SE455671B - Flytande farmaceutisk komposition for nasal administration innefattande en kalcitonin och bensalkoniumklorid samt behallare for denna komposition - Google Patents
Flytande farmaceutisk komposition for nasal administration innefattande en kalcitonin och bensalkoniumklorid samt behallare for denna kompositionInfo
- Publication number
- SE455671B SE455671B SE8305485A SE8305485A SE455671B SE 455671 B SE455671 B SE 455671B SE 8305485 A SE8305485 A SE 8305485A SE 8305485 A SE8305485 A SE 8305485A SE 455671 B SE455671 B SE 455671B
- Authority
- SE
- Sweden
- Prior art keywords
- nasal
- composition
- calcitonin
- administration
- composition according
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 73
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 title claims description 39
- 102000055006 Calcitonin Human genes 0.000 title claims description 20
- 108060001064 Calcitonin Proteins 0.000 title claims description 20
- 229960004015 calcitonin Drugs 0.000 title claims description 20
- 239000007788 liquid Substances 0.000 title claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 title 1
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- 108010068072 salmon calcitonin Proteins 0.000 claims description 20
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- 229940097496 nasal spray Drugs 0.000 claims description 12
- 239000004094 surface-active agent Substances 0.000 claims description 11
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 9
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 9
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- KSIYPKPZIBBUFR-LJNLPFSOSA-N CSCC[C@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(N)=O Chemical compound CSCC[C@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(N)=O KSIYPKPZIBBUFR-LJNLPFSOSA-N 0.000 claims 1
- 101000741445 Homo sapiens Calcitonin Proteins 0.000 claims 1
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- 235000019515 salmon Nutrition 0.000 description 3
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- BQPPJGMMIYJVBR-UHFFFAOYSA-N (10S)-3c-Acetoxy-4.4.10r.13c.14t-pentamethyl-17c-((R)-1.5-dimethyl-hexen-(4)-yl)-(5tH)-Delta8-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C)CCC21C BQPPJGMMIYJVBR-UHFFFAOYSA-N 0.000 description 2
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- CAHGCLMLTWQZNJ-RGEKOYMOSA-N lanosterol Chemical compound C([C@]12C)C[C@@H](O)C(C)(C)[C@H]1CCC1=C2CC[C@]2(C)[C@H]([C@H](CCC=C(C)C)C)CC[C@@]21C CAHGCLMLTWQZNJ-RGEKOYMOSA-N 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Otolaryngology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8228390 | 1982-10-05 | ||
| GB8236928 | 1982-12-30 | ||
| GB838320865A GB8320865D0 (en) | 1983-08-03 | 1983-08-03 | Organic compounds |
| GB838322528A GB8322528D0 (en) | 1983-08-22 | 1983-08-22 | Organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8305485D0 SE8305485D0 (sv) | 1983-10-05 |
| SE8305485L SE8305485L (sv) | 1984-04-06 |
| SE455671B true SE455671B (sv) | 1988-08-01 |
Family
ID=27449393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8305485A SE455671B (sv) | 1982-10-05 | 1983-10-05 | Flytande farmaceutisk komposition for nasal administration innefattande en kalcitonin och bensalkoniumklorid samt behallare for denna komposition |
Country Status (21)
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL70489A0 (en) * | 1982-12-29 | 1984-03-30 | Armour Pharma | Pharmaceutical compositions containing calcitonin |
