SG11201808756XA - Process for the preparation of isoxazoline compounds - Google Patents

Process for the preparation of isoxazoline compounds

Info

Publication number
SG11201808756XA
SG11201808756XA SG11201808756XA SG11201808756XA SG11201808756XA SG 11201808756X A SG11201808756X A SG 11201808756XA SG 11201808756X A SG11201808756X A SG 11201808756XA SG 11201808756X A SG11201808756X A SG 11201808756XA SG 11201808756X A SG11201808756X A SG 11201808756XA
Authority
SG
Singapore
Prior art keywords
international
pct
preparation
isoxazoline compounds
co7d
Prior art date
Application number
SG11201808756XA
Other languages
English (en)
Inventor
Chunhua Yang
Hir De Fallois Loic Le
Charles Meng
Alan Long
De Vries Roelof Gorter
Bruno Baillon
Sylvaine Lafont
De Saint Michel Myriam Gay
Stephane Kozlovic
Original Assignee
Merial Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Inc filed Critical Merial Inc
Publication of SG11201808756XA publication Critical patent/SG11201808756XA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A01N43/42Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647Triazoles; Hydrogenated triazoles
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N55/00Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
    • A01N55/08Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/107Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG11201808756XA 2016-04-06 2017-04-05 Process for the preparation of isoxazoline compounds SG11201808756XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662319207P 2016-04-06 2016-04-06
PCT/US2017/026245 WO2017176948A1 (fr) 2016-04-06 2017-04-05 Procédé de préparation de composés d'isoxazoline énantiomériquement enrichis et de solvate de toluène cristallin de (s)-afoxolaner

Publications (1)

Publication Number Publication Date
SG11201808756XA true SG11201808756XA (en) 2018-11-29

Family

ID=58549312

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201808756XA SG11201808756XA (en) 2016-04-06 2017-04-05 Process for the preparation of isoxazoline compounds

Country Status (31)

Country Link
