SE9704544D0 - Novel compounds - Google Patents
Novel compoundsInfo
- Publication number
- SE9704544D0 SE9704544D0 SE9704544A SE9704544A SE9704544D0 SE 9704544 D0 SE9704544 D0 SE 9704544D0 SE 9704544 A SE9704544 A SE 9704544A SE 9704544 A SE9704544 A SE 9704544A SE 9704544 D0 SE9704544 D0 SE 9704544D0
- Authority
- SE
- Sweden
- Prior art keywords
- novel compounds
- pharmaceutical compositions
- therapy
- preparing
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
- C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
- C07D203/14—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom with carbocyclic rings directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (28)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9704544A SE9704544D0 (sv) | 1997-12-05 | 1997-12-05 | Novel compounds |
PL98340906A PL340906A1 (en) | 1997-12-05 | 1998-12-01 | Adamantane derivatives |
DK98962751T DK1036059T3 (da) | 1997-12-05 | 1998-12-01 | Adamantanderivater |
DE69808130T DE69808130T2 (de) | 1997-12-05 | 1998-12-01 | Adamantan-derivate |
IL13636998A IL136369A0 (en) | 1997-12-05 | 1998-12-01 | Adamantane derivatives |
HU0004434A HUP0004434A3 (en) | 1997-12-05 | 1998-12-01 | Adamantane derivatives and pharmaceuticals containing them |
SK843-2000A SK8432000A3 (en) | 1997-12-05 | 1998-12-01 | Adamantane derivatives |
CA002312420A CA2312420A1 (en) | 1997-12-05 | 1998-12-01 | Adamantane derivatives |
EP98962751A EP1036059B1 (en) | 1997-12-05 | 1998-12-01 | Adamantane derivatives |
CN98813491A CN1284057A (zh) | 1997-12-05 | 1998-12-01 | 金刚烷衍生物 |
AT98962751T ATE224360T1 (de) | 1997-12-05 | 1998-12-01 | Adamantan-derivate |
US09/230,478 US6201024B1 (en) | 1997-12-05 | 1998-12-01 | Adamantane derivatives |
NZ504447A NZ504447A (en) | 1997-12-05 | 1998-12-01 | Substituted-N-(tricyclo[3.3.1.1]dec-1-methyl)-benzamides and their use in treating inflammatory, immune or cardiovascular diseases |
SI9830276T SI1036059T1 (en) | 1997-12-05 | 1998-12-01 | Adamantane derivatives |
PCT/SE1998/002188 WO1999029661A1 (en) | 1997-12-05 | 1998-12-01 | Adamantane derivatives |
AU17913/99A AU744280B2 (en) | 1997-12-05 | 1998-12-01 | Adamantane derivatives |
RU2000117574/04A RU2214997C2 (ru) | 1997-12-05 | 1998-12-01 | Производные адамантана, способ их получения, фармацевтическая композиция и способ получения фармацевтической композиции |
BR9813390-0A BR9813390A (pt) | 1997-12-05 | 1998-12-01 | Composto, processo para a preparação do mesmo, e uso do mesmo, composição farmacêutica, processo para a preparação da mesma, e, processo para efetuar a imunossupressão |
ES98962751T ES2184352T3 (es) | 1997-12-05 | 1998-12-01 | Derivados de adamantano. |
JP2000524258A JP2001525392A (ja) | 1997-12-05 | 1998-12-01 | アダマンタン誘導体 |
PT98962751T PT1036059E (pt) | 1997-12-05 | 1998-12-01 | Derivados de adamantano |
KR1020007006132A KR20010032814A (ko) | 1997-12-05 | 1998-12-01 | 아다만탄 유도체 |
IDW20001019A ID28003A (id) | 1997-12-05 | 1998-12-01 | Turunan-turunan adamantana |
