SG11201807404XA - Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease - Google Patents

Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease

Info

Publication number
SG11201807404XA
SG11201807404XA SG11201807404XA SG11201807404XA SG11201807404XA SG 11201807404X A SG11201807404X A SG 11201807404XA SG 11201807404X A SG11201807404X A SG 11201807404XA SG 11201807404X A SG11201807404X A SG 11201807404XA SG 11201807404X A SG11201807404X A SG 11201807404XA
Authority
SG
Singapore
Prior art keywords
international
madrid
crohn
disease
stem cells
Prior art date
Application number
SG11201807404XA
Other languages
English (en)
Inventor
Eduardo Bravo
Maria Pascual
Original Assignee
Tigenix S A U
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tigenix S A U filed Critical Tigenix S A U
Publication of SG11201807404XA publication Critical patent/SG11201807404XA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0667Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653Adipocytes; Adipose tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201807404XA 2016-03-14 2017-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease SG11201807404XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1604304.4A GB201604304D0 (en) 2016-03-14 2016-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
PCT/IB2017/051468 WO2017158509A1 (en) 2016-03-14 2017-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease

Publications (1)

Publication Number Publication Date
SG11201807404XA true SG11201807404XA (en) 2018-09-27

Family

ID=55952284

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202008992YA SG10202008992YA (en) 2016-03-14 2017-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
SG11201807404XA SG11201807404XA (en) 2016-03-14 2017-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10202008992YA SG10202008992YA (en) 2016-03-14 2017-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease

Country Status (26)

Country Link
US (3) US10357518B2 (he)
EP (2) EP3219321B1 (he)
JP (2) JP6931656B2 (he)
KR (1) KR102277789B1 (he)
CN (2) CN108883135B (he)
AU (1) AU2017232718B2 (he)
BE (1) BE1024781B1 (he)
CA (1) CA3017694C (he)
DE (1) DE102017002458B4 (he)
DK (1) DK3219321T3 (he)
ES (2) ES2911718T3 (he)
FR (1) FR3048614B1 (he)
GB (2) GB201604304D0 (he)
HR (1) HRP20220539T1 (he)
HU (1) HUE058739T2 (he)
IL (2) IL261730B2 (he)
LT (1) LT3219321T (he)
MX (1) MX2018010699A (he)
NL (1) NL2018512B1 (he)
NO (1) NO345415B1 (he)
PL (1) PL3219321T3 (he)
RS (1) RS63163B1 (he)
RU (1) RU2742308C2 (he)
SG (2) SG10202008992YA (he)
SI (1) SI3219321T1 (he)
WO (1) WO2017158509A1 (he)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
GB201604304D0 (en) * 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
US20210401895A1 (en) 2017-03-30 2021-12-30 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with live biotherapeutics
KR20210133988A (ko) * 2019-02-27 2021-11-08 타이제닉스, 에스.에이.유. 동종 요법을 위한 개선된 줄기세포 집단
BR112022018022A2 (pt) * 2020-03-11 2022-10-18 Mesoblast Int Sarl Método para tratar doença inflamatória intestinal ii
AU2021234104A1 (en) * 2020-03-11 2022-09-29 Mesoblast International Sàrl Method for treating inflammatory bowel disease I
CN111481573A (zh) * 2020-03-26 2020-08-04 卡替(上海)生物技术股份有限公司 牙髓间充质干细胞在制备克罗恩病治疗药物中的用途
AU2021388154A1 (en) * 2020-11-25 2023-06-22 Flagship Pioneering, Inc. Adipogenic cell compositions and methods
WO2023230524A1 (en) * 2022-05-25 2023-11-30 Flagship Pioneering Innovations Vi, Llc Compositions of secretory and/or catalytic cells and methods using the same

