MX2019009135A - Ingenieria metabolica para la produccion microbiana de productos terpenoides. - Google Patents

Ingenieria metabolica para la produccion microbiana de productos terpenoides.

Info

Publication number
MX2019009135A
MX2019009135A MX2019009135A MX2019009135A MX2019009135A MX 2019009135 A MX2019009135 A MX 2019009135A MX 2019009135 A MX2019009135 A MX 2019009135A MX 2019009135 A MX2019009135 A MX 2019009135A MX 2019009135 A MX2019009135 A MX 2019009135A
Authority
MX
Mexico
Prior art keywords
metabolic engineering
microbial production
terpenoid
terpenoid products
products
Prior art date
Application number
MX2019009135A
Other languages
English (en)
Inventor
Parayil Kumaran Ajikumar
Donald Jason
Tseng Hsien-Chung
PHILIPPE Ryan
LIM Chin-giaw
Ghosh Souvik
Pirie Christopher
Love Aaron
Nan Hong
Nicole S Santos Christine
Original Assignee
Manus Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Manus Bio Inc filed Critical Manus Bio Inc
Publication of MX2019009135A publication Critical patent/MX2019009135A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0093—Oxidoreductases (1.) acting on CH or CH2 groups (1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01267—1-Deoxy-D-xylulose-5-phosphate reductoisomerase (1.1.1.267)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y117/00—Oxidoreductases acting on CH or CH2 groups (1.17)
    • C12Y117/07—Oxidoreductases acting on CH or CH2 groups (1.17) with an iron-sulfur protein as acceptor (1.17.7)
    • C12Y117/07001—(E)-4-Hydroxy-3-methylbut-2-enyl-diphosphate synthase (1.17.7.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/0109—All-trans-octaprenyl-diphosphate synthase (2.5.1.90)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

En varios aspectos y modalidades, la invención se refiere a cepas bacterianas y métodos para elaborar terpeno y productos terpenoides. La invención proporciona cepas bacterianas con flujo de carbono mejorado a través de la vía de MEP, para de este modo aumentar el rendimiento de terpenos y/o producto terpenoide mediante fermentación con fuentes de carbono tales como glucosa.
MX2019009135A 2017-02-03 2018-02-05 Ingenieria metabolica para la produccion microbiana de productos terpenoides. MX2019009135A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762454121P 2017-02-03 2017-02-03
PCT/US2018/016848 WO2018144996A1 (en) 2017-02-03 2018-02-05 Metabolic engineering for microbial production of terpenoid products

Publications (1)

Publication Number Publication Date
MX2019009135A true MX2019009135A (es) 2019-10-09

Family

ID=63041209

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019009135A MX2019009135A (es) 2017-02-03 2018-02-05 Ingenieria metabolica para la produccion microbiana de productos terpenoides.

Country Status (10)

Country Link
US (3) US10662442B2 (es)
EP (1) EP3577212A4 (es)
JP (2) JP7433048B2 (es)
KR (1) KR20190139202A (es)
CN (1) CN110869487B (es)
AU (1) AU2018215537B2 (es)
BR (1) BR112019016036A2 (es)
CA (1) CA3051463A1 (es)
MX (1) MX2019009135A (es)
WO (1) WO2018144996A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3574095T3 (da) * 2017-01-26 2023-10-02 Manus Bio Inc Metabolisk manipulation til mikrobiel fremstilling af terpenoidprodukter
EP3577212A4 (en) * 2017-02-03 2020-12-16 Manus Bio, Inc. METABOLIC ENGINEERING FOR THE MICROBIAL MANUFACTURING OF TERPENOID PRODUCTS
EP3847268A4 (en) * 2018-09-06 2022-06-08 Manus Bio Inc. MICROBIAL PRODUCTION OF ROTUNDON
WO2020072908A1 (en) * 2018-10-05 2020-04-09 Manus Bio, Inc. Biosynthesis and recovery of secondary metabolites
CN109370937A (zh) * 2018-10-29 2019-02-22 河南中烟工业有限责任公司 一种烟草薄片质量调节用复合微生物菌剂
NL2031120B1 (en) * 2022-02-16 2023-08-22 Sestina Bio Llc Engineered alpha-guaiene synthases
CN117165502A (zh) * 2022-05-26 2023-12-05 牛津大学(苏州)科技有限公司 一种合成萜类化合物的共培养系统和方法
CN115927134A (zh) * 2022-07-25 2023-04-07 中国科学院青岛生物能源与过程研究所 一种可合成倍半萜的工程藻株及其制备方法
CN116732081B (zh) * 2023-08-07 2023-12-29 中国科学院天津工业生物技术研究所 一种提高枯草芽孢杆菌合成七烯甲萘醌的方法、获得重组菌株及其应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10201458A1 (de) * 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
CA2626900C (en) * 2005-08-20 2013-07-23 Scarab Genomics, Llc Reduced genome e. coli
DE602007008067D1 (de) 2006-02-14 2010-09-09 Firmenich & Cie Verfahren zur herstellung von terpenen und mep-transformierte mikroorganismen dafür
WO2009116566A1 (ja) * 2008-03-18 2009-09-24 協和発酵キリン株式会社 工業的に有用な微生物
TW201412988A (zh) * 2009-06-17 2014-04-01 Danisco Us Inc 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
US8927241B2 (en) 2009-11-10 2015-01-06 Massachusetts Institute Of Technology Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
KR101834020B1 (ko) 2009-11-10 2018-03-02 메사추세츠 인스티튜트 오브 테크놀로지 이소프레노이드 경로로부터 화학 및 제약 제품의 생산을 위한 미생물 조작
CA2819253A1 (en) 2010-11-30 2012-06-07 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
WO2013040210A2 (en) 2011-09-14 2013-03-21 The Regents Of The University Of California Methods for increasing production of 3-methyl-2-butenol using fusion proteins
US9834800B2 (en) 2012-08-17 2017-12-05 Evolva Sa Increased production of terpenes and terpenoids
CN103773729B (zh) * 2012-10-22 2017-07-11 中国科学院上海生命科学研究院 高效合成萜类化合物的重组大肠杆菌底盘细胞及其制法和应用
US20150315599A1 (en) * 2012-12-07 2015-11-05 Ginkgo Bioworks, Inc Methods and Systems for Methylotrophic Production of Organic Compounds
CN106574289A (zh) * 2014-06-13 2017-04-19 德诺芙公司 生产萜烯或类萜烯的方法
KR101582259B1 (ko) * 2014-07-04 2016-01-04 명지대학교 산학협력단 이소프렌을 생산하는 대장균 균주 fmis2 및 이의 용도
JP6735750B2 (ja) * 2014-08-21 2020-08-05 マナス バイオシンセシス インコーポレイテッド 含酸素テルペンの産生方法
MY182396A (en) * 2014-11-05 2021-01-23 Manus Biosynthesis Inc Microbial production of steviol glycosides
WO2017034942A1 (en) 2015-08-21 2017-03-02 Manus Biosynthesis, Inc. Increasing productivity of e. coli host cells that functionally express p450 enzymes
WO2017142993A1 (en) 2016-02-16 2017-08-24 Manus Biosynthesis, Inc. Secondary metabolite screening system
EP3577212A4 (en) * 2017-02-03 2020-12-16 Manus Bio, Inc. METABOLIC ENGINEERING FOR THE MICROBIAL MANUFACTURING OF TERPENOID PRODUCTS