US (3) US10433552B2 (fr)
EP (2) EP3440062B1 (fr)
KR (2) KR102438541B1 (fr)
CN (2) CN109195955B (fr)
AR (1) AR108184A1 (fr)
AU (2) AU2017246305B2 (fr)
BR (1) BR112018070663A2 (fr)
CA (2) CA3019947A1 (fr)
CL (2) CL2018002838A1 (fr)
CO (3) CO2019013841A2 (fr)
CY (1) CY1124797T1 (fr)
DK (1) DK3440062T3 (fr)
EA (1) EA201892245A1 (fr)
ES (1) ES2903286T3 (fr)
HR (1) HRP20211979T1 (fr)
HU (1) HUE056909T2 (fr)
IL (2) IL262093B (fr)
LT (1) LT3440062T (fr)
MD (2) MD20220052A2 (fr)
MX (2) MX2018012184A (fr)
MY (1) MY189534A (fr)
NZ (1) NZ747676A (fr)
PL (1) PL3440062T3 (fr)
PT (1) PT3440062T (fr)
RS (1) RS62755B1 (fr)
SG (1) SG11201808756XA (fr)
SI (1) SI3440062T1 (fr)
TW (1) TWI753897B (fr)
UA (1) UA127309C2 (fr)
UY (1) UY37196A (fr)
WO (1) WO2017176948A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10662163B2 (en) 2017-04-05 2020-05-26 Boehringer Ingelheim Animal Health USA Inc. Crystalline forms of (S)-afoxolaner
WO2019099669A1 (fr) 2017-11-16 2019-05-23 Avista Pharma Solutions, Inc. Composés antiparasitaires à énantiomère unique
BR112020012018A2 (pt) 2017-12-15 2020-11-24 Tarsus Pharmaceuticals, Inc. formulações de parasiticida de isoxazolina e métodos para tratar blefarite
TWI812673B (zh) * 2018-02-12 2023-08-21 美商富曼西公司 用於防治無脊椎害蟲之萘異噁唑啉化合物
CA3113874A1 (fr) 2018-10-29 2020-05-07 Basf Se Procede de preparation de composes d'aldol optiquement enrichis
CN115768753B (zh) * 2020-06-19 2024-04-26 东莞市东阳光动物保健药品有限公司 一种gaba抑制剂的晶型及其制备方法
KR20230043904A (ko) 2020-07-24 2023-03-31 엘랑코 유에스 인코포레이티드 이속사졸린 화합물 및 이의 중간체의 제조 공정
CN112724095A (zh) * 2020-09-25 2021-04-30 安徽省公众检验研究院有限公司 氟雷拉钠晶型及其制备方法
CN117915782A (zh) * 2021-06-25 2024-04-19 碗中动物健康公司 猫科动物口服饲料和在猫科动物中控制蚤侵袭的方法
AU2022326468A1 (en) 2021-08-11 2023-11-30 ELANCO US, Inc. Process for making diaryl isoxazoline derivative
CN114113388B (zh) * 2021-11-24 2023-05-23 丽珠集团新北江制药股份有限公司 一种4-肟甲基-1-萘甲酸中有关物质的检测方法
CN116253658B (zh) * 2022-11-25 2023-08-11 济南久隆医药科技有限公司 一种阿福拉纳中间体合成方法
CN115959979A (zh) * 2022-12-29 2023-04-14 南京正荣医药化学有限公司 一种3-氯-4-氟-5-三氟甲基三氟苯乙酮的制备方法
CN116143652A (zh) * 2023-01-13 2023-05-23 四川青木制药有限公司 一种阿福拉纳中间体及其制备方法和应用

