ATE246938T1 - Anwendung der mesenchymalen stammzellen als immunsuppressiva - Google Patents
Anwendung der mesenchymalen stammzellen als immunsuppressivaInfo
- Publication number
- ATE246938T1 ATE246938T1 AT99911322T AT99911322T ATE246938T1 AT E246938 T1 ATE246938 T1 AT E246938T1 AT 99911322 T AT99911322 T AT 99911322T AT 99911322 T AT99911322 T AT 99911322T AT E246938 T1 ATE246938 T1 AT E246938T1
- Authority
- AT
- Austria
- Prior art keywords
- stem cells
- mesenchymal stem
- immunosuppressants
- application
- provides
- Prior art date
Links
- 210000002901 mesenchymal stem cell Anatomy 0.000 title abstract 3
- 229960003444 immunosuppressant agent Drugs 0.000 title 1
- 239000003018 immunosuppressive agent Substances 0.000 title 1
- 230000017274 T cell anergy Effects 0.000 abstract 2
- 230000028993 immune response Effects 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4636—Immune checkpoint inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4648—Bacterial antigens
- A61K39/46482—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1352—Mesenchymal stem cells
- C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Transplantation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8067898P | 1998-04-03 | 1998-04-03 | |
PCT/US1999/005350 WO1999051275A2 (en) | 1998-04-03 | 1999-03-12 | Mesenchymal stem cells as immunosuppressants |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE246938T1 true ATE246938T1 (de) | 2003-08-15 |
Family
ID=22158925
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99911322T ATE246938T1 (de) | 1998-04-03 | 1999-03-12 | Anwendung der mesenchymalen stammzellen als immunsuppressiva |
Country Status (11)
Country | Link |
---|---|
US (1) | US6797269B2 (de) |
EP (1) | EP1066060B1 (de) |
JP (1) | JP2002510655A (de) |
AT (1) | ATE246938T1 (de) |
AU (1) | AU2999199A (de) |
CA (1) | CA2326838C (de) |
DE (1) | DE69910362T2 (de) |
DK (1) | DK1066060T3 (de) |
ES (1) | ES2205792T3 (de) |
PT (1) | PT1066060E (de) |
WO (1) | WO1999051275A2 (de) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
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EP1062321B1 (de) * | 1998-03-13 | 2004-12-29 | Osiris Therapeutics, Inc. | Anwendungen für humane nicht autologe, mesenchymale stammzellen |
US6368636B1 (en) * | 1998-03-18 | 2002-04-09 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
US8147824B2 (en) * | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
US7094874B2 (en) | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
US20040022787A1 (en) | 2000-07-03 | 2004-02-05 | Robert Cohen | Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID |
SK287940B6 (sk) * | 2000-07-03 | 2012-05-03 | Bristol-Myers Squibb Company | Soluble CTLA4 fusion molecule, pharmaceutical composition comprising thereof and its use |
US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
WO2002046373A1 (en) | 2000-12-06 | 2002-06-13 | Hariri Robert J | Method of collecting placental stem cells |
EP2316919B1 (de) * | 2001-02-14 | 2015-10-07 | Anthrogenesis Corporation | Post-partum Säugetier-Plazenta, deren Verwendung und daraus gewonnene Stammzellen |
ES2558626T3 (es) * | 2001-02-14 | 2016-02-05 | Anthrogenesis Corporation | Placenta post-parto de mamíferos, su uso y células madre placentarias de la misma |
