SG11201808796TA - Microbial Fermentation Method for Production of N-Acetyl-D-Glucosamine and/or D-Glucosamine Salt - Google Patents

Microbial Fermentation Method for Production of N-Acetyl-D-Glucosamine and/or D-Glucosamine Salt

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Publication number
SG11201808796TA
SG11201808796TA SG11201808796TA SG11201808796TA SG11201808796TA SG 11201808796T A SG11201808796T A SG 11201808796TA SG 11201808796T A SG11201808796T A SG 11201808796TA SG 11201808796T A SG11201808796T A SG 11201808796TA SG 11201808796T A SG11201808796T A SG 11201808796TA
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SG
Singapore
Prior art keywords
glucosamine
acetyl
production
salt
microbial fermentation
Prior art date
Application number
SG11201808796TA
Other languages
English (en)
Inventor
Lan Sun
Original Assignee
Lan Sun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lan Sun filed Critical Lan Sun
Priority claimed from PCT/CN2017/080649 external-priority patent/WO2017174036A1/zh
Publication of SG11201808796TA publication Critical patent/SG11201808796TA/en

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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
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    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01157—Glucosamine-1-phosphate N-acetyltransferase (2.3.1.157)
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    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01016—Glutamine-fructose-6-phosphate transaminase (isomerizing) (2.6.1.16), i.e. glucosamine-6-phosphate-synthase
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/0106—N-Acylmannosamine kinase (2.7.1.60)
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    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01025—N-Acetylglucosamine-6-phosphate deacetylase (3.5.1.25)
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    • C12Y305/99—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in other compounds (3.5.99)
    • C12Y305/99006—Glucosamine-6-phosphate deaminase (3.5.99.6)
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    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/03—Oxo-acid-lyases (4.1.3)
    • C12Y401/03003—N-Acetylneuraminate lyase (4.1.3.3)
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    • C12Y501/03—Racemaces and epimerases (5.1) acting on carbohydrates and derivatives (5.1.3)
    • C12Y501/03009—N-Acylglucosamine-6-phosphate 2-epimerase (5.1.3.9)
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    • C12Y501/03—Racemaces and epimerases (5.1) acting on carbohydrates and derivatives (5.1.3)
    • C12Y501/03014—UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) (5.1.3.14)
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    • C12Y504/02—Phosphotransferases (phosphomutases) (5.4.2)
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    • C12Y504/02—Phosphotransferases (phosphomutases) (5.4.2)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
SG11201808796TA 2016-04-05 2017-04-14 Microbial Fermentation Method for Production of N-Acetyl-D-Glucosamine and/or D-Glucosamine Salt SG11201808796TA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610208203 2016-04-05
CN201710217601.1A CN107267578B (zh) 2016-04-05 2017-04-05 微生物发酵生产n-乙酰-d-氨基葡萄糖和/或d-氨基葡萄糖盐的方法
PCT/CN2017/080649 WO2017174036A1 (zh) 2016-04-05 2017-04-14 微生物发酵生产n-乙酰-d-氨基葡萄糖和/或d-氨基葡萄糖盐的方法

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SG11201808796TA true SG11201808796TA (en) 2018-11-29

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SG11201808796TA SG11201808796TA (en) 2016-04-05 2017-04-14 Microbial Fermentation Method for Production of N-Acetyl-D-Glucosamine and/or D-Glucosamine Salt

Country Status (7)

