SG139553A1 - 7-substituted-hept-6-enoic and -heptanoic acids and derivatives thereof - Google Patents

7-substituted-hept-6-enoic and -heptanoic acids and derivatives thereof

Info

Publication number
SG139553A1
SG139553A1 SG200602066-3A SG200602066A SG139553A1 SG 139553 A1 SG139553 A1 SG 139553A1 SG 200602066 A SG200602066 A SG 200602066A SG 139553 A1 SG139553 A1 SG 139553A1
Authority
SG
Singapore
Prior art keywords
enoic
hept
derivatives
substituted
heptanoic acids
Prior art date
Application number
SG200602066-3A
Other languages
English (en)
Inventor
Kau Min Chen
Prasad Koteswara Kapa
George T Lee
Oljan Repic
Petr Hess
Michel Crevoisier
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26945992&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG139553(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SG139553A1 publication Critical patent/SG139553A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C223/00Compounds containing amino and —CHO groups bound to the same carbon skeleton
    • C07C223/02Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/42Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SG200602066-3A 1988-10-13 1989-10-11 7-substituted-hept-6-enoic and -heptanoic acids and derivatives thereof SG139553A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25747588A 1988-10-13 1988-10-13
US35553189A 1989-05-22 1989-05-22

Publications (1)

Publication Number Publication Date
SG139553A1 true SG139553A1 (en) 2008-02-29

Family

ID=26945992

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200602066-3A SG139553A1 (en) 1988-10-13 1989-10-11 7-substituted-hept-6-enoic and -heptanoic acids and derivatives thereof

Country Status (24)

Country Link
EP (2) EP0363934B1 (fi)
JP (1) JP2853227B2 (fi)
KR (1) KR0162656B1 (fi)
AT (1) ATE99281T1 (fi)
AU (1) AU636122B2 (fi)
BG (1) BG60555B1 (fi)
CA (1) CA2000553C (fi)
CZ (1) CZ283316B6 (fi)
DE (1) DE68911834T2 (fi)
DK (1) DK175073B1 (fi)
ES (1) ES2060712T3 (fi)
FI (1) FI98063C (fi)
HK (1) HK49496A (fi)
HU (1) HU207993B (fi)
IE (2) IE940109L (fi)
IL (1) IL91941A (fi)
MY (1) MY105067A (fi)
NO (1) NO174623C (fi)
NZ (1) NZ230973A (fi)
RO (1) RO109732B1 (fi)
SG (1) SG139553A1 (fi)
SK (1) SK280845B6 (fi)
WO (1) WO1990003962A1 (fi)
YU (1) YU48466B (fi)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118853A (en) * 1988-10-13 1992-06-02 Sandoz Ltd. Processes for the synthesis of 3-disubstituted aminoacroleins
US5290946A (en) * 1988-10-13 1994-03-01 Sandoz Ltd. Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes
CA2027179A1 (en) * 1989-10-10 1991-04-11 Barry C. Ross Chemical compounds
DE4424525A1 (de) * 1994-07-12 1995-01-26 Elmar Meyer Dauermagnet-Kolbenmotor
GT199800127A (es) 1997-08-29 2000-02-01 Combinaciones terapeuticas.
DE60022525T2 (de) 1999-08-30 2006-06-14 Sanofi Aventis Deutschland Ramipril zur vorbeugung von kardiovaskulären vorfällen
US6743926B2 (en) 2000-05-26 2004-06-01 Ciba Specialty Chemicals Corporation Process for the preparation of indole derivatives and intermediates of the process
US7777006B2 (en) 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
JPWO2004094377A1 (ja) * 2003-04-24 2006-07-13 ダイセル化学工業株式会社 光学活性なジヒドロキシヘプテン酸エステルの分離方法
KR20070092993A (ko) 2003-06-18 2007-09-14 테바 파마슈티컬 인더스트리즈 리미티드 플루바스타틴 나트륨 결정형 xiv, lxxiii,lxxix, lxxx 및 lxxxvii, 이의 제조 방법,이를 포함하는 조성물 및 이를 사용하는 방법
US7368468B2 (en) 2003-06-18 2008-05-06 Teva Pharmaceutical Industries Ltd. Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them
US7368581B2 (en) 2003-06-18 2008-05-06 Teva Pharmaceutical Industries Ltd. Process for the preparation of fluvastatin sodium crystal from XIV
WO2005053683A1 (en) 2003-11-26 2005-06-16 Duke University A method of preventing or treating glaucoma
US7851624B2 (en) 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
US20060211752A1 (en) 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
ES2327668T3 (es) 2006-04-20 2009-11-02 F.I.S. Fabbrica Italiana Sintetici S.P.A. Procedimiento para la preparacion de sal sodica de fluvastatina.
WO2010069593A1 (en) 2008-12-19 2010-06-24 Krka, D. D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
WO2013113067A1 (en) 2012-02-02 2013-08-08 The University Of Sydney Improvements in tear film stability
JP2016516804A (ja) 2013-04-17 2016-06-09 ファイザー・インク 心血管疾患を治療するためのn−ピペリジン−3−イルベンズアミド誘導体
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
JOP20210193A1 (ar) 2019-01-18 2023-01-30 Astrazeneca Ab مثبطات pcsk9 وطرق استخدامها