CA2564679C (en) * | 2004-03-22 | 2015-06-23 | Osiris Therapeutics, Inc. | Mesenchymal stem cells and uses therefor |
CA3135582A1 (en) * | 2004-03-22 | 2005-10-06 | Mesoblast International Sarl | Mesenchymal stem cells and uses therefor |
US20080095749A1 (en) * | 2004-03-22 | 2008-04-24 | Sudeepta Aggarwal | Mesenchymal stem cells and uses therefor |
AU2012205269B2 (en) * | 2004-03-22 | 2015-08-27 | Mesoblast International Sarl | Mesenchymal stem cells and uses therefor |
US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
CA2512667A1 (en) * | 2005-01-07 | 2006-07-07 | Takahiro Ochiya | Human hepatocyte-like cells and uses thereof |
US20090130067A1 (en) * | 2005-09-23 | 2009-05-21 | Dirk Buscher | Cell Population Having Immunoregulatory Activity, Method for Isolation and Uses |
NZ612132A (en) | 2005-10-13 | 2015-01-30 | Anthrogenesis Corp | Immunomodulation using placental stem cells |
US10117900B2 (en) | 2005-11-09 | 2018-11-06 | Athersys, Inc. | MAPC treatment of brain injuries and diseases |
US11000546B2 (en) | 2005-11-09 | 2021-05-11 | Athersys, Inc. | Immunomodulatory properties of MAPCs and uses thereof |
EP1976978A2 (de) | 2005-12-29 | 2008-10-08 | Anthrogenesis Corporation | Cokultur von plazentastammzellen und stammzellen anderen ursprungs |
CN108559725A (zh) | 2005-12-29 | 2018-09-21 | 人类起源公司 | 胎盘干细胞群 |
EP2465922B1 (de) | 2006-01-13 | 2018-08-01 | Mesoblast International Sàrl | Mesenchymale Stammzellen zur TNF-Rezeptor-Expression |
CN101410126A (zh) | 2006-01-23 | 2009-04-15 | 阿特西斯公司 | 无附加的免疫抑制治疗的mapc治疗法 |
EP2772535B1 (de) * | 2006-05-31 | 2022-04-06 | Children's Medical Center Corporation | Positive mesenchymale ABC5-Stammzellen als Immunmodulatoren |
US7993918B2 (en) | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
ES2441560T3 (es) | 2006-11-03 | 2014-02-05 | Aastrom Biosciences, Inc. | Poblaciones celulares mixtas para la reparación de tejidos y técnica de separación para el procesamiento celular |
EP3103462A1 (de) | 2007-02-12 | 2016-12-14 | Anthrogenesis Corporation | Behandlung von infektionskrankheiten mithilfe von plazenta-stammzellen |
WO2008137115A1 (en) | 2007-05-03 | 2008-11-13 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
DE102007028687A1 (de) * | 2007-06-21 | 2008-12-24 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Therapeutische Zusammensetzung zur Behandlung einer Autoimmunerkrankung, umfassend eine autologe Antigenzusammensetzung, sowie Verfahren und Vorrichtungen zur autologen Antikörper- und Antigenproduktion |
EP2185689A2 (de) * | 2007-08-09 | 2010-05-19 | Genzyme Corporation | Verfahren zur behandlung von autoimmunerkrankungen mit mesenchymalen stammzellen |
KR20190132556A (ko) | 2007-09-28 | 2019-11-27 | 안트로제네시스 코포레이션 | 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법 |
AU2008313693B2 (en) * | 2007-10-17 | 2014-04-24 | Txcell | Tr1 cells, mesenchymal stem cells and uses thereof |
WO2009114860A2 (en) * | 2008-03-14 | 2009-09-17 | The Board Of Trustees Of The University Of Illinois | Activated mesenchymal stem cells for the prevention and repair of inflammatory states |
US9011840B2 (en) | 2008-03-14 | 2015-04-21 | The Board Of Trustees Of The University Of Illinois | Activated mesenchymal stem cells for wound healing and impaired tissue regeneration |
