MA42397B1 - 4-azaindoles substituées et leur utilisation comme modulatoeurs de la récepteur glun2b - Google Patents

4-azaindoles substituées et leur utilisation comme modulatoeurs de la récepteur glun2b

Info

Publication number
MA42397B1
MA42397B1 MA42397A MA42397A MA42397B1 MA 42397 B1 MA42397 B1 MA 42397B1 MA 42397 A MA42397 A MA 42397A MA 42397 A MA42397 A MA 42397A MA 42397 B1 MA42397 B1 MA 42397B1
Authority
MA
Morocco
Prior art keywords
azaindoles
substituted
modulators
receptor
glun2b receptor
Prior art date
Application number
MA42397A
Other languages
English (en)
Inventor
Akinola Soyode-Johnson
Christa C Chrovian
Michael A Letavic
Jason C Rech
Jessica L Wall
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MA42397B1 publication Critical patent/MA42397B1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des 4-azaindoles substitués utilisés en tant que ligands du récepteur de nr2b. De tels composés peuvent être utilisés dans la modulation de récepteurs de nr2b ainsi que dans des compositions pharmaceutiques et des méthodes pour le traitement d'états pathologiques, de troubles et d'affections médiés par l'activité du récepteur de nr2b.
MA42397A 2015-07-09 2016-07-07 4-azaindoles substituées et leur utilisation comme modulatoeurs de la récepteur glun2b MA42397B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562190416P 2015-07-09 2015-07-09
PCT/US2016/041339 WO2017007938A1 (fr) 2015-07-09 2016-07-07 4-azaindoles substitués et leur utilisation comme modulateurs du récepteur de glun2b
EP16741469.7A EP3319963B1 (fr) 2015-07-09 2016-07-07 4-azaindoles substituées et leur utilisation comme modulatoeurs de la récepteur glun2b

Publications (1)

Publication Number Publication Date
MA42397B1 true MA42397B1 (fr) 2020-02-28

Family

ID=56497884

Family Applications (1)

Application Number Title Priority Date Filing Date
MA42397A MA42397B1 (fr) 2015-07-09 2016-07-07 4-azaindoles substituées et leur utilisation comme modulatoeurs de la récepteur glun2b

Country Status (25)

Country Link
US (2) US9963447B2 (fr)
EP (1) EP3319963B1 (fr)
JP (2) JP6964576B2 (fr)
KR (1) KR20180026760A (fr)
CN (1) CN108026094B (fr)
AU (1) AU2016291158B2 (fr)
BR (1) BR112018000468A2 (fr)
CA (1) CA2991765C (fr)
CY (1) CY1123007T1 (fr)
DK (1) DK3319963T3 (fr)
EA (1) EA033197B1 (fr)
ES (1) ES2781867T3 (fr)
HK (1) HK1255160A1 (fr)
HR (1) HRP20200410T1 (fr)
HU (1) HUE047460T2 (fr)
IL (1) IL256758A (fr)
LT (1) LT3319963T (fr)
MA (1) MA42397B1 (fr)
MD (1) MD3319963T2 (fr)
MX (1) MX2018000352A (fr)
PL (1) PL3319963T3 (fr)
PT (1) PT3319963T (fr)
SI (1) SI3319963T1 (fr)
WO (1) WO2017007938A1 (fr)
ZA (1) ZA201800827B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10155727B2 (en) 2014-08-15 2018-12-18 Janssen Pharmaceuticals, Inc. Pyrazoles
EP3180329B1 (fr) 2014-08-15 2020-03-18 Janssen Pharmaceuticals, Inc. Derives de triazole comme des inhibiteurs de recepteur nr2b
WO2017007938A1 (fr) 2015-07-09 2017-01-12 Janssen Pharmaceutica Nv 4-azaindoles substitués et leur utilisation comme modulateurs du récepteur de glun2b
CN109071488B (zh) 2016-02-10 2021-08-13 詹森药业有限公司 取代的1,2,3-三唑作为nr2b-选择性nmda调节剂
TW201819376A (zh) 2016-10-06 2018-06-01 比利時商健生藥品公司 經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途
EP3774732A4 (fr) * 2018-04-04 2022-02-09 Janssen Pharmaceutica NV Pyridine et pyrimidines substituées et leur utilisation en tant que modulateurs du récepteur glun2b
AU2020293642A1 (en) * 2019-06-14 2022-01-20 Janssen Pharmaceutica Nv Substituted pyrazolo[4,3-b]pyridines and their use as GluN2B receptor modulators
PE20220386A1 (es) * 2019-06-14 2022-03-18 Janssen Pharmaceutica Nv Amidas de pirazolo-piridina sustituidas y su uso como moduladores del receptor glun2b
JOP20210330A1 (ar) 2019-06-14 2023-01-30 Janssen Pharmaceutica Nv مركبات بيرازولو-بيريدين عطرية غير متجانسة مستبدلة واستخدامها كمعدِّلات لمستقبل الغلوتومات "glun2b"
CN114007691A (zh) 2019-06-14 2022-02-01 詹森药业有限公司 吡啶氨基甲酸酯及其作为GluN2B受体调节剂的用途
MX2021015500A (es) * 2019-06-14 2022-02-10 Janssen Pharmaceutica Nv Pirazolo-pirazinas sustituidas y su uso como moduladores del receptor glun2b.
JP2022538795A (ja) 2019-06-14 2022-09-06 ヤンセン ファーマシューティカ エヌ．ベー． ピラジンカルバメート及びＧｌｕＮ２Ｂ受容体調節因子としての使用
WO2022127655A1 (fr) * 2020-12-14 2022-06-23 中国科学技术大学 Inhibiteur de l'inflammasome nlrp3 et son utilisation

