SE458446B - 3-aminoalkyl-1h-indol-5-alkansulfonamider, saett att framstaella dessa och en farmaceutisk komposition - Google Patents

3-aminoalkyl-1h-indol-5-alkansulfonamider, saett att framstaella dessa och en farmaceutisk komposition

Info

Publication number
SE458446B
SE458446B SE8406200A SE8406200A SE458446B SE 458446 B SE458446 B SE 458446B SE 8406200 A SE8406200 A SE 8406200A SE 8406200 A SE8406200 A SE 8406200A SE 458446 B SE458446 B SE 458446B
Authority
SE
Sweden
Prior art keywords
group
compound
general formula
formula
solution
Prior art date
Application number
SE8406200A
Other languages
English (en)
Swedish (sv)
Other versions
SE8406200L (sv
SE8406200D0 (sv
Inventor
A W Oxford
B Evans
M D Dowle
I H Coates
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of SE8406200D0 publication Critical patent/SE8406200D0/xx
Publication of SE8406200L publication Critical patent/SE8406200L/xx
Publication of SE458446B publication Critical patent/SE458446B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SE8406200A 1983-12-06 1984-12-06 3-aminoalkyl-1h-indol-5-alkansulfonamider, saett att framstaella dessa och en farmaceutisk komposition SE458446B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838332435A GB8332435D0 (en) 1983-12-06 1983-12-06 Chemical compounds

Publications (3)

Publication Number Publication Date
SE8406200D0 SE8406200D0 (sv) 1984-12-06
SE8406200L SE8406200L (sv) 1985-06-07
SE458446B true SE458446B (sv) 1989-04-03

Family

ID=10552845

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8406200A SE458446B (sv) 1983-12-06 1984-12-06 3-aminoalkyl-1h-indol-5-alkansulfonamider, saett att framstaella dessa och en farmaceutisk komposition

Country Status (27)

Country Link
US (1) US4994483A (de)
JP (2) JPH062733B2 (de)
KR (1) KR850004459A (de)
CN (2) CN85104233A (de)
AT (1) AT381934B (de)
AU (1) AU575365B2 (de)
BE (1) BE901224A (de)
CA (1) CA1233183A (de)
CH (1) CH663411A5 (de)
CY (1) CY1562A (de)
DE (1) DE3444572C2 (de)
DK (2) DK583684A (de)
ES (2) ES8607234A1 (de)
FI (1) FI80260C (de)
FR (1) FR2555987B1 (de)
GB (2) GB8332435D0 (de)
HK (1) HK85690A (de)
HU (2) HU196752B (de)
IL (1) IL73756A (de)
IT (1) IT1178268B (de)
NL (1) NL8403719A (de)
NO (1) NO162764C (de)
NZ (1) NZ210469A (de)
PT (1) PT80572B (de)
SE (1) SE458446B (de)
SG (1) SG65790G (de)
ZA (1) ZA849498B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
AU584142B2 (en) * 1984-12-04 1989-05-18 Glaxo Group Limited Indole derivatives
GB8430624D0 (en) * 1984-12-04 1985-01-09 Glaxo Group Ltd Chemical compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8601959D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Indole derivatives
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
KR0131327B1 (en) * 1987-08-13 1998-04-17 Glaxo Group Ltd Indole derivatives
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
JPH01312506A (ja) * 1988-06-13 1989-12-18 Mitsui Petrochem Ind Ltd カラーフィルター
HU219974B (hu) * 1990-06-07 2001-10-28 Astrazeneca Ab, Heterociklusos csoporttal helyettesített indolszármazék, előállítása és a vegyületet hatóanyagként tartalmazó gyógyszerkészítmények
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
IT1264813B1 (it) * 1993-07-28 1996-10-10 Oxon Italia Spa Procedimento per la preparazione di alcansolfonammidi
EP0875513A1 (de) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituierte heteroaromatische 5-HT1F Agoniste
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
CN1729174B (zh) * 2002-12-20 2015-10-21 西巴特殊化学品控股有限公司 胺的合成以及用于合成胺的中间体
WO2004099141A1 (en) * 2003-05-12 2004-11-18 Ramesh Babu Potluri A novel process for preparation of indole derivatives
EP1765300A2 (de) * 2004-06-10 2007-03-28 Duramed Pharmaceuticals, Inc. Formulierungen von sumatriptan zur absorption durch biologische membranen, und herstellungs- und anwendungsverfahren
ZA200709038B (en) 2005-04-13 2009-01-28 Neuraxon Inc Substituted indole compounds having nos inhibitory activity
CA2643822A1 (en) * 2006-04-13 2007-10-25 Neuraxon, Inc 1,5 and 3,6- substituted indole compounds having nos inhibitory activity
WO2008056378A2 (en) * 2006-11-09 2008-05-15 Natco Pharma Limited Novel process for the preparation of naratriptan hydrochloride
CA2677838C (en) * 2007-02-11 2017-08-01 Map Pharmaceuticals, Inc. Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile
CA2705422A1 (en) * 2007-11-16 2009-05-22 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods for treating visceral pain
US20090131503A1 (en) * 2007-11-16 2009-05-21 Annedi Subhash C 3,5 - substituted indole compounds having nos and norepinephrine reuptake inhibitory activity
NZ586082A (en) 2007-11-16 2013-03-28 Neuraxon Inc Indole compounds and methods for treating visceral pain
US20110171141A1 (en) * 2009-06-26 2011-07-14 Kellerman Donald J Administration of dihydroergotamine mesylate particles using a metered dose inhaler
US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
EP2480197B1 (de) 2009-09-25 2015-11-11 Dr. Reddy's Laboratories Ltd. Formulierungen mit triptanverbindungen
JPWO2012165262A1 (ja) * 2011-05-27 2015-02-23 国立大学法人徳島大学 ベンジルアミン誘導体
EP2734634B1 (de) 2011-07-22 2019-08-21 The University of Chicago Igf-1 zur behandlung von migräne
CN102827062A (zh) * 2012-09-17 2012-12-19 扬子江药业集团四川海蓉药业有限公司 苹果酸阿莫曲坦的制备方法
US9394314B2 (en) 2012-12-21 2016-07-19 Map Pharmaceuticals, Inc. 8′-hydroxy-dihydroergotamine compounds and compositions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322787A (en) * 1964-09-25 1967-05-30 Merck & Co Inc Alpha-hydrazino-beta-(3-indolyl) alkanoic acid derivatives
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
US3468882A (en) * 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
IT1036004B (it) * 1968-05-21 1979-10-30 Abc Ist Biolog Chem Spa Acidt 3 indolil adetoidrossamici
US3730723A (en) * 1971-06-17 1973-05-01 Eastman Kodak Co Direct positive processes utilizing silver halide surface image emulsions containing desensitizers
US4283410A (en) * 1978-06-15 1981-08-11 Miles Laboratories, Inc. 3-Amino or amido-2-(1H-indol-3-yl) propanoic acid derivatives
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
BE889929A (fr) * 1980-08-12 1982-02-11 Glaxo Group Ltd Derives de l'indole, leur preparation et leurs utilisations therapeutiques
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
GB2083463B (en) * 1980-08-12 1984-05-10 Glaxo Group Ltd Heterocyclic compounds
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
AU584142B2 (en) * 1984-12-04 1989-05-18 Glaxo Group Limited Indole derivatives