JP5541845B2 (ja) * | 2008-03-28 | 2014-07-09 | Jcrファーマ株式会社 | アトピー性皮膚炎治療剤 |
EP2279246A4 (de) * | 2008-05-02 | 2012-03-28 | Massachusetts Inst Technology | Verfahren und zusammensetzungen zur modulation immunologischer toleranz |
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NZ591294A (en) | 2008-08-20 | 2012-10-26 | Anthrogenesis Corp | Treatment of stroke using isolated placental cells |
AU2009283161A1 (en) | 2008-08-22 | 2010-02-25 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
JP5869342B2 (ja) | 2008-11-19 | 2016-02-24 | アンスロジェネシス コーポレーション | 羊膜由来接着細胞 |
US10098333B2 (en) * | 2008-12-09 | 2018-10-16 | University Of Southern California | Method for treating an SLE-like autoimmune disease in a human subject consisting of administering stem cells from human exfoliated deciduous teeth (SHED) and erythropoietin (EPO) to said human subject |
US9301975B2 (en) | 2009-05-01 | 2016-04-05 | Biocardia, Inc. | Method of preparing autologous cells and method of use for therapy |
SG10201404280XA (en) * | 2009-07-21 | 2014-10-30 | Abt Holding Co | Use of stem cells to reduce leukocyte extravasation |
EP2510084B1 (de) * | 2009-12-08 | 2020-02-05 | The Board of Trustees of the University of Illionis | Stammzellen-immunmodulierung, verfahren zur verwendung und vorrichtung |
CA2787992A1 (en) | 2010-01-26 | 2011-08-04 | Anthrogenesis Corporation | Treatment of bone-related cancers using placental stem cells |
TW201703777A (zh) | 2010-04-07 | 2017-02-01 | 安瑟吉納西斯公司 | 利用胎盤幹細胞之血管新生 |
US8562973B2 (en) | 2010-04-08 | 2013-10-22 | Anthrogenesis Corporation | Treatment of sarcoidosis using placental stem cells |
CA2798895A1 (en) | 2010-05-12 | 2011-11-17 | Abt Holding Company | Modulation of splenocytes in cell therapy |
MX342995B (es) | 2010-07-13 | 2016-10-21 | Anthrogenesis Corp | Métodos de generar células asesinas naturales. |
US20120087868A1 (en) | 2010-10-08 | 2012-04-12 | Gabriele Todd | Nanoparticle-loaded cells |
WO2012048275A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
AU2011352036A1 (en) | 2010-12-31 | 2013-07-18 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory RNA molecules |
CN113559126A (zh) | 2011-06-01 | 2021-10-29 | 人类起源公司 | 利用胎盘干细胞治疗疼痛 |
US9925221B2 (en) | 2011-09-09 | 2018-03-27 | Celularity, Inc. | Treatment of amyotrophic lateral sclerosis using placental stem cells |
US8735359B2 (en) * | 2012-05-24 | 2014-05-27 | Orban Biotech Llc | Combinations of modalities for the treatment of diabetes |
CN104519900A (zh) | 2012-06-27 | 2015-04-15 | 欧尔本生物科技有限责任公司 | 用于治疗糖尿病的ctla4融合蛋白 |
US9763983B2 (en) | 2013-02-05 | 2017-09-19 | Anthrogenesis Corporation | Natural killer cells from placenta |
CA2901931C (en) | 2013-02-19 | 2023-03-07 | Children's Medical Center Corporation | Abcb5(+) stem cells for treating ocular disease |
PT2983680T (pt) | 2013-04-12 | 2020-10-29 | Abt Holding Co | Melhoria de órgãos para transplante |
AU2014262590B2 (en) | 2013-05-10 | 2018-05-10 | Children's Medical Center Corporation | Wound healing and tissue engineering |
WO2015023147A1 (ko) * | 2013-08-16 | 2015-02-19 | 가톨릭대학교 산학협력단 | mTOR/STAT3 신호억제제 처리된 면역조절능을 갖는 간엽 줄기세포 및 이를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물 |