Also Published As

Publication number Publication date
CN110869487A (zh) 2020-03-06
US20200299735A1 (en) 2020-09-24
BR112019016036A2 (pt) 2020-05-26
US20180245103A1 (en) 2018-08-30
US20220364127A1 (en) 2022-11-17
WO2018144996A1 (en) 2018-08-09
US10662442B2 (en) 2020-05-26
JP2023171783A (ja) 2023-12-05
JP7433048B2 (ja) 2024-02-19
CN110869487B (zh) 2024-01-02
CA3051463A1 (en) 2018-08-09
JP2020505930A (ja) 2020-02-27
EP3577212A1 (en) 2019-12-11
US11339412B2 (en) 2022-05-24
AU2018215537A1 (en) 2019-08-22
AU2018215537B2 (en) 2023-11-09
EP3577212A4 (en) 2020-12-16
KR20190139202A (ko) 2019-12-17

Similar Documents

Publication Publication Date Title
MX2019009135A (es) Ingenieria metabolica para la produccion microbiana de productos terpenoides.
MX2019008882A (es) Ingeniería metabólica para la producción microbiana de productos terpenoides.
MX2022005890A (es) Metodos para mejorar la produccion de leche mediante la administracion de consorcios microbianos.
SG11201808796TA (en) Microbial Fermentation Method for Production of N-Acetyl-D-Glucosamine and/or D-Glucosamine Salt
WO2015010103A3 (en) Microorganisms and methods for the production of fatty acids and fatty acid derived products
NZ701895A (en) Strains of lactobacillus with antifungal properties
MX2020000369A (es) Metodos biologicos para preparar terpenos.
MY165103A (en) Recombinant microorganisms and methods of use thereof
AU2018271755A1 (en) Method for culturing natural killer cell, using transformed T cell
MX2019010195A (es) Nuevo medio de fermentacion para crecimiento de bacterias metanotrofas y metodo para producir dicho medio.
PH12018500150A1 (en) Microorganisms for producing putrescine or ornithine and process for producing putrescine or ornithine using them
NZ701896A (en) Strains of propionibacterium
MX2020013565A (es) Produccion microbiana de dioles grasos.
MX2018002307A (es) Bacteria lactobacillus fermentum que reduce la concentracion de acetaldehido.
MY182946A (en) Production of organic acids by fermentation at low ph
MY186949A (en) Genetically modified microorganisms having improved tolerance towards l-serine
MY193225A (en) Methods for continuous production of products from microorganisms
SG11201811132SA (en) Lactic acid bacterial fermentation promoting agent
MY183393A (en) Tien-cha extract essence and application therefor
PH12019550231A1 (en) Probiotic bacteria preconditioned in a gos-containing medium and use thereof
PH12019500096A1 (en) Leuconostoc mesenteroides cjlm119 strain producing reduced amount of gas, and kimchi production method using same
PH12017500971A1 (en) Synergistic bacterial consortia for mobilizing soil phosphorus
PH12019500264A1 (en) Lactobacillus salivarius cjls1511, animal feed additive composition comprising same bacterium or dead cells thereof, and method for producing same dead cells
PH12018500069A1 (en) Novel lactobacillus sp. microorganisms, and composition for animal feed comprising same
MX2018000941A (es) Ingrediente alimenticio rico en proteinas a partir de biomasa y metodos de produccion.