SG11201810123SA - Treatment of intrahepatic cholestatic diseases - Google Patents
Treatment of intrahepatic cholestatic diseasesInfo
- Publication number
- SG11201810123SA SG11201810123SA SG11201810123SA SG11201810123SA SG11201810123SA SG 11201810123S A SG11201810123S A SG 11201810123SA SG 11201810123S A SG11201810123S A SG 11201810123SA SG 11201810123S A SG11201810123S A SG 11201810123SA SG 11201810123S A SG11201810123S A SG 11201810123SA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- suite
- newark
- pct
- treatment
- Prior art date
Links
- 230000001587 cholestatic effect Effects 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- JWHYSEDOYMYMNM-QGZVFWFLSA-N 2-[4-[(2r)-2-ethoxy-3-[4-(trifluoromethyl)phenoxy]propyl]sulfanyl-2-methylphenoxy]acetic acid Chemical compound C([C@@H](OCC)CSC=1C=C(C)C(OCC(O)=O)=CC=1)OC1=CC=C(C(F)(F)F)C=C1 JWHYSEDOYMYMNM-QGZVFWFLSA-N 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229950009639 seladelpar Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Farming Of Fish And Shellfish (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111 11111111111111111111111111111111111111111111111111011111101111011111 Organization 0 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/209865 Al 07 December 2017 (07.12.2017) WIP0 I PCT (51) International Patent Classification: A61K 31/192 (2006.01) A61P 1/16 (2006.01) (21) International Application Number: PCT/US2017/029620 (22) International Filing Date: 26 April 2017 (26.04.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/343,688 31 May 2016 (31.05.2016) US (71) Applicant: CYMABAY THERAPEUTICS, INC. [US/US]; 7999 Gateway Blvd., Suite 130, Newark, CA 94560 (US). (72) Inventors: BOUDES, Pol; c/o CymaBay Therapeutics, Inc., 7999 Gateway Blvd., Suite 130, Newark, CA 94560 (US). MCWHERTER, Charles, A.; c/o CymaBay Thera- — peutics, Inc., 7999 Gateway Blvd., Suite 130, Newark, CA 94560 (US). = Agent: NGUYEN, Sam, L. et al.; Hamilton, Desanctis & (74) Cha, LLP, 3239 El Camino Real, Suite 220, Palo Alto, CA = 94306 (US). = Designated States (unless otherwise indicated, for every (81) kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, = = = KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, = MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, = PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, = = SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = = Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, = GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, — EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = — 1-1 -•!! Published: in — with international search report (Art. 21(3)) GC 0\ C0 ei IN 1-1 (54) Title: TREATMENT OF INTRAHEPATIC CHOLESTATIC DISEASES 0 ei (57) : Treatment of intrahepatic cholestatic diseases by therapy with seladelpar or a salt thereof.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662343688P | 2016-05-31 | 2016-05-31 | |
PCT/US2017/029620 WO2017209865A1 (en) | 2016-05-31 | 2017-04-26 | Treatment of intrahepatic cholestatic diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201810123SA true SG11201810123SA (en) | 2018-12-28 |
Family
ID=58699276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201810123SA SG11201810123SA (en) | 2016-05-31 | 2017-04-26 | Treatment of intrahepatic cholestatic diseases |
Country Status (25)
Country | Link |
---|---|
US (5) | US10272058B2 (en) |
EP (1) | EP3463328B1 (en) |
