SE462261B - Farmaceutisk komposition och konjugat av melfalan och normalt humanimmunoglobulin med antitumoerverkan samt foerfarande foer dess framstaellning - Google Patents
Farmaceutisk komposition och konjugat av melfalan och normalt humanimmunoglobulin med antitumoerverkan samt foerfarande foer dess framstaellningInfo
- Publication number
- SE462261B SE462261B SE8401942A SE8401942A SE462261B SE 462261 B SE462261 B SE 462261B SE 8401942 A SE8401942 A SE 8401942A SE 8401942 A SE8401942 A SE 8401942A SE 462261 B SE462261 B SE 462261B
- Authority
- SE
- Sweden
- Prior art keywords
- human immunoglobulin
- tumor
- aqueous
- solution
- binding
- Prior art date
Links
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- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
- 230000035617 depilation Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 201000011523 endocrine gland cancer Diseases 0.000 description 1
- 230000007071 enzymatic hydrolysis Effects 0.000 description 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
- 201000004101 esophageal cancer Diseases 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 208000021045 exocrine pancreatic carcinoma Diseases 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000010200 folin Substances 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 201000010536 head and neck cancer Diseases 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
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- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229960003058 methotrexate sodium Drugs 0.000 description 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 description 1
- YHYUQHQOUXSXQE-ZDUSSCGKSA-N methyl (2s)-2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoate Chemical compound COC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 YHYUQHQOUXSXQE-ZDUSSCGKSA-N 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000010460 mustard Nutrition 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 229940012957 plasmin Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 206010038038 rectal cancer Diseases 0.000 description 1
- 201000001275 rectum cancer Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- ILFPCMXTASDZKM-UHFFFAOYSA-N sarkomycin Natural products OC(=O)C1CCC(=O)C1=C ILFPCMXTASDZKM-UHFFFAOYSA-N 0.000 description 1
- 206010040400 serum sickness Diseases 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/809—Drug, bio-affecting and body treating compositions involving immunoglobulin or antibody fragment, e.g. fab', fv, fc, heavy chain or light chain
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58061923A JPS59186924A (ja) | 1983-04-08 | 1983-04-08 | ヒト免疫グロブリン結合抗腫瘍剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8401942D0 SE8401942D0 (sv) | 1984-04-06 |
| SE8401942L SE8401942L (sv) | 1984-11-13 |
| SE462261B true SE462261B (sv) | 1990-05-28 |
Family
ID=13185161
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8401942A SE462261B (sv) | 1983-04-08 | 1984-04-06 | Farmaceutisk komposition och konjugat av melfalan och normalt humanimmunoglobulin med antitumoerverkan samt foerfarande foer dess framstaellning |
| SE8904004A SE8904004L (sv) | 1983-04-08 | 1989-11-27 | Anti-tumoersubstans och foerfarande foer framstaellning av densamma |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8904004A SE8904004L (sv) | 1983-04-08 | 1989-11-27 | Anti-tumoersubstans och foerfarande foer framstaellning av densamma |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US4738843A (ja) |
| EP (1) | EP0122132A3 (ja) |
| JP (1) | JPS59186924A (ja) |
| CA (1) | CA1301066C (ja) |
| DK (1) | DK181484A (ja) |
| SE (2) | SE462261B (ja) |
| ZA (1) | ZA842272B (ja) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0653682B2 (ja) * | 1983-04-08 | 1994-07-20 | 呉羽化学工業株式会社 | ヒト免疫グロブリン結合抗腫瘍剤 |
| CA1260828A (en) * | 1983-07-04 | 1989-09-26 | Masakazu Iwai | Therapeutic and prophylactic agent for gastrointestinal ulcers |
