SG11202112407PA - Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators - Google Patents
Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulatorsInfo
- Publication number
- SG11202112407PA SG11202112407PA SG11202112407PA SG11202112407PA SG11202112407PA SG 11202112407P A SG11202112407P A SG 11202112407PA SG 11202112407P A SG11202112407P A SG 11202112407PA SG 11202112407P A SG11202112407P A SG 11202112407PA SG 11202112407P A SG11202112407P A SG 11202112407PA
- Authority
- SG
- Singapore
- Prior art keywords
- receptor modulators
- substituted pyrazolo
- pyridine amides
- glun2b receptor
- glun2b
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962861656P | 2019-06-14 | 2019-06-14 | |
PK35020 | 2020-06-03 | ||
ARP200101623A AR119125A1 (es) | 2019-06-14 | 2020-06-09 | Amidas de pirazolo-piridina sustituidas y su uso como moduladores del receptor glun2b |
PCT/EP2020/066392 WO2020249792A1 (fr) | 2019-06-14 | 2020-06-12 | Pyrazolo-pyridine amides substitués et leur utilisation en tant que modulateurs du récepteur glun2b |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202112407PA true SG11202112407PA (en) | 2021-12-30 |
Family
ID=73781829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202112407PA SG11202112407PA (en) | 2019-06-14 | 2020-06-12 | Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators |
Country Status (21)
Country | Link |
---|---|
US (2) | US11618750B2 (fr) |
EP (1) | EP3983075A1 (fr) |
JP (1) | JP2022536522A (fr) |
KR (1) | KR20220024511A (fr) |
CN (1) | CN113993868A (fr) |
AU (1) | AU2020290016A1 (fr) |
BR (1) | BR112021024856A2 (fr) |
CA (1) | CA3142996A1 (fr) |
CL (1) | CL2021003277A1 (fr) |
CO (1) | CO2021016003A2 (fr) |
CR (1) | CR20210580A (fr) |
DO (1) | DOP2021000251A (fr) |
EC (1) | ECSP21090478A (fr) |
IL (1) | IL288859A (fr) |
JO (1) | JOP20210328A1 (fr) |
MA (1) | MA56196A (fr) |
MX (1) | MX2021015506A (fr) |
PE (1) | PE20220386A1 (fr) |
SG (1) | SG11202112407PA (fr) |
TW (1) | TW202112774A (fr) |
WO (1) | WO2020249792A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201819376A (zh) | 2016-10-06 | 2018-06-01 | 比利時商健生藥品公司 | 經取代之1H-咪唑並[4,5-b]吡啶-2(3H)-酮及其作為GLUN2B受體調節劑之用途 |
CA3142996A1 (fr) | 2019-06-14 | 2020-12-17 | Janssen Pharmaceutica Nv | Pyrazolo-pyridine amides substitues et leur utilisation en tant que modulateurs du recepteur glun2b |
CN113993583A (zh) | 2019-06-14 | 2022-01-28 | 詹森药业有限公司 | 取代的吡唑并[4,3-b]吡啶及其作为GLUN2B受体调节剂的用途 |
MX2021015503A (es) | 2019-06-14 | 2022-04-20 | Janssen Pharmaceutica Nv | Pirazolo piridinas heteroaromáticas sustituidas y su uso como moduladores del receptor glun2b. |
KR20220020915A (ko) | 2019-06-14 | 2022-02-21 | 얀센 파마슈티카 엔.브이. | GluN2B 수용체 조절제로서의 피라진 카르바메이트 및 이들의 용도 |
JP2022538774A (ja) | 2019-06-14 | 2022-09-06 | ヤンセン ファーマシューティカ エヌ.ベー. | ピリジンカルバメート及びglun2b受容体調節因子としてのそれらの使用 |
CN114008052A (zh) | 2019-06-14 | 2022-02-01 | 詹森药业有限公司 | 取代的吡唑并-吡嗪以及它们作为GluN2B受体调节剂的用途 |
Family Cites Families (54)
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CA2262502C (fr) | 1996-07-31 | 2002-11-26 | Nikken Chemicals Co., Ltd. | Derives de 6-phenyltetrahydro-1,3-oxazine-2-one et compositions medicinales a base de ces composes |
WO2002000629A1 (fr) | 2000-06-26 | 2002-01-03 | Merck & Co., Inc. | Antagonistes des recepteurs nmda nr2b de l'iminopyrimidine |
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WO2003101968A1 (fr) | 2002-05-31 | 2003-12-11 | Eisai Co., Ltd. | Compose de pyrazole et composition medicinale le contenant |
EP1720860A1 (fr) | 2004-02-18 | 2006-11-15 | AstraZeneca AB | Composes de triazole et leur utilisation en tant qu'antagonistes du recepteur metabotrope du glutamate |
EP1805142A4 (fr) | 2004-09-23 | 2009-06-10 | Reddy Us Therapeutics Inc | Composes a base de pyridine, leur procede de preparation et compositions les contenant |
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ES2554375T3 (es) | 2008-11-25 | 2015-12-18 | University Of Rochester | Inhibidores de las MLK y métodos de uso |
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MA41803A (fr) | 2015-03-24 | 2018-01-30 | Almirall Sa | Dérivés amino-indazoles utilisés comme inhibiteurs des canaux sodiques |
