SG11201703305SA - Production method for nerve tissue - Google Patents

Production method for nerve tissue

Info

Publication number
SG11201703305SA
SG11201703305SA SG11201703305SA SG11201703305SA SG11201703305SA SG 11201703305S A SG11201703305S A SG 11201703305SA SG 11201703305S A SG11201703305S A SG 11201703305SA SG 11201703305S A SG11201703305S A SG 11201703305SA SG 11201703305S A SG11201703305S A SG 11201703305SA
Authority
SG
Singapore
Prior art keywords
production method
nerve tissue
nerve
tissue
production
Prior art date
Application number
SG11201703305SA
Other languages
English (en)
Inventor
Atsushi Kuwahara
Suguru YAMASAKI
Yasushi Hiramine
Yoshiki Sasai
Masayo Takahashi
Original Assignee
Sumitomo Dainippon Pharma Co Ltd
Riken
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Dainippon Pharma Co Ltd, Riken, Sumitomo Chemical Co filed Critical Sumitomo Dainippon Pharma Co Ltd
Publication of SG11201703305SA publication Critical patent/SG11201703305SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/062—Sensory transducers, e.g. photoreceptors; Sensory neurons, e.g. for hearing, taste, smell, pH, touch, temperature, pain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/383—Nerve cells, e.g. dendritic cells, Schwann cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/99—Serum-free medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases (EC 2.)
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
SG11201703305SA 2014-10-24 2015-10-23 Production method for nerve tissue SG11201703305SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014217867 2014-10-24
PCT/JP2015/080016 WO2016063985A1 (ja) 2014-10-24 2015-10-23 神経組織の製造方法

Publications (1)

Publication Number Publication Date
SG11201703305SA true SG11201703305SA (en) 2017-05-30

Family

ID=55761015

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201703305SA SG11201703305SA (en) 2014-10-24 2015-10-23 Production method for nerve tissue

Country Status (12)