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EP3180329B1 (fr) 2014-08-15 2020-03-18 Janssen Pharmaceuticals, Inc. Derives de triazole comme des inhibiteurs de recepteur nr2b
US10155727B2 (en) 2014-08-15 2018-12-18 Janssen Pharmaceuticals, Inc. Pyrazoles
WO2017007938A1 (fr) 2015-07-09 2017-01-12 Janssen Pharmaceutica Nv 4-azaindoles substitués et leur utilisation comme modulateurs du récepteur de glun2b
CN109071488B (zh) 2016-02-10 2021-08-13 詹森药业有限公司 取代的1,2,3-三唑作为nr2b-选择性nmda调节剂
TW201819376A (zh) 2016-10-06 2018-06-01 比利時商健生藥品公司 經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途

Also Published As

Publication number Publication date
EP3319963A1 (fr) 2018-05-16
ES2781867T3 (es) 2020-09-08
EP3319963B1 (fr) 2020-01-08
US20170008890A1 (en) 2017-01-12
PL3319963T3 (pl) 2020-06-01
HK1255160A1 (zh) 2019-08-09
EA201890245A1 (ru) 2018-06-29
MD3319963T2 (ro) 2020-05-31
CA2991765C (fr) 2023-10-03
CN108026094A (zh) 2018-05-11
CN108026094B (zh) 2021-02-09
JP2021193099A (ja) 2021-12-23
HRP20200410T1 (hr) 2020-08-21
JP2018520170A (ja) 2018-07-26
US9963447B2 (en) 2018-05-08
CA2991765A1 (fr) 2017-01-12
WO2017007938A1 (fr) 2017-01-12
JP7369743B2 (ja) 2023-10-26
HUE047460T2 (hu) 2020-04-28
AU2016291158B2 (en) 2020-04-30
CY1123007T1 (el) 2021-10-29
JP6964576B2 (ja) 2021-11-10
MX2018000352A (es) 2018-08-15
EA033197B1 (ru) 2019-09-30
US20180208595A1 (en) 2018-07-26
PT3319963T (pt) 2020-04-09
KR20180026760A (ko) 2018-03-13
SI3319963T1 (sl) 2020-02-28
DK3319963T3 (da) 2020-02-03
BR112018000468A2 (pt) 2018-09-18
LT3319963T (lt) 2020-03-25
IL256758A (en) 2018-03-29
AU2016291158A1 (en) 2018-02-01
US10377753B2 (en) 2019-08-13
ZA201800827B (en) 2019-09-25

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