SG11201805506YA - Modulators of 5'-nucleotidase, ecto and the use thereof - Google Patents

Modulators of 5'-nucleotidase, ecto and the use thereof

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Publication number
SG11201805506YA
SG11201805506YA SG11201805506YA SG11201805506YA SG11201805506YA SG 11201805506Y A SG11201805506Y A SG 11201805506YA SG 11201805506Y A SG11201805506Y A SG 11201805506YA SG 11201805506Y A SG11201805506Y A SG 11201805506YA SG 11201805506Y A SG11201805506Y A SG 11201805506YA
Authority
SG
Singapore
Prior art keywords
ecto
international
avenue
nucleotidase
street
Prior art date
Application number
SG11201805506YA
Other languages
English (en)
Inventor
Laurent Debien
Juan Jaen
Jaroslaw Kalisiak
Kenneth V Lawson
Manmohan Reddy Leleti
Erick Lindsey
Dillon Harding Miles
Eric Newcomb
Jay Patrick Powers
Brandon Reid Rosen
Ehesan Ui Sharif
Original Assignee
Arcus Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arcus Biosciences Inc filed Critical Arcus Biosciences Inc
Publication of SG11201805506YA publication Critical patent/SG11201805506YA/en

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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
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    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide

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SG11201805506YA 2016-01-08 2017-01-06 Modulators of 5'-nucleotidase, ecto and the use thereof SG11201805506YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662276564P 2016-01-08 2016-01-08
US201662324077P 2016-04-18 2016-04-18
PCT/US2017/012587 WO2017120508A1 (en) 2016-01-08 2017-01-06 Modulators of 5'-nucleotidase, ecto and the use thereof

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US (4) US10239912B2 (ko)
EP (2) EP3399984B1 (ko)
JP (3) JP6920344B2 (ko)
KR (1) KR20180100638A (ko)
CN (2) CN114395005A (ko)
AU (2) AU2017206061B2 (ko)
BR (1) BR112018013827B1 (ko)
CA (2) CA3009196C (ko)
CL (1) CL2018001845A1 (ko)
DK (1) DK3399984T3 (ko)
EA (1) EA038565B1 (ko)
ES (1) ES2963759T3 (ko)
FI (1) FI3399984T3 (ko)
HR (1) HRP20231155T1 (ko)
HU (1) HUE063388T2 (ko)
IL (1) IL260260B2 (ko)
LT (1) LT3399984T (ko)
MX (2) MX2018008350A (ko)
PH (1) PH12018501361A1 (ko)
PL (1) PL3399984T3 (ko)
PT (1) PT3399984T (ko)
SA (1) SA518391985B1 (ko)
SG (1) SG11201805506YA (ko)
SI (1) SI3399984T1 (ko)
TW (2) TW202227095A (ko)
UA (1) UA124529C2 (ko)
WO (1) WO2017120508A1 (ko)
ZA (2) ZA201804350B (ko)

