DK3574095T3 - Metabolisk manipulation til mikrobiel fremstilling af terpenoidprodukter - Google Patents
Metabolisk manipulation til mikrobiel fremstilling af terpenoidprodukter Download PDFInfo
- Publication number
- DK3574095T3 DK3574095T3 DK18744050.8T DK18744050T DK3574095T3 DK 3574095 T3 DK3574095 T3 DK 3574095T3 DK 18744050 T DK18744050 T DK 18744050T DK 3574095 T3 DK3574095 T3 DK 3574095T3
- Authority
- DK
- Denmark
- Prior art keywords
- microbial production
- metabolic manipulation
- terpenoid products
- terpenoid
- products
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0093—Oxidoreductases (1.) acting on CH or CH2 groups (1.17)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/07—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with an iron-sulfur protein as acceptor (1.2.7)
- C12Y102/07001—Pyruvate synthase (1.2.7.1), i.e. pyruvate ferredoxin oxidoreductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y117/00—Oxidoreductases acting on CH or CH2 groups (1.17)
- C12Y117/07—Oxidoreductases acting on CH or CH2 groups (1.17) with an iron-sulfur protein as acceptor (1.17.7)
- C12Y117/07001—(E)-4-Hydroxy-3-methylbut-2-enyl-diphosphate synthase (1.17.7.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762450707P | 2017-01-26 | 2017-01-26 | |
| PCT/US2018/015527 WO2018140778A1 (en) | 2017-01-26 | 2018-01-26 | Metabolic engineering for microbial production of terpenoid products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3574095T3 true DK3574095T3 (da) | 2023-10-02 |
Family
ID=62977213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18744050.8T DK3574095T3 (da) | 2017-01-26 | 2018-01-26 | Metabolisk manipulation til mikrobiel fremstilling af terpenoidprodukter |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10480015B2 (da) |
| EP (1) | EP3574095B1 (da) |
| JP (1) | JP7330888B2 (da) |
| KR (1) | KR102656420B1 (da) |
| CN (1) | CN110869500B (da) |
| AU (1) | AU2018211953A1 (da) |
| BR (1) | BR112019015454A2 (da) |
| CA (1) | CA3051472C (da) |
| DK (1) | DK3574095T3 (da) |
| ES (1) | ES2959508T3 (da) |
| MX (1) | MX2019008882A (da) |
| UA (1) | UA127758C2 (da) |
| WO (1) | WO2018140778A1 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2959508T3 (es) * | 2017-01-26 | 2024-02-26 | Manus Bio Inc | Ingeniería metabólica para la producción microbiana de productos terpenoides |
| CN113195726A (zh) | 2018-09-06 | 2021-07-30 | 马努斯生物合成股份有限公司 | 莎草奥酮的微生物生产 |
| CN109321494B (zh) * | 2018-09-30 | 2020-06-23 | 浙江工业大学 | 中间克吕沃尔菌zjb-17004及其应用 |
| WO2020072908A1 (en) * | 2018-10-05 | 2020-04-09 | Manus Bio, Inc. | Biosynthesis and recovery of secondary metabolites |
| CN109913380B (zh) * | 2019-03-25 | 2021-12-10 | 南京工业大学 | 生产(-)-α-红没药醇的重组解脂耶氏酵母菌及其构建方法和应用 |
| CN110106129B (zh) * | 2019-05-20 | 2022-08-30 | 福建师范大学 | 谷氨酸脱氢酶基因受抑制的类球红细菌及其制备方法和法尼醇的生产方法 |
| US11813549B1 (en) * | 2020-03-04 | 2023-11-14 | Eco-Logic Environmental Engineering Inc. | Devices and methods for essential oils, terpenes, flavonoids, and hydrosols extraction |
| CN112342163A (zh) * | 2020-11-13 | 2021-02-09 | 华中农业大学 | 一种伯克霍尔德菌及其应用 |
| CN114990147A (zh) * | 2021-03-01 | 2022-09-02 | 深圳蓝晶生物科技有限公司 | 构建生产香叶醇的重组需钠弧菌的方法以及通过该方法构建的重组需钠弧菌及其应用 |
| WO2023015279A1 (en) * | 2021-08-05 | 2023-02-09 | Miami University | Methods for the production of methylated tryptamine derivatives, intermediates or side products |
| KR102518841B1 (ko) * | 2021-11-09 | 2023-04-10 | 경상국립대학교산학협력단 | 레티노이드 제조용 조성물 및 이를 이용한 레티노이드의 제조 방법 |
| WO2023150533A1 (en) * | 2022-02-01 | 2023-08-10 | Conagen Inc. | Microorganisms and methods for producing menaquinone-7 |
| CN114921463B (zh) * | 2022-04-11 | 2023-12-01 | 中国农业科学院生物技术研究所 | 一种调控萜类化合物合成产量的人工非编码RNA分子CsiY及其应用 |
| CN115927427A (zh) * | 2022-07-25 | 2023-04-07 | 中国科学院青岛生物能源与过程研究所 | 一种可合成瓦伦烯的工程藻株及其制备方法 |
| CN115948456A (zh) * | 2022-10-18 | 2023-04-11 | 重庆大学 | 一种可提升广藿香醇合成量的融合基因及方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0314979B1 (pt) | 2002-10-04 | 2019-10-22 | Firmenich & Cie | método de produção de um valenceno e microorganismo transgênico |
| BRPI0709540A2 (pt) | 2006-02-14 | 2011-07-19 | Firmenich & Cie | método para produzir terpenos e, portanto, microorganismos transformados por mep |
