BR112018010937A2 - composições de anticorpos enxertados com citocina e métodos de uso para imunorregulação - Google Patents
composições de anticorpos enxertados com citocina e métodos de uso para imunorregulaçãoInfo
- Publication number
- BR112018010937A2 BR112018010937A2 BR112018010937-1A BR112018010937A BR112018010937A2 BR 112018010937 A2 BR112018010937 A2 BR 112018010937A2 BR 112018010937 A BR112018010937 A BR 112018010937A BR 112018010937 A2 BR112018010937 A2 BR 112018010937A2
- Authority
- BR
- Brazil
- Prior art keywords
- grafted antibody
- cytokine
- antibody proteins
- methods
- immunoregulation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562263008P | 2015-12-04 | 2015-12-04 | |
US62/263,008 | 2015-12-04 | ||
PCT/IB2016/057283 WO2017093947A1 (en) | 2015-12-04 | 2016-12-01 | Antibody cytokine engrafted compositions and methods of use for immunoregulation |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018010937A2 true BR112018010937A2 (pt) | 2018-12-04 |
Family
ID=57543103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018010937-1A BR112018010937A2 (pt) | 2015-12-04 | 2016-12-01 | composições de anticorpos enxertados com citocina e métodos de uso para imunorregulação |
Country Status (25)
Country | Link |
---|---|
US (3) | US10144768B2 (pt) |
EP (1) | EP3383891A1 (pt) |
JP (2) | JP6794448B2 (pt) |
KR (2) | KR20210016479A (pt) |
CN (1) | CN108602870A (pt) |
AR (1) | AR106908A1 (pt) |
AU (1) | AU2016362777B2 (pt) |
BR (1) | BR112018010937A2 (pt) |
CA (1) | CA3006477A1 (pt) |
CL (1) | CL2018001427A1 (pt) |
CO (1) | CO2018005678A2 (pt) |
CU (1) | CU20180047A7 (pt) |
EA (1) | EA201891341A1 (pt) |
EC (1) | ECSP18041733A (pt) |
IL (1) | IL259529A (pt) |
MA (1) | MA43372A (pt) |
MX (1) | MX2018006778A (pt) |
PE (1) | PE20181358A1 (pt) |
PH (1) | PH12018501160A1 (pt) |
RU (1) | RU2018124307A (pt) |
SA (1) | SA518391711B1 (pt) |
SG (1) | SG11201804259UA (pt) |
TW (1) | TW201726716A (pt) |
UY (1) | UY37003A (pt) |
WO (1) | WO2017093947A1 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018215937A1 (en) * | 2017-05-24 | 2018-11-29 | Novartis Ag | Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer |
EA201992765A1 (ru) * | 2017-05-24 | 2020-03-25 | Новартис Аг | Белки на основе антител с привитым цитокином и способы их применения в лечении рака |
WO2018215938A1 (en) * | 2017-05-24 | 2018-11-29 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use |
JOP20190271A1 (ar) * | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
CN109521192B (zh) * | 2018-11-27 | 2021-07-13 | 柏荣诊断产品(上海)有限公司 | 一种提高胶乳比浊试剂检测灵敏度的方法 |
CA3132385A1 (en) * | 2019-03-06 | 2020-09-10 | Deka Biosciences, Inc. | Il-10 variant molecules and methods of treating inflammatory disease and oncology |
BR112021024852A2 (pt) * | 2019-06-10 | 2022-02-15 | Takeda Pharmaceuticals Co | Métodos de cultura de célula e composições para produção de anticorpo |
KR20210006302A (ko) * | 2019-07-08 | 2021-01-18 | 주식회사 프로젠 | 신규 il-10 변이체 단백질 및 그의 용도 |
CN110472294B (zh) * | 2019-07-19 | 2022-09-30 | 河南科技大学 | 一种嫁接涡旋光束的掩模板的设计方法 |
EP4247857A1 (en) | 2020-11-23 | 2023-09-27 | Novartis AG | Expression technology for antibody constructs |
EP4330383A1 (en) | 2021-04-29 | 2024-03-06 | Novartis AG | Hypersialylating cells |
TW202325746A (zh) * | 2021-11-02 | 2023-07-01 | 大陸商廣東菲鵬製藥股份有限公司 中國廣東省東莞市松山湖園區桃園路1號10棟301室 郵編:523808 | Il10單體融合蛋白及其應用 |
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JP2017506075A (ja) * | 2014-02-06 | 2017-03-02 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | インターロイキン−10イムノコンジュゲート |
MX370283B (es) | 2014-02-06 | 2019-12-09 | Hoffmann La Roche | Proteinas de fusion de interleucina-2 y usos de las mismas. |
-
2016
- 2016-12-01 JP JP2018528732A patent/JP6794448B2/ja active Active
- 2016-12-01 WO PCT/IB2016/057283 patent/WO2017093947A1/en active Application Filing
- 2016-12-01 MX MX2018006778A patent/MX2018006778A/es unknown
- 2016-12-01 PE PE2018001044A patent/PE20181358A1/es unknown
- 2016-12-01 CN CN201680080872.0A patent/CN108602870A/zh active Pending
- 2016-12-01 MA MA043372A patent/MA43372A/fr unknown
- 2016-12-01 KR KR1020217003359A patent/KR20210016479A/ko active Application Filing
- 2016-12-01 RU RU2018124307A patent/RU2018124307A/ru not_active Application Discontinuation
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