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Publication number Priority date Publication date Assignee Title
US10239912B2 (en) 2016-01-08 2019-03-26 Arcus Biosciences, Inc. Modulators of 5′-nucleotidase, ecto and the use thereof
US10472364B2 (en) 2016-09-09 2019-11-12 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
EP3541396A4 (en) 2016-11-18 2020-07-22 Arcus Biosciences, Inc. CD73-MEDIATED IMMUNOSUPPRESSION INHIBITORS
MA48594B1 (fr) 2016-12-08 2022-05-31 Hoffmann La Roche Nouveaux dérivés d'éther d'isoxazolyle en tant que pam alpha5 gaba a
AU2017382888B2 (en) * 2016-12-22 2021-12-23 Antengene Therapeutics Limited Ectonucleotidase inhibitors and methods of use thereof
WO2018167267A1 (en) 2017-03-16 2018-09-20 Innate Pharma Compositions and methods for treating cancer
US11129841B2 (en) 2017-05-10 2021-09-28 Oric Pharmaceuticals, Inc. CD73 inhibitors
AU2018346447A1 (en) 2017-10-06 2020-03-19 Innate Pharma Restoration of T cell activity via the CD39/CD73 axis
WO2019090111A1 (en) * 2017-11-03 2019-05-09 Oric Pharmaceuticals, Inc. Cd73 inhibitors
CN111094317B (zh) * 2017-12-29 2023-03-31 上海和誉生物医药科技有限公司 一种具有cd73抑制活性的膦酸衍生物、其制备方法和应用
TWI702954B (zh) * 2018-03-01 2020-09-01 美商美國禮來大藥廠 Cd73抑制劑
EP3761993A4 (en) * 2018-03-09 2022-03-09 Arcus Biosciences, Inc. PARENTERAL IMMUNITY-BOOSTING DRUGS
CA3098493A1 (en) * 2018-04-30 2019-11-07 Oric Pharmaceuticals, Inc. Cd73 inhibitors
US11377503B2 (en) 2018-06-18 2022-07-05 Innate Pharma Antibodies that bind human CD39 and inhibit ATPase activity of a soluble extracellular domain human CD39 polypeptide
US20210169911A1 (en) * 2018-08-17 2021-06-10 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Purine and pyrimidine nucleotides as ecto-5'-nucleotidase inhibitors
EP3843742A4 (en) 2018-08-28 2022-04-20 Jiangsu Hengrui Medicine Co., Ltd. CD73 INHIBITORS AND THEIR THERAPEUTIC USES
US11530234B2 (en) 2018-09-11 2022-12-20 Risen (Suzhou) Pharma Tech Co., Ltd. CD73 inhibitors and pharmaceutical uses thereof
MX2021002878A (es) * 2018-09-11 2021-08-16 Risen Suzhou Pharma Tech Co Ltd Inhibidores de cd73 y usos farmaceuticos de los mismos.
CN110885352B (zh) * 2018-09-11 2023-02-24 润佳（苏州）医药科技有限公司 Cd73抑制剂及其药学应用
WO2020123772A1 (en) * 2018-12-13 2020-06-18 Arcus Biosciences, Inc. Solid forms of a cd73 inhibitor and the use thereof
WO2020146795A1 (en) 2019-01-11 2020-07-16 Omeros Corporation Methods and compositions for treating cancer
CN112955444B (zh) * 2019-01-22 2023-12-12 江苏恒瑞医药股份有限公司 一种新型的小分子cd73抑制剂、其制备方法及其在医药上的应用
KR20210137162A (ko) * 2019-03-12 2021-11-17 아르커스 바이오사이언시즈 인코포레이티드 종양유전자-유발 암의 치료
WO2020205538A1 (en) * 2019-03-29 2020-10-08 Eternity Bioscience Inc. Cd73 inhibitors and therapeutic uses thereof
US20220211701A1 (en) * 2019-03-29 2022-07-07 Arcus Biosciences, Inc. Treatment of cancer utilizing an identified adenosine fingerprint
EP3952874A4 (en) * 2019-04-05 2022-12-28 Prelude Therapeutics, Incorporated SELECTIVE ARGININE METHYLTRANSFERASE 5 PROTEIN INHIBITORS
WO2020210938A1 (en) * 2019-04-15 2020-10-22 Bioardis Llc Quinazoline derivatives as cd73 inhibitors
WO2020210970A1 (en) * 2019-04-16 2020-10-22 Bioardis Llc Imidazotriazine derivatives as cd73 inhibitors
TWI821559B (zh) * 2019-04-28 2023-11-11 大陸商上海和譽生物醫藥科技有限公司 一種cd73抑制劑，其製備方法和應用
US20220251134A1 (en) * 2019-06-14 2022-08-11 Southern Research Institute 2,4,7-substituted-7-deaza-2'-deoxy-2'-fluoroarabinosyl nucleoside and nucleotide pro-drugs and uses thereof
WO2021040356A1 (en) * 2019-08-23 2021-03-04 Kainos Medicine, Inc. C-nucleosides, c-nucleotides and their analogs, equivalents and prodrugs thereof for ectonucleotidase inhibition
WO2021041319A1 (en) * 2019-08-29 2021-03-04 Eli Lilly And Company Crystalline forms of a cd73 inhibitor
AU2020375914B2 (en) 2019-10-30 2024-05-23 Oric Pharmaceuticals, Inc. CD73 inhibitors
TW202131932A (zh) * 2019-11-05 2021-09-01 美商博奥阿迪斯有限公司 作為cd73抑制劑的化合物
US11633416B1 (en) 2020-03-06 2023-04-25 Arcus Biosciences, Inc. Oral formulations of CD73 compounds
CN115298165B (zh) 2020-03-19 2024-09-17 艾库斯生物科学有限公司 作为HIF-2α抑制剂的四氢化萘和四氢喹啉化合物
EP4157875A1 (en) 2020-06-02 2023-04-05 Arcus Biosciences, Inc. Antibodies to tigit
WO2021247188A1 (en) 2020-06-05 2021-12-09 Bristol-Myers Squibb Company Cd73 antagonist potency assay and methods of use thereof
KR20230026312A (ko) 2020-06-17 2023-02-24 아르커스 바이오사이언시즈 인코포레이티드 Cd73 억제제의 결정형 및 이의 용도
WO2022007677A1 (zh) * 2020-07-07 2022-01-13 贝达药业股份有限公司 Cd73抑制剂及其在医药上的应用
TW202220976A (zh) * 2020-09-08 2022-06-01 大陸商貝達藥業股份有限公司 Cd73抑制劑及其在醫藥上的應用
JP2023548204A (ja) * 2020-11-05 2023-11-15 武漢人福創新薬物研発中心有限公司 Ｃｄ７３阻害剤及びその応用
CN114437038A (zh) * 2020-11-05 2022-05-06 武汉人福创新药物研发中心有限公司 哒嗪炔烃类化合物及其用途
EP4251633A4 (en) * 2020-11-25 2024-09-25 Risen Suzhou Pharma Tech Co Ltd CD73 INHIBITORS AND PHARMACEUTICAL USES THEREOF
US20240024346A1 (en) * 2020-11-25 2024-01-25 Risen (Suzhou) Pharma Tech Co., Ltd. Cd73 inhibitors and pharmaceutical uses thereof
AU2021413448A1 (en) * 2020-12-29 2023-07-20 Zhejiang Vimgreen Pharmaceuticals, Ltd Adenosine a3 receptor agonists, preparation methods and uses thereof
TW202308657A (zh) * 2021-05-11 2023-03-01 大陸商四川海思科製藥有限公司 小分子cd73拮抗劑及其用途
JP2024521706A (ja) 2021-05-21 2024-06-04 アーカス バイオサイエンシーズ，インコーポレーテッド Ａｘｌ化合物
CN117337288A (zh) 2021-05-21 2024-01-02 艾库斯生物科学有限公司 Axl抑制剂化合物
WO2023061319A1 (zh) * 2021-10-11 2023-04-20 南京明德新药研发有限公司 三并环杂环衍生物
US12103943B2 (en) 2021-10-26 2024-10-01 Southern Research Institute Development of novel clofarabine analogs for cancer therapy
US12071411B2 (en) 2021-10-29 2024-08-27 Arcus Biosciences, Inc. Inhibitors of HIF-2α and methods of use thereof
WO2023201267A1 (en) 2022-04-13 2023-10-19 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
TW202409083A (zh) 2022-05-02 2024-03-01 美商阿克思生物科學有限公司 抗-tigit抗體及其用途
WO2024015251A1 (en) 2022-07-15 2024-01-18 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
WO2024020034A1 (en) 2022-07-20 2024-01-25 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2024059142A1 (en) 2022-09-14 2024-03-21 Arcus Biosciences, Inc. Dispersions of etrumadenant
US20240140980A1 (en) * 2022-10-03 2024-05-02 Teon Therapeutics, Inc. Heterocyclic inhibitors of cd73 for treatment of disease
WO2024076872A1 (en) * 2022-10-03 2024-04-11 Teon Therapeutics, Inc. Heterocyclic inhibitors of cd73 for treatment of disease
WO2024081385A1 (en) 2022-10-14 2024-04-18 Arcus Biosciences, Inc. Hpk1 inhibitors and methods of use thereof
TW202428286A (zh) 2022-10-20 2024-07-16 美商阿克思生物科學有限公司 Ｃｄ７３化合物之凍乾配方