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB945536A (en) * 1961-09-08 1964-01-02 Istituto Chemioterapico Method of preparing ª -amino-acroleins
US4739073A (en) * 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
AU570021B2 (en) * 1982-11-22 1988-03-03 Novartis Ag Analogs of mevalolactone
US4571428A (en) * 1983-07-08 1986-02-18 Sandoz, Inc. 6-Substituted-4-hydroxy-tetrahydropyran-2-ones
US4650890A (en) * 1984-04-03 1987-03-17 Sandoz Corp. Preparation of olefinic compounds and intermediates thereof
WO1986000307A2 (en) * 1984-06-22 1986-01-16 Sandoz Ag Pyrazole analogs of mevalonolactone and derivatives thereof, processes for their production and their use
KR910003427B1 (ko) * 1984-12-04 1991-05-31 산도즈 파마슈티칼스 코포레이션 메발로노락톤의 인덴동족체 및 이들의 유도체의 제법
US4668794A (en) * 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs
EP0244364A3 (en) * 1986-04-30 1992-04-01 Sandoz Ag Preparation of olefinic compounds
PT85662B (pt) * 1986-09-10 1990-06-29 Sandoz Sa Processo para a preparacao de derivados de aza-indol e de indolizina e de composicoes farmaceuticas que os contem

Also Published As

Publication number Publication date
YU197389A (en) 1990-12-31
DK144690D0 (da) 1990-06-13
IE893277L (en) 1990-04-13
NZ230973A (en) 1993-03-26
CA2000553C (en) 2001-12-04
HU207993B (en) 1993-07-28
FI902935A0 (fi) 1990-06-12
EP0363934B1 (en) 1993-12-29
DE68911834D1 (de) 1994-02-10
MY105067A (en) 1994-07-30
IL91941A (en) 1994-10-21
YU48466B (sh) 1998-08-14
SK579789A3 (en) 2000-08-14
HU896048D0 (en) 1990-11-28
FI98063B (fi) 1996-12-31
EP0562643A2 (en) 1993-09-29
EP0562643A3 (en) 1994-05-18
CZ579789A3 (en) 1997-11-12
NO174623B (no) 1994-02-28
ES2060712T3 (es) 1994-12-01
DK175073B1 (da) 2004-05-24
AU4344889A (en) 1990-05-01
IE63477B1 (en) 1995-04-19
JPH03501735A (ja) 1991-04-18
IE940109L (en) 1990-04-13
JP2853227B2 (ja) 1999-02-03
HUT53860A (en) 1990-12-28
NO902598L (no) 1990-08-07
KR900701723A (ko) 1990-12-04
NO174623C (no) 1994-06-08
CA2000553A1 (en) 1990-04-13
ATE99281T1 (de) 1994-01-15
IL91941A0 (en) 1990-06-10
AU636122B2 (en) 1993-04-22
KR0162656B1 (ko) 1999-01-15
WO1990003962A1 (en) 1990-04-19
DK144690A (da) 1990-06-13
NO902598D0 (no) 1990-06-12
RO109732B1 (ro) 1995-05-30
HK49496A (en) 1996-03-29
CZ283316B6 (cs) 1998-02-18
DE68911834T2 (de) 1994-06-23
EP0363934A1 (en) 1990-04-18
SK280845B6 (sk) 2000-08-14
FI98063C (fi) 1997-04-10
BG60555B1 (en) 1995-08-28

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