29626B1 (hr)
MX (1) MX2008000899A (hr)
MY (1) MY148554A (hr)
NI (1) NI200800017A (hr)
NO (1) NO341930B1 (hr)
NZ (1) NZ564409A (hr)
PE (1) PE20070214A1 (hr)
PH (1) PH12013501590A1 (hr)
PL (2) PL1912973T3 (hr)
PT (2) PT2284167T (hr)
RS (1) RS55929B2 (hr)
SG (1) SG163620A1 (hr)
SI (2) SI1912973T1 (hr)
SM (1) SMP200800011B (hr)
TN (1) TNSN08029A1 (hr)
TW (1) TWI406661B (hr)
UA (1) UA94234C2 (hr)
WO (1) WO2007015870A2 (hr)

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US20140288073A1 (en) 2011-10-28 2014-09-25 Novartis Ag Method of Treating Gastrointestinal Stromal Tumors
PE20141337A1 (es) 2011-11-14 2014-10-16 Novartis Ag Formulacion de liberacion inmediata de 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida
EP2626355B1 (en) * 2012-02-09 2016-02-03 Natco Pharma Limited Process for the preparation of nilotinib hydrochloride
GB2514285B (en) 2012-02-13 2018-07-18 Grindeks Jsc Intermediates for a novel process of preparing imatinib and related tyrosine kinase inhibitors
US9061028B2 (en) 2012-02-15 2015-06-23 Natco Pharma Limited Process for the preparation of Nilotinib
BR112015000349A2 (pt) 2012-07-11 2017-06-27 Novartis Ag método de tratamento de tumores estromais gastrointestinais
WO2014059518A1 (en) * 2012-10-15 2014-04-24 Apotex Technologies Inc. Solid forms of nilotinib hydrochloride
AU2013333953B2 (en) * 2012-10-19 2017-08-31 Basf Se Multicomponent crystalline system comprising nilotinib and selected co-crystal formers
SG11201505680RA (en) * 2013-02-21 2015-09-29 Pfizer Solid forms of a selective cdk4/6 inhibitor
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CA2912902A1 (en) 2013-04-24 2014-10-30 Dr. Reddy's Laboratories Limited Polymorphic forms of nilotinib hydrochloride
RU2551359C9 (ru) * 2013-11-28 2021-08-20 Общество с ограниченной ответственностью "Мамонт Фарм" Наноразмерная слабо закристаллизованная модификация 4-метил-N-[3-(4-метилимидазол-1-ил)-5-(трифторметил)фенил]-3-[(4-пиридин-3-илпиримидин-2-ил)амино]бензамида гидрохлорида моногидрата, способ ее получения и фармацевтическая композиция на ее основе
WO2015092624A1 (en) 2013-12-16 2015-06-25 Ranbaxy Laboratories Limited Nilotinib mono-oxalate and its crystalline form
EP3177610A4 (en) 2014-08-08 2018-01-10 Dr. Reddy's Laboratories Ltd. Process for the preparation of polymorphic forms of nilotinib
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WO2017129694A1 (en) 2016-01-26 2017-08-03 Farma Grs, D.O.O. Nilotinib dinitrate (v) and crystalline forms thereof
WO2017149550A1 (en) * 2016-03-02 2017-09-08 Msn Laboratories Private Limited Amorphous form of 4-methyl-n-[3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-benzamide
PT3430004T (pt) 2016-03-14 2020-08-21 Pliva Hrvatska D O O Formas em estado sólido de sais de nilotinib
CN106496193A (zh) * 2016-09-13 2017-03-15 福格森（武汉）生物科技股份有限公司 一种高纯度尼罗替尼的制备方法
EP3404025B1 (en) * 2017-05-16 2019-12-04 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of pure nilotinib and its salt
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TWI815137B (zh) 2018-06-15 2023-09-11 漢達生技醫藥股份有限公司 尼洛替尼十二烷基硫酸鹽之結晶
JP2020007240A (ja) * 2018-07-04 2020-01-16 住友化学株式会社 ベンズアミド化合物の製造方法
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Also Published As