JP (1) | JP7079735B2 (en) |
KR (1) | KR102408288B1 (en) |
CN (1) | CN109195594A (en) |
AU (1) | AU2017274293B2 (en) |
BR (1) | BR112018074147A2 (en) |
CA (1) | CA3024155C (en) |
DK (1) | DK3463328T3 (en) |
ES (1) | ES2921230T3 (en) |
HR (1) | HRP20220903T1 (en) |
HU (1) | HUE059838T2 (en) |
IL (1) | IL263372B2 (en) |
LT (1) | LT3463328T (en) |
MX (1) | MX2018014915A (en) |
NZ (1) | NZ748721A (en) |
PL (1) | PL3463328T3 (en) |
PT (1) | PT3463328T (en) |
RS (1) | RS63345B1 (en) |
RU (1) | RU2765460C2 (en) |
SG (1) | SG11201810123SA (en) |
SI (1) | SI3463328T1 (en) |
UA (1) | UA122719C2 (en) |
WO (1) | WO2017209865A1 (en) |
ZA (1) | ZA201808360B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3119384B1 (en) | 2014-03-20 | 2018-09-12 | CymaBay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
US10272058B2 (en) | 2014-03-20 | 2019-04-30 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
US10512622B2 (en) | 2017-07-14 | 2019-12-24 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
AU2019378845A1 (en) * | 2018-11-16 | 2021-06-03 | Cymabay Therapeutics, Inc. | Combination treatment of NAFLD and NASH |
RS65546B1 (en) * | 2021-02-01 | 2024-06-28 | Cymabay Therapeutics Inc | Treatment of cholangiopathies with seladelpar |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7101993B1 (en) | 1990-01-11 | 2006-09-05 | Isis Pharmaceuticals, Inc. | Oligonucleotides containing 2′-O-modified purines |
US7015315B1 (en) | 1991-12-24 | 2006-03-21 | Isis Pharmaceuticals, Inc. | Gapped oligonucleotides |
US5739135A (en) | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
US6166197A (en) | 1995-03-06 | 2000-12-26 | Isis Pharmaceuticals, Inc. | Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions |
DE69636160D1 (en) | 1995-03-06 | 2006-06-29 | Isis Pharmaceuticals Inc | PROCESS FOR SYNTHESIS OF 2'-O-SUBSTITUTED PYRIMIDINES AND OLIGOMERS THEREOF |
TR199801581T2 (en) | 1996-02-14 | 1998-10-21 | Isis Pharmaceuticals, Inc. | �ekerle de�i�tirilmi� bo�luklu oligon�kleotid’ler. |
US5883109A (en) | 1996-07-24 | 1999-03-16 | Bristol-Myers Squibb Company | Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug |
US6066653A (en) | 1997-01-17 | 2000-05-23 | Bristol-Myers Squibb Co. | Method of treating acid lipase deficiency diseases with an MTP inhibitor and cholesterol lowering drugs |
US7407943B2 (en) | 2001-08-01 | 2008-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein B expression |
US7511131B2 (en) | 2002-11-13 | 2009-03-31 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
US7981915B2 (en) | 2003-04-30 | 2011-07-19 | Beth Israel Deaconess Medical Center | Methods for modulating PPAR biological activity for the treatment of diseases caused by mutations in the CFTR gene |
WO2005042478A2 (en) | 2003-09-19 | 2005-05-12 | Janssen Pharmaceutica, N.V. | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
US7932268B2 (en) | 2004-03-05 | 2011-04-26 | The Trustees Of The University Of Pennsylvania | Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects |
JO3006B1 (en) | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | Novel Lysine Salts of 4-((Phenoxy Alkyl)Thio)-Phenoxy Acetic Acid Derivatives |
ES2712052T3 (en) | 2008-10-17 | 2019-05-09 | Cymabay Therapeutics Inc | Methods to reduce small and dense LDL particles |
KR101357438B1 (en) * | 2009-04-29 | 2014-02-06 | 아마린 코포레이션 피엘씨 | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