| IT1250691B (it) * | 1991-07-22 | 1995-04-21 | Giancarlo Santus | Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac. |
| US5571788A (en) * | 1991-12-09 | 1996-11-05 | Ciba-Geigy Corporation | Stable calcitonin pharmaceutical compositions |
| US5482931A (en) * | 1993-06-29 | 1996-01-09 | Ferring Ab | Stabilized pharmaceutical peptide compositions |
| EP0726075A1 (en) * | 1995-02-08 | 1996-08-14 | Therapicon Srl | Pharmaceutical non-inorganic saline solutions for endonasal administration |
| US6861053B1 (en) * | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| TWI243687B (en) | 1998-04-21 | 2005-11-21 | Teijin Ltd | Pharmaceutical composition for application to mucosa |
| US6063395A (en) * | 1998-11-12 | 2000-05-16 | Leiras Oy | Drug delivery device especially for the delivery of progestins and estrogens |
| US6056976A (en) * | 1998-11-12 | 2000-05-02 | Leiras Oy | Elastomer, its preparation and use |
| AR026073A1 (es) | 1999-10-20 | 2002-12-26 | Nycomed Gmbh | Composicion farmaceutica acuosa que contiene ciclesonida |
| WO2001056594A1 (en) | 2000-02-04 | 2001-08-09 | Unigene Laboratories, Inc. | Nasal calcitonin formulations |
| US6531112B2 (en) * | 2000-05-15 | 2003-03-11 | Delrx Pharmaceutical Corporation | Formulations for administering calcitonin and processes for preparing the same |
| US20090035260A1 (en) * | 2002-07-29 | 2009-02-05 | Therapicon Srl | Enhanced nasal composition of active peptide |
| US7186692B2 (en) * | 2002-12-17 | 2007-03-06 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery and non-infused administration of Y2 receptor-binding peptides and methods for treating and preventing obesity |
| US7166575B2 (en) * | 2002-12-17 | 2007-01-23 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity |
| EA008829B1 (ru) * | 2002-12-17 | 2007-08-31 | Нэстек Фармасьютикал Кампани Инк. | Композиции и способы для усовершенствованной доставки пептидов, связывающихся с y-рецепторами, которую осуществляют через слизистые оболочки, и способы лечения и предотвращения ожирения |
| US7229966B2 (en) * | 2002-12-17 | 2007-06-12 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity |
| WO2004084859A2 (en) * | 2003-03-21 | 2004-10-07 | Nastech Pharmaceutical Company Inc. | Nasal calcitonin formulations containing chlorobutanol |
| US20040265238A1 (en) * | 2003-06-27 | 2004-12-30 | Imtiaz Chaudry | Inhalable formulations for treating pulmonary hypertension and methods of using same |
| ATE350024T1 (de) * | 2003-10-15 | 2007-01-15 | Pari Gmbh | Flüssige zubereitung enthaltend tobramycin |
| ITMI20040235A1 (it) * | 2004-02-13 | 2004-05-13 | Therapicon Srl | Preparazione farmaceutica per il cavo orale |
| US20100256060A1 (en) * | 2009-04-02 | 2010-10-07 | Unigene Laboratories Inc. | Peptide pharmaceuticals for nasal delivery |
| WO2013112912A1 (en) | 2012-01-26 | 2013-08-01 | Soares Christopher J | Peptide antagonists of the calcitonin cgrp family of peptide hormones and their use |
| IL265099B2 (en) | 2016-09-02 | 2024-09-01 | Christopher J Soares | Pharmaceutical compositions comprising an effective amount of calcitonin gene-related peptide (cgrp) receptor antagonist or pharmaceutically acceptable salt thereof, for treating glaucoma |
| US10723716B2 (en) | 2016-12-21 | 2020-07-28 | New York University | Alpha-helix mimetics as modulators of Abeta self-assembly |
| US11124479B2 (en) | 2017-07-14 | 2021-09-21 | New York University | Oligopyrroles as antagonists of islet amyloid polypeptide oligomerization |