TR2000/01605T TR200001605T2 (tr) | 1997-12-05 | 1998-12-01 | Adamantan türevleri. |
EEP200000378A EE200000378A (et) | 1997-12-05 | 1998-12-01 | Adamantaani derivaadid |
NO20002786A NO20002786L (no) | 1997-12-05 | 2000-05-31 | Adamantanderivater |
US09/745,346 US6258838B1 (en) | 1997-12-05 | 2000-12-26 | Compounds |
US09/745,740 US6303659B2 (en) | 1997-12-05 | 2000-12-26 | Compounds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9704544A SE9704544D0 (sv) | 1997-12-05 | 1997-12-05 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9704544D0 true SE9704544D0 (sv) | 1997-12-05 |
Family
ID=20409281
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9704544A SE9704544D0 (sv) | 1997-12-05 | 1997-12-05 | Novel compounds |
Country Status (25)
Country | Link |
---|---|
US (3) | US6201024B1 (tr) |
EP (1) | EP1036059B1 (tr) |
JP (1) | JP2001525392A (tr) |
KR (1) | KR20010032814A (tr) |
CN (1) | CN1284057A (tr) |
AT (1) | ATE224360T1 (tr) |
AU (1) | AU744280B2 (tr) |
BR (1) | BR9813390A (tr) |
CA (1) | CA2312420A1 (tr) |
DE (1) | DE69808130T2 (tr) |
DK (1) | DK1036059T3 (tr) |
EE (1) | EE200000378A (tr) |
ES (1) | ES2184352T3 (tr) |
HU (1) | HUP0004434A3 (tr) |
ID (1) | ID28003A (tr) |
IL (1) | IL136369A0 (tr) |
NO (1) | NO20002786L (tr) |
NZ (1) | NZ504447A (tr) |
PL (1) | PL340906A1 (tr) |
PT (1) | PT1036059E (tr) |
RU (1) | RU2214997C2 (tr) |
SE (1) | SE9704544D0 (tr) |
SK (1) | SK8432000A3 (tr) |
TR (1) | TR200001605T2 (tr) |
WO (1) | WO1999029661A1 (tr) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002539185A (ja) * | 1999-03-16 | 2002-11-19 | グラクソ グループ リミテッド | 核内受容体アリール化化合物 |
NZ514477A (en) * | 1999-04-09 | 2003-04-29 | Astrazeneca Ab | Adamantane derivatives |
SE9904505D0 (sv) * | 1999-12-09 | 1999-12-09 | Astra Pharma Prod | Novel compounds |
TWI258462B (en) * | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
SE9904738D0 (sv) * | 1999-12-22 | 1999-12-22 | Astra Pharma Prod | Novel compounds |
CN1431999A (zh) | 2000-05-31 | 2003-07-23 | 阿斯特拉曾尼卡有限公司 | 具有血管损伤活性的吲哚衍生物 |
GB0013737D0 (en) * | 2000-06-07 | 2000-07-26 | Astrazeneca Ab | Novel compounds |
JP2002330787A (ja) * | 2000-10-21 | 2002-11-19 | Astrazeneca Ab | 化学物質 |
US7795468B2 (en) * | 2001-01-19 | 2010-09-14 | Chevron U.S.A. Inc. | Functionalized higher diamondoids |
EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
SE524951C2 (sv) * | 2001-09-02 | 2004-10-26 | Sandvik Ab | Användning av en duplex rostfri stållegering |
SE524952C2 (sv) * | 2001-09-02 | 2004-10-26 | Sandvik Ab | Duplex rostfri stållegering |
WO2003042190A1 (en) | 2001-11-12 | 2003-05-22 | Pfizer Products Inc. | N-alkyl-adamantyl derivatives as p2x7-receptor antagonists |
PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
SE0103836D0 (sv) | 2001-11-16 | 2001-11-16 | Astrazeneca Ab | Novel compounds |
SE0200920D0 (sv) * | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
