DK3467100T3 - Mikroorganismer og fremgangsmåder til fremstilling af sialylerede og n-acetylglucosamin-holdige oligosaccharider - Google Patents
Mikroorganismer og fremgangsmåder til fremstilling af sialylerede og n-acetylglucosamin-holdige oligosaccharider Download PDFInfo
- Publication number
- DK3467100T3 DK3467100T3 DK18192520.7T DK18192520T DK3467100T3 DK 3467100 T3 DK3467100 T3 DK 3467100T3 DK 18192520 T DK18192520 T DK 18192520T DK 3467100 T3 DK3467100 T3 DK 3467100T3
- Authority
- DK
- Denmark
- Prior art keywords
- acetyglucosamine
- sialylated
- microorganisms
- production
- methods
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361782999P | 2013-03-14 | 2013-03-14 | |
EP14769797.3A EP2970872B1 (en) | 2013-03-14 | 2014-03-14 | Microorganisms and methods for producing sialylated and n-acetylglucosamine-containing oligosaccharides |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3467100T3 true DK3467100T3 (da) | 2022-11-14 |
Family
ID=51581464
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14769797.3T DK2970872T3 (da) | 2013-03-14 | 2014-03-14 | Mikroorganismer og fremgangsmåder til fremstilling af sialylerede og N-acetylglucosamin-holdige oligosaccharider |
DK18192520.7T DK3467100T3 (da) | 2013-03-14 | 2014-03-14 | Mikroorganismer og fremgangsmåder til fremstilling af sialylerede og n-acetylglucosamin-holdige oligosaccharider |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14769797.3T DK2970872T3 (da) | 2013-03-14 | 2014-03-14 | Mikroorganismer og fremgangsmåder til fremstilling af sialylerede og N-acetylglucosamin-holdige oligosaccharider |
Country Status (8)
Country | Link |
---|---|
US (3) | US9758803B2 (da) |
EP (3) | EP2970872B1 (da) |
CA (1) | CA2904091A1 (da) |
DE (1) | DE14769797T1 (da) |
DK (2) | DK2970872T3 (da) |
ES (2) | ES2930286T3 (da) |
HU (1) | HUE060672T2 (da) |
WO (1) | WO2014153253A1 (da) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
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US9567361B2 (en) | 2011-05-13 | 2017-02-14 | Glycosyn LLC | Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
US10228081B2 (en) * | 2012-11-16 | 2019-03-12 | Kongsberg Actuation Systems Ii, Inc. | Method of forming a hose assembly |
HUE060672T2 (hu) | 2013-03-14 | 2023-04-28 | Glycosyn LLC | Mikroorganizmusok és eljárások szialilált és N-acetilglükózamint tartalmazó oligoszacharidok elõállítására |
US9688970B2 (en) | 2013-10-01 | 2017-06-27 | Kentucky Bioprocessing, Inc. | Plant-based recombinant butyrylcholinesterase production methods |
US11926858B2 (en) | 2014-06-27 | 2024-03-12 | Glycom A/S | Oligosaccharide production |
US10731193B2 (en) * | 2014-06-27 | 2020-08-04 | Glycom A/S | Oligosaccharide production |
JP2017520267A (ja) * | 2014-07-14 | 2017-07-27 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | LNT、LNnTおよびそれらのフコシル化誘導体の生物工学的産生 |
WO2016094836A1 (en) * | 2014-12-12 | 2016-06-16 | The Regents Of The University Of California | Reduction of milk glycans and their degradation products in the neonate gut |
DE202017007249U1 (de) | 2016-03-07 | 2020-04-23 | Glycom A/S | Abtrennung von Oligosacchariden aus der Fermentationsbrühe |
WO2017174037A1 (zh) * | 2016-04-05 | 2017-10-12 | 孙镧 | 微生物发酵生产n-乙酰-d-氨基葡萄糖和/或d-氨基葡萄糖盐的方法 |
WO2017174039A1 (zh) * | 2016-04-05 | 2017-10-12 | 孙镧 | 微生物发酵生产n-乙酰-d-氨基葡萄糖和/或d-氨基葡萄糖盐的方法 |
CN107267576B (zh) | 2016-04-05 | 2020-08-21 | 孙镧 | 微生物发酵生产n-乙酰-d-氨基葡萄糖和/或d-氨基葡萄糖盐的方法 |
DE202017007248U1 (de) | 2016-04-19 | 2020-04-23 | Glycom A/S | Abtrennung von Oligosacchariden aus der Fermentationsbrühe |