Country Link
US (2) US11214771B2 (zh)
EP (1) EP3211072A4 (zh)
JP (4) JP6746499B2 (zh)
KR (1) KR102500914B1 (zh)
CN (2) CN107109367B (zh)
AU (1) AU2015336453B2 (zh)
CA (1) CA2965248A1 (zh)
IL (2) IL251855B2 (zh)
MY (1) MY191740A (zh)
SG (1) SG11201703305SA (zh)
TW (1) TWI810142B (zh)
WO (1) WO2016063985A1 (zh)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8642334B2 (en) 2009-02-17 2014-02-04 Memorial Sloan Kettering Cancer Center Methods of neural conversion of human embryonic stem cells
AU2012332269B2 (en) 2011-11-04 2018-05-31 Memorial Sloan-Kettering Cancer Center Midbrain dopamine (DA) neurons for engraftment
WO2014176606A1 (en) 2013-04-26 2014-10-30 Memorial Sloan-Kettering Center Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
CA2965248A1 (en) 2014-10-24 2016-04-28 Sumitomo Dainippon Pharma Co., Ltd. Production method for nerve tissue
DK3211071T3 (da) 2014-10-24 2021-07-26 Sumitomo Dainippon Pharma Co Ltd Fremstillingsfremgangsmåde til retinalt væv
US20180245039A1 (en) * 2015-09-08 2018-08-30 Sumitomo Dainippon Pharma Co., Ltd. Method for producing retinal tissue
CA2997528C (en) 2015-09-08 2024-02-13 Sumitomo Dainippon Pharma Co., Ltd. Method for producing retinal pigment epithelial cells
EP3411472A4 (en) 2016-02-01 2020-01-22 Cedars-Sinai Medical Center SYSTEMS AND METHODS FOR GROWING INTESTINAL CELLS IN MICROFLUIDIC DEVICES
CN107151691B (zh) * 2016-03-02 2020-04-24 中国农业科学院北京畜牧兽医研究所 一种基于BMP7基因鉴定猪达100kg体重日龄和眼肌面积的方法
SG11201809201UA (en) * 2016-04-22 2018-11-29 Sumitomo Dainippon Pharma Co Ltd Method for producing retinal tissue
SG11201809279YA (en) 2016-04-22 2018-11-29 Univ Kyoto Method for producing dopamine-producing neural precursor cells
WO2018097253A1 (ja) 2016-11-25 2018-05-31 国立研究開発法人理化学研究所 移植用細胞集団及びその製造方法
WO2018140647A1 (en) 2017-01-25 2018-08-02 Cedars-Sinai Medical Center In vitro induction of mammary-like differentiation from human pluripotent stem cells
CA3055706A1 (en) * 2017-03-08 2018-09-13 Sumitomo Dainippon Pharma Co., Ltd. Method for producing retinal pigment epithelial cells
US11767513B2 (en) 2017-03-14 2023-09-26 Cedars-Sinai Medical Center Neuromuscular junction
WO2018176001A2 (en) 2017-03-24 2018-09-27 Cedars-Sinai Medical Center Methods and compositions for production of fallopian tube epithelium
EP3630951A4 (en) * 2017-05-25 2021-03-17 New York Stem Cell Foundation, Inc. METHOD AND COMPOSITION FOR GENERATING CHOLINERGIC NEURONS OF THE ANTERIOR BASAL BRAIN (BFCN)
CN107435050B (zh) * 2017-06-20 2021-02-09 向孟清 一种将人或动物体细胞诱导为神经干细胞的方法
KR20200029479A (ko) 2017-07-20 2020-03-18 고쿠리쓰 겐큐 가이하쓰 호징 리가가쿠 겐큐소 신경 조직의 보존 방법
EP3656852A4 (en) 2017-07-20 2021-04-21 Riken RETINAL TISSUE MATURATION PROCESS CONTAINING A CONTINUOUS EPITHELIUM
CN111164205B (zh) 2017-09-08 2024-05-17 国立研究开发法人理化学研究所 包含视网膜组织的细胞聚集体及其制造方法