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US6010696A (en) 1990-11-16 2000-01-04 Osiris Therapeutics, Inc. Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5733542A (en) 1990-11-16 1998-03-31 Haynesworth; Stephen E. Enhancing bone marrow engraftment using MSCS
JPH09502421A (ja) 1992-12-02 1997-03-11 シエル・インターナシヨナル・リサーチ・マートシヤツピイ・ベー・ブイ アゾキシシアノベンゼン誘導体
US5578475A (en) 1993-07-12 1996-11-26 Life Technologies, Inc. Composition and methods for transfecting eukaryotic cells
US5472183A (en) 1994-03-17 1995-12-05 Nisca Corporation Sheet feeding device with multiple sheet stackers
US6174333B1 (en) 1994-06-06 2001-01-16 Osiris Therapeutics, Inc. Biomatrix for soft tissue regeneration using mesenchymal stem cells
AU686823B2 (en) 1994-06-06 1998-02-12 Case Western Reserve University Biomatrix for tissue regeneration
DE69634084T2 (de) 1995-06-07 2005-12-08 Inex Pharmaceuticals Corp. Herstellung von lipid-nukleinsäure partikeln duch ein hydrophobische lipid-nukleinsäuree komplexe zwischenprodukt und zur verwendung in der gentransfer
US6051429A (en) 1995-06-07 2000-04-18 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
US5744335A (en) 1995-09-19 1998-04-28 Mirus Corporation Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
US6546106B2 (en) 1996-09-03 2003-04-08 New Transducers Limited Acoustic device
US5705308A (en) 1996-09-30 1998-01-06 Eastman Kodak Company Infrared-sensitive, negative-working diazonaphthoquinone imaging composition and element
EP1036163B1 (en) 1997-12-02 2010-08-18 Artecel Sciences, Inc. Differentiation of adipose stromal cells into osteoblasts and uses thereof
US6368636B1 (en) 1998-03-18 2002-04-09 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
US9585916B2 (en) 1999-03-26 2017-03-07 Northern Therapeutics Inc. Cell based therapy for the pulmonary system
ATE246938T1 (de) 1998-04-03 2003-08-15 Osiris Therapeutics Inc Anwendung der mesenchymalen stammzellen als immunsuppressiva
US6546105B1 (en) 1998-10-30 2003-04-08 Matsushita Electric Industrial Co., Ltd. Sound image localization device and sound image localization method
US20030082152A1 (en) 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
EP1165830B1 (en) 1999-03-10 2017-07-12 University of Pittsburgh of the Commonwealth System of Higher Education Adipose-derived stem cells and lattices
US20050153442A1 (en) 1999-03-10 2005-07-14 Adam Katz Adipose-derived stem cells and lattices
US6777231B1 (en) 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
US7670628B2 (en) 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
US6555374B1 (en) 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
US20020155096A1 (en) 2001-02-23 2002-10-24 Chancellor Michael B. Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair
US20030054331A1 (en) 2001-09-14 2003-03-20 Stemsource, Inc. Preservation of non embryonic cells from non hematopoietic tissues
MXPA04004311A (es) * 2001-11-09 2005-03-31 Artecel Sciences Inc DIFERENCIACION DEL PáNCREAS ENDOCRINOS DE CELULAS ESTROMALES DERIVADAS DEL TEJIDO ADIPOSO Y USOS DE LAS MISMAS.
MXPA04004310A (es) 2001-11-09 2005-03-31 Artecel Sciences Inc Metodos y composiciones para el uso de celulas estromales para soportar celulas madre embrionarias y adultas.
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
EP1499347A2 (en) 2002-03-15 2005-01-26 Department of Veterans Affairs, Rehabilitation R&D Service Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
DE60318706T2 (de) 2002-06-14 2009-04-30 Cartela R & D Ab Marker für stammzellen und dessen verwendung
US20040101959A1 (en) 2002-11-21 2004-05-27 Olga Marko Treatment of tissue with undifferentiated mesenchymal cells
ATE482725T1 (de) 2003-04-01 2010-10-15 Us Dept Of Veteran S Affaires Auf stammzellen, vorläuferzellen oder targetzellen basierende behandlung von multiorganversagen.
