SG11201407875UA - Compostions and methods for cancer immunotherapy - Google Patents
Compostions and methods for cancer immunotherapyInfo
- Publication number
- SG11201407875UA SG11201407875UA SG11201407875UA SG11201407875UA SG11201407875UA SG 11201407875U A SG11201407875U A SG 11201407875UA SG 11201407875U A SG11201407875U A SG 11201407875UA SG 11201407875U A SG11201407875U A SG 11201407875UA SG 11201407875U A SG11201407875U A SG 11201407875UA
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- SG
- Singapore
- Prior art keywords
- lllll
- international
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- Prior art date
Links
- 238000002619 cancer immunotherapy Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 101000643024 Homo sapiens Stimulator of interferon genes protein Proteins 0.000 abstract 2
- 102100035533 Stimulator of interferon genes protein Human genes 0.000 abstract 2
- 238000002648 combination therapy Methods 0.000 abstract 2
- XRILCFTWUCUKJR-INFSMZHSSA-N 2'-3'-cGAMP Chemical compound C([C@H]([C@H]1O)O2)OP(O)(=O)O[C@H]3[C@@H](O)[C@H](N4C5=NC=NC(N)=C5N=C4)O[C@@H]3COP(O)(=O)O[C@H]1[C@@H]2N1C=NC2=C1NC(N)=NC2=O XRILCFTWUCUKJR-INFSMZHSSA-N 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 abstract 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000007399 Nuclear hormone receptor Human genes 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000000735 allogeneic effect Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 108091007930 cytoplasmic receptors Proteins 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000007115 recruitment Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
 
- 
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
 
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
 
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
 
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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        - A—HUMAN NECESSITIES
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- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
 
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        - A—HUMAN NECESSITIES
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
 
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        - A—HUMAN NECESSITIES
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- 
        - C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
 