US20210154370A1 (en) * 2017-09-14 2021-05-27 Riken Method for producing retinal tissues
WO2019054515A1 (ja) 2017-09-14 2019-03-21 国立研究開発法人理化学研究所 背側化シグナル伝達物質又は腹側化シグナル伝達物質による錐体視細胞又は桿体視細胞の増加方法
CN111386338A (zh) * 2017-11-24 2020-07-07 住友化学株式会社 包含神经系统细胞或神经组织和非神经上皮组织的细胞团块的制备方法及该细胞团块
SG11202004829WA (en) * 2017-11-24 2020-06-29 Sumitomo Chemical Co Method for producing cell mass including pituitary tissue, and cell mass thereof
CN108865997B (zh) * 2017-12-27 2022-02-11 华南师范大学 一种用于体外培养星形胶质细胞的培养基及培养方法
KR102119148B1 (ko) * 2018-03-08 2020-06-04 고려대학교 산학협력단 신경조직 오가노이드의 제조방법, 이를 이용한 신경조직 형성 억제 물질의 스크리닝 방법 및 운동신경세포의 제조방법
US11981918B2 (en) 2018-04-06 2024-05-14 Cedars-Sinai Medical Center Differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells
US20210308188A1 (en) * 2018-08-24 2021-10-07 Sumitomo Chemical Company, Limited Cell cluster including olfactory neuron or precursor cell thereof, and method for producing same
CN111254118A (zh) * 2018-11-30 2020-06-09 中国科学院大连化学物理研究所 一种hiPSCs来源的类脑组织产生方法
JPWO2020138430A1 (ja) 2018-12-28 2021-11-11 国立研究開発法人理化学研究所 網膜系細胞又は網膜組織の障害を伴う疾患の治療薬
AU2020234344A1 (en) 2019-03-13 2021-10-07 Riken Method for evaluating quality of transplant neural retina, and transplant neural retina sheet
JPWO2020218480A1 (zh) * 2019-04-26 2020-10-29
GB2584664B (en) * 2019-06-10 2023-05-24 Newcells Biotech Ltd Improved retinal organoids and methods of making the same
CN114585366A (zh) * 2019-10-22 2022-06-03 西达-赛奈医疗中心 来自iPSC的皮质神经祖细胞
CN112760280A (zh) * 2019-11-04 2021-05-07 北京基石生命科技有限公司 一种胆囊胆管癌原代细胞的培养方法
CN112760286B (zh) * 2019-11-04 2022-12-02 北京基石生命科技有限公司 一种脑肿瘤实体瘤原代细胞的培养方法
CN112760284A (zh) * 2019-11-04 2021-05-07 北京基石生命科技有限公司 一种用于培养胆囊胆管癌原代细胞的培养基
JPWO2021090877A1 (zh) * 2019-11-06 2021-05-14
WO2022005023A1 (ko) * 2020-06-29 2022-01-06 주식회사 오간팩토리 중뇌 오가노이드, 이의 고속 및 대량 제조 방법, 이를 이용한 신경독성물질 스크리닝 방법 및 도파민성 신경세포 관련 질환 치료제 스크리닝 방법
KR102346243B1 (ko) * 2020-06-29 2022-01-04 주식회사 오간팩토리 중뇌 오가노이드, 이의 고속 및 대량 제조 방법, 이를 이용한 신경독성물질 스크리닝 방법 및 도파민성 신경세포 관련 질환 치료제 스크리닝 방법
CA3194364A1 (en) 2020-09-11 2022-03-17 Sumitomo Pharma Co., Ltd. Medium for tissue for transplantation
WO2022054925A1 (ja) 2020-09-11 2022-03-17 国立研究開発法人理化学研究所 神経網膜を含む細胞凝集体とマトリクスとを含む複合体及びその製造方法
EP4357449A1 (en) 2021-06-17 2024-04-24 Kyoto University Method for producing cerebral cortical cell preparation derived from human pluripotent stem cells
CN113528441B (zh) * 2021-08-05 2022-09-13 呈诺再生医学科技(珠海横琴新区)有限公司 快速高效的临床级色素上皮细胞诱导方法、试剂盒及应用
CN113564122B (zh) * 2021-08-05 2022-04-08 呈诺再生医学科技(珠海横琴新区)有限公司 人诱导性多能干细胞向少突胶质细胞分化的方法，试剂盒以及应用
KR102637401B1 (ko) * 2022-09-05 2024-02-16 주식회사 스마트셀랩 레노그라스팀에 의한 줄기세포의 운동신경전구세포로의 유도 및 운동신경세포로의 분화
CN117448267A (zh) * 2023-12-22 2024-01-26 上海元戊医学技术有限公司 一种用于骨关节炎药物的间充质干细胞构建方法与应用
CN117551612B (zh) * 2024-01-12 2024-03-08 苏州艾凯利元生物科技有限公司 一种视网膜类器官及其制备方法和应用