Also Published As

Publication number Publication date
FR2555987B1 (fr) 1987-07-17
GB8430810D0 (en) 1985-01-16
AT381934B (de) 1986-12-10
FI80260B (fi) 1990-01-31
IT8449265A0 (it) 1984-12-06
FR2555987A1 (fr) 1985-06-07
FI844789L (fi) 1985-06-07
FI80260C (fi) 1990-05-10
PT80572A (en) 1985-06-01
NZ210469A (en) 1989-01-27
DK583684A (da) 1985-06-07
BE901224A (fr) 1985-06-06
GB2150932B (en) 1987-10-28
US4994483A (en) 1991-02-19
IL73756A0 (en) 1985-03-31
FI844789A0 (fi) 1984-12-05
GB2150932A (en) 1985-07-10
CA1233183A (en) 1988-02-23
AU3636784A (en) 1985-06-13
GB8332435D0 (en) 1984-01-11
KR850004459A (ko) 1985-07-15
JPS60155156A (ja) 1985-08-15
AU575365B2 (en) 1988-07-28
SE8406200L (sv) 1985-06-07
SG65790G (en) 1990-10-26
DE3444572A1 (de) 1985-06-20
CY1562A (en) 1991-05-17
NO162764B (no) 1989-11-06
ES546631A0 (es) 1987-10-16
HU196752B (en) 1989-01-30
JPH03184958A (ja) 1991-08-12
ZA849498B (en) 1986-09-24
CN1015055B (zh) 1991-12-11
IL73756A (en) 1988-02-29
CN85106225A (zh) 1987-02-18
PT80572B (en) 1986-12-22
HUT40624A (en) 1987-01-28
ES538336A0 (es) 1986-06-01
JPH062733B2 (ja) 1994-01-12
NL8403719A (nl) 1985-07-01
DK214090D0 (da) 1990-09-06
DK214090A (da) 1990-09-06
CN85104233A (zh) 1987-01-07
HUT36455A (en) 1985-09-30
ES8607234A1 (es) 1986-06-01
DE3444572C2 (de) 1993-10-14
ATA387384A (de) 1986-05-15
CH663411A5 (fr) 1987-12-15
DK583684D0 (da) 1984-12-06
ES8800150A1 (es) 1987-10-16
NO162764C (no) 1990-02-14
IT1178268B (it) 1987-09-09
HK85690A (en) 1990-10-25
SE8406200D0 (sv) 1984-12-06
NO844879L (no) 1985-06-07

Similar Documents

Publication Publication Date Title
SE458446B (sv) 3-aminoalkyl-1h-indol-5-alkansulfonamider, saett att framstaella dessa och en farmaceutisk komposition
US4816470A (en) Heterocyclic compounds
US4650810A (en) Indole-5-acetamides for treatment of migraine
SE454881B (sv) N-(3-(aminoalkyl)-1h-indol-5-yl-metyl) sulfonamider, forfarande for framstellning av dessa och en farmaceutisk komposition for behandling av migren
JPS62228056A (ja) 化学的化合物
JP2001039871A (ja) ゴナドトロピン放出ホルモン拮抗剤を含有する医薬組成物
JP3553071B2 (ja) ５ｈｔ１様、５ｈｔ１ｂおよび５ｈｔ１ｄレセプターのリガンドとしてのインドール誘導アリールピペラジン
EP0147107A1 (de) Indolderivate
SE454777B (sv) 5-substituerade 3-aminoalkyl-1h-indoler, forfarande for framstellning av dessa och en farmaceutisk komposition for behandling av migren
CH667647A5 (fr) 5-alkenesulfonamides indoles.
US4870096A (en) 5-substituted 3-aninoalkyl indoles
GB2082175A (en) Heterocyclic compounds
GB2186874A (en) Pharmaceutically active 5-acylaminoalkyl-3-aminoalkyl-1H-indoles
JP2005526054A (ja) 化合物
ES2352725T3 (es) 2-fenil-indoles como antagonistas del receptor de la prostaglandina d2.
LU85915A1 (fr) Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8406200-9

Effective date: 19920704

Format of ref document f/p: F