SE445828B - Salter och estrar av monakolin k till anvendning sasom antihyperkolesterolemiska medel - Google Patents
Salter och estrar av monakolin k till anvendning sasom antihyperkolesterolemiska medelInfo
- Publication number
- SE445828B SE445828B SE8005386A SE8005386A SE445828B SE 445828 B SE445828 B SE 445828B SE 8005386 A SE8005386 A SE 8005386A SE 8005386 A SE8005386 A SE 8005386A SE 445828 B SE445828 B SE 445828B
- Authority
- SE
- Sweden
- Prior art keywords
- monacoline
- salts
- monacolin
- salt
- solution
- Prior art date
Links
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- 239000002184 metal Substances 0.000 claims description 10
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- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
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- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 2
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- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 description 27
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- 159000000003 magnesium salts Chemical class 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000000401 methanolic extract Substances 0.000 description 1
- 229930185723 monacolin Natural products 0.000 description 1
- 230000005868 ontogenesis Effects 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000001965 potato dextrose agar Substances 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000004455 soybean meal Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/46—Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9581479A JPS5621594A (en) | 1979-07-27 | 1979-07-27 | Mb-530b carboxylic acid metal salt and its preparation |
| JP12346179A JPS5646841A (en) | 1979-09-26 | 1979-09-26 | Mb-530b carboxylic acid ester and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8005386L SE8005386L (sv) | 1981-01-28 |
| SE445828B true SE445828B (sv) | 1986-07-21 |
Family
ID=26436995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8005386A SE445828B (sv) | 1979-07-27 | 1980-07-25 | Salter och estrar av monakolin k till anvendning sasom antihyperkolesterolemiska medel |
Country Status (16)
| Country | Link |
|---|---|
| AT (1) | AT375334B (OSRAM) |
| AU (1) | AU6083980A (OSRAM) |
| CH (1) | CH647749A5 (OSRAM) |
| DD (1) | DD153827A5 (OSRAM) |
| DE (1) | DE3028284A1 (OSRAM) |
| DK (1) | DK322380A (OSRAM) |
| ES (1) | ES493726A0 (OSRAM) |
| FI (1) | FI71300C (OSRAM) |
| FR (1) | FR2462417A1 (OSRAM) |
| GB (1) | GB2055100A (OSRAM) |
| IT (1) | IT1147763B (OSRAM) |
| NL (1) | NL8004303A (OSRAM) |
| NO (1) | NO156210C (OSRAM) |
| NZ (1) | NZ194445A (OSRAM) |
| PL (1) | PL225901A1 (OSRAM) |
| SE (1) | SE445828B (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1327360C (en) * | 1983-11-14 | 1994-03-01 | William F. Hoffman | Oxo-analogs of mevinolin-like antihypercholesterolemic agents |
| DE3580863D1 (de) * | 1984-06-04 | 1991-01-24 | Merck & Co Inc | Herstellungsverfahren von hemmstoffen der hmg-coa-reduktase mit einer 3,5-dihydroxypentanoatteilstruktur. |
| EP0204287A3 (en) * | 1985-06-04 | 1987-07-01 | Merck & Co. Inc. | Process for the preparation of hmg-coa reductase inhibitors with a 3,5-dihydroxypentanoate subunit |
| USRE33033E (en) * | 1985-07-05 | 1989-08-22 | Merck & Co., Inc. | Process for the preparation of HMG-CoA reductase inhibitors intermediates |
| US4611081A (en) * | 1985-07-05 | 1986-09-09 | Merck & Co., Inc. | Process for the preparation of HMG-CoA reductase inhibitors intermediates |