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69431993T2 (de) 1993-11-09 2003-11-27 Neurospheres Holding Ltd In situ modifikation und manipulation von stammzellen des zentralen nervensystems
US6878544B2 (en) 1996-04-19 2005-04-12 Neurotech Sa Retinal cell lines with extended life-span and their applications
US20030180947A1 (en) 2001-09-21 2003-09-25 J.H. David Wu Circadian control of stem/progenitor cell self-renewal and differentiation and of clock controlled gene expression
US20060003446A1 (en) 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
CA2514971C (en) 2003-02-03 2012-08-14 Japan Science And Technology Agency Regeneration and neogenesis of retinal photoreceptor cell using otx2 gene
EP1783205B1 (en) * 2004-06-18 2024-02-21 Riken Method of inducing the differentiation of embryonic stem cells into nerve by serum-free suspension culture
DE102004055615A1 (de) 2004-11-16 2006-05-18 Universitätsklinikum Hamburg-Eppendorf In vitro aus Knochenmarkstammzellen differenzierte Retina-spezifische Zellen, ihre Herstellung und Verwendung
AU2006202209B2 (en) 2005-05-27 2011-04-14 Lifescan, Inc. Amniotic fluid derived cells
WO2007046775A1 (en) 2005-10-21 2007-04-26 Cellresearch Corporation Pte Ltd Isolation and cultivation of stem/progenitor cells from the amniotic membrane of umbilical cord and uses of cells differentiated therefrom
US7541186B2 (en) * 2006-02-22 2009-06-02 University Of Washington Method of generating human retinal progenitors from embryonic stem cells
JP2008099662A (ja) * 2006-09-22 2008-05-01 Institute Of Physical & Chemical Research 幹細胞の培養方法
EP2128244A4 (en) 2007-01-18 2012-05-09 Riken INDUCTION / DIFFERENTIATION METHOD IN PHOTORECEPTOR CELL
AU2008242106B2 (en) 2007-04-18 2013-05-16 Hadasit Medical Research Services And Development Ltd. Stem cell-derived retinal pigment epithelial cells
CA2702386C (en) 2007-10-12 2018-07-24 Advanced Cell Technology, Inc. Improved methods of producing rpe cells and compositions of rpe cells
US10227563B2 (en) 2008-06-06 2019-03-12 Riken Method for culture of stem cell
CA2741426C (en) 2008-10-31 2020-04-21 Meredith Hans Method and device for activating stem cells
JP5390624B2 (ja) 2008-11-04 2014-01-15 バイアサイト インク 幹細胞集合体懸濁液組成物、その分化方法
CA2770753C (en) * 2009-08-12 2019-01-15 Kyoto University Method for inducing differentiation of pluripotent stem cells into neural precursor cells
CN102712900B (zh) 2009-10-06 2015-07-01 首尔大学校产学协力团 干细胞分化成为视网膜细胞的方法
US10793830B2 (en) 2009-11-05 2020-10-06 Riken Method for producing retinal tissue in vitro
JP5928681B2 (ja) * 2010-08-31 2016-06-01 国立大学法人 千葉大学 ヒト多能性幹細胞からの造血幹細胞の効率的な誘導方法
US9181529B2 (en) 2010-10-19 2015-11-10 Cellular Dynamics International, Inc. Titration of differentiation medium components
US9487752B2 (en) 2011-03-30 2016-11-08 Cellular Dynamics International, Inc. Priming of pluripotent stem cells for neural differentiation
JP5588951B2 (ja) * 2011-10-28 2014-09-10 京セラドキュメントソリューションズ株式会社 割り込み制御回路
WO2013065763A1 (ja) 2011-10-31 2013-05-10 独立行政法人理化学研究所 幹細胞の培養方法
CA2856867C (en) * 2011-11-25 2021-06-01 Sumitomo Chemical Company, Limited Methods for producing retinal tissue and retina-related cell
JP5985208B2 (ja) * 2011-11-25 2016-09-06 住友化学株式会社 網膜組織の製造方法
CA2876047C (en) 2012-06-08 2021-11-23 Sumitomo Chemical Company, Limited Method for producing ciliary marginal zone-like structure
CA3173076A1 (en) 2013-02-27 2014-09-04 The Regents Of The University Of California Generation of thymic epithelial progenitor cells in vitro
EP2981605B1 (en) 2013-04-03 2019-06-19 FUJIFILM Cellular Dynamics, Inc. Methods and compositions for culturing endoderm progenitor cells in suspension
MX2016000557A (es) 2013-07-23 2016-04-20 Hoffmann La Roche Conversion basada en moleculas pequeñas de celulas somaticas en celulas de cresta neural.
KR102297580B1 (ko) 2013-08-06 2021-09-03 고쿠리쓰 겐큐 가이하쓰 호징 리가가쿠 겐큐소 전안부 조직의 제조 방법
DK3037524T3 (da) 2013-08-23 2020-03-16 Sumitomo Chemical Co Fremgangsmåde til at fremstille nethindevæv og nethinderelaterede celler
EP3047017A4 (en) 2013-10-09 2017-10-11 The Regents of the University of California Methods of mammalian retinal stem cell production and applications
JP6518878B2 (ja) 2013-10-09 2019-05-29 株式会社ヘリオス 網膜色素上皮細胞の製造方法
JP6495176B2 (ja) 2013-11-11 2019-04-03 住友化学株式会社 網膜色素上皮細胞の製造方法
CA2933258C (en) 2013-12-11 2023-05-23 Sumitomo Chemical Company, Limited Method for manufacturing ciliary marginal zone-like structure
MY193954A (en) 2014-01-17 2022-11-02 Sumitomo Chemical Co Method for manufacturing ciliary margin stem cells
EP3194572B1 (en) 2014-07-30 2023-10-25 Yeda Research and Development Co. Ltd. Media for culturing pluripotent stem cells
KR101712556B1 (ko) 2014-08-27 2017-03-08 서울대학교산학협력단 줄기세포를 망막신경절세포로 분화시키는 방법
SG11201701857QA (en) 2014-09-08 2017-04-27 Riken Method for producing cerebellar progenitor tissue
CA2965248A1 (en) 2014-10-24 2016-04-28 Sumitomo Dainippon Pharma Co., Ltd. Production method for nerve tissue
DK3211071T3 (da) 2014-10-24 2021-07-26 Sumitomo Dainippon Pharma Co Ltd Fremstillingsfremgangsmåde til retinalt væv
CA2997528C (en) 2015-09-08 2024-02-13 Sumitomo Dainippon Pharma Co., Ltd. Method for producing retinal pigment epithelial cells
CA2997763A1 (en) 2015-09-08 2017-03-16 Cellular Dynamics International, Inc. Macs-based purification of stem cell-derived retinal pigment epithelium
US20180245039A1 (en) 2015-09-08 2018-08-30 Sumitomo Dainippon Pharma Co., Ltd. Method for producing retinal tissue
SG11201809201UA (en) 2016-04-22 2018-11-29 Sumitomo Dainippon Pharma Co Ltd Method for producing retinal tissue
CN107326009B (zh) 2017-05-02 2019-03-08 深圳百年干细胞技术研究院有限公司 使血液单个核细胞逆向分化产生人血源性自体视网膜干细胞的方法、试剂盒及用途
EP3656852A4 (en) 2017-07-20 2021-04-21 Riken RETINAL TISSUE MATURATION PROCESS CONTAINING A CONTINUOUS EPITHELIUM
CN111164205B (zh) 2017-09-08 2024-05-17 国立研究开发法人理化学研究所 包含视网膜组织的细胞聚集体及其制造方法
US20210154370A1 (en) 2017-09-14 2021-05-27 Riken Method for producing retinal tissues
US20210308188A1 (en) 2018-08-24 2021-10-07 Sumitomo Chemical Company, Limited Cell cluster including olfactory neuron or precursor cell thereof, and method for producing same