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Communicable Diseases (AREA)
- Dispersion Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title | 
|---|---|---|---|
| US201261657574P | 2012-06-08 | 2012-06-08 | |
| PCT/US2013/044744 WO2013185052A1 (en) | 2012-06-08 | 2013-06-07 | Compostions and methods for cancer immunotherapy | 
Publications (1)
| Publication Number | Publication Date | 
|---|---|
| SG11201407875UA true SG11201407875UA (en) | 2014-12-30 | 
Family
ID=49712686
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date | 
|---|---|---|---|
| SG11201407875UA SG11201407875UA (en) | 2012-06-08 | 2013-06-07 | Compostions and methods for cancer immunotherapy | 
| SG10201610251PA SG10201610251PA (en) | 2012-06-08 | 2013-06-07 | Compositions and methods for cancer immunotherapy | 
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date | 
|---|---|---|---|
| SG10201610251PA SG10201610251PA (en) | 2012-06-08 | 2013-06-07 | Compositions and methods for cancer immunotherapy | 
Country Status (11)
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title | 
|---|---|---|---|---|
| KR20150022996A (ko) | 2012-06-08 | 2015-03-04 | 아두로 바이오테크 | 암 면역요법을 위한 조성물 및 방법 | 
| PT2931738T (pt) | 2012-12-13 | 2019-04-10 | Aduro Biotech Inc | Composições compreendendo nucleótidos cíclicos de purina com estereoquímica definida e métodos para a sua preparação e utilização | 
| KR102255996B1 (ko) * | 2012-12-19 | 2021-05-26 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 포유동물 시클릭 디-뉴클레오티드 신호 경로의 약학적 표적화 | 
| MX374828B (es) | 2013-04-29 | 2025-03-06 | Memorial Sloan Kettering Cancer Center | Composiciones y metodos para alterar la señalizacion del segundo mensajero. | 
| ES2822584T3 (es) | 2013-05-03 | 2021-05-04 | Univ California | Inducción de dinucleótidos cíclicos del interferón tipo I | 
| US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling | 
| CN105188373B (zh) * | 2013-05-18 | 2017-09-22 | 艾杜罗生物科技公司 | 抑制“干扰素基因刺激蛋白”依赖性信号传导的组合物和方法 | 
| CA2904536A1 (en) * | 2013-05-18 | 2014-11-27 | Aduro Biotech, Inc. | Compositions and methods for activating "stimulator of interferon gene"-dependent signalling | 
| JP2016526532A (ja) * | 2013-06-14 | 2016-09-05 | インターベット インターナショナル ベー. フェー. | GpGオリゴデオキシヌクレオチドおよびサイクリックdi‐GMPを含む医薬組成物 | 
| WO2015017652A1 (en) | 2013-07-31 | 2015-02-05 | Memorial Sloan-Kettering Cancer Center | Sting crystals and modulators | 
| DE202014011600U1 (de) | 2013-10-18 | 2023-05-31 | Deutsches Krebsforschungszentrum, Stiftung Des Öffentlichen Rechts | Markierte Inhibitoren des prostataspezifischen Membranantigens (PSMA), deren Verwendung als bildgebende Mittel und pharmazeutische Wirkstoffe für die Behandlung von Prostatakrebs | 
| EP3094342A4 (en) * | 2014-01-15 | 2017-12-27 | Nikolai Khodarev | Anti-tumor therapy | 
| WO2015109391A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer | 
| CN103908468B (zh) * | 2014-04-21 | 2017-02-08 | 上海捌加壹医药科技有限公司 | 环二核苷酸cGAMP在制备抗肿瘤药物中的应用 | 
| CN106459131B (zh) | 2014-06-04 | 2019-04-12 | 葛兰素史克知识产权开发有限公司 | 作为sting调节剂的环状二核苷酸 | 
| AU2015315324A1 (en) * | 2014-09-08 | 2017-03-09 | Dana-Farber Cancer Institute, Inc. | Methods of treating cancer comprising administering a PPAR-gamma agonist | 
| US10010607B2 (en) | 2014-09-16 | 2018-07-03 | Institut Curie | Method for preparing viral particles with cyclic dinucleotide and use of said particles for inducing immune response | 
| JP7305300B2 (ja) * | 2014-11-05 | 2023-07-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 併用免疫療法 | 
| JP6762030B2 (ja) * | 2014-11-20 | 2020-09-30 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 異なる核酸アジュバントの組み合わせによる、新規Th1誘導性アジュバントおよびその用途 | 
| US20170340658A1 (en) * | 2014-12-16 | 2017-11-30 | Invivogen | Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment | 