| US20110236927A1 (en) | 2008-08-27 | 2011-09-29 | Massachusetts Institute Of Technology | Genetically stabilized tandem gene duplication |
| TWI427149B (zh) * | 2009-06-17 | 2014-02-21 | Danisco Us Inc | 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造 |
| BR112012011073B8 (pt) * | 2009-11-10 | 2023-01-10 | Massachusetts Inst Technology | Método para aumentar a produção de terpenoide em uma célula que produz um ou mais terpenoides |
| US8927241B2 (en) | 2009-11-10 | 2015-01-06 | Massachusetts Institute Of Technology | Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway |
| MX349121B (es) | 2010-06-02 | 2017-07-12 | Evolva Inc | Produccion recombinante de esteviol glucosidos. |
| BR112013010244A2 (pt) | 2010-10-29 | 2016-07-05 | Allylix Inc | polipeptídeos de valenceno sintase modificados que codificam moléculas de ácido nucleico e seus usos |
| EP2645847B1 (en) | 2010-11-30 | 2018-01-17 | Massachusetts Institute of Technology | Microbial production of natural sweeteners, diterpenoid steviol glycosides |
| WO2013040210A2 (en) * | 2011-09-14 | 2013-03-21 | The Regents Of The University Of California | Methods for increasing production of 3-methyl-2-butenol using fusion proteins |
| AU2013304001B2 (en) * | 2012-08-17 | 2019-01-03 | Evolva Sa | Increased production of terpenes and terpenoids |
| WO2014122328A1 (en) | 2013-02-11 | 2014-08-14 | Evolva Sa | Efficient production of steviol glycosides in recombinant hosts |
| EP3155103A1 (en) | 2014-06-13 | 2017-04-19 | Deinove | Method of producing terpenes or terpenoids |
| US10934564B2 (en) | 2014-08-21 | 2021-03-02 | Manus Bio Inc. | Methods for production of oxygenated terpenes |
| US10463062B2 (en) | 2014-11-05 | 2019-11-05 | Manus Bio Inc. | Microbial production of steviol glycosides |
| US10774314B2 (en) | 2015-08-21 | 2020-09-15 | Manus Bio Inc. | Increasing productivity of E. coli host cells that functionally express P450 enzymes |
| WO2017142993A1 (en) | 2016-02-16 | 2017-08-24 | Manus Biosynthesis, Inc. | Secondary metabolite screening system |
| ES2959508T3 (es) * | 2017-01-26 | 2024-02-26 | Manus Bio Inc | Ingeniería metabólica para la producción microbiana de productos terpenoides |
| KR20190139202A (ko) * | 2017-02-03 | 2019-12-17 | 마누스 바이오, 인크. | 터페노이드 산물의 미생물 생산을 위한 대사 조작 |
-
2018
- 2018-01-26 ES ES18744050T patent/ES2959508T3/es active Active
- 2018-01-26 EP EP18744050.8A patent/EP3574095B1/en active Active
- 2018-01-26 BR BR112019015454-0A patent/BR112019015454A2/pt unknown
- 2018-01-26 MX MX2019008882A patent/MX2019008882A/es unknown
- 2018-01-26 AU AU2018211953A patent/AU2018211953A1/en active Pending
- 2018-01-26 CN CN201880021786.1A patent/CN110869500B/zh active Active
- 2018-01-26 DK DK18744050.8T patent/DK3574095T3/da active
- 2018-01-26 JP JP2019541325A patent/JP7330888B2/ja active Active
- 2018-01-26 CA CA3051472A patent/CA3051472C/en active Active
- 2018-01-26 UA UAA201909447A patent/UA127758C2/uk unknown
- 2018-01-26 KR KR1020197024903A patent/KR102656420B1/ko active IP Right Grant
- 2018-01-26 US US15/881,386 patent/US10480015B2/en active Active
- 2018-01-26 WO PCT/US2018/015527 patent/WO2018140778A1/en unknown
-
2019
- 2019-09-13 US US16/570,251 patent/US10774346B2/en active Active
-
2020
- 2020-08-13 US US16/992,773 patent/US11352648B2/en active Active
-
2022
- 2022-04-26 US US17/729,096 patent/US20220251607A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US10480015B2 (en) | 2019-11-19 |
| JP7330888B2 (ja) | 2023-08-22 |
| US20210002672A1 (en) | 2021-01-07 |
| ES2959508T3 (es) | 2024-02-26 |
| EP3574095A1 (en) | 2019-12-04 |
| US20180216137A1 (en) | 2018-08-02 |
| AU2018211953A1 (en) | 2019-08-15 |
| WO2018140778A1 (en) | 2018-08-02 |
| KR102656420B1 (ko) | 2024-04-09 |
| KR20190113851A (ko) | 2019-10-08 |
| JP2020505051A (ja) | 2020-02-20 |
| CN110869500B (zh) | 2023-10-27 |
| MX2019008882A (es) | 2019-12-16 |
| CN110869500A (zh) | 2020-03-06 |
| US20220251607A1 (en) | 2022-08-11 |
| US11352648B2 (en) | 2022-06-07 |
| CA3051472C (en) | 2024-05-28 |
| US10774346B2 (en) | 2020-09-15 |
| EP3574095B1 (en) | 2023-07-05 |
| US20200002733A1 (en) | 2020-01-02 |
| CA3051472A1 (en) | 2018-08-02 |
| UA127758C2 (uk) | 2023-12-27 |
| EP3574095A4 (en) | 2020-12-02 |
| BR112019015454A2 (pt) | 2020-03-24 |
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