Country Link
US (3) US11136608B2 (zh)
JP (1) JP6771644B2 (zh)
CN (5) CN107267578B (zh)
AU (1) AU2017247309B2 (zh)
CA (1) CA3020193C (zh)
SG (1) SG11201808796TA (zh)
ZA (1) ZA201807355B (zh)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108330095B (zh) * 2018-03-01 2020-12-29 江南大学 一种积累n-乙酰神经氨酸的重组谷氨酸棒杆菌及其应用
CN110343624B (zh) * 2018-04-03 2021-06-15 中国科学院微生物研究所 一种重组菌及其在提高纤维素酶产量中的应用
CN114732822B (zh) * 2019-03-13 2023-06-30 中国人民解放军军事科学院军事医学研究院 氨基葡萄糖及其衍生物作为抗病毒药物的应用
CN110029068B (zh) * 2019-04-10 2022-03-25 天津科技大学 一种低溶氧条件下高产有机酸的黑曲霉基因工程菌株及应用
CN110028533A (zh) * 2019-04-10 2019-07-19 浙江中医药大学 一种从微生物发酵液中精制氨基葡萄糖盐酸盐的方法及应用
KR102472558B1 (ko) * 2019-06-28 2022-12-01 씨제이제일제당 주식회사 황 함유 아미노산 또는 그 유도체 제조방법
CN110590867B (zh) * 2019-09-12 2021-07-20 河南巨龙生物工程股份有限公司 一种d-氨基葡萄糖盐酸盐的合成方法
CN110938666B (zh) * 2019-11-20 2022-03-18 上海应用技术大学 一种微生物源壳聚糖的制备方法
CN111018957A (zh) * 2019-12-03 2020-04-17 天津科技大学 一种介导PGase分泌表达的信号肽及其应用
CN111018926B (zh) * 2019-12-17 2023-10-10 大自然生物集团有限公司 从氨基葡萄糖发酵液中提取高纯氨基葡萄糖盐酸盐的方法
CN110760622B (zh) * 2019-12-17 2023-06-27 大自然生物集团有限公司 一种枯草芽孢杆菌发酵生产氨基葡萄糖的补料方法
CN111548979B (zh) * 2020-05-25 2022-08-30 江南大学 合成乳酰n-新四糖的重组大肠杆菌及其构建方法与应用
CN111518857A (zh) * 2020-06-11 2020-08-11 江苏海飞生物科技有限公司 酶法生产氨基葡萄糖盐及其提纯方法
CN112011584A (zh) * 2020-07-23 2020-12-01 南京先之达医药科技有限公司 一种酶转化法制备乙酰壳糖胺的方法
CN114592020B (zh) * 2020-12-07 2023-07-14 上海医药工业研究院 一种发酵生产n-乙酰氨基葡萄糖的方法
CN112760348B (zh) * 2020-12-31 2022-03-08 安徽丰原发酵技术工程研究有限公司 一种n-乙酰氨基葡萄糖的发酵生产方法
KR102254635B1 (ko) * 2021-01-27 2021-05-21 씨제이제일제당 주식회사 신규한 글루코사민-6-포스페이트 디아미나제 변이체 및 이를 이용한 l-글루탐산 생산 방법
CN113817788B (zh) * 2021-03-10 2024-02-02 江苏澳新生物工程有限公司 氨基葡萄糖的酶催化制备方法
CN113845553A (zh) * 2021-10-09 2021-12-28 山东润德生物科技有限公司 一种低水分活度n-乙酰氨基葡萄糖的制备方法及n-乙酰氨基葡萄糖
CN114645070B (zh) * 2022-02-28 2022-12-20 北京焉支山科技有限公司 一种己糖-6-磷酸组合物的制备方法及其在化妆品中的应用
CN115444102A (zh) * 2022-09-19 2022-12-09 四川饭扫光食品集团股份有限公司 一种低盐发酵豆瓣及其制备方法
CN116731934B (zh) * 2023-08-08 2023-10-13 欧铭庄生物科技(天津)有限公司滨海新区分公司 一株大肠埃希氏菌及其在生产氨基葡萄糖中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5960498A (en) 1997-01-14 1998-08-03 Bio-Technical Resources Process for production of (n)-glucosamine
US6372457B1 (en) * 1997-01-14 2002-04-16 Arkion Life Sciences Llc Process and materials for production of glucosamine
JP2003334081A (ja) * 2002-05-16 2003-11-25 Japan Science & Technology Corp 遺伝子、酵素、酵素の製造方法、キチンオリゴ糖の製造方法
KR101035043B1 (ko) * 2002-07-01 2011-05-19 아르키온 라이프 사이언씨즈 엘엘씨 글루코사민 및 ｎ-아세틸글루코사민의 제조를 위한 물질및 공정
EP2076601B1 (en) * 2006-10-03 2011-03-30 Centre National De La Recherche Scientifique -Cnrs- High yield production of sialic acid (neu5ac) by fermentation
CN103060301A (zh) * 2011-10-20 2013-04-24 中国科学院微生物研究所 乳酸片球菌的n-乙酰神经氨酸醛缩酶及其基因与应用
CN103060252B (zh) * 2012-12-25 2015-04-15 江南大学 一种高产乙酰氨基葡萄糖的枯草芽孢杆菌工程菌及其应用
DK3467100T3 (da) * 2013-03-14 2022-11-14 Glycosyn LLC Mikroorganismer og fremgangsmåder til fremstilling af sialylerede og n-acetylglucosamin-holdige oligosaccharider
CN103602627B (zh) 2013-11-25 2015-03-18 武汉中科光谷绿色生物技术有限公司 一种产n-乙酰神经氨酸大肠杆菌工程菌及其构建方法和应用
CN104059872B (zh) * 2014-07-16 2017-01-11 华东理工大学 高产n-乙酰氨基葡萄糖代谢工程菌及其构建方法和应用
CN104293724A (zh) * 2014-09-22 2015-01-21 上海工业生物技术研发中心 一种高效生产n-乙酰氨基葡萄糖的基因工程菌
CN104498517B (zh) * 2014-11-29 2017-04-12 滨州市金朗生物科技有限公司 一种高产n‑乙酰氨基葡萄糖大肠杆菌的构建及应用方法
CN104988108A (zh) * 2015-05-27 2015-10-21 武汉中科光谷绿色生物技术有限公司 一种高产n-乙酰神经氨酸代谢工程菌及构建方法和应用
CN106148262B (zh) * 2016-07-01 2019-09-03 江南大学 提高乙酰氨基葡萄糖产量的重组枯草芽孢杆菌及其构建方法
EP3441473A4 (en) * 2017-04-05 2019-10-09 Sun, Lan PROCESS FOR THE PREPARATION OF N-ACETYL-D-GLUCOSAMINE AND / OR D-GLUCOSAMINE HYDROCHLORIDE BY MICROBIAL FERMENTATION

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