SE437521B - Ett forbettrat forfarande for framstellning av 7-(d-alfa-amino-alfa-(p-hydroxifenyl)-acetamido)-3-metyl-3-cefem-4-karboxylsyra - Google Patents

Ett forbettrat forfarande for framstellning av 7-(d-alfa-amino-alfa-(p-hydroxifenyl)-acetamido)-3-metyl-3-cefem-4-karboxylsyra

Info

Publication number
SE437521B
SE437521B SE7704739A SE7704739A SE437521B SE 437521 B SE437521 B SE 437521B SE 7704739 A SE7704739 A SE 7704739A SE 7704739 A SE7704739 A SE 7704739A SE 437521 B SE437521 B SE 437521B
Authority
SE
Sweden
Prior art keywords
alfa
hydroxifenyl
cefem
acetamido
amino
Prior art date
Application number
SE7704739A
Other languages
English (en)
Swedish (sv)
Other versions
SE7704739L (sv
Inventor
D Bouzard
A Weber
J Stemer
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10087928&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE437521(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE7704739L publication Critical patent/SE7704739L/
Publication of SE437521B publication Critical patent/SE437521B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE7704739A 1976-04-27 1977-04-25 Ett forbettrat forfarande for framstellning av 7-(d-alfa-amino-alfa-(p-hydroxifenyl)-acetamido)-3-metyl-3-cefem-4-karboxylsyra SE437521B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB17028/76A GB1532682A (en) 1976-04-27 1976-04-27 Process for the preparation of cephadroxil

Publications (2)

Publication Number Publication Date
SE7704739L SE7704739L (sv) 1977-12-01
SE437521B true SE437521B (sv) 1985-03-04

Family

ID=10087928

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7704739A SE437521B (sv) 1976-04-27 1977-04-25 Ett forbettrat forfarande for framstellning av 7-(d-alfa-amino-alfa-(p-hydroxifenyl)-acetamido)-3-metyl-3-cefem-4-karboxylsyra

Country Status (26)

