PL3227023T3 - Sposób wytwarzania kropel - Google Patents

Sposób wytwarzania kropel

Info

Publication number
PL3227023T3
PL3227023T3 PL15763938T PL15763938T PL3227023T3 PL 3227023 T3 PL3227023 T3 PL 3227023T3 PL 15763938 T PL15763938 T PL 15763938T PL 15763938 T PL15763938 T PL 15763938T PL 3227023 T3 PL3227023 T3 PL 3227023T3
Authority
PL
Poland
Prior art keywords
producing drops
drops
producing
Prior art date
Application number
PL15763938T
Other languages
English (en)
Inventor
Frank Schwemmer
Friedrich Schuler
Original Assignee
Hahn-Schickard-Gesellschaft für angewandte Forschung e.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. filed Critical Hahn-Schickard-Gesellschaft für angewandte Forschung e.V.
Publication of PL3227023T3 publication Critical patent/PL3227023T3/pl

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4336—Mixers with a diverging cross-section
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71725—Feed mechanisms characterised by the means for feeding the components to the mixer using centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/48—Mixing water in water-taps with other ingredients, e.g. air, detergents or disinfectants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
PL15763938T 2014-12-02 2015-09-18 Sposób wytwarzania kropel PL3227023T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102014224664.4A DE102014224664B3 (de) 2014-12-02 2014-12-02 Vorrichtung und verfahren zur tropfenerzeugung
PCT/EP2015/071435 WO2016087068A1 (de) 2014-12-02 2015-09-18 Vorrichtung und verfahren zur tropfenerzeugung
EP15763938.6A EP3227023B8 (de) 2014-12-02 2015-09-18 Verfahren zur tropfenerzeugung

Publications (1)

Publication Number Publication Date
PL3227023T3 true PL3227023T3 (pl) 2020-09-07

Family

ID=54145784

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15763938T PL3227023T3 (pl) 2014-12-02 2015-09-18 Sposób wytwarzania kropel

Country Status (7)

Country Link
US (1) US10369536B2 (pl)
EP (1) EP3227023B8 (pl)
CN (1) CN107206334B (pl)
DE (1) DE102014224664B3 (pl)
ES (1) ES2794634T3 (pl)
PL (1) PL3227023T3 (pl)
WO (1) WO2016087068A1 (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11207685B2 (en) * 2017-02-13 2021-12-28 Bio-Rad Laboratories, Inc. System, method, and device for forming an array of emulsions
DE102017204002B4 (de) * 2017-03-10 2019-05-23 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Zentrifugo-pneumatisches schalten von flüssigkeit
US10544413B2 (en) 2017-05-18 2020-01-28 10X Genomics, Inc. Methods and systems for sorting droplets and beads
CN110945139B (zh) 2017-05-18 2023-09-05 10X基因组学有限公司 用于分选液滴和珠的方法和系统
US10549279B2 (en) 2017-08-22 2020-02-04 10X Genomics, Inc. Devices having a plurality of droplet formation regions
WO2019043106A1 (en) * 2017-08-31 2019-03-07 miDiagnostics NV DEVICE FOR MIXING FLUIDS IN A CAPILLARITY FLUID SYSTEM
CN107442191A (zh) * 2017-09-20 2017-12-08 厦门大学 一种用于油包水液滴生成的离心式微流控芯片
WO2019083852A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. MICROFLUIDIC CHANNEL NETWORKS FOR PARTITIONING
JPWO2019159905A1 (ja) * 2018-02-14 2021-02-25 株式会社エンプラス 流体取扱装置および流体取扱システム
CN109289952B (zh) * 2018-11-08 2024-03-08 沈阳化工大学 一种高粘度微米级通道的微流控芯片制备方法
WO2020124301A1 (zh) * 2018-12-17 2020-06-25 深圳先进技术研究院 一种液滴阵列生成装置及其制备方法和应用
CN111921469A (zh) * 2020-08-24 2020-11-13 天津大学 一种“笔记本型”台阶式乳化或反应微装置模块

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0104077D0 (sv) * 2001-10-21 2001-12-05 Gyros Ab A method and instrumentation for micro dispensation of droplets
DE10361411B4 (de) * 2003-12-29 2007-12-20 Albert-Ludwigs-Universität Freiburg, vertreten durch den Rektor Mischervorrichtung und Verfahren zum Mischen von zumindest zwei Flüssigkeiten
US7655470B2 (en) * 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
TWI261572B (en) * 2005-08-09 2006-09-11 Univ Tsinghua Micro-fluid separation and delivering device
US8273310B2 (en) * 2006-09-05 2012-09-25 Samsung Electronics Co., Ltd. Centrifugal force-based microfluidic device for nucleic acid extraction and microfluidic system including the microfluidic device
CN101850231B (zh) * 2009-07-03 2012-08-29 中国科学院上海微系统与信息技术研究所 一种微流体反应器、使用方法及其应用
CN103765068B (zh) * 2011-03-30 2016-09-07 努拜欧有限公司 将多个体积注入或注出液滴
AU2013220890B2 (en) * 2012-02-16 2016-03-10 National Research Council Of Canada Centrifugal microfluidic mixing apparatus and method
FR2996544B1 (fr) * 2012-10-08 2015-03-13 Ecole Polytech Circuit microfluidique permettant la mise en contact de gouttes de plusieurs fluides, et procede microfluidique correspondant.
FR2996545B1 (fr) * 2012-10-08 2016-03-25 Ecole Polytech Procede microfluidique de traitement et d'analyse d'une solution contenant un materiel biologique, et circuit microfluidique correspondant.
US11219896B2 (en) * 2013-06-25 2022-01-11 University Of Washington Through Its Center For Commercialization Self-digitization of sample volumes

Also Published As

Publication number Publication date
ES2794634T3 (es) 2020-11-18
DE102014224664B3 (de) 2015-10-08
EP3227023B1 (de) 2020-03-25
CN107206334A (zh) 2017-09-26
US10369536B2 (en) 2019-08-06
US20170266633A1 (en) 2017-09-21
CN107206334B (zh) 2020-05-12
WO2016087068A1 (de) 2016-06-09
EP3227023A1 (de) 2017-10-11
EP3227023B8 (de) 2020-05-27

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