| FR2581313A1 (fr) * | 1985-05-02 | 1986-11-07 | Pasteur Institut | Composes suscitant la formation d'anticorps, compositions immunogeniques et compositions immunoprotectrices les contenant et procede d'obtention d'anticorps les mettant en oeuvre |
| AU605132B2 (en) * | 1986-01-03 | 1991-01-10 | Consolidated Pharmaceuticals Limited | Melphalan derivatives |
| CA1330378C (en) * | 1986-05-08 | 1994-06-21 | Daniel J. Coughlin | Amine derivatives of folic acid analogs |
| JPH0662438B1 (ja) * | 1986-08-28 | 1994-08-17 | Teijin Ltd | |
| US5030719A (en) * | 1986-08-28 | 1991-07-09 | Teijin Limited | Cytotoxic antibody conjugates and a process for preparation thereof |
| NZ223834A (en) * | 1987-03-11 | 1990-05-28 | Erba Carlo Spa | Immunoglobulin conjugate of an antibody and idarubicin |
| US4900547A (en) * | 1987-10-23 | 1990-02-13 | University Of British Columbia | Method to immunize mammals against tumors |
| GB8727157D0 (en) * | 1987-11-19 | 1987-12-23 | Wellcome Found | Pharmaceutical formulations |
| US4994440A (en) * | 1989-02-13 | 1991-02-19 | Creaven Patrick J | Method for the treatment of renal cell carcinoma |
| US6326467B1 (en) * | 1989-02-23 | 2001-12-04 | Colorado State University Research Foundation | Hormone-recombinant toxin compounds and methods for using same |
| CA2021942C (en) * | 1989-08-10 | 2001-04-10 | Michel Page | Coupling of an anti-tumor to an antibody using glutaraldehyde preactivated anti-tumor agent |
| GB2246779B (en) * | 1990-08-03 | 1994-08-17 | Delta Biotechnology Ltd | Tumour-associated protease inhibitors targeted to tumour cells |
| DE69300409T2 (de) * | 1992-03-06 | 1996-02-01 | Fiutowski Leszek | Pharmazeutische Zusammensetzung mit antiviraler und antibakterieller Wirkung. |
| JP2578044B2 (ja) * | 1992-03-14 | 1997-02-05 | 呉羽化学工業株式会社 | フェニルアラニン−グリシン誘導体、その製造方法、及びその誘導体を含有する抗腫瘍剤 |
| EP0679083A4 (en) * | 1992-12-21 | 1999-03-24 | Ophidian Pharm Inc | PREVENTION AND TREATMENT OF SEPTICEMIA. |
| EP0608546A3 (en) * | 1992-12-22 | 1995-09-27 | Takeda Chemical Industries Ltd | Glia activating factor (gaf), antibodies against it and their uses. |
| US5382582A (en) * | 1993-03-26 | 1995-01-17 | Chan; Carcy L. | Methotrexate analogs and methods of using same |
| US5502037A (en) * | 1993-07-09 | 1996-03-26 | Neuromed Technologies, Inc. | Pro-cytotoxic drug conjugates for anticancer therapy |
| US5698556A (en) * | 1995-06-07 | 1997-12-16 | Chan; Carcy L. | Methotrexate analogs and methods of using same |
| US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| DK0923941T3 (da) * | 1996-06-27 | 2006-09-18 | Chugai Pharmaceutical Co Ltd | Midler mod myelom der skal anvendes sammen med nitrogensennepantitumormidler |
| US20080312201A1 (en) * | 2004-09-10 | 2008-12-18 | Patrick Fogarty | Reduced Toxicity Methotrexate Formulations and Methods for Using the Same |
| CA2622180C (en) | 2005-09-20 | 2012-03-20 | John O. Hui | Method for generating f(ab')2 antibody fragments |
| BRPI0619036A2 (pt) | 2005-11-28 | 2011-09-20 | Vernon D Rowe | composições úteis para reduzir a nefrotoxicidade, e uso destas |
| ATE432955T1 (de) * | 2005-12-05 | 2009-06-15 | Nitto Denko Corp | Polyglutamat-aminosäure-konjugate und verfahren |
| US20080181852A1 (en) * | 2007-01-29 | 2008-07-31 | Nitto Denko Corporation | Multi-functional Drug Carriers |
| WO2008124735A2 (en) * | 2007-04-10 | 2008-10-16 | Nitto Denko Corporation | Multi-functional polyglutamate drug carriers |
| CN101707869A (zh) * | 2007-05-09 | 2010-05-12 | 日东电工株式会社 | 具有多种药物的聚谷氨酸盐结合物和聚谷氨酸盐-氨基酸结合物 |
| EP2155254B1 (en) * | 2007-05-09 | 2012-11-28 | Nitto Denko Corporation | Polymers conjugated with platinum drugs |
| DK2155255T3 (da) | 2007-05-09 | 2013-09-02 | Nitto Denko Corp | Sammensætninger der omfatter en hydrofob forbindelse og et polyaminosyrekonjugat |
| AU2009223453B2 (en) | 2008-03-03 | 2014-05-01 | Tosk, Inc. | Methotrexate adjuvants to reduce toxicity and methods for using the same |
