SE470006B - Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet - Google Patents

Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet

Info

Publication number
SE470006B
SE470006B SE9102798A SE9102798A SE470006B SE 470006 B SE470006 B SE 470006B SE 9102798 A SE9102798 A SE 9102798A SE 9102798 A SE9102798 A SE 9102798A SE 470006 B SE470006 B SE 470006B
Authority
SE
Sweden
Prior art keywords
conjugate
heparin
glycosaminoglycan
polymer
polymer backbone
Prior art date
Application number
SE9102798A
Other languages
English (en)
Swedish (sv)
Other versions
SE9102798L (sv
SE9102798D0 (sv
Inventor
R Larsson
D Westberg
B Formgren
A Uhlin
Original Assignee
Corline Systems Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corline Systems Ab filed Critical Corline Systems Ab
Priority to SE9102798A priority Critical patent/SE470006B/sv
Publication of SE9102798D0 publication Critical patent/SE9102798D0/xx
Priority to PCT/SE1992/000672 priority patent/WO1993005793A1/en
Priority to EP92920440A priority patent/EP0658112B1/en
Priority to US08/211,224 priority patent/US5529986A/en
Priority to JP50599593A priority patent/JP3398150B2/ja
Priority to AU26646/92A priority patent/AU2664692A/en
Priority to DE69231935T priority patent/DE69231935T2/de
Publication of SE9102798L publication Critical patent/SE9102798L/xx
Publication of SE470006B publication Critical patent/SE470006B/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
SE9102798A 1991-09-26 1991-09-26 Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet SE470006B (sv)

Priority Applications (7)

Application Number Priority Date Filing Date Title
SE9102798A SE470006B (sv) 1991-09-26 1991-09-26 Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet
PCT/SE1992/000672 WO1993005793A1 (en) 1991-09-26 1992-09-25 A novel conjugate, its preparation and use and a substrate prepared with the conjugate
EP92920440A EP0658112B1 (en) 1991-09-26 1992-09-25 A conjugate comprising a straight-chained polymer having bound sulphated glucosaminoglucans such as heparin, its preparation, use and a corresponding substrate
US08/211,224 US5529986A (en) 1991-09-26 1992-09-25 Conjugate, its preparation and use and a substrate prepared with the conjugate
JP50599593A JP3398150B2 (ja) 1991-09-26 1992-09-25 新規接合体、その調製および使用ならびにその接合体を用いて調製された基体
AU26646/92A AU2664692A (en) 1991-09-26 1992-09-25 A novel conjugate, its preparation and use and a substrate prepared with the conjugate
DE69231935T DE69231935T2 (de) 1991-09-26 1992-09-25 Konjugat enthaltend ein geradkettiges organisches polymer mit gebundenen sulfatierten glukosaminoglukanen wie zum beispiel heparin, seine herstellung, verwendung und ein entsprechendes substrat

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9102798A SE470006B (sv) 1991-09-26 1991-09-26 Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet

Publications (3)

Publication Number Publication Date
SE9102798D0 SE9102798D0 (sv) 1991-09-26
SE9102798L SE9102798L (sv) 1993-03-27
SE470006B true SE470006B (sv) 1993-10-25

Family

ID=20383839

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9102798A SE470006B (sv) 1991-09-26 1991-09-26 Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet

Country Status (7)

Country Link
US (1) US5529986A (ja)
EP (1) EP0658112B1 (ja)
JP (1) JP3398150B2 (ja)
AU (1) AU2664692A (ja)
DE (1) DE69231935T2 (ja)
SE (1) SE470006B (ja)
WO (1) WO1993005793A1 (ja)

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Also Published As

Publication number Publication date
WO1993005793A1 (en) 1993-04-01
EP0658112A1 (en) 1995-06-21
JP3398150B2 (ja) 2003-04-21
JPH06510783A (ja) 1994-12-01
AU2664692A (en) 1993-04-27
DE69231935D1 (de) 2001-08-16
DE69231935T2 (de) 2002-04-04
EP0658112B1 (en) 2001-07-11
SE9102798L (sv) 1993-03-27
SE9102798D0 (sv) 1991-09-26
US5529986A (en) 1996-06-25

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