Also Published As

Publication number Publication date
MY191740A (en) 2022-07-13
JP2022088579A (ja) 2022-06-14
JPWO2016063985A1 (ja) 2017-08-03
CN107109367B (zh) 2021-08-10
CN107109367A (zh) 2017-08-29
IL251855B2 (en) 2023-09-01
US20170313976A1 (en) 2017-11-02
JP2020141698A (ja) 2020-09-10
AU2015336453A1 (en) 2017-05-25
AU2015336453B2 (en) 2021-05-20
IL251855A0 (en) 2017-06-29
KR102500914B1 (ko) 2023-02-17
WO2016063985A1 (ja) 2016-04-28
TW201629214A (zh) 2016-08-16
KR20170072940A (ko) 2017-06-27
EP3211072A1 (en) 2017-08-30
JP2024026153A (ja) 2024-02-28
TWI810142B (zh) 2023-08-01
CN113564123A (zh) 2021-10-29
EP3211072A4 (en) 2018-10-10
IL292509A (en) 2022-06-01
JP7075556B2 (ja) 2022-05-26
CA2965248A1 (en) 2016-04-28
IL251855B1 (en) 2023-05-01
US20220112457A1 (en) 2022-04-14
JP6746499B2 (ja) 2020-08-26
JP7397448B2 (ja) 2023-12-13
US11214771B2 (en) 2022-01-04

Similar Documents

Publication Publication Date Title
IL292509A (en) A method for producing nerve tissue
IL251856B (en) A method for producing retinal tissue
PL3227023T3 (pl) Sposób wytwarzania kropel
PL3196196T3 (pl) Sposób wytwarzania kalcobutrolu
EP3220739A4 (en) Fabric treatment method
IL252173A0 (en) Methods for the production of methyl dichlorophosphane
GB201410116D0 (en) Method of treatment
HRP20181805T1 (hr) Postupak za proizvodnju poligvanidina
SG11201701326YA (en) Method for producing oligosilane
IL253028B (en) treatment method
SG10201912688YA (en) A method of treatment
EP3133680A4 (en) Method for producing electrode
IL246831B (en) A method for the production of 1-indanols and 1-indanamines
PL3138556T3 (pl) Sposób wytwarzania liposomu
PL3134243T3 (pl) Sposób wytwarzania zmielonego elastomeru
HUE052742T2 (hu) Eljárás alkaltrészek gyártására
EP3196184A4 (en) Iridium complex production method
ZA201700478B (en) Method for producing 2-amino-6-methylnicotinic acid
SG11201608114QA (en) Method for producing tri-carbobenzoxy-arginine
EP3214088A4 (en) Method for producing eushearilides
GB201507268D0 (en) Method for stimulating aerogenosis
GB201421980D0 (en) Method of treatment
GB201421982D0 (en) Method of treatment
AU2014903921A0 (en) Therapeutic method
GB201414611D0 (en) Method for processing tissue