| RU2010137032A (ru) * | 2008-03-06 | 2012-04-20 | Нитто Денко Корпорейшн (Jp) | Конъюгаты паклитаксела с полимером и способы лечения рака |
| AR077384A1 (es) | 2010-07-05 | 2011-08-24 | Eriochem Sa | Una formulacion farmaceutica inyectable de melfalano. |
| EP2872161B1 (en) | 2012-06-26 | 2020-12-16 | Del Mar Pharmaceuticals | Dianhydrogalactitol for use in treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations |
| US11491154B2 (en) | 2013-04-08 | 2022-11-08 | Dennis M. Brown | Therapeutic benefit of suboptimally administered chemical compounds |
| US10723160B2 (en) | 2018-01-23 | 2020-07-28 | Ferro Corporation | Carbide, nitride and silicide enhancers for laser absorption |
| US10854554B2 (en) | 2018-01-23 | 2020-12-01 | Ferro Corporation | Carbide, nitride and silicide enhancers for laser absorption |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1509707A (en) * | 1974-09-20 | 1978-05-04 | Searle & Co | Immunological compounds |
| GB1541435A (en) * | 1975-02-04 | 1979-02-28 | Searle & Co | Immunological materials |
| IL47372A (en) * | 1975-05-27 | 1979-10-31 | Yeda Res & Dev | Fab'dimers bound to daunomycin or adriamycin,their preparation and pharmaceutical compositions containing same |
| US4263279A (en) * | 1975-08-19 | 1981-04-21 | Yeda Research & Development Co. Ltd | Pharmaceutically active compositions containing adriamycin and daunomycin |
| US4017471A (en) * | 1975-09-15 | 1977-04-12 | G. D. Searle & Co. | Immunological compounds |
| JPS5364617A (en) * | 1976-11-22 | 1978-06-09 | Furukawa Electric Co Ltd:The | Manufacture of oxygen-free high-conductivity copper |
| JPS54132503A (en) * | 1978-04-07 | 1979-10-15 | Kayaku Antibiotic Research Co | Immune globulin combined neocarcinostatin |
| FR2437213A1 (fr) * | 1978-09-28 | 1980-04-25 | Cm Ind | Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation |
| US4493793A (en) * | 1978-12-26 | 1985-01-15 | E-Y Laboratories | Soluble immunoassay reagent comprising lectin covalently bonded to reactive component |
| US4315851A (en) * | 1978-12-29 | 1982-02-16 | Kureha Kagaku Kogyo Kabushiki Kaisha | Pharmaceutical composition having antitumor activity |
| JPS5616418A (en) * | 1979-07-20 | 1981-02-17 | Teijin Ltd | Antitumor protein complex and its preparation |
| US4359457A (en) * | 1980-09-30 | 1982-11-16 | Neville Jr David M | Anti Thy 1.2 monoclonal antibody-ricin hybrid utilized as a tumor suppressant |
| FR2504010B1 (fr) * | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
| US4489710A (en) * | 1981-06-23 | 1984-12-25 | Xoma Corporation | Composition and method for transplantation therapy |
| JPH0651643B2 (ja) * | 1983-01-19 | 1994-07-06 | 帝人株式会社 | 殺細胞性修飾免疫グロブリン及びその製造方法 |
-
1983
- 1983-04-08 JP JP58061923A patent/JPS59186924A/ja active Granted
-
1984
- 1984-03-27 ZA ZA842272A patent/ZA842272B/xx unknown
- 1984-03-30 CA CA000451028A patent/CA1301066C/en not_active Expired - Fee Related
- 1984-04-06 EP EP84302364A patent/EP0122132A3/en not_active Ceased
- 1984-04-06 SE SE8401942A patent/SE462261B/sv not_active IP Right Cessation
- 1984-04-06 DK DK181484A patent/DK181484A/da not_active Application Discontinuation
-
1987
- 1987-01-20 US US07/005,302 patent/US4738843A/en not_active Expired - Fee Related
-
1988
- 1988-01-14 US US07/143,747 patent/US4925662A/en not_active Expired - Fee Related
-
1989
- 1989-11-27 SE SE8904004A patent/SE8904004L/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SE8904004L (sv) | 1991-05-28 |
| JPS6330289B2 (ja) | 1988-06-17 |
| SE8401942D0 (sv) | 1984-04-06 |
| US4738843A (en) | 1988-04-19 |
| SE8401942L (sv) | 1984-11-13 |
| EP0122132A3 (en) | 1985-11-27 |
| CA1301066C (en) | 1992-05-19 |
| ZA842272B (en) | 1984-11-28 |
| SE8904004D0 (sv) | 1989-11-27 |
| DK181484A (da) | 1984-10-09 |
| JPS59186924A (ja) | 1984-10-23 |
| US4925662A (en) | 1990-05-15 |
| EP0122132A2 (en) | 1984-10-17 |
| DK181484D0 (da) | 1984-04-06 |
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