SG162732A1 - Phenoxypropylpiperidines and -pyrrolidines and their use as histamine h3 - receptor ligands - Google Patents

Phenoxypropylpiperidines and -pyrrolidines and their use as histamine h3 - receptor ligands

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Publication number
SG162732A1
SG162732A1 SG201003753-9A SG2010037539A SG162732A1 SG 162732 A1 SG162732 A1 SG 162732A1 SG 2010037539 A SG2010037539 A SG 2010037539A SG 162732 A1 SG162732 A1 SG 162732A1
Authority
SG
Singapore
Prior art keywords
phenoxypropylpiperidines
pyrrolidines
histamine
receptor ligands
alzheimer
Prior art date
Application number
SG201003753-9A
Other languages
English (en)
Inventor
Isabelle Bertrand
Marc Capet
Jeanne-Marie Lecomte
Nicolas Levoin
Xavier Ligneau
Olivia Poupardin-Olivier
Philippe Robert
Jean-Charles Schwartz
Olivier Labeeuw
Original Assignee
Bioprojet Soc Civ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05290950A external-priority patent/EP1717234A1/en
Application filed by Bioprojet Soc Civ filed Critical Bioprojet Soc Civ
Publication of SG162732A1 publication Critical patent/SG162732A1/en

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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PL1874746T3 (pl) 2016-06-30
NO20075624L (no) 2007-11-28
HUE026549T2 (hu) 2016-06-28
SI1874746T1 (sl) 2016-03-31
CN101258138B (zh) 2013-06-12
DK1874746T3 (en) 2016-02-15
EA200702363A1 (ru) 2008-04-28
CA2606262A1 (en) 2006-11-09
EA019594B1 (ru) 2014-04-30
NZ562873A (en) 2011-03-31
BRPI0612957B8 (pt) 2021-05-25
NO340728B1 (no) 2017-06-06
AU2006242950A1 (en) 2006-11-09
BRPI0612957A2 (pt) 2010-12-07
BRPI0612957B1 (pt) 2020-10-27
EP1717235A3 (en) 2007-02-28
AU2006242950B2 (en) 2013-01-10
PT1874746E (pt) 2016-03-22
CA2606262C (en) 2013-08-20
ES2563065T3 (es) 2016-03-10
WO2006117609A2 (en) 2006-11-09
MX2007013384A (es) 2008-01-21
US20090111808A1 (en) 2009-04-30
MA29399B1 (fr) 2008-04-01
JP5693814B2 (ja) 2015-04-01
TNSN07393A1 (fr) 2009-03-17
EP1717235A2 (en) 2006-11-02
CN101258138A (zh) 2008-09-03
KR20080005997A (ko) 2008-01-15
US8076329B2 (en) 2011-12-13
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