JPS5646841A - Mb-530b carboxylic acid ester and its preparation - Google Patents

Mb-530b carboxylic acid ester and its preparation

Info

Publication number
JPS5646841A
JPS5646841A JP12346179A JP12346179A JPS5646841A JP S5646841 A JPS5646841 A JP S5646841A JP 12346179 A JP12346179 A JP 12346179A JP 12346179 A JP12346179 A JP 12346179A JP S5646841 A JPS5646841 A JP S5646841A
Authority
JP
Japan
Prior art keywords
carboxylic acid
alkyl
acid ester
preparation
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12346179A
Other languages
Japanese (ja)
Other versions
JPS6320215B2 (en
Inventor
Yoshio Tsujita
Masao Kuroda
Kazuhiko Tanzawa
Seigo Iwato
Kiyoshi Hamano
Akira Terahara
Sadao Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP12346179A priority Critical patent/JPS5646841A/en
Priority to ES493726A priority patent/ES493726A0/en
Priority to DK322380A priority patent/DK322380A/en
Priority to FI802357A priority patent/FI71300C/en
Priority to DE19803028284 priority patent/DE3028284A1/en
Priority to FR8016452A priority patent/FR2462417A1/en
Priority to DE19803051206 priority patent/DE3051206C2/en
Priority to NO802244A priority patent/NO156210C/en
Priority to NZ194445A priority patent/NZ194445A/en
Priority to SE8005386A priority patent/SE445828B/en
Priority to CH5736/80A priority patent/CH647749A5/en
Priority to PL22590180A priority patent/PL225901A1/xx
Priority to NL8004303A priority patent/NL8004303A/en
Priority to GB8024665A priority patent/GB2055100A/en
Priority to AT0392380A priority patent/AT375334B/en
Priority to AU60839/80A priority patent/AU6083980A/en
Priority to IT68211/80A priority patent/IT1147763B/en
Priority to DD80222916A priority patent/DD153827A5/en
Publication of JPS5646841A publication Critical patent/JPS5646841A/en
Publication of JPS6320215B2 publication Critical patent/JPS6320215B2/ja
Granted legal-status Critical Current

Links

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:An MB-530B carboxylic acid ester of formula (R is alkyl, benzyl which may be substituted with alkyl, alkoxy or halogen, or phenacyl which may be substituted with alkyl, alkoxy or halogen).
EXAMPLE: MB-530B carboxylic acid methyl ester.
USE: It is effective to inhibit the synthesis of cholesterol and depress the lipid level in blood, and is useful, e.g. as an antilipemic agent, anti-arteriosclerotic agent, etc. It is preferably administered orally.
PROCESS: The compound of the formula is prepared by reacting an alcohol with MB-530B obtained by culturing MB-530B-producing bacteria belonging to Monascus genus, e.g. Monascus anca SANK 10171 (IFO 6540), etc.
COPYRIGHT: (C)1981,JPO&Japio
JP12346179A 1979-07-27 1979-09-26 Mb-530b carboxylic acid ester and its preparation Granted JPS5646841A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
JP12346179A JPS5646841A (en) 1979-09-26 1979-09-26 Mb-530b carboxylic acid ester and its preparation
ES493726A ES493726A0 (en) 1979-07-27 1980-07-24 A PROCEDURE FOR THE PREPARATION OF SALTS AND ESTERS OF MONACOLINE K USEFUL AS ANTITLIPERCOLESTEREMIC AGENTS.
DK322380A DK322380A (en) 1979-07-27 1980-07-25 PROCEDURE FOR THE PREPARATION OF MONACOLIN K SALTS OR ESTERS
FI802357A FI71300C (en) 1979-07-27 1980-07-25 FOERFARANDE FOER FRAMSTAELLNING AV SALTER OCH ESTRAR AV SYRAN SOM SVARAR MOT MONACOLIN-K VILKA HAR ANTIHYPERKOLESTEREMISK EFFEKT
DE19803028284 DE3028284A1 (en) 1979-07-27 1980-07-25 MONACOLIN K DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE DERIVATIVES
FR8016452A FR2462417A1 (en) 1979-07-27 1980-07-25 NOVEL MONACOLIN K DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
DE19803051206 DE3051206C2 (en) 1979-07-27 1980-07-25 Hypocholesterolaemic salts and ester(s) from monacolin K - are prepd. by cultivation of monascus strains followed by salification or esterification
NO802244A NO156210C (en) 1979-07-27 1980-07-25 PROCEDURE FOR THE PREPARATION OF MONACOLIN K DERIVATIVES.
NZ194445A NZ194445A (en) 1979-07-27 1980-07-25 Monacolin k salts and esters
SE8005386A SE445828B (en) 1979-07-27 1980-07-25 SALTS AND ESTERS OF MONACOLINE K FOR USE AS ANTI-HYPERCOLESTEROLEMIC AGENTS
CH5736/80A CH647749A5 (en) 1979-07-27 1980-07-25 MONACOLIN-K SALTS AND ESTERS, PRODUCTION METHOD AND PHARMACEUTICAL PREPARATIONS.
PL22590180A PL225901A1 (en) 1979-07-27 1980-07-26
NL8004303A NL8004303A (en) 1979-07-27 1980-07-27 MONACOLINE K CONNECTIONS.
GB8024665A GB2055100A (en) 1979-07-27 1980-07-28 Monacolin K derivatives
AT0392380A AT375334B (en) 1979-07-27 1980-07-28 METHOD FOR PRODUCING NEW SALTS OR ESTERS
AU60839/80A AU6083980A (en) 1979-07-27 1980-07-28 Monacolin k derivatives
IT68211/80A IT1147763B (en) 1979-07-27 1980-07-28 COMPOUNDS THAT CAN BE USED AS CHOLESTEROL BIOSYNTHESIS INHIBITORS AND PROCEDURE FOR THEIR PREPARATION
DD80222916A DD153827A5 (en) 1979-07-27 1980-07-28 PROCESS FOR PREPARING ANTIHYPERCHOLESTERINA MIXTURES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12346179A JPS5646841A (en) 1979-09-26 1979-09-26 Mb-530b carboxylic acid ester and its preparation

Publications (2)

Publication Number Publication Date
JPS5646841A true JPS5646841A (en) 1981-04-28
JPS6320215B2 JPS6320215B2 (en) 1988-04-26

Family

ID=14861197

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12346179A Granted JPS5646841A (en) 1979-07-27 1979-09-26 Mb-530b carboxylic acid ester and its preparation

Country Status (1)

Country Link
JP (1) JPS5646841A (en)

Also Published As

Publication number Publication date
JPS6320215B2 (en) 1988-04-26

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