| US6046022A (en) | 1996-09-30 | 2000-04-04 | Peking University | Methods and compositions employing red rice fermentation products |
| US7238348B2 (en) | 1996-09-30 | 2007-07-03 | Beijing Peking University Wbl Corporation Ltd. | Method of treatment of osteoporosis with compositions of red rice fermentation products |
| JP2002518448A (ja) * | 1998-06-24 | 2002-06-25 | メルク エンド カムパニー インコーポレーテッド | 高血中コレステロールを治療する組成物および方法 |
| SI20070A (sl) | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nove soli inhibitorjev HMG-CoA reduktaze |
| SK16982002A3 (sk) * | 2000-06-09 | 2003-04-01 | Lek Pharmaceuticals D. D. | Stabilizovaná farmaceuticky účinná kompozícia a liečivý prípravok túto kompozíciu obsahujúci |
| US6806290B2 (en) | 2000-06-09 | 2004-10-19 | Lek Pharmaceuticals D.D. | Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same |
| WO2002020457A1 (en) * | 2000-09-06 | 2002-03-14 | Merck & Co., Inc. | Dihydroxy open-acid salt of simvastatin |
| WO2002100323A2 (en) | 2001-06-13 | 2002-12-19 | Ranbaxy Laboratories Limited | METHYL ANALOGS OF SIMVASTATIN AS NOVEL HMG-CoA REDUCTASE INHIBITORS |
| KR100379075B1 (en) | 2002-03-07 | 2003-04-08 | Jinis Biopharmaceuticals Co | Method for producing low cholesterol animal food product and food product therefrom |
| US8158362B2 (en) | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4137322A (en) * | 1976-11-02 | 1979-01-30 | Sankyo Company Limited | ML-236B carboxylic acid derivatives and their use as antihyperlipemic agents |
| JPS55150898A (en) * | 1979-05-11 | 1980-11-25 | Sankyo Co Ltd | Preparation of a new physiologically active substance mb-530b |
-
1980
- 1980-07-24 ES ES493726A patent/ES493726A0/es active Granted
- 1980-07-25 FR FR8016452A patent/FR2462417A1/fr active Granted
- 1980-07-25 NZ NZ194445A patent/NZ194445A/en unknown
- 1980-07-25 DE DE19803028284 patent/DE3028284A1/de active Granted
- 1980-07-25 NO NO802244A patent/NO156210C/no unknown
- 1980-07-25 FI FI802357A patent/FI71300C/fi not_active IP Right Cessation
- 1980-07-25 CH CH5736/80A patent/CH647749A5/de not_active IP Right Cessation
- 1980-07-25 DK DK322380A patent/DK322380A/da not_active Application Discontinuation
- 1980-07-25 SE SE8005386A patent/SE445828B/sv not_active IP Right Cessation
- 1980-07-26 PL PL22590180A patent/PL225901A1/xx unknown
- 1980-07-27 NL NL8004303A patent/NL8004303A/nl not_active Application Discontinuation
- 1980-07-28 GB GB8024665A patent/GB2055100A/en not_active Withdrawn
- 1980-07-28 IT IT68211/80A patent/IT1147763B/it active
- 1980-07-28 AT AT0392380A patent/AT375334B/de not_active IP Right Cessation
- 1980-07-28 DD DD80222916A patent/DD153827A5/de unknown
- 1980-07-28 AU AU60839/80A patent/AU6083980A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| FI71300C (fi) | 1986-12-19 |
| GB2055100A (en) | 1981-02-25 |
| NO156210C (no) | 1987-08-12 |
| DK322380A (da) | 1981-01-28 |
| AU6083980A (en) | 1981-01-29 |
| NO802244L (no) | 1981-01-28 |
| DE3028284A1 (de) | 1981-02-19 |
| FR2462417B1 (OSRAM) | 1984-01-20 |
| PL225901A1 (OSRAM) | 1982-07-19 |
| DD153827A5 (de) | 1982-02-03 |
| FI802357A7 (fi) | 1981-01-28 |
| AT375334B (de) | 1984-07-25 |
| FR2462417A1 (fr) | 1981-02-13 |
| SE8005386L (sv) | 1981-01-28 |
| IT1147763B (it) | 1986-11-26 |
| ES8105781A1 (es) | 1981-06-16 |
| ATA392380A (de) | 1983-12-15 |
| NZ194445A (en) | 1984-07-06 |
| DE3028284C2 (OSRAM) | 1990-08-09 |
| ES493726A0 (es) | 1981-06-16 |
| NO156210B (no) | 1987-05-04 |
| NL8004303A (nl) | 1981-01-29 |
| IT8068211A0 (it) | 1980-07-28 |
| FI71300B (fi) | 1986-09-09 |
| CH647749A5 (de) | 1985-02-15 |
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