SG11201804259UA - Antibody cytokine engrafted compositions and methods of use for immunoregulation - Google Patents

Antibody cytokine engrafted compositions and methods of use for immunoregulation

Info

Publication number
SG11201804259UA
SG11201804259UA SG11201804259UA SG11201804259UA SG11201804259UA SG 11201804259U A SG11201804259U A SG 11201804259UA SG 11201804259U A SG11201804259U A SG 11201804259UA SG 11201804259U A SG11201804259U A SG 11201804259UA SG 11201804259U A SG11201804259U A SG 11201804259UA
Authority
SG
Singapore
Prior art keywords
novartis
antibody cytokine
institute
cytokine engrafted
international
Prior art date
Application number
SG11201804259UA
Other languages
English (en)
Inventor
Michael Didonato
Mark Knuth
Shelly Meeusen
Glen Spraggon
John Trauger
Bernhard Hubert Geierstanger
Carolina Nicole Simpson
Tobias Junt
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57543103&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201804259U(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SG11201804259UA publication Critical patent/SG11201804259UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5428—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2066—IL-10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
SG11201804259UA 2015-12-04 2016-12-01 Antibody cytokine engrafted compositions and methods of use for immunoregulation SG11201804259UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562263008P 2015-12-04 2015-12-04
PCT/IB2016/057283 WO2017093947A1 (en) 2015-12-04 2016-12-01 Antibody cytokine engrafted compositions and methods of use for immunoregulation

Publications (1)

Publication Number Publication Date
SG11201804259UA true SG11201804259UA (en) 2018-06-28

Family

ID=57543103

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201804259UA SG11201804259UA (en) 2015-12-04 2016-12-01 Antibody cytokine engrafted compositions and methods of use for immunoregulation

Country Status (25)

Country Link
US (3) US10144768B2 (es)
EP (1) EP3383891A1 (es)
JP (2) JP6794448B2 (es)
KR (2) KR102213790B1 (es)
CN (1) CN108602870A (es)
AR (1) AR106908A1 (es)
AU (1) AU2016362777B2 (es)
BR (1) BR112018010937A2 (es)
CA (1) CA3006477A1 (es)
CL (1) CL2018001427A1 (es)
CO (1) CO2018005678A2 (es)
CU (1) CU20180047A7 (es)
EA (1) EA201891341A1 (es)
EC (1) ECSP18041733A (es)
IL (1) IL259529A (es)
MA (1) MA43372A (es)
MX (1) MX2018006778A (es)
PE (1) PE20181358A1 (es)
PH (1) PH12018501160A1 (es)
RU (1) RU2018124307A (es)
SA (1) SA518391711B1 (es)
SG (1) SG11201804259UA (es)
TW (1) TW201726716A (es)
UY (1) UY37003A (es)
WO (1) WO2017093947A1 (es)

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JOP20190271A1 (ar) * 2017-05-24 2019-11-21 Novartis Ag بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة
WO2018215937A1 (en) * 2017-05-24 2018-11-29 Novartis Ag Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer
BR112019024556A2 (pt) * 2017-05-24 2020-06-23 Novartis Ag Proteínas enxertadas com citocina de anticorpo e métodos para uso no tratamento de câncer
EP3630162A1 (en) * 2017-05-24 2020-04-08 Novartis AG Antibody-cytokine engrafted proteins and methods of use
CN109521192B (zh) * 2018-11-27 2021-07-13 柏荣诊断产品（上海）有限公司 一种提高胶乳比浊试剂检测灵敏度的方法
EP3934681A4 (en) * 2019-03-06 2023-12-20 Deka Biosciences, Inc. IL-10 VARIANT MOLECULES AND METHODS OF TREATMENT OF INFLAMMATORY DISEASE AND ONCOLOGY
WO2020252082A1 (en) * 2019-06-10 2020-12-17 Millennium Pharmaceuticals, Inc. Cell culture methods and compositions for antibody production
US20220267396A1 (en) * 2019-07-08 2022-08-25 Progen Co., Ltd. Novel il-10 variant protein and use thereof
CN110472294B (zh) * 2019-07-19 2022-09-30 河南科技大学 一种嫁接涡旋光束的掩模板的设计方法
EP4247857A1 (en) 2020-11-23 2023-09-27 Novartis AG Expression technology for antibody constructs
WO2022229854A1 (en) 2021-04-29 2022-11-03 Novartis Ag Hypersialylating cells
WO2023078245A1 (zh) * 2021-11-02 2023-05-11 广东菲鹏制药股份有限公司 Il10单体融合蛋白及其应用

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Also Published As

Publication number Publication date
JP6794448B2 (ja) 2020-12-02
AU2016362777A1 (en) 2018-06-07
CA3006477A1 (en) 2017-06-08
MX2018006778A (es) 2018-08-01
UY37003A (es) 2017-06-30
ECSP18041733A (es) 2018-06-30
RU2018124307A3 (es) 2020-05-13
SA518391711B1 (ar) 2021-07-27
IL259529A (en) 2018-07-31
KR20210016479A (ko) 2021-02-15
US20170158747A1 (en) 2017-06-08
US20190241636A1 (en) 2019-08-08
KR20180081622A (ko) 2018-07-16
CU20180047A7 (es) 2018-07-05
US10144768B2 (en) 2018-12-04
EP3383891A1 (en) 2018-10-10
PE20181358A1 (es) 2018-08-22
JP2019505173A (ja) 2019-02-28
US20220127321A1 (en) 2022-04-28
CO2018005678A2 (es) 2018-06-12
PH12018501160A1 (en) 2019-01-21
RU2018124307A (ru) 2020-01-14
AU2016362777B2 (en) 2020-01-30
MA43372A (fr) 2018-10-10
AR106908A1 (es) 2018-02-28
WO2017093947A1 (en) 2017-06-08
BR112018010937A2 (pt) 2018-12-04
US11136366B2 (en) 2021-10-05
CN108602870A (zh) 2018-09-28
EA201891341A1 (ru) 2018-11-30
KR102213790B1 (ko) 2021-02-09
TW201726716A (zh) 2017-08-01
JP2021040637A (ja) 2021-03-18
CL2018001427A1 (es) 2018-07-27

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