EP1515716A2 (en) | 2002-04-03 | 2005-03-23 | Astrazeneca AB | Indole derivatives having anti-angiogenetic activity |
US7582309B2 (en) * | 2002-11-15 | 2009-09-01 | Etex Corporation | Cohesive demineralized bone compositions |
PA8591801A1 (es) | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
US7071223B1 (en) * | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
SE0300480D0 (sv) * | 2003-02-21 | 2003-02-21 | Astrazeneca Ab | Novel compounds |
ATE355273T1 (de) * | 2003-05-12 | 2006-03-15 | Pfizer Prod Inc | Benzamidinhibitoren des p2x7-rezeptors |
EP1644041A1 (en) * | 2003-05-29 | 2006-04-12 | AstraZeneca AB | A pharmaceutical composition comprising a p2x7 antagonist and sulfasalazine |
TW200507829A (en) * | 2003-05-29 | 2005-03-01 | Astrazeneca Ab | New combination |
US20070281931A1 (en) * | 2003-05-29 | 2007-12-06 | Nigel Boughton-Smith | Pharmaceutical Composition Containing a P2x7 Receptor Antagonist and Methotrexate |
GB0312609D0 (en) * | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
GB0324498D0 (en) | 2003-07-21 | 2003-11-26 | Aventis Pharma Inc | Heterocyclic compounds as P2X7 ion channel blockers |
SE0302192D0 (sv) * | 2003-08-08 | 2003-08-08 | Astrazeneca Ab | Novel compounds |
SE0302488D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | New combination |
WO2005080388A1 (en) | 2004-02-20 | 2005-09-01 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
CA2572119A1 (en) * | 2004-06-29 | 2006-01-12 | Warner-Lambert Company Llc | Combination therapies utilizing benzamide inhibitors of the p2x7 receptor |
JP2008504360A (ja) * | 2004-06-29 | 2008-02-14 | ファイザー・プロダクツ・インク | ヒドロキシル保護された前駆体を脱保護することによる5−[4−(2−ヒドロキシ−プロピル)−3,5−ジオキソ−4,5−ジヒドロ−3h−1,2,4−トリアジン−2−イル]−ベンズアミド誘導体の製造方法 |
AU2005258924A1 (en) * | 2004-06-29 | 2006-01-12 | Pfizer Products Inc. | Method for preparing 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3H-`1,2,4!-triazin-2-YK!benzamide derivatives with P2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid |
SA05260265A (ar) * | 2004-08-30 | 2005-12-03 | استرازينيكا ايه بي | مركبات جديدة |
US20060063834A1 (en) * | 2004-09-09 | 2006-03-23 | Frangioni John V | Substituted adamantanes, and methods of making the same |
SE0402925D0 (sv) * | 2004-11-30 | 2004-11-30 | Astrazeneca Ab | Novel Compounds |
EP2527337A1 (en) * | 2005-04-14 | 2012-11-28 | Bristol-Myers Squibb Company | Inhibitors of 11-beta hydroxysteroid dehydrogenase type I |
JP5281395B2 (ja) * | 2005-06-06 | 2013-09-04 | メルク シャープ エンド ドーム リミテッド | 統合失調症の治療用のglyt1阻害剤としてのシクロヘキサンスルホニル誘導体 |
WO2007109160A2 (en) | 2006-03-16 | 2007-09-27 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
EP2001474B1 (en) | 2006-03-16 | 2016-03-09 | Second Genome, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
TWI464148B (zh) | 2006-03-16 | 2014-12-11 | Evotec Us Inc | 作為p2x7調節劑之雙環雜芳基化合物與其用途 |
KR20140016431A (ko) * | 2006-07-06 | 2014-02-07 | 글락소 그룹 리미티드 | P2x7수용체 길항제로서의 치환된 n페닐메틸5옥소프롤린2아미드 및 그의 사용 방법 |