ES2265199B1 (es) 2003-06-12 2008-02-01 Cellerix, S.L. Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones.
CA2530422C (en) 2003-06-27 2016-01-05 Ian Ross Harris Postpartum-derived cells for use in treatment of disease of the heart and circulatory system
US7645229B2 (en) 2003-09-26 2010-01-12 Armstrong David N Instrument and method for endoscopic visualization and treatment of anorectal fistula
US9074190B2 (en) 2003-10-07 2015-07-07 Biomaster, Inc. Cell differentiation of adipose-derived precursor cells
DE602004030823D1 (de) 2003-11-04 2011-02-10 Biomaster Inc Verfahren und system zur herstellung von stammzellen aus fettgewebe
JP2007530543A (ja) 2004-03-22 2007-11-01 オシリス セラピューティクス,インコーポレイテッド 間葉幹細胞及びその使用法
US20080095749A1 (en) 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
RU2252252C1 (ru) 2004-04-09 2005-05-20 Тепляшин Александр Сергеевич Способ выделения мезенхимальных стволовых клеток
ES2264862B8 (es) 2004-08-25 2017-01-20 Cellerix, S.L. Biomaterial para sutura.
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
ES2313805B1 (es) 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
WO2006029347A2 (en) 2004-09-03 2006-03-16 University Of Maryland, Baltimore Integrin cd18 is a novel stromal stem cell marker and functions to promote osteogenesis
WO2006110582A1 (en) 2005-04-08 2006-10-19 Xcyte Therapies, Inc. Compositions and methods for the treatment of burns and sepsis
AU2006299144A1 (en) 2005-09-23 2007-04-12 Cellerix, S.L. Cell populations having immunoregulatory activity, method for isolation and uses
EP1795588A1 (en) 2005-12-07 2007-06-13 Cellerix, S.L. Use of adipose tissue derived mesenchymal stem cells for the treatment of graft versus host disease
US20120269774A1 (en) 2006-09-21 2012-10-25 Medistem Laboratories, Inc Allogeneic stem cell transplants in non-conditioned recipients
JPWO2009031606A1 (ja) 2007-09-07 2010-12-16 日本ケミカルリサーチ株式会社 関節炎治療及び予防剤
EP3103463B1 (en) 2007-09-19 2020-01-01 Pluristem Ltd. Adherent cells from adipose or placenta tissues and use thereof in therapy
JP5539886B2 (ja) 2007-10-17 2014-07-02 ティクセル Tr1細胞、間葉系幹細胞およびその使用
GB0814249D0 (en) 2008-08-04 2008-09-10 Cellerix Sa Uses of mesenchymal stem cells
ES2345867B1 (es) * 2009-04-03 2011-07-28 Fundacion Instituto Mediterraneo Para La Biotecnologia Y La Investigacion Sanitaria (Imabis) Celulas madre multipotentes derivadas de estroma de mesenterio.
DK2425844T3 (da) * 2009-04-28 2014-06-16 Anterogen Co Ltd Autolog og allogen stromastamcellesammensætning, der stammer fra fedtvæv, til behandling af fistler
KR101788885B1 (ko) 2009-07-09 2017-10-20 타이제닉스, 에스.에이.유. 세포 요법에 사용하기 위한 방법 및 조성물
CN103298939A (zh) * 2010-12-06 2013-09-11 夸克医药公司 包含位置修饰的双链寡核苷酸化合物
ES2479544T1 (es) 2011-01-12 2014-08-20 Tigenix, S.A.U. Células madre mesenquimales derivadas de tejido adiposo para administración intralinfática en enfermedades autoimmunes e inflamatorias
ES2479565T1 (es) 2011-03-11 2014-08-20 Tigenix, S.A.U. Poblaciones celulares que tienen actividad immunoreguladora, método para el aislamiento y usos
US20140134140A1 (en) 2012-11-09 2014-05-15 Case Western Reserve University Mesenchymal stem cell compositions for the treatment of microbial infections
EP2972368B1 (en) * 2013-03-15 2019-07-24 TiGenix, S.A.U. Lymphocyte biomarkers for determining the clinical response to cell therapy
JP6412933B2 (ja) 2013-06-25 2018-10-24 ティジェニクス エス.エー.ユー. 免疫調節活性を有する細胞集団、その調製方法および使用
EP3160481B1 (en) * 2014-06-30 2020-09-09 TiGenix, S.A.U. Mesenchymal stromal cells for treating sepsis
AU2016327285A1 (en) * 2015-09-24 2018-04-12 Cellect Biotherapeutics Ltd. Methods for propagating mesenchymal stem cells (MSC) for use in transplantation
GB201604304D0 (en) * 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease

Also Published As

Publication number Publication date
CA3017694A1 (en) 2017-09-21
HRP20220539T1 (hr) 2022-06-10
SI3219321T1 (sl) 2022-05-31
EP4074322A1 (en) 2022-10-19
BR112018068493A2 (pt) 2019-01-22
US20220249574A1 (en) 2022-08-11
NL2018512B1 (en) 2017-09-07
FR3048614B1 (fr) 2020-02-21
ES2681774A1 (es) 2018-09-14
US20170258851A1 (en) 2017-09-14
IL298107B2 (he) 2024-02-01
CA3017694C (en) 2024-02-27
JP6931656B2 (ja) 2021-09-08
SG10202008992YA (en) 2020-10-29
HUE058739T2 (hu) 2022-09-28
CN108883135A (zh) 2018-11-23
IL298107B1 (he) 2023-10-01
US20190381106A1 (en) 2019-12-19
GB2548490B (en) 2020-09-02
IL298107A (he) 2023-01-01
CN115569151A (zh) 2023-01-06
BE1024781B1 (de) 2018-07-02
GB201604304D0 (en) 2016-04-27
US11273182B2 (en) 2022-03-15
LT3219321T (lt) 2022-05-10
BE1024781A1 (de) 2018-06-27
RU2742308C2 (ru) 2021-02-04
WO2017158509A1 (en) 2017-09-21
RS63163B1 (sr) 2022-05-31
AU2017232718B2 (en) 2024-01-18
AU2017232718A1 (en) 2018-10-04
FR3048614A1 (he) 2017-09-15
ES2681774B1 (es) 2019-12-26
MX2018010699A (es) 2019-01-14
NO345415B1 (en) 2021-01-18
JP2021119789A (ja) 2021-08-19
PL3219321T3 (pl) 2022-05-30
BR112018068493A8 (pt) 2022-06-28
CN108883135B (zh) 2022-11-04
DE102017002458B4 (de) 2019-04-25
JP2019508455A (ja) 2019-03-28
DE102017002458A1 (de) 2017-09-14
RU2018131519A (ru) 2020-04-15
GB2548490A (en) 2017-09-20
KR102277789B1 (ko) 2021-07-15
NO20170376A1 (en) 2017-09-15
ES2911718T3 (es) 2022-05-20
EP3219321A1 (en) 2017-09-20
NL2018512A (en) 2017-03-30
DK3219321T3 (da) 2022-04-25
IL261730A (he) 2018-10-31
US10357518B2 (en) 2019-07-23
IL261730B2 (he) 2024-05-01
RU2018131519A3 (he) 2020-07-10
IL261730B1 (he) 2024-01-01
GB201704065D0 (en) 2017-04-26
EP3219321B1 (en) 2022-03-30
KR20180120261A (ko) 2018-11-05

Similar Documents

Publication Publication Date Title
SG11201807404XA (en) Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
SG11201907857RA (en) Edible and biodegradable utensils
SG11201811431VA (en) Multispecific antibodies against cd40 and cd137
SG11201901141WA (en) Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof
SG11201804758QA (en) Aqueous pharmaceutical formulation comprising anti-pd-1 antibody avelumab
SG11201807252QA (en) Anti-lag-3 antibodies
SG11201809499UA (en) Processes for preparing phosphorodiamidate morpholino oligomers
SG11201805120YA (en) Zika virus vaccine
SG11201808990QA (en) Compositions for topical application of compounds
SG11201804901WA (en) Compounds for the treatment of cancer and inflammatory disease
SG11201808222RA (en) Methods of treatment of cholestatic diseases
SG11201810429UA (en) Anti-cd19 antibody formulations
SG11201806544XA (en) Compounds and methods of treating rna-mediated diseases
SG11201906436VA (en) Novel heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same
SG11201804916PA (en) Three-dimensional polymer networks with channels situated therein
SG11201805204WA (en) Nicotine particle capsule
SG11202000333UA (en) Bicyclic ketone compounds and methods of use thereof
SG11201804123VA (en) Modulators of kv3 channels to treat pain
SG11201901438VA (en) Solid forms of cenicriviroc mesylate and processes of making solid forms of cenicriviroc mesylate
SG11201407570SA (en) Surface covering system and method for producing such a system
SG11201804774YA (en) Diastereoselective synthesis of phosphate derivatives and of the gemcitabine prodrug nuc-1031
SG11201803918VA (en) Production of steviol glycosides in recombinant hosts
SG11201909841RA (en) Antitumoral compounds
SG11201807549TA (en) Combination of a cxcr4 antagonist and an immune checkpoint inhibitor
SG11201806424TA (en) Therapeutic compounds