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3060084A (en) 1961-06-09 1962-10-23 Du Pont Improved homogeneous, readily dispersed, pesticidal concentrate
US3299566A (en) 1964-06-01 1967-01-24 Olin Mathieson Water soluble film containing agricultural chemicals
US4144050A (en) 1969-02-05 1979-03-13 Hoechst Aktiengesellschaft Micro granules for pesticides and process for their manufacture
US3920442A (en) 1972-09-18 1975-11-18 Du Pont Water-dispersible pesticide aggregates
US4172714A (en) 1976-12-20 1979-10-30 E. I. Du Pont De Nemours And Company Dry compactible, swellable herbicidal compositions and pellets produced therefrom
GB2095558B (en) 1981-03-30 1984-10-24 Avon Packers Ltd Formulation of agricultural chemicals
US5180587A (en) 1988-06-28 1993-01-19 E. I. Du Pont De Nemours And Company Tablet formulations of pesticides
ES2126553T3 (es) 1989-08-30 1999-04-01 Aeci Ltd Dispositivo dosificador y su uso.
DE69106349T2 (de) 1990-03-12 1995-06-01 Du Pont Wasserdispergierbare oder wasserlösliche pestizide granulate aus hitzeaktivierten bindemitteln.
EP0480679B1 (fr) 1990-10-11 1996-09-18 Sumitomo Chemical Company Limited Composition pesticide
DE4322211A1 (de) 1993-07-03 1995-01-12 Basf Ag Wäßrige, mehrphasige, stabile Fertigformulierung für Pflanzenschutz-Wirkstoffe und Verfahren zu ihrer Herstellung
JP4883296B2 (ja) 2004-03-05 2012-02-22 日産化学工業株式会社 イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
JP5293921B2 (ja) 2005-09-02 2013-09-18 日産化学工業株式会社 イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤
WO2007070606A2 (fr) 2005-12-14 2007-06-21 E. I. Du Pont De Nemours And Company Isoxazolines destinees au controle des invertebres nuisibles
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
AU2007240954A1 (en) 2006-04-20 2007-11-01 E. I. Du Pont De Nemours And Company Pyrazolines for controlling invertebrate pests
JP2008044880A (ja) 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
US8466150B2 (en) 2006-12-28 2013-06-18 Abbott Laboratories Inhibitors of poly(ADP-ribose)polymerase
JP5256753B2 (ja) 2007-03-29 2013-08-07 住友化学株式会社 イソオキサゾリン化合物とその有害生物防除用途
BRPI0810196A2 (pt) 2007-04-10 2011-12-06 Bayer Cropscience Ag inseticidas de derivados de aril isoxazolina
MX2009013469A (es) * 2007-06-13 2010-01-20 Du Pont Insecticidas de isoxazolina.
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
JP5349303B2 (ja) 2007-06-27 2013-11-20 日産化学工業株式会社 3−ヒドロキシプロパン−1−オン化合物、2−プロペン−1−オン化合物およびイソキサゾリン化合物の製造方法
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
TWI649303B (zh) 2007-08-17 2019-02-01 杜邦股份有限公司 製備4-乙醯基-n-〔2-側氧基-2-〔(2,2,2-三氟乙基)胺基〕乙基〕-1-萘甲醯胺之化合物及方法
MX2010003557A (es) 2007-10-03 2010-04-12 Du Pont Compuestos de isoxazolina de naftaleno para el control de plagas de invertebrados.
WO2009063910A1 (fr) 2007-11-12 2009-05-22 Nissan Chemical Industries, Ltd. Procédé de synthèse catalytique asymétrique d'un composé d'isoxazoline optiquement actif
CN102088856B (zh) 2008-07-09 2015-11-25 巴斯夫欧洲公司 包含异*唑啉化合物的杀虫活性混合物i
JP5608676B2 (ja) 2008-12-19 2014-10-15 ノバルティス アーゲー イソオキサゾリン誘導体及びその殺虫剤としての使用
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
WO2011104089A1 (fr) 2010-02-25 2011-09-01 Syngenta Participations Ag Procédé de préparation de dérivés d'isoxazoline
US20130203591A1 (en) 2010-06-09 2013-08-08 Syngenta Crop Protection Llc Pesticidal mixtures including isoxazoline derivatives
RU2566083C3 (ru) 2011-03-10 2017-11-09 Зоетис Сервисиз ЛЛК Спироциклические производные изоксазолина в качестве противопаразитарных агентов
WO2013069731A1 (fr) 2011-11-08 2013-05-16 日産化学工業株式会社 Procédé de synthèse asymétrique catalytique de composé isoxazoline optiquement actif et composé isoxazoline optiquement actif
US20140371464A1 (en) 2012-02-03 2014-12-18 Zoetis Llc Process for the preparation of chiral isoxazoline azetidine derivatives as antiparasitic agents
EP4056572A1 (fr) 2012-11-21 2022-09-14 Zoetis Services LLC Synthèse de dérivés d'isoxazoline spirocyclique
WO2014090918A1 (fr) 2012-12-13 2014-06-19 Novartis Ag Procédé pour l'enrichissement énantiomérique de dérivés de diaryloxazoline
PT2950795T (pt) * 2013-01-31 2018-07-30 Merial Inc Método de tratamento e cura de leishmaniose utilizando fexinidazole
AR096022A1 (es) * 2013-04-11 2015-12-02 Basf Se Compuestos de pirimidinio sustituido, útiles para combatir plagas de animales