ZA200904477B (en) | 2006-11-27 | 2010-09-29 | Lundbeck & Co As H | Heteroaryl amide derivatives |
CA2680275C (en) | 2007-03-09 | 2016-08-23 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
MX2009010059A (es) | 2007-03-22 | 2009-10-12 | Astrazeneca Ab | Derivados de quinolina para el tratamiento de enfermedades inflamatorias. |
GB0705882D0 (en) * | 2007-03-27 | 2007-05-02 | Glaxo Group Ltd | Novel compounds |
JP2010522711A (ja) * | 2007-03-28 | 2010-07-08 | グラクソ グループ リミテッド | P2x7調節因子としてのピペリジノンカルボキサミド誘導体 |
NZ580394A (en) | 2007-04-10 | 2011-10-28 | Lundbeck & Co As H | Heteroaryl amide analogues as p2x7 antagonists |
UA105758C2 (uk) | 2007-07-19 | 2014-06-25 | Х. Луннбек А/С | 5-членні гетероциклічні аміди та споріднені сполуки |
CA2704266A1 (en) * | 2007-11-02 | 2009-06-11 | Vertex Pharmaceuticals Incorporated | [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or -pyridin-2-yle derivatives as protein kinase c-theta |
US8106073B2 (en) | 2007-11-30 | 2012-01-31 | Astrazeneca Ab | Quinoline derivatives 057 |
US8232290B2 (en) | 2008-03-25 | 2012-07-31 | Affectis Pharmaceuticals Ag | P2X7R antagonists and their use |
RU2386616C2 (ru) | 2008-04-23 | 2010-04-20 | Общество С Ограниченной Ответственностью "Бинатех" | Производные 5-гидрокси-4-аминометил-1-циклогексил (или циклогептил)-3-алкоксикарбонилиндолов, их фармацевтически приемлемые соли, обладающие противовирусной активностью, и способ их получения |
WO2010072605A1 (en) | 2008-12-23 | 2010-07-01 | F. Hoffmann-La Roche Ag | Dihydropyridone amides as p2x7 modulators |
JP2012513435A (ja) | 2008-12-23 | 2012-06-14 | エフ.ホフマン−ラ ロシュ アーゲー | P2x7調節薬としてのジヒドロピリドンアミド |
MX2011006232A (es) * | 2008-12-23 | 2011-06-24 | Hoffmann La Roche | Dihidropiridona amidas como moduladores de p2x7. |
PT2243772E (pt) | 2009-04-14 | 2012-03-28 | Affectis Pharmaceuticals Ag | Novos antagonistas de p2x7r e sua utilização |
EP2322149A1 (en) | 2009-11-03 | 2011-05-18 | Universidad del Pais Vasco | Methods and compositions for the treatment of ischemia |
WO2011143430A1 (en) | 2010-05-12 | 2011-11-17 | Abbott Laboratories | Indazole inhibitors of kinase |
CN102858741A (zh) | 2010-05-14 | 2013-01-02 | 阿费克蒂斯制药股份公司 | 制备p2x7r拮抗剂的新方法 |
WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
KR101957843B1 (ko) * | 2011-10-06 | 2019-03-14 | (주)아모레퍼시픽 | 신규 아다만탄 유도체 화합물 |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
MX2015004511A (es) | 2012-10-11 | 2015-07-06 | Grünenthal GmbH | Tratamiento y/o profilaxis de enfermedades y/o trastornos provocados por tspo. |
EA029644B1 (ru) * | 2012-12-12 | 2018-04-30 | Идорсиа Фармасьютиклз Лтд | Индолкарбоксамидные производные в качестве антагонистов p2xрецепторов |
US9556117B2 (en) * | 2012-12-18 | 2017-01-31 | Actelion Pharmaceuticals Ltd. | Indole carboxamide derivatives as P2X7 receptor antagonists |
US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
KR102529578B1 (ko) | 2014-08-29 | 2023-05-09 | (주)아모레퍼시픽 | 신규 아다만탄 유도체 화합물 |