| US10500197B2 (en) | 2017-07-18 | 2019-12-10 | New York University | Use of oligopyridylamides to inhibit mutant p53 amyloid formation and restore its tumor suppressor function |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3769405A (en) * | 1970-04-17 | 1973-10-30 | Armour Pharma | Methods for obtaining diuresis |
| CH539556A (de) * | 1971-03-16 | 1973-07-31 | Ciba Geigy Ag | Applikator zur dosierten Ausgabe einer Flüssigkeit |
| GB1354526A (en) * | 1971-04-19 | 1974-06-05 | Armour Pharma | Preparation for obtaining diuresis in animals |
| GB1527605A (en) * | 1975-08-20 | 1978-10-04 | Takeda Chemical Industries Ltd | Insulin preparation for intranasal administration |
| GB2008403B (en) * | 1977-11-04 | 1982-07-28 | Christie R B Parsons J A | Pharmaceutical compositions |
| US4241051A (en) * | 1977-11-04 | 1980-12-23 | Christie Robert B | Calcitonin |
| DE2903957A1 (de) * | 1979-02-02 | 1980-08-07 | Boehringer Sohn Ingelheim | Mittel zur behandlung der nasalen hypersekretion |
| JPS5625197A (en) * | 1979-07-19 | 1981-03-10 | Microbial Chem Res Found | Cleomycin and its preparation |
| JPS56100714A (en) * | 1980-01-16 | 1981-08-12 | Teijin Ltd | Pharmaceutical adhering to oral mucous membrane or nasal mucous membrane |
| JPS56122309A (en) * | 1980-03-03 | 1981-09-25 | Teijin Ltd | Calcitonin pharmaceutical for rectal administration |
| EP0053754B1 (de) * | 1980-12-06 | 1986-04-23 | Reichert, Dietrich, Dr. med. | Mittel zur Bekämpfung des Schnarchens und Verfahren zu dessen Anwendung |
| IL70489A0 (en) * | 1982-12-29 | 1984-03-30 | Armour Pharma | Pharmaceutical compositions containing calcitonin |
| GB8514090D0 (en) * | 1985-06-04 | 1985-07-10 | Sandoz Ltd | Organic compounds |
| IT1222734B (it) * | 1987-09-25 | 1990-09-12 | Scalvo S P A | Formulaziopne farmaceutiche e forme di dosaggio per la somminaistarzione rettale di calcitonina |
-
1983
- 1983-09-27 CH CH5226/83A patent/CH657779A5/de not_active IP Right Cessation
- 1983-09-28 DE DE19833335086 patent/DE3335086A1/de active Granted
- 1983-10-03 AU AU19849/83A patent/AU572800B2/en not_active Expired
- 1983-10-03 NL NL8303386A patent/NL192563C/nl not_active IP Right Cessation
- 1983-10-03 NZ NZ205846A patent/NZ205846A/en unknown
- 1983-10-03 PT PT77443A patent/PT77443B/pt unknown
- 1983-10-03 IL IL69892A patent/IL69892A/xx not_active IP Right Cessation
- 1983-10-03 FR FR8315837A patent/FR2533826B1/fr not_active Expired
- 1983-10-03 AT AT0349483A patent/AT394947B/de not_active IP Right Cessation
- 1983-10-04 HU HU833443A patent/HU192246B/hu unknown
- 1983-10-04 DK DK458183A patent/DK161800C/da not_active IP Right Cessation
- 1983-10-04 PH PH29651A patent/PH22725A/en unknown
- 1983-10-05 CA CA000438434A patent/CA1220138A/en not_active Expired
- 1983-10-05 SE SE8305485A patent/SE455671B/sv not_active IP Right Cessation
- 1983-10-05 IT IT49105/83A patent/IT1172324B/it active Protection Beyond IP Right Term
-
1987
- 1987-12-30 MY MY271/87A patent/MY8700271A/xx unknown
-
1988
- 1988-08-17 AU AU21035/88A patent/AU2103588A/en not_active Abandoned
- 1988-11-15 SG SG763/88A patent/SG76388G/en unknown
- 1988-11-25 KE KE3848A patent/KE3848A/xx unknown
-
1989
- 1989-03-30 HK HK273/89A patent/HK27389A/xx not_active IP Right Cessation
-
1990
- 1990-03-12 JP JP2060862A patent/JPH07103043B2/ja not_active Expired - Lifetime
-
1991
- 1991-12-31 US US07/815,457 patent/US5759565A/en not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/471,118 patent/US5733569A/en not_active Expired - Lifetime
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