Also Published As

Publication number Publication date
CA3214922A1 (fr) 2017-10-12
US20190133129A1 (en) 2019-05-09
US10433552B2 (en) 2019-10-08
KR20180132834A (ko) 2018-12-12
KR102438541B1 (ko) 2022-08-30
CO2018010719A2 (es) 2018-12-28
AU2021203129A1 (en) 2021-06-10
CN109195955B (zh) 2022-10-18
CY1124797T1 (el) 2022-11-25
AU2017246305B2 (en) 2021-04-29
MD20220052A2 (ro) 2023-05-31
CA3019947A1 (fr) 2017-10-12
CL2019003235A1 (es) 2020-02-14
EP3978483A1 (fr) 2022-04-06
MD20180090A2 (ro) 2019-02-28
SI3440062T1 (sl) 2021-12-31
CN109195955A (zh) 2019-01-11
TW201739740A (zh) 2017-11-16
MD4846C1 (ro) 2023-10-31
CO2019013500A2 (es) 2020-02-28
IL280679A (en) 2021-03-25
HRP20211979T1 (hr) 2022-04-01
IL280679B (en) 2021-12-01
PL3440062T3 (pl) 2022-02-07
LT3440062T (lt) 2021-12-10
UA127309C2 (uk) 2023-07-19
CO2019013841A2 (es) 2020-04-01
KR102403531B1 (ko) 2022-05-27
MX2020013754A (es) 2022-07-25
AU2021203129B2 (en) 2023-03-16
US10750744B2 (en) 2020-08-25
AR108184A1 (es) 2018-07-25
NZ747676A (en) 2023-05-26
UY37196A (es) 2017-10-31
CN114805234A (zh) 2022-07-29
MY189534A (en) 2022-02-16
US11324220B2 (en) 2022-05-10
DK3440062T3 (da) 2022-01-03
EP3440062B1 (fr) 2021-10-06
EA201892245A1 (ru) 2019-07-31
HUE056909T2 (hu) 2022-04-28
WO2017176948A1 (fr) 2017-10-12
AU2017246305A1 (en) 2018-11-15
CL2018002838A1 (es) 2018-11-30
IL262093A (en) 2018-11-29
PT3440062T (pt) 2021-12-24
US20170311601A1 (en) 2017-11-02
BR112018070663A2 (pt) 2019-02-05
EP3440062A1 (fr) 2019-02-13
US20210022344A1 (en) 2021-01-28
TWI753897B (zh) 2022-02-01
MD4846B1 (ro) 2023-02-28
ES2903286T3 (es) 2022-03-31
RS62755B1 (sr) 2022-01-31
KR20220003635A (ko) 2022-01-10
MX2018012184A (es) 2019-02-07
IL262093B (en) 2021-02-28

Similar Documents

Publication Publication Date Title
SG11201808756XA (en) Process for the preparation of isoxazoline compounds
SG11201810117WA (en) Human platelet lysate derived extracellular vesicles for use in medicine
SG11201903287PA (en) Anti-respiratory syncytial virus antibodies, and methods of their generation and use
SG11201807301SA (en) Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (dub) inhibitors
SG11201908721TA (en) Conjugation of a cytotoxic drug with bis-linkage
SG11201806419RA (en) Anti-cd74 antibody conjugates, compositions comprising anti-cd74 antibody conjugates and methods of using anti-cd74 antibody conjugates
SG11201808125RA (en) Methods for solid tumor treatment
SG11201808566WA (en) Polymorphic form of n-{6-(2-hydroxypropan-2-yl)-2-[2-(methylsulphonyl)ethyl]-2h-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide
SG11201810579YA (en) Pyrimidin-2-ylamino-1h-pyrazols as lrrk2 inhibitors for use in the treatment of neurodegenerative disorders
SG11201908640TA (en) Pyrrolidinones and a process to prepare them
SG11201500005SA (en) Pyrimidine pyrazolyl derivatives
SG11201900618WA (en) Permanently polarized hydroxyapatite, a process for its manufacture and uses thereof
SG11201811559WA (en) Cancer treatment combinations
SG11201808686VA (en) Synthesis of indazoles
SG11201809830WA (en) Selective reduction of cysteine-engineered antibodies
SG11201810143PA (en) Exon skipping oligomers for muscular dystrophy
SG11201807540UA (en) Novel compounds and pharmaceutical compositions thereof for the treatment of fibrosis
SG11201903076QA (en) Carbamoyl phenylalaninol compounds and uses therof
SG11201804589TA (en) Piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
SG11201903230QA (en) TCRa HOMING ENDONUCLEASE VARIANTS
SG11201810123SA (en) Treatment of intrahepatic cholestatic diseases
SG11201901986SA (en) Process for the manufacture of a solid pharmaceutical adminstration form
SG11201900633XA (en) Piperidine cxcr7 receptor modulators
SG11201809561WA (en) 9-aminomethyl minocycline compounds and methods of use thereof in urinary tract infection (uti) treatment
SG11201906313SA (en) A polypeptide linker for preparing multispecific antibodies