WO2016032182A1 (ko) * | 2014-08-29 | 2016-03-03 | (주)아모레퍼시픽 | 신규 아다만탄 유도체 화합물 |
WO2020037350A1 (en) * | 2018-08-24 | 2020-02-27 | The University Of Sydney | Adamantanyl-substituted benzamide compounds and their use as p2x7 receptor antagonists |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3464998A (en) * | 1968-03-04 | 1969-09-02 | Searle & Co | Adamantyl esters and amides of pyridinecarboxylic acids |
US3732305A (en) * | 1970-03-03 | 1973-05-08 | Us Army | S-substituted thiosulfuric acid derivatives and preparation thereof |
US3789072A (en) | 1970-04-22 | 1974-01-29 | Squibb & Sons Inc | Carboxamides |
CA2015473C (en) | 1989-04-28 | 1998-04-14 | Iwao Kinoshita | Triphenylmethane derivatives |
CA2091194A1 (en) * | 1992-04-08 | 1993-10-09 | Richard D. Connell | 2-oxo-ethyl derivatives as immunosuppressants |
SG52229A1 (en) * | 1993-08-10 | 1998-09-28 | Black James Foundation | Gastrin and cck receptor ligands |
GB9409150D0 (en) * | 1994-05-09 | 1994-06-29 | Black James Foundation | Cck and gastrin receptor ligands |
-
1997
- 1997-12-05 SE SE9704544A patent/SE9704544D0/xx unknown
-
1998
- 1998-12-01 ES ES98962751T patent/ES2184352T3/es not_active Expired - Lifetime
- 1998-12-01 WO PCT/SE1998/002188 patent/WO1999029661A1/en not_active Application Discontinuation
- 1998-12-01 DK DK98962751T patent/DK1036059T3/da active
- 1998-12-01 PL PL98340906A patent/PL340906A1/xx unknown
- 1998-12-01 AU AU17913/99A patent/AU744280B2/en not_active Ceased
- 1998-12-01 SK SK843-2000A patent/SK8432000A3/sk unknown
- 1998-12-01 HU HU0004434A patent/HUP0004434A3/hu unknown
- 1998-12-01 BR BR9813390-0A patent/BR9813390A/pt not_active IP Right Cessation
- 1998-12-01 EE EEP200000378A patent/EE200000378A/xx unknown
- 1998-12-01 KR KR1020007006132A patent/KR20010032814A/ko not_active Application Discontinuation
- 1998-12-01 JP JP2000524258A patent/JP2001525392A/ja active Pending
- 1998-12-01 EP EP98962751A patent/EP1036059B1/en not_active Expired - Lifetime
- 1998-12-01 DE DE69808130T patent/DE69808130T2/de not_active Expired - Lifetime
- 1998-12-01 CA CA002312420A patent/CA2312420A1/en not_active Abandoned
- 1998-12-01 US US09/230,478 patent/US6201024B1/en not_active Expired - Lifetime
- 1998-12-01 AT AT98962751T patent/ATE224360T1/de not_active IP Right Cessation
- 1998-12-01 PT PT98962751T patent/PT1036059E/pt unknown
- 1998-12-01 ID IDW20001019A patent/ID28003A/id unknown
- 1998-12-01 CN CN98813491A patent/CN1284057A/zh active Pending
- 1998-12-01 RU RU2000117574/04A patent/RU2214997C2/ru not_active IP Right Cessation
- 1998-12-01 NZ NZ504447A patent/NZ504447A/en unknown
- 1998-12-01 TR TR2000/01605T patent/TR200001605T2/tr unknown
- 1998-12-01 IL IL13636998A patent/IL136369A0/xx unknown
-
2000
- 2000-05-31 NO NO20002786A patent/NO20002786L/no not_active Application Discontinuation
- 2000-12-26 US US09/745,346 patent/US6258838B1/en not_active Expired - Fee Related
