SG11201403445YA - Full length antibody display system for eukaryotic cells and its use - Google Patents

Full length antibody display system for eukaryotic cells and its use

Info

Publication number
SG11201403445YA
SG11201403445YA SG11201403445YA SG11201403445YA SG11201403445YA SG 11201403445Y A SG11201403445Y A SG 11201403445YA SG 11201403445Y A SG11201403445Y A SG 11201403445YA SG 11201403445Y A SG11201403445Y A SG 11201403445YA SG 11201403445Y A SG11201403445Y A SG 11201403445YA
Authority
SG
Singapore
Prior art keywords
display system
full length
eukaryotic cells
length antibody
antibody display
Prior art date
Application number
SG11201403445YA
Other languages
English (en)
Inventor
Peter Michael Huelsmann
Hendrik Knoetgen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG11201403445YA publication Critical patent/SG11201403445YA/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SG11201403445YA 2011-12-22 2012-12-19 Full length antibody display system for eukaryotic cells and its use SG11201403445YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11195375 2011-12-22
EP12179029 2012-08-02
PCT/EP2012/076163 WO2013092720A1 (en) 2011-12-22 2012-12-19 Full length antibody display system for eukaryotic cells and its use

Publications (1)

Publication Number Publication Date
SG11201403445YA true SG11201403445YA (en) 2014-07-30

Family

ID=47458959

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201403445YA SG11201403445YA (en) 2011-12-22 2012-12-19 Full length antibody display system for eukaryotic cells and its use

Country Status (12)

Country Link
US (1) US20150038354A1 (ru)
EP (1) EP2794662A1 (ru)
JP (1) JP2015503907A (ru)
KR (1) KR20140107295A (ru)
CN (1) CN104011080B (ru)
BR (1) BR112014013035A2 (ru)
CA (1) CA2854246A1 (ru)
HK (1) HK1200849A1 (ru)
MX (1) MX2014007262A (ru)
RU (1) RU2625033C2 (ru)
SG (1) SG11201403445YA (ru)
WO (1) WO2013092720A1 (ru)

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WO2017165245A2 (en) * 2016-03-19 2017-09-28 F1 Oncology, Inc. Methods and compositions for transducing lymphocytes and regulated expansion thereof
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CN110872356B (zh) * 2018-09-03 2023-06-13 广西慧宝源健康产业有限公司 双特异性抗体及其使用方法
WO2020177719A1 (zh) * 2019-03-05 2020-09-10 信达生物制药(苏州)有限公司 展示与分泌目的多肽的酵母展示系统及其用途
WO2021057726A1 (zh) * 2019-09-23 2021-04-01 南开大学 利用哺乳动物展示筛选FcγR特异性结合Fc
CN113150122B (zh) * 2021-05-19 2023-03-17 上海儒克生物科技有限公司 高通量全兔源单克隆抗体的制备方法
KR20240123808A (ko) * 2021-12-23 2024-08-14 헬싱인 일리오피스토 포유동물 세포에서 이종 폴리펩티드의 효율적인 발현 및 분비를 위한 신호 펩티드 스크리닝 방법

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Also Published As

Publication number Publication date
EP2794662A1 (en) 2014-10-29
KR20140107295A (ko) 2014-09-04
WO2013092720A1 (en) 2013-06-27
RU2625033C2 (ru) 2017-07-11
MX2014007262A (es) 2014-08-01
JP2015503907A (ja) 2015-02-05
RU2014129736A (ru) 2016-02-20
CA2854246A1 (en) 2013-06-27
US20150038354A1 (en) 2015-02-05
CN104011080A (zh) 2014-08-27
BR112014013035A2 (pt) 2018-10-09
HK1200849A1 (en) 2015-08-14
CN104011080B (zh) 2017-10-20

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