Country Link
US (3) US4234721A (fr)
JP (2) JPS6022717B2 (fr)
AT (1) AT350183B (fr)
AU (1) AU510338B2 (fr)
BE (1) BE853974A (fr)
CA (1) CA1115268A (fr)
CH (1) CH632270A5 (fr)
CY (1) CY1066A (fr)
DE (1) DE2718741C2 (fr)
DK (1) DK157026C (fr)
ES (1) ES458241A1 (fr)
FI (1) FI67704C (fr)
FR (2) FR2349589A1 (fr)
GB (1) GB1532682A (fr)
GR (1) GR72788B (fr)
HK (1) HK39780A (fr)
IE (1) IE44872B1 (fr)
IT (1) IT8049917A0 (fr)
KE (1) KE3064A (fr)
LU (1) LU77202A1 (fr)
MY (1) MY8100135A (fr)
NL (1) NL7704618A (fr)
PH (2) PH16581A (fr)
SE (1) SE437521B (fr)
YU (2) YU39801B (fr)
ZA (1) ZA772485B (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR820001564B1 (ko) * 1981-05-09 1982-09-02 동신제약 주식회사 새로운 실릴화제를 이용한 세팔로스포린 유도체의 제조방법
FR2555989B1 (fr) * 1983-12-06 1987-02-20 Bristol Myers Sa Monohydrate de chlorocephadroxyle
JPS60169486A (ja) * 1984-02-10 1985-09-02 Yamanouchi Pharmaceut Co Ltd ７−アミノ−３−置換メチル−３−セフエム−４−カルボン酸およびその低級アルキルシリル誘導体の製造法
GB8714180D0 (en) * 1987-06-17 1987-07-22 Rifar Srl Anhydrous crystalline cefadroxil
US4904776A (en) * 1987-04-24 1990-02-27 Rifar S.R.L. Method for producing crystalline cefadroxil hemihydrate
US4962195A (en) * 1987-04-24 1990-10-09 Rifar S.R.L. Solvate of cefadroxyl
US5023331A (en) * 1987-04-24 1991-06-11 Rifar S.R.L. Cefadroxil solvates
US4898938A (en) * 1987-08-03 1990-02-06 Rifar S.R.L. Method for preparing crystalline cefadroxil monohydrate
IT1233863B (it) * 1988-02-24 1992-04-21 Opos Biochimica Srl Procedimento per la preparazione dell'acido 7-(d(-)-alfa-amino-alfa- (p-idrossifenil)acetamido)-3-metil-3-cefem-4-carbossilico monoidrato
US5034522A (en) * 1988-08-02 1991-07-23 Biocraft Laboratories, Inc. Method for the production of 3-methyl cephem derivatives
DE69013305T2 (de) * 1989-07-10 1995-05-18 Chemferm Vof Stabile form von cephradin, verfahren zu dessen herstellung und darin verwendete zwischenprodukte.
US5142043A (en) * 1990-05-10 1992-08-25 Biocraft Laboratories, Inc. Process for preparing cephalexin monohydrate
AT396106B (de) * 1991-03-08 1993-06-25 Biochemie Gmbh Neues verfahren zur herstellung von 3-vinylcephalosporinverbindungen
ES2157199T3 (es) 1991-03-08 2001-08-16 Biochemie Gmbh Nuevo procedimiento para la produccion de cefalosporinas y nuevos compuestos intermedios para este procedimiento.
US6248881B1 (en) 1991-03-08 2001-06-19 Biochemie Gmbh Intermediates and process for the production of 3-vinyl cephalosporins
DK0690864T3 (da) * 1993-03-12 2001-09-17 Upjohn Co Krystallinsk ceftiofur på fri syreform
US5604222A (en) * 1993-12-27 1997-02-18 Lupin Laboratories, Ltd. Method for the preparation of 2-chloro sulfinyl azetidinones
CN1147253A (zh) 1994-04-15 1997-04-09 法玛西雅厄普约翰公司 新晶型的1-[5-甲亚磺酰氨基吲哚基-2-羰基]-4-[3-(1-甲基乙基氨基)-2-吡啶基]哌嗪
US5578721A (en) * 1994-07-11 1996-11-26 Lupin Laboratories Limited Process for preparation of 3-exomethylene cepham sulfoxide esters
US5574154A (en) * 1994-09-29 1996-11-12 Alnejma Bulk Pharmaceutical Co. A.B.P.C. Process for the preparation of cephalosporanic compounds
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
IT1289955B1 (it) * 1997-02-21 1998-10-19 Solchem Italiana Spa Acyclovir sale sodico biidrato e sua preparazione
US6080427A (en) * 1997-04-17 2000-06-27 Bristol-Myers Squibb Company Cefadroxil monohydrate tablet formulation
WO2001004126A1 (fr) * 1999-07-14 2001-01-18 Ranbaxy Laboratories Limited Procede de preparation de semi-hydrate cefadroxil cristallin a partir d'un produit de solvatation cefadroxil dimethyl formamide
IN190389B (fr) 1999-07-14 2003-07-26 Ranbaxy Lab Ltd
US6569887B2 (en) * 2001-08-24 2003-05-27 Dov Pharmaceuticals Inc. (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US20060173064A1 (en) * 2001-08-24 2006-08-03 Lippa Arnold S (-)-1-(3,4-Dichlorophenyl)-3-azabi cyclo[3.1.0]hexane, compositions thereof, and uses for treating alcohol-related disorders
US7235655B2 (en) * 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
US20080081834A1 (en) 2002-07-31 2008-04-03 Lippa Arnold S Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