- 2000-12-26 US US09/745,740 patent/US6303659B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6303659B2 (en) | 2001-10-16 |
EP1036059B1 (en) | 2002-09-18 |
JP2001525392A (ja) | 2001-12-11 |
CN1284057A (zh) | 2001-02-14 |
US6201024B1 (en) | 2001-03-13 |
HUP0004434A3 (en) | 2002-12-28 |
AU744280B2 (en) | 2002-02-21 |
EE200000378A (et) | 2001-12-17 |
US6258838B1 (en) | 2001-07-10 |
KR20010032814A (ko) | 2001-04-25 |
BR9813390A (pt) | 2000-10-03 |
IL136369A0 (en) | 2001-06-14 |
EP1036059A1 (en) | 2000-09-20 |
AU1791399A (en) | 1999-06-28 |
ES2184352T3 (es) | 2003-04-01 |
PL340906A1 (en) | 2001-03-12 |
WO1999029661A1 (en) | 1999-06-17 |
RU2214997C2 (ru) | 2003-10-27 |
HUP0004434A2 (hu) | 2001-05-28 |
US20010003121A1 (en) | 2001-06-07 |
NZ504447A (en) | 2002-04-26 |
NO20002786L (no) | 2000-07-31 |
SK8432000A3 (en) | 2000-12-11 |
ID28003A (id) | 2001-05-03 |
ATE224360T1 (de) | 2002-10-15 |
TR200001605T2 (tr) | 2000-10-23 |
DE69808130T2 (de) | 2003-05-28 |
PT1036059E (pt) | 2003-02-28 |
CA2312420A1 (en) | 1999-06-17 |
NO20002786D0 (no) | 2000-05-31 |
DK1036059T3 (da) | 2002-12-02 |
DE69808130D1 (de) | 2002-10-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE9704545D0 (sv) | Novel compounds | |
SE9704544D0 (sv) | Novel compounds | |
SE9704546D0 (sv) | Novel compounds | |
MY125978A (en) | Admantane derivatives | |
SE9904505D0 (sv) | Novel compounds | |
MX9602683A (es) | Compuestos de 6-dimetilaminometil-1-fenil-ciclohexano como substancias farmaceuticamente activas. | |
AP9801392A0 (en) | Concentrated antibody preparation. | |
EE200000318A (et) | Uudsed ühendid | |
SE9901875D0 (sv) | Novel compounds | |
ATE231872T1 (de) | Thiazolopyrimidinderivate | |
HUP0001508A3 (en) | 4-arylmethylene-2-imino-2,3-dihydrothiazole derivatives, their use, process for the preparation thereof and pharmaceutical compositions containing them | |
GR1003350B (el) | Νεες ενωσεις | |
ZA965752B (en) | Triphenylethylenes, process for their production, pharmaceutical preparations that contain these triphenylethylenes as well as their use for the production of pharmaceutical agents. | |
IL117091A0 (en) | Methylphenyloxazolidinone derivatives pharmaceutical compositions containing the same and processes for the preparation thereof | |
SE9802937D0 (sv) | Novel compounds | |
ZA9610460B (en) | New phenylamidine derivatives, processes for preparing them and their use as pharmaceutical compositions. | |
EE03996B1 (et) | Farmatseutilised kompositsioonid, nende valmistamismeetod ja kasutamine | |
IL134039A0 (en) | Polyhydroxybutylpyrazines, their preparation and medicines containing them | |
PT83253A (en) | Process for preparing p-acylaminobenzamides | |
SE9803277D0 (sv) | Novel compounds | |
ZA9811804B (en) | 11ß-halogen-7Ó-substituted estratrienes, process for the production of pharmaceutical preparations that contain these 11ß-halogen-7Ó-substituted estratrienes as well as their use for the production of pharmaceutical agents. |