SG11201900744SA - Fc engineered anti-tnfr superfamily member antibodies having enhanced agonistic activity and methods of using them - Google Patents

Fc engineered anti-tnfr superfamily member antibodies having enhanced agonistic activity and methods of using them

Info

Publication number
SG11201900744SA
SG11201900744SA SG11201900744SA SG11201900744SA SG11201900744SA SG 11201900744S A SG11201900744S A SG 11201900744SA SG 11201900744S A SG11201900744S A SG 11201900744SA SG 11201900744S A SG11201900744S A SG 11201900744SA SG 11201900744S A SG11201900744S A SG 11201900744SA
Authority
SG
Singapore
Prior art keywords
international
johnson
rule
methods
superfamily member
Prior art date
Application number
SG11201900744SA
Other languages
English (en)
Inventor
Mark Chiu
Di Zhang
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of SG11201900744SA publication Critical patent/SG11201900744SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG11201900744SA 2016-08-12 2017-08-04 Fc engineered anti-tnfr superfamily member antibodies having enhanced agonistic activity and methods of using them SG11201900744SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662374347P 2016-08-12 2016-08-12
PCT/US2017/045466 WO2018031400A1 (en) 2016-08-12 2017-08-04 Fc engineered anti-tnfr superfamily member antibodies having enhanced agonistic activity and methods of using them

Publications (1)

Publication Number Publication Date
SG11201900744SA true SG11201900744SA (en) 2019-02-27

Family

ID=61158615

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201900744SA SG11201900744SA (en) 2016-08-12 2017-08-04 Fc engineered anti-tnfr superfamily member antibodies having enhanced agonistic activity and methods of using them

Country Status (11)

Country Link
US (2) US20180044430A1 (ja)
EP (1) EP3497126A4 (ja)
JP (2) JP7009448B2 (ja)
KR (1) KR102554331B1 (ja)
CN (1) CN109843916B (ja)
AU (1) AU2017308734A1 (ja)
CA (1) CA3033665A1 (ja)
IL (1) IL264515A (ja)
MA (1) MA45941A (ja)
SG (1) SG11201900744SA (ja)
WO (1) WO2018031400A1 (ja)

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Also Published As

Publication number Publication date
US20200231693A1 (en) 2020-07-23
WO2018031400A1 (en) 2018-02-15
JP2022033769A (ja) 2022-03-02
JP7009448B2 (ja) 2022-02-10
MA45941A (fr) 2019-06-19
JP2019532025A (ja) 2019-11-07
KR102554331B1 (ko) 2023-07-10
EP3497126A1 (en) 2019-06-19
CN109843916B (zh) 2023-10-31
IL264515A (en) 2019-02-28
EP3497126A4 (en) 2020-04-08
CA3033665A1 (en) 2018-02-15
US11359029B2 (en) 2022-06-14
US20180044430A1 (en) 2018-02-15
CN109843916A (zh) 2019-06-04
KR20190038629A (ko) 2019-04-08
AU2017308734A1 (en) 2019-02-14

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