EP3474861A4 (en) | 2016-06-24 | 2020-04-15 | Glycom A/S | COMPOUNDS COMPRISING HMOS FOR THE PREVENTION AND / OR TREATMENT OF VIRAL AND / OR BACTERIAL INFECTIONS. |
US10407516B2 (en) | 2016-10-31 | 2019-09-10 | Glycom A/S | Crystalline HMO |
US10767205B2 (en) | 2017-03-07 | 2020-09-08 | DePuy Synthes Products, Inc. | Bacterium for the production of an exopolysaccharide comprising N-acetylglucosamine and D-glucose |
US10633682B2 (en) | 2017-03-07 | 2020-04-28 | DePuy Synthes Products, Inc. | Bioresorbable exopolysaccharides |
EP3645545A4 (en) | 2017-06-30 | 2021-05-05 | Glycom A/S | PURIFICATION OF OLIGOSACCHARIDES |
EP3652189A4 (en) | 2017-07-12 | 2021-04-21 | Glycom A/S | AMORPHIC MIXTURE CONSISTING OF A NEUTRAL MONO- OR OLIGOSACCHARIDE AND A NON-GLUCIDIC ACID COMPONENT |
CN107312738B (zh) * | 2017-07-26 | 2020-03-06 | 江南大学 | 一种高效生产果糖软骨素的重组大肠杆菌及其构建方法 |
JP2020528280A (ja) | 2017-07-26 | 2020-09-24 | イェネヴァイン ビオテヒノロギー ゲーエムベーハー | シアリルトランスフェラーゼ及びシアリル化オリゴ糖の生産におけるその使用 |
WO2019063757A1 (en) | 2017-09-29 | 2019-04-04 | Frieslandcampina Nederland B.V. | PROCESS FOR PURIFYING NEUTRAL HUMAN MILK (HMO) OLIGOSACCHARIDE FROM MICROBIAL FERMENTATION |
EP3473644A1 (en) * | 2017-10-17 | 2019-04-24 | Jennewein Biotechnologie GmbH | Fermentative production of n-acetylneuraminic acid |
CN107739728A (zh) * | 2017-10-19 | 2018-02-27 | 江南大学 | 一种高效生产氨基葡萄糖的重组大肠杆菌及其应用 |
EP3486326A1 (en) * | 2017-11-21 | 2019-05-22 | Jennewein Biotechnologie GmbH | Method for the purification of n-acetylneuraminic acid from a fermentation broth |
EP3724344A4 (en) * | 2017-12-15 | 2021-11-24 | Glycosyn LLC | SIALYL TRANSFERASES AND USES THEREOF |
PL3575404T3 (pl) | 2018-05-28 | 2023-02-06 | Chr. Hansen HMO GmbH | Fermentacyjna produkcja sacharydów sialilowanych |
CN109825465B (zh) * | 2019-02-27 | 2021-11-12 | 光明乳业股份有限公司 | 基于平衡udp-糖供给合成乳酰-n-新四糖的重组枯草芽孢杆菌及其构建方法与应用 |
CN109735480B (zh) * | 2019-02-27 | 2021-11-12 | 光明乳业股份有限公司 | 一种合成乳酰-n-新四糖的重组枯草芽孢杆菌及其构建方法与应用 |
CN110066801B (zh) * | 2019-04-30 | 2021-01-29 | 江南大学 | 一种枯草芽孢杆菌中唾液酸诱导表达元件及构建方法 |
EP3772539A1 (en) * | 2019-08-08 | 2021-02-10 | Jennewein Biotechnologie GmbH | Sialyltransferases for the production of 6'-sialyllactose |
EP3789495A1 (en) * | 2019-09-03 | 2021-03-10 | Jennewein Biotechnologie GmbH | Production of sialylated oligosaccharides in bacillus cells |
WO2021019104A2 (en) | 2019-09-18 | 2021-02-04 | Basf Se | A production host for producing human milk oligosaccharides |
WO2021160828A1 (en) | 2020-02-14 | 2021-08-19 | Inbiose N.V. | Kdo-free production hosts for oligosaccharide synthesis |
JP2023526271A (ja) | 2020-05-13 | 2023-06-21 | グリコシン リミテッド ライアビリティー カンパニー | コロナウイルスによって誘導される炎症の防止および処置のための2’-フコシルラクトース |
EP4149950A4 (en) | 2020-05-13 | 2024-05-29 | Glycosyn LLC | FUCOSYLATED OLIGOSACCHARIDES FOR THE PREVENTION OF CORONAVIRUS INFECTION |
KR20230048380A (ko) | 2020-08-10 | 2023-04-11 | 인바이오스 엔.브이. | 세포에 의한 올리고당 혼합물의 제조 |
DK3954778T5 (da) | 2020-08-10 | 2024-08-05 | Inbiose Nv | Produktion af en blanding af neutrale ikke-fucosylerede oligosaccharider af en celle |
TW202221129A (zh) * | 2020-08-10 | 2022-06-01 | 比利時商因比奧斯公司 | 雙醣及/或寡醣的細胞生產 |
WO2022034080A1 (en) * | 2020-08-10 | 2022-02-17 | Inbiose N.V. | Cellular production of sialylated di- and/or oligosaccharides |
AU2021359711A1 (en) | 2020-10-16 | 2023-03-23 | Société des Produits Nestlé S. A. | Nutritional composition comprising human milk oligosaccharides |
JP2023547175A (ja) | 2020-11-10 | 2023-11-09 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 栄養組成物 |
MX2023007480A (es) * | 2020-12-22 | 2023-07-05 | Chr Hansen Hmo Gmbh | Sialiltransferasas para la producción de 6´-sialilactosa. |