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5569650A (en) * 1993-06-11 1996-10-29 Sloan-Kettering Institute For Cancer Research C-nucleoside isosters of analogs thereof and pharmaceutical compositions
PT934325E (pt) * 1996-10-09 2004-10-29 Pharmasset Ltd Trisanidridos biciclicos de tetrafosfonato
BR0116221A (pt) 2000-12-15 2005-09-13 Pharmasset Ltd Agentes antivirais para tratamento de infecções por flaviviridae
WO2012032513A1 (en) * 2010-09-07 2012-03-15 Bar-Ilan University Boranophosphate derivatives for the treatment of osteoarthritis
US9090697B2 (en) 2013-03-15 2015-07-28 Bayer Healthcare Llc Methods for treating bleeding disorders
FR3011240A1 (fr) * 2013-10-01 2015-04-03 Centre Nat Rech Scient Inhibiteurs de 5'-nucleotidases et leurs utilisations therapeutiques
KR102248804B1 (ko) * 2014-03-12 2021-05-11 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 Cns의 질환 및 손상을 치료하기 위한 전신적 조절 t 세포 수준 또는 활성의 감소
MA39986A (fr) 2014-04-25 2017-03-01 Vitae Pharmaceuticals Inc Dérivés de purine en tant qu'inhibiteurs de cd73 pour le traitement du cancer
KR20180037265A (ko) 2015-08-17 2018-04-11 루핀 리미티드 Parp 억제제로서의 헤테로아릴 유도체
US10239912B2 (en) 2016-01-08 2019-03-26 Arcus Biosciences, Inc. Modulators of 5′-nucleotidase, ecto and the use thereof
UY37062A (es) 2016-01-08 2017-08-31 Syngenta Participations Ag Derivados de aryl oxadiazol fungicidas
ES2957477T3 (es) 2016-01-08 2024-01-19 Celgene Corp Compuestos antiproliferativos para usar en el tratamiento de leucemia
EP3761993A4 (en) 2018-03-09 2022-03-09 Arcus Biosciences, Inc. PARENTERAL IMMUNITY-BOOSTING DRUGS
WO2020123772A1 (en) 2018-12-13 2020-06-18 Arcus Biosciences, Inc. Solid forms of a cd73 inhibitor and the use thereof
KR20230026312A (ko) 2020-06-17 2023-02-24 아르커스 바이오사이언시즈 인코포레이티드 Cd73 억제제의 결정형 및 이의 용도

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