MA42397B1 (fr) | 2015-07-09 | 2020-02-28 | Janssen Pharmaceutica Nv | 4-azaindoles substituées et leur utilisation comme modulatoeurs de la récepteur glun2b |
BR112018016329A2 (pt) | 2016-02-10 | 2018-12-18 | Janssen Pharmaceutica Nv | 1,2,3-triazóis substituídos como moduladores de nmda seletivos para nr2b |
TW201819376A (zh) | 2016-10-06 | 2018-06-01 | 比利時商健生藥品公司 | 經取代之1H-咪唑並[4,5-b]吡啶-2(3H)-酮及其作為GLUN2B受體調節劑之用途 |
JP7252908B2 (ja) | 2017-06-14 | 2023-04-05 | トレベナ・インコーポレイテッド | S1p1活性を調節するための化合物およびその使用法 |
US10766893B2 (en) | 2017-12-20 | 2020-09-08 | H. Lundbeck A/S | 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors |
JP7346441B2 (ja) | 2018-04-04 | 2023-09-19 | ヤンセン ファーマシューティカ エヌ.ベー. | 置換ピリジン及びピリミジン並びにglun2b受容体調節物質としてのそれらの使用 |
CN110294756A (zh) | 2019-06-04 | 2019-10-01 | 广州市原子高科同位素医药有限公司 | GluN2B亚基靶向型中枢神经系统正电子示踪剂及其制备 |
CN114008052A (zh) | 2019-06-14 | 2022-02-01 | 詹森药业有限公司 | 取代的吡唑并-吡嗪以及它们作为GluN2B受体调节剂的用途 |
CA3142996A1 (fr) | 2019-06-14 | 2020-12-17 | Janssen Pharmaceutica Nv | Pyrazolo-pyridine amides substitues et leur utilisation en tant que modulateurs du recepteur glun2b |
CN113993583A (zh) | 2019-06-14 | 2022-01-28 | 詹森药业有限公司 | 取代的吡唑并[4,3-b]吡啶及其作为GLUN2B受体调节剂的用途 |
MX2021015503A (es) | 2019-06-14 | 2022-04-20 | Janssen Pharmaceutica Nv | Pirazolo piridinas heteroaromáticas sustituidas y su uso como moduladores del receptor glun2b. |
JP2022538774A (ja) | 2019-06-14 | 2022-09-06 | ヤンセン ファーマシューティカ エヌ.ベー. | ピリジンカルバメート及びglun2b受容体調節因子としてのそれらの使用 |
KR20220020915A (ko) | 2019-06-14 | 2022-02-21 | 얀센 파마슈티카 엔.브이. | GluN2B 수용체 조절제로서의 피라진 카르바메이트 및 이들의 용도 |
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2020
- 2020-06-12 CA CA3142996A patent/CA3142996A1/fr active Pending
- 2020-06-12 BR BR112021024856A patent/BR112021024856A2/pt unknown
- 2020-06-12 KR KR1020227001089A patent/KR20220024511A/ko unknown
- 2020-06-12 MX MX2021015506A patent/MX2021015506A/es unknown
- 2020-06-12 AU AU2020290016A patent/AU2020290016A1/en active Pending
- 2020-06-12 PE PE2021001941A patent/PE20220386A1/es unknown
- 2020-06-12 EP EP20737362.2A patent/EP3983075A1/fr active Pending
- 2020-06-12 CN CN202080043675.8A patent/CN113993868A/zh active Pending
- 2020-06-12 MA MA056196A patent/MA56196A/fr unknown
- 2020-06-12 JP JP2021573898A patent/JP2022536522A/ja active Pending
- 2020-06-12 CR CR20210580A patent/CR20210580A/es unknown
- 2020-06-12 JO JOP/2021/0328A patent/JOP20210328A1/ar unknown
- 2020-06-12 WO PCT/EP2020/066392 patent/WO2020249792A1/fr unknown
- 2020-06-12 US US16/899,823 patent/US11618750B2/en active Active
- 2020-06-12 TW TW109119835A patent/TW202112774A/zh unknown
- 2020-06-12 SG SG11202112407PA patent/SG11202112407PA/en unknown
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2021
- 2021-11-26 CO CONC2021/0016003A patent/CO2021016003A2/es unknown
- 2021-12-02 DO DO2021000251A patent/DOP2021000251A/es unknown
- 2021-12-09 IL IL288859A patent/IL288859A/en unknown
- 2021-12-09 CL CL2021003277A patent/CL2021003277A1/es unknown
- 2021-12-14 EC ECSENADI202190478A patent/ECSP21090478A/es unknown
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2022
- 2022-10-14 US US17/966,696 patent/US20230151006A1/en active Pending
Also Published As
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MA56196A (fr) | 2022-04-20 |
WO2020249792A1 (fr) | 2020-12-17 |
US11618750B2 (en) | 2023-04-04 |
CA3142996A1 (fr) | 2020-12-17 |
JP2022536522A (ja) | 2022-08-17 |
IL288859A (en) | 2022-02-01 |
US20230151006A1 (en) | 2023-05-18 |
CO2021016003A2 (es) | 2021-12-10 |
ECSP21090478A (es) | 2022-01-31 |
PE20220386A1 (es) | 2022-03-18 |
US20210017168A1 (en) | 2021-01-21 |
CN113993868A (zh) | 2022-01-28 |
MX2021015506A (es) | 2022-02-10 |
BR112021024856A2 (pt) | 2022-01-18 |
DOP2021000251A (es) | 2022-04-18 |
CR20210580A (es) | 2022-01-31 |
KR20220024511A (ko) | 2022-03-03 |
CL2021003277A1 (es) | 2022-08-19 |
AU2020290016A1 (en) | 2022-01-06 |
JOP20210328A1 (ar) | 2023-01-30 |
TW202112774A (zh) | 2021-04-01 |
EP3983075A1 (fr) | 2022-04-20 |
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