US20040077849A1 (en) * 2002-10-16 2004-04-22 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefadroxil
RU2005117630A (ru) * 2002-11-08 2006-01-20 Дов Фармасьютикал, Инк. (Us) Полиморфы гидрохлорида бицифадина
US7842791B2 (en) * 2002-12-19 2010-11-30 Nancy Jean Britten Dispersible pharmaceutical compositions
US7230097B2 (en) 2003-03-10 2007-06-12 Lupin Ltd. Process for preparation of 7-[α-Amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid
US20070072945A1 (en) * 2004-03-31 2007-03-29 Pohoreski Anton Sulphur-containing oils for controlling plant pathogens and stimulating nutrient uptake
US20070043100A1 (en) * 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
US20060100263A1 (en) * 2004-11-05 2006-05-11 Anthony Basile Antipyretic compositions and methods
WO2007016155A2 (fr) * 2005-07-27 2007-02-08 Dov Pharmaceutical, Inc. Nouveaux 1-aryl-3-azabicyclo[3.1.0]hexanes : synthèse et emploi dans le traitement des troubles neuropsychiatriques
US20080045725A1 (en) * 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
CN101448842A (zh) * 2006-05-19 2009-06-03 帝斯曼知识产权资产管理有限公司 一种用于结晶头孢羟氨苄的方法
US20080269348A1 (en) * 2006-11-07 2008-10-30 Phil Skolnick Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use
US8138377B2 (en) * 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
EP2118074B1 (fr) 2007-02-01 2014-01-22 Resverlogix Corp. Composés destinés à la prévention et au traitement de maladies cardiovasculaires
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
EP2167083B1 (fr) * 2007-06-06 2015-10-28 Euthymics Bioscience, Inc. 1- hétéroaryl-3-azabicyclo[3.1.0]hexanes, leurs méthodes de préparation et leur utilisation comme médicaments
MX337352B (es) 2009-03-18 2016-02-29 Resverlogix Corp Nuevos agentes anti-inflamatorios.
CN102408438B (zh) * 2010-09-26 2015-01-07 石药集团中奇制药技术（石家庄）有限公司 一种头孢丙烯一水合物的制备方法
CN102134250B (zh) * 2011-01-19 2013-03-13 天津大学 一种头孢羟氨苄单水合物的结晶方法及结晶
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US29164A (en) * 1860-07-17 Improvement in fish-oils
CY773A (en) 1967-09-05 1975-03-01 Bristol Myers Co Antibacterial agents and a process for the preparation thereof
USRE29164E (en) 1967-09-05 1977-03-29 Bristol-Myers Company 7-Amino-cephalosporanic and decephalosporanic acid derivatives
US3655656A (en) * 1970-06-04 1972-04-11 Lilly Co Eli Crystalline cephalexin monohydrate
US3694437A (en) * 1970-08-19 1972-09-26 Lilly Co Eli Process for preparing cephalosporin compounds
US3781282A (en) * 1971-01-20 1973-12-25 W Garbrecht Cephalosporin process and product
JPS5318515B2 (fr) 1971-12-17 1978-06-15
DE2163514A1 (de) * 1971-12-21 1973-07-05 Toyama Chemical Co Ltd Verfahren zur herstellung von cephalosporinen
FR2166316A1 (en) * 1972-01-07 1973-08-17 Toyama Chemical Co Ltd 7-acylcephalosporins - prepd via a silylated inter
US3985741A (en) * 1972-09-15 1976-10-12 Bristol-Myers Company Production of p-hydroxycephalexin
DE2354427A1 (de) 1972-11-02 1974-05-16 Lorenzini Sas Inst Biochim Verfahren zur herstellung von 7-(dalpha-aminophenylacetamido)-3-desacetoxycephalosporansaeure
GB1472746A (en) * 1973-07-05 1977-05-04 Glaxo Lab Ltd Cephalosporin compounds
US4091215A (en) * 1974-06-05 1978-05-23 Bristol-Myers Company 7-D-α-Amino-.alpha.-(p-acetoxyphenyl)acetamido-3-methyl-3-cephem-4-carboxylic acid
GB1476981A (en) 1974-06-05 1977-06-16 Bristol Myers Co Substituted penicillanic acids
AU2550077A (en) * 1976-06-14 1978-11-30 Merck Patent Gmbh Penicillins and cephalosporins
US4160863A (en) * 1977-04-07 1979-07-10 Bristol-Myers Company Process for the preparation of the crystalline monohydrate of 7-[D-α-aα-(p-hydroxyphenyl)acetamido]-3-methyl-3-cephem-4-carboxylic acid
NL162387C (nl) * 1977-09-06 1980-05-16 Gist Brocades Nv Werkwijze voor het bereiden van 6-(d-alpha-amino-p- -hydroxyfenylacetamido)penicillanzuur.
IT1126544B (it) * 1979-12-07 1986-05-21 Dobfar Spa Procedimento per la preparazione di derivati dell'acido 7-amino-desacetossi cefalosporanico