CN102834099B (en) | 2010-03-30 | 2015-05-27 | 诺华有限公司 | Uses of DGAT1 inhibitors |
JOP20200043A1 (en) | 2011-05-10 | 2017-06-16 | Amgen Inc | Methods of treating or preventing cholesterol related disorders |
US20150139987A1 (en) | 2013-11-20 | 2015-05-21 | Cymabay Therapeutics, Inc. | Treatment of homozygous familial hypercholesterolemia |
US20160279085A1 (en) | 2013-11-20 | 2016-09-29 | Cymabay Therapeutics, Inc. | Treatment of Severe Hyperlipidemia |
US10272058B2 (en) | 2014-03-20 | 2019-04-30 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
EP3119384B1 (en) | 2014-03-20 | 2018-09-12 | CymaBay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
PT3129018T (en) | 2014-04-11 | 2020-01-15 | Cymabay Therapeutics Inc | Treatment of nafld and nash |
EA201790091A1 (en) | 2014-06-26 | 2017-07-31 | Саймабэй Терапьютикс, Инк. | TREATMENT OF HEAVY HYPERTRIGLICERIDEMIA |
US10512622B2 (en) | 2017-07-14 | 2019-12-24 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
JP7023371B2 (en) | 2017-09-26 | 2022-02-21 | サイマベイ・セラピューティクス・インコーポレイテッド | Treatment of cholestasis pruritus |
AU2019378845A1 (en) | 2018-11-16 | 2021-06-03 | Cymabay Therapeutics, Inc. | Combination treatment of NAFLD and NASH |
MX2021005725A (en) | 2018-11-16 | 2021-07-21 | Cymabay Therapeutics Inc | Treatment of obesity and its complications. |
-
2017
- 2017-04-25 US US15/496,875 patent/US10272058B2/en active Active
- 2017-04-26 NZ NZ748721A patent/NZ748721A/en unknown
- 2017-04-26 SG SG11201810123SA patent/SG11201810123SA/en unknown
- 2017-04-26 BR BR112018074147-7A patent/BR112018074147A2/en not_active Application Discontinuation
- 2017-04-26 RS RS20220620A patent/RS63345B1/en unknown
- 2017-04-26 DK DK17722943.2T patent/DK3463328T3/en active
- 2017-04-26 EP EP17722943.2A patent/EP3463328B1/en active Active
- 2017-04-26 KR KR1020187037704A patent/KR102408288B1/en active IP Right Grant
- 2017-04-26 CN CN201780033512.XA patent/CN109195594A/en active Pending
- 2017-04-26 ES ES17722943T patent/ES2921230T3/en active Active
- 2017-04-26 SI SI201731175T patent/SI3463328T1/en unknown
- 2017-04-26 AU AU2017274293A patent/AU2017274293B2/en active Active
- 2017-04-26 HR HRP20220903TT patent/HRP20220903T1/en unknown
- 2017-04-26 CA CA3024155A patent/CA3024155C/en active Active
- 2017-04-26 WO PCT/US2017/029620 patent/WO2017209865A1/en unknown
- 2017-04-26 RU RU2018146504A patent/RU2765460C2/en active
- 2017-04-26 UA UAA201811776A patent/UA122719C2/en unknown
- 2017-04-26 HU HUE17722943A patent/HUE059838T2/en unknown
- 2017-04-26 PL PL17722943.2T patent/PL3463328T3/en unknown
- 2017-04-26 MX MX2018014915A patent/MX2018014915A/en unknown
- 2017-04-26 JP JP2018562567A patent/JP7079735B2/en active Active
- 2017-04-26 PT PT177229432T patent/PT3463328T/en unknown
- 2017-04-26 LT LTEPPCT/US2017/029620T patent/LT3463328T/en unknown
-
2018
- 2018-11-29 IL IL263372A patent/IL263372B2/en unknown
- 2018-12-11 ZA ZA2018/08360A patent/ZA201808360B/en unknown
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2019
- 2019-03-28 US US16/367,660 patent/US10478411B2/en active Active
- 2019-10-09 US US16/597,313 patent/US10813895B2/en active Active
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2020
- 2020-09-18 US US17/024,971 patent/US11000494B2/en active Active
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2021
- 2021-04-03 US US17/221,784 patent/US11596614B2/en active Active
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