KR101723265B1 (ko) | 2013-08-16 | 2017-04-04 | 가톨릭대학교 산학협력단 | mTOR/STAT3 신호억제제 처리된 면역조절능을 갖는 간엽줄기세포 및 이를 포함하는 면역질환의 예방 또는 치료용 세포치료제 조성물 |
JP6612227B2 (ja) | 2013-11-16 | 2019-11-27 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
WO2015088414A1 (en) * | 2013-12-13 | 2015-06-18 | Isletone Ab | Immunomodulatory compositions |
GB2523399B (en) | 2014-02-25 | 2019-03-13 | Orban Tihamer | A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence |
EP3122866B1 (de) | 2014-03-25 | 2019-11-20 | Terumo BCT, Inc. | Passives ersetzen von medien |
KR20150136389A (ko) * | 2014-05-27 | 2015-12-07 | 삼성전자주식회사 | 관절염 예방 또는 치료용 조성물, 키트, 및 이를 이용한 관절염 예방 또는 치료 방법 |
JP6830059B2 (ja) | 2014-09-26 | 2021-02-17 | テルモ ビーシーティー、インコーポレーテッド | スケジュール化された細胞フィーディング |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
KR20180105705A (ko) | 2016-02-04 | 2018-09-28 | 롱에버론 엘엘씨 | 백신 보조제로서의 중간엽 줄기 세포 및 그의 사용 방법 |
GB201604304D0 (en) | 2016-03-14 | 2016-04-27 | Tigenix S A U | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
JP7034949B2 (ja) | 2016-05-25 | 2022-03-14 | テルモ ビーシーティー、インコーポレーテッド | 細胞の増殖 |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
CN110612344B (zh) | 2017-03-31 | 2023-09-12 | 泰尔茂比司特公司 | 细胞扩增 |
GB2619893A (en) | 2021-03-23 | 2023-12-20 | Terumo Bct Inc | Cell capture and expansion |
CN114480413B (zh) * | 2022-01-14 | 2022-11-04 | 北京贝来生物科技有限公司 | 一种活化肿瘤免疫应答的基因修饰干细胞制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69435010T2 (de) * | 1993-04-20 | 2008-04-30 | Hipler Partners Llp | Verfahren und stoffe für die behandlung von individuen, die infiziert sind mit intrazellulär infektiösen agentien |
US5591625A (en) * | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
US5747299A (en) * | 1994-06-23 | 1998-05-05 | The Board Of Trustees Of The Leland Stanford Junior University | Anergy genes |
-
1999
- 1999-03-12 PT PT99911322T patent/PT1066060E/pt unknown
- 1999-03-12 EP EP99911322A patent/EP1066060B1/de not_active Expired - Lifetime
- 1999-03-12 DK DK99911322T patent/DK1066060T3/da active
- 1999-03-12 US US09/267,456 patent/US6797269B2/en not_active Expired - Lifetime
- 1999-03-12 WO PCT/US1999/005350 patent/WO1999051275A2/en active IP Right Grant
- 1999-03-12 ES ES99911322T patent/ES2205792T3/es not_active Expired - Lifetime
- 1999-03-12 CA CA002326838A patent/CA2326838C/en not_active Expired - Fee Related
- 1999-03-12 AT AT99911322T patent/ATE246938T1/de active
- 1999-03-12 DE DE69910362T patent/DE69910362T2/de not_active Expired - Lifetime
- 1999-03-12 AU AU29991/99A patent/AU2999199A/en not_active Abandoned
- 1999-03-12 JP JP2000542045A patent/JP2002510655A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2999199A (en) | 1999-10-25 |
US20020044923A1 (en) | 2002-04-18 |
US6797269B2 (en) | 2004-09-28 |
ES2205792T3 (es) | 2004-05-01 |
WO1999051275A3 (en) | 1999-12-09 |
CA2326838A1 (en) | 1999-10-14 |
DE69910362D1 (de) | 2003-09-18 |
WO1999051275A2 (en) | 1999-10-14 |
CA2326838C (en) | 2008-12-23 |
DK1066060T3 (da) | 2003-11-24 |
PT1066060E (pt) | 2003-12-31 |
EP1066060A2 (de) | 2001-01-10 |
DE69910362T2 (de) | 2004-06-24 |
EP1066060B1 (de) | 2003-08-13 |
JP2002510655A (ja) | 2002-04-09 |
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