Also Published As

Publication number Publication date
PH16581A (en) 1983-11-22
YU108677A (en) 1982-10-31
AU2460777A (en) 1978-11-02
JPH0246009B2 (fr) 1990-10-12
AU510338B2 (en) 1980-06-19
DE2718741A1 (de) 1977-11-17
DE2718741C2 (de) 1985-03-21
GB1532682A (en) 1978-11-22
US4234721A (en) 1980-11-18
JPS52142091A (en) 1977-11-26
GR72788B (fr) 1983-12-05
CH632270A5 (de) 1982-09-30
SE7704739L (sv) 1977-12-01
US4504657A (en) 1985-03-12
FR2365570B1 (fr) 1980-06-06
AT350183B (de) 1979-05-10
JPS6022717B2 (ja) 1985-06-03
FI771339A (fr) 1977-10-28
FR2349589A1 (fr) 1977-11-25
ES458241A1 (es) 1978-11-01
NL7704618A (nl) 1977-10-31
FI67704B (fi) 1985-01-31
KE3064A (en) 1980-07-25
IE44872B1 (en) 1982-04-21
LU77202A1 (fr) 1977-11-22
YU137982A (en) 1983-04-30
FR2349589B1 (fr) 1981-11-20
YU39801B (en) 1985-04-30
ZA772485B (en) 1978-03-29
CY1066A (en) 1980-10-24
FR2365570A1 (fr) 1978-04-21
PH17254A (en) 1984-07-03
JPS60185718A (ja) 1985-09-21
CA1115268A (fr) 1981-12-29
ATA296277A (de) 1978-10-15
DK157026B (da) 1989-10-30
FI67704C (fi) 1985-05-10
BE853974A (fr) 1977-10-26
HK39780A (en) 1980-08-08
USRE31730E (en) 1984-11-13
DK183277A (da) 1977-10-28
IE44872L (en) 1977-10-27
MY8100135A (en) 1981-12-31
DK157026C (da) 1990-04-02
YU43081B (en) 1989-02-28
IT8049917A0 (it) 1980-10-16

Similar Documents

Publication Publication Date Title
SE437521B (sv) Ett forbettrat forfarande for framstellning av 7-(d-alfa-amino-alfa-(p-hydroxifenyl)-acetamido)-3-metyl-3-cefem-4-karboxylsyra
TR19755A (tr) Tereftalik asidin hazirlanmasina mahsus usul
SE425294B (sv) Forfarande for framstellning av ett enzymgranulat
NO803470L (no) Fremgangsmaate for fremstilling av 7-acylamino-3-vinylcefalosporansyrederivater.
NO161495C (no) Fremgangsmaate for fremstilling av (d-alfa-amino-(p-hydroksyfenyl)acetamido))-gruppeholdige cefalosporansyrederivater.
SE7707621L (sv) Forfarande for framstellning av xyloslosning
SE7707125L (sv) Forfarande for framstellning av 7-(alfa-(2,3, - dihydro-2-oxo-1h- bensimidazol -1- ylkarbomyl-amino) arylacetamido ) cefalasporiner
NO152451C (no) Fremgangsmaate for fremstilling av fosfonsyrederivater
SE437990B (sv) Forfarande for framstellning av 7beta-(d-2-amino-2-(lagalkylsulfonylaminofenyl)-acetamido)-3rŸ-cefem-4-karbonsyror
NO773622L (no) Fremgangsmaate til fremstilling av tereftalsyre
SE421787B (sv) Forfarande for framstellning av kvadratsyra
DK47677A (da) Fremgangsmade til fremstilling af 3-carbamoyloxymethyl-7-(amino-4-thiazolylacetamido)-cephalosporansyrederivater
SE435380B (sv) Forfarande for framstellning av kinazolinforeningar
SE432254B (sv) Analogiforfarande for framstellning av 3-substituerade 7-(alfa,alfa-disubstituerade acetamido)-3-cefem-4-karboxylsyror
SE7702922L (sv) Forfarande for framstellning av (2-pyrimidinyl-tio)-alkansyraamider
DK153554C (da) Fremgangsmaade til fremstilling af 7-aminocephalosporansyrederivater
SE7607026L (sv) Forfarande for framstellning av 5-alkylpikolinsyra
AR209825A1 (es) Procedimiento para la fabricacion de derivados de acido hidroxialcanoico
DK296676A (da) Fremgangsmade til fremstilling af 7-(alfa-amino-omega-(2,3-methylen-dioxyphenyl)acylamido)cephalosporansyrederivater
MX147685A (es) Procedimiento mejorado para la preparacion de fosfitos de polialcholes estables durante hidrolisis
SE427037B (sv) Forfarande for framstellning av deoxiklavulansyra
NO774147L (no) Fremgangsmaate for fremstilling av kinazolinonforbindelser
AR209222A1 (es) Procedimiento para la preparacion de acido 7-(d-2-amino-3-fenilacetamido)-3-metil-3-cefem-4-carboxilico
SE7714765L (sv) Forfarande for framstellning av omega-aryl-13-prostyn-syraderivat
AR212814A1 (es) Procedimiento de preparacion de derivados de acido n-2'-carboxifenil-4-cloroantranilico

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 7704739-7

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 7704739-7

Format of ref document f/p: F