SG10202001146PA - Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disorders - Google Patents
Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disordersInfo
- Publication number
- SG10202001146PA SG10202001146PA SG10202001146PA SG10202001146PA SG10202001146PA SG 10202001146P A SG10202001146P A SG 10202001146PA SG 10202001146P A SG10202001146P A SG 10202001146PA SG 10202001146P A SG10202001146P A SG 10202001146PA SG 10202001146P A SG10202001146P A SG 10202001146PA
- Authority
- SG
- Singapore
- Prior art keywords
- tlr7
- polycyclic
- antagonists
- treatment
- immune disorders
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 208000026278 immune system disease Diseases 0.000 title 1
- 125000003367 polycyclic group Chemical group 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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- C07D—HETEROCYCLIC COMPOUNDS
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- C—CHEMISTRY; METALLURGY
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D471/04—Ortho-condensed systems
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- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562268765P | 2015-12-17 | 2015-12-17 | |
US201662353603P | 2016-06-23 | 2016-06-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10202001146PA true SG10202001146PA (en) | 2020-03-30 |
Family
ID=58191545
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201804170RA SG11201804170RA (en) | 2015-12-17 | 2016-12-16 | Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disorders |
SG10202001146PA SG10202001146PA (en) | 2015-12-17 | 2016-12-16 | Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disorders |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201804170RA SG11201804170RA (en) | 2015-12-17 | 2016-12-16 | Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disorders |
Country Status (24)
Country | Link |
---|---|
US (6) | US10399957B2 (he) |
EP (3) | EP3889145B1 (he) |
JP (3) | JP6882299B2 (he) |
KR (1) | KR20180094939A (he) |
CN (2) | CN113603675A (he) |
AU (3) | AU2016371014B2 (he) |
CA (1) | CA3005766A1 (he) |
CL (1) | CL2018001624A1 (he) |
DK (1) | DK3889145T3 (he) |
ES (1) | ES2883285T3 (he) |
FI (1) | FI3889145T3 (he) |
IL (4) | IL279751B (he) |
LT (1) | LT3889145T (he) |
MX (2) | MX2021006804A (he) |
MY (1) | MY196319A (he) |
NZ (1) | NZ742476A (he) |
PH (1) | PH12018501068A1 (he) |
PT (1) | PT3889145T (he) |
RS (1) | RS65319B1 (he) |
SG (2) | SG11201804170RA (he) |
TW (3) | TW202332674A (he) |
UA (1) | UA124802C2 (he) |
WO (1) | WO2017106607A1 (he) |
ZA (1) | ZA201803367B (he) |
Families Citing this family (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017106607A1 (en) | 2015-12-17 | 2017-06-22 | Merck Patent Gmbh | Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disorders |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
HRP20221279T1 (hr) | 2016-07-14 | 2022-12-23 | Crinetics Pharmaceuticals, Inc. | Modulatori somatostatina i njihove uporabe |
ES2944573T3 (es) * | 2016-08-08 | 2023-06-22 | Merck Patent Gmbh | Antagonistas de TLR7/8 y usos de los mismos |
IL265921B2 (he) | 2016-10-14 | 2024-05-01 | Prec Biosciences Inc | מגאנוקליאזים מהונדסים ספציפיים לרצפי זיהוי בגנום וירוס צהבת b |
US11370794B2 (en) * | 2016-11-11 | 2022-06-28 | Dynavax Technologies Corporation | Toll-like receptor antagonist compounds and methods of use |
ES2965044T3 (es) * | 2017-07-18 | 2024-04-10 | Merck Patent Gmbh | Antagonistas de TLR7/8 y sus usos |
US11466010B2 (en) | 2017-10-30 | 2022-10-11 | The Regents Of The University Of Colorado, A Body Corporate | Toll-like receptor 8 (TLR8) specific antagonists and methods of making and uses thereof |
AU2018390444A1 (en) * | 2017-12-19 | 2020-08-06 | Merck Patent Gmbh | TLR7/8 antagonists and uses thereof |
EP3728283B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
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ES2965044T3 (es) | 2017-07-18 | 2024-04-10 | Merck Patent Gmbh | Antagonistas de TLR7/8 y sus usos |
AU2018390444A1 (en) | 2017-12-19 | 2020-08-06 | Merck Patent Gmbh | TLR7/8 antagonists and uses thereof |
BR122023023308A2 (pt) | 2018-07-31 | 2024-02-20 | Merck Patent Gmbh | Antagonistas tlr7/8, seus usos, composição farmacêutica, e kit |
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