| EP3233882B1 (en) | 2014-12-16 | 2019-10-30 | Kayla Therapeutics | Fluorinated cyclic dinucleotides for cytokine induction | 
| GB201501462D0 (en) | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds | 
| CA3013713A1 (en) | 2015-02-11 | 2016-08-18 | The Johns Hopkins University | Bacteria over-expressing c-di-amp and therapeutic methods | 
| WO2016179475A1 (en) * | 2015-05-07 | 2016-11-10 | Baylor College Of Medicine | Dendritic cell immunotherapy | 
| US11453697B1 (en) | 2015-08-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists | 
| HK1249109A1 (zh) | 2015-08-13 | 2018-10-26 | Merck Sharp & Dohme Corp. | 作為sting激動劑的環狀二核苷酸化合物 | 
| CN106540255A (zh) * | 2015-09-18 | 2017-03-29 | 聊城市奥润生物医药科技有限公司 | 环二核苷酸cGAMP联合贝伐珠单抗在抗肿瘤中的应用 | 
| CN106540254A (zh) * | 2015-09-22 | 2017-03-29 | 聊城市奥润生物医药科技有限公司 | 环二核苷酸cGAMP及其衍生物是潜在免疫佐剂 | 
| CN106540253A (zh) * | 2015-09-24 | 2017-03-29 | 聊城市奥润生物医药科技有限公司 | cGAMP及其衍生物在制备抗肿瘤疫苗中的应用 | 
| CN105367617A (zh) * | 2015-09-25 | 2016-03-02 | 武汉品生科技有限公司 | 一种基于环二腺核苷酸的衍生物、tat多肽及其在一型干扰素小分子中抑制剂的应用 | 
| AU2016362697B2 (en) | 2015-12-03 | 2018-07-12 | Glaxosmithkline Intellectual Property Development Limited | Cyclic purine dinucleotides as modulators of STING | 
| PE20181330A1 (es) | 2016-01-11 | 2018-08-20 | Innate Tumor Immunity Inc | Dinucleotidos ciclicos para tratar condiciones asociadas con actividad del estimulador de genes del interferon (sting) tales como cancer | 
| CN106544319A (zh) * | 2016-01-24 | 2017-03-29 | 聊城市奥润生物医药科技有限公司 | 一种用于刺激树突状细胞成熟的组合物及其用于刺激树突状细胞成熟的方法 | 
| EP3430147B1 (en) | 2016-03-16 | 2020-09-09 | Institut Curie | Method for preparing viral particles with cyclic dinucleotide and use of said particles for treating cancer | 
| SG11201807660QA (en) | 2016-03-18 | 2018-10-30 | Immune Sensor Llc | Cyclic di-nucleotide compounds and methods of use | 
| CN113549110B (zh) | 2016-04-07 | 2024-08-16 | 葛兰素史密斯克莱知识产权发展有限公司 | 用作蛋白质调节剂的杂环酰胺 | 
| AU2017247806B2 (en) | 2016-04-07 | 2019-11-14 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides useful as protein modulators | 
| EP3448393A1 (en) | 2016-04-25 | 2019-03-06 | Invivogen | Novel complexes of immunostimulatory compounds, and uses thereof | 
| SG11201811709WA (en) | 2016-07-06 | 2019-01-30 | Sperovie Biosciences Inc | Compounds, compositions, and methods for the treatment of disease | 
| EP4559479A3 (en) | 2016-08-30 | 2025-06-11 | Dana-Farber Cancer Institute, Inc. | Drug delivery compositions and uses thereof | 
| EA037513B1 (ru) * | 2016-09-17 | 2021-04-06 | ИММЬЮН СЕНСОР, ЭлЭлСи | Циклические динуклеотидные соединения и способы их применения | 
| CR20190168A (es) | 2016-10-04 | 2019-05-17 | Merck Sharp & Dohme | Compuestos de benzo[b]tiofeno como agonistas de sting | 
| JOP20170192A1 (ar) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي | 
| KR101889181B1 (ko) * | 2016-12-19 | 2018-08-16 | 주식회사 포스코 | 굽힘성 및 신장플랜지성이 우수한 고장력강 및 이의 제조방법 | 
| EP3558319A4 (en) * | 2016-12-22 | 2020-07-22 | AbbVie Inc. | COMPOSITIONS AND PROCESSES FOR IMPROVING OR INCREASING THE PRODUCTION OF TYPE I IFN | 
| US20190351039A1 (en) | 2017-02-01 | 2019-11-21 | Modernatx, Inc. | Immunomodulatory therapeutic mrna compositions encoding activating oncogene mutation peptides | 
| US20200055883A1 (en) | 2017-02-17 | 2020-02-20 | Eisai R&D Management Co., Ltd. | Cyclic di-nucleotides derivative for the treatment of cancer | 
| JP7591348B2 (ja) | 2017-02-21 | 2024-11-28 | ボード オブ レジェンツ,ザ ユニバーシティ オブ テキサス システム | インターフェロン遺伝子刺激因子依存性シグナル伝達のアゴニストとしての環状ジヌクレオチド | 
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo | 
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| AU2013271375A1 (en) | 2014-12-18 | 
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