CN114350584B (zh) * | 2021-12-17 | 2024-03-01 | 嘉必优生物技术(武汉)股份有限公司 | 高产唾液酸乳糖的工程菌及其构建方法与应用 |
DK202201117A1 (en) | 2022-12-09 | 2024-08-08 | Dsm Ip Assets Bv | Genetically modified udp-n-acetylgalactosamine producing cells |
WO2024165611A1 (en) * | 2023-02-07 | 2024-08-15 | Inbiose N.V. | Production of a disaccharide and/or milk oligosaccharide by a cell with reduced synthesis of udp-glcnac |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2796082B1 (fr) * | 1999-07-07 | 2003-06-27 | Centre Nat Rech Scient | Procede de production d'oligosaccharides |
WO2006034225A2 (en) | 2004-09-17 | 2006-03-30 | Neose Technologies, Inc. | Production of oligosaccharides by microorganisms |
AU2007222375B2 (en) * | 2006-03-09 | 2012-12-20 | Centre National De La Recherche Scientifique (Cnrs) | Method of producing sialylated oligosaccharides |
CN101809143A (zh) | 2006-09-26 | 2010-08-18 | 锡拉丘兹大学 | 用于增加唾液酸产量的代谢工程大肠杆菌 |
DE602007013588D1 (de) | 2006-10-03 | 2011-05-12 | Centre Nat Rech Scient | Fermentative produktion von sialinsäure (neu5ac) mit hoher ausbeute |
CA2682735C (en) * | 2007-04-16 | 2015-06-23 | Momenta Pharmaceuticals, Inc. | Multi-dimensional chromatographic methods for separating n-glycans |
CA2827313C (en) | 2011-02-16 | 2023-08-22 | Glycosyn LLC | Biosynthesis of human milk oligosaccharides in engineered bacteria |
US9567361B2 (en) | 2011-05-13 | 2017-02-14 | Glycosyn LLC | Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
US9029136B2 (en) | 2012-07-25 | 2015-05-12 | Glycosyn LLC | Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides |
HUE060672T2 (hu) | 2013-03-14 | 2023-04-28 | Glycosyn LLC | Mikroorganizmusok és eljárások szialilált és N-acetilglükózamint tartalmazó oligoszacharidok elõállítására |
EP3083938B1 (en) | 2014-05-15 | 2023-11-08 | Glycosyn LLC | Alpha (1,2) fucosyltransferase syngenes for use in the production of fucosylated oligosaccharides |
-
2014
- 2014-03-14 HU HUE18192520A patent/HUE060672T2/hu unknown
- 2014-03-14 ES ES18192520T patent/ES2930286T3/es active Active
- 2014-03-14 EP EP14769797.3A patent/EP2970872B1/en active Active
- 2014-03-14 CA CA2904091A patent/CA2904091A1/en active Pending
- 2014-03-14 EP EP18192520.7A patent/EP3467100B1/en active Active
- 2014-03-14 WO PCT/US2014/029804 patent/WO2014153253A1/en active Application Filing
- 2014-03-14 ES ES14769797T patent/ES2700274T3/es active Active
- 2014-03-14 DE DE14769797.3T patent/DE14769797T1/de active Pending
- 2014-03-14 EP EP22196607.0A patent/EP4166650A1/en active Pending
- 2014-03-14 DK DK14769797.3T patent/DK2970872T3/da active
- 2014-03-14 US US14/776,216 patent/US9758803B2/en active Active
- 2014-03-14 DK DK18192520.7T patent/DK3467100T3/da active
-
2017
- 2017-09-11 US US15/700,978 patent/US10415069B2/en active Active
-
2019
- 2019-08-28 US US16/554,460 patent/US11618912B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
ES2930286T3 (es) | 2022-12-09 |
US11618912B2 (en) | 2023-04-04 |
EP4166650A1 (en) | 2023-04-19 |
EP3467100A1 (en) | 2019-04-10 |
EP2970872B1 (en) | 2018-09-05 |
DE14769797T1 (de) | 2016-06-23 |
HUE060672T2 (hu) | 2023-04-28 |
EP2970872A4 (en) | 2016-11-09 |
CA2904091A1 (en) | 2014-09-25 |
US20200190548A1 (en) | 2020-06-18 |
EP3467100B1 (en) | 2022-09-21 |
US9758803B2 (en) | 2017-09-12 |
ES2700274T3 (es) | 2019-02-14 |
WO2014153253A1 (en) | 2014-09-25 |
US20160024543A1 (en) | 2016-01-28 |
US20180057849A1 (en) | 2018-03-01 |
DK2970872T1 (da) | 2016-05-09 |
EP2970872A1 (en) | 2016-01-20 |
US10415069B2 (en) | 2019-09-17 |
DK2970872T3 (da) | 2019-01-02 |
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