Publication number Publication date
EP2284167B1 (en) 2017-02-01
DK2284167T3 (en) 2017-05-01
ES2623608T5 (es) 2020-06-18
EP2284167A2 (en) 2011-02-16
PT2284167T (pt) 2017-05-15
JO3308B1 (ar) 2018-09-16
AR054846A1 (es) 2007-07-18
HUE031791T2 (en) 2017-08-28
EP2284167B2 (en) 2019-11-27
UA94234C2 (uk) 2011-04-26
HK1116783A1 (hr) 2009-01-02
CU23916B1 (es) 2013-07-31
NO20080820L (no) 2008-04-15
EP2535337A1 (en) 2012-12-19
IL188189A0 (en) 2008-03-20
ES2386974T3 (es) 2012-09-10
MY148554A (en) 2013-04-30
EA200800201A1 (ru) 2008-06-30
SMAP200800011A (it) 2008-02-27
SI2284167T1 (sl) 2017-05-31
CN102358736A (zh) 2012-02-22
EP1912973A2 (en) 2008-04-23
EP1912973B1 (en) 2012-06-13
WO2007015870A3 (en) 2007-06-07
ES2623608T3 (es) 2017-07-11
CU20080006A7 (es) 2011-02-24
MA29626B1 (fr) 2008-07-01
KR20130085444A (ko) 2013-07-29
CY1119624T1 (el) 2018-04-04
DK1912973T3 (da) 2012-07-23
BRPI0613615A2 (pt) 2011-01-18
US20130165465A1 (en) 2013-06-27
PL1912973T3 (pl) 2012-09-28
KR20080027853A (ko) 2008-03-28
US20080269269A1 (en) 2008-10-30
JP2014221831A (ja) 2014-11-27
EP2284168A3 (en) 2011-04-13
TNSN08029A1 (en) 2009-07-14
TWI406661B (zh) 2013-09-01
EA013464B1 (ru) 2010-04-30
HRP20120573T1 (hr) 2012-08-31
JP2013018789A (ja) 2013-01-31
ECSP088119A (es) 2008-02-20
DK2284167T4 (da) 2020-03-02
CA2614334C (en) 2015-04-21
CN103804356A (zh) 2014-05-21
KR20130077915A (ko) 2013-07-09
CY1113076T1 (el) 2016-04-13
EA201000145A1 (ru) 2010-06-30
SMP200800011B (it) 2008-02-27
PL2284167T3 (pl) 2017-07-31
EP2284168A2 (en) 2011-02-16
GEP20115302B (en) 2011-10-10
MX2008000899A (es) 2008-03-18
RS55929B1 (sr) 2017-09-29
PE20070214A1 (es) 2007-04-02
WO2007015870A2 (en) 2007-02-08
PT1912973E (pt) 2012-09-03
HN2008000311A (es) 2011-01-24
TW200740793A (en) 2007-11-01
EP2543665A2 (en) 2013-01-09
CA2614334A1 (en) 2007-02-08
JP2009502795A (ja) 2009-01-29
LT2284167T (lt) 2017-04-25
EP2535337B1 (en) 2017-08-23
GT200600315A (es) 2007-03-19
EP2284167A3 (en) 2011-03-02
SI1912973T1 (sl) 2012-08-31
EA016856B1 (ru) 2012-08-30
JP5798101B2 (ja) 2015-10-21
NI200800017A (es) 2009-03-03
IL214659A0 (en) 2011-09-27
KR101651288B1 (ko) 2016-08-25
US8415363B2 (en) 2013-04-09
NZ564409A (en) 2011-07-29
JP5289948B2 (ja) 2013-09-11
PL2284167T5 (pl) 2020-07-27
BRPI0613615B1 (pt) 2022-02-08
EP2543665A3 (en) 2013-05-29
US20140343087A1 (en) 2014-11-20
NO341930B1 (no) 2018-02-19
US20130023548A1 (en) 2013-01-24
HRP20170634T4 (hr) 2020-02-07
AU2011202047A1 (en) 2011-05-26
PH12013501590A1 (en) 2015-09-21
ES2648288T3 (es) 2017-12-29
US8829015B2 (en) 2014-09-09
CR9657A (es) 2008-04-16
AU2006276204A1 (en) 2007-02-08
SI2284167T2 (sl) 2020-03-31
RS55929B2 (sr) 2020-12-31
US8343984B2 (en) 2013-01-01
HRP20170634T1 (hr) 2017-06-30

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