SE432192B - En lokalanestetisk emulsionsalva for utvertes bruk av typen olja-i-vatten-emulsion - Google Patents
En lokalanestetisk emulsionsalva for utvertes bruk av typen olja-i-vatten-emulsionInfo
- Publication number
- SE432192B SE432192B SE7812020A SE7812020A SE432192B SE 432192 B SE432192 B SE 432192B SE 7812020 A SE7812020 A SE 7812020A SE 7812020 A SE7812020 A SE 7812020A SE 432192 B SE432192 B SE 432192B
- Authority
- SE
- Sweden
- Prior art keywords
- local anesthetic
- oil
- emulsion
- ointment
- weight
- Prior art date
Links
- 239000003589 local anesthetic agent Substances 0.000 title claims abstract description 44
- 239000000839 emulsion Substances 0.000 title claims abstract description 39
- 239000007764 o/w emulsion Substances 0.000 title claims abstract description 5
- 230000003444 anaesthetic effect Effects 0.000 claims abstract description 20
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 4
- 239000002674 ointment Substances 0.000 claims description 53
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 29
- 229960004194 lidocaine Drugs 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 14
- -1 butanilicain Chemical compound 0.000 claims description 11
- 239000003995 emulsifying agent Substances 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 7
- UXAWFWFJXIANHZ-UHFFFAOYSA-N 1-[2-[2-[di(propan-2-yl)amino]ethoxy]phenyl]butan-1-one Chemical compound CCCC(=O)C1=CC=CC=C1OCCN(C(C)C)C(C)C UXAWFWFJXIANHZ-UHFFFAOYSA-N 0.000 claims description 6
- 229950001903 ketocaine Drugs 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 229960001807 prilocaine Drugs 0.000 claims description 6
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 claims description 6
- 229960002372 tetracaine Drugs 0.000 claims description 6
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims description 6
- 239000002562 thickening agent Substances 0.000 claims description 6
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims description 5
- 229960003150 bupivacaine Drugs 0.000 claims description 5
- 229960002409 mepivacaine Drugs 0.000 claims description 5
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 claims description 5
- 229950002569 trimecaine Drugs 0.000 claims description 5
- GOZBHBFUQHMKQB-UHFFFAOYSA-N trimecaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=C(C)C=C1C GOZBHBFUQHMKQB-UHFFFAOYSA-N 0.000 claims description 5
- 229960001747 cinchocaine Drugs 0.000 claims description 3
- PUFQVTATUTYEAL-UHFFFAOYSA-N cinchocaine Chemical compound C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCCN(CC)CC)=C21 PUFQVTATUTYEAL-UHFFFAOYSA-N 0.000 claims description 3
- 230000001804 emulsifying effect Effects 0.000 claims description 3
- HQFWVSGBVLEQGA-UHFFFAOYSA-N 4-aminobenzoic acid 3-(dibutylamino)propyl ester Chemical compound CCCCN(CCCC)CCCOC(=O)C1=CC=C(N)C=C1 HQFWVSGBVLEQGA-UHFFFAOYSA-N 0.000 claims description 2
- 229960003369 butacaine Drugs 0.000 claims description 2
- 229960001290 butanilicaine Drugs 0.000 claims description 2
- VWYQKFLLGRBICZ-UHFFFAOYSA-N butanilicaine Chemical compound CCCCNCC(=O)NC1=C(C)C=CC=C1Cl VWYQKFLLGRBICZ-UHFFFAOYSA-N 0.000 claims description 2
- OECNHRSNFLARHZ-UHFFFAOYSA-N n-[2-(2-butoxyphenoxy)ethyl]-n-propan-2-ylpropan-2-amine Chemical compound CCCCOC1=CC=CC=C1OCCN(C(C)C)C(C)C OECNHRSNFLARHZ-UHFFFAOYSA-N 0.000 claims description 2
- 229960003502 oxybuprocaine Drugs 0.000 claims description 2
- CMHHMUWAYWTMGS-UHFFFAOYSA-N oxybuprocaine Chemical compound CCCCOC1=CC(C(=O)OCCN(CC)CC)=CC=C1N CMHHMUWAYWTMGS-UHFFFAOYSA-N 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 239000006071 cream Substances 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 11
- 230000000694 effects Effects 0.000 description 7
- 229920002125 Sokalan® Polymers 0.000 description 6
- 238000009472 formulation Methods 0.000 description 4
- 206010002091 Anaesthesia Diseases 0.000 description 3
- 241000700198 Cavia Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000037005 anaesthesia Effects 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000700199 Cavia porcellus Species 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 229920001983 poloxamer Polymers 0.000 description 2
- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 2
- 239000012047 saturated solution Substances 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- XNMYNYSCEJBRPZ-UHFFFAOYSA-N 2-[(3-butyl-1-isoquinolinyl)oxy]-N,N-dimethylethanamine Chemical compound C1=CC=C2C(OCCN(C)C)=NC(CCCC)=CC2=C1 XNMYNYSCEJBRPZ-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 208000035859 Drug effect increased Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229920003091 Methocel™ Polymers 0.000 description 1
- 208000012266 Needlestick injury Diseases 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 229940068939 glyceryl monolaurate Drugs 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000007388 punch biopsy Methods 0.000 description 1
- 229960005038 quinisocaine Drugs 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 210000003454 tympanic membrane Anatomy 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7713618A SE7713618L (sv) | 1977-12-01 | 1977-12-01 | Lokalanestetisk blandning |
| SE7713617A SE7713617L (sv) | 1977-12-01 | 1977-12-01 | Antitranspirationsmedel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7812020L SE7812020L (sv) | 1979-06-02 |
| SE432192B true SE432192B (sv) | 1984-03-26 |
Family
ID=26656921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7812020A SE432192B (sv) | 1977-12-01 | 1978-11-22 | En lokalanestetisk emulsionsalva for utvertes bruk av typen olja-i-vatten-emulsion |
Country Status (4)
| Country | Link |
|---|---|
| AU (1) | AU524406B2 (de) |
| DE (1) | DE2851369A1 (de) |
| GB (1) | GB2008946B (de) |
| SE (1) | SE432192B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3066859D1 (en) | 1979-10-26 | 1984-04-12 | Smith & Nephew Ass | Autoclavable emulsions |
| US5439672A (en) * | 1980-07-01 | 1995-08-08 | L'oreal | Cosmetic composition based on an aqueous dispersion of small lipid spheres |
| US5489426A (en) * | 1980-07-01 | 1996-02-06 | L'oreal | Cosmetic composition based on an aqueous dispersion of small lipid spheres |
| SE9704031D0 (sv) * | 1997-11-05 | 1997-11-05 | Astra Ab | Novel formulation |
| US9642912B2 (en) | 2006-03-06 | 2017-05-09 | Crescita Therapeutics Inc. | Topical formulations for treating skin conditions |
| US9308181B2 (en) | 2006-03-06 | 2016-04-12 | Nuvo Research Inc. | Topical formulations, systems and methods |
| US9012477B2 (en) | 2009-01-06 | 2015-04-21 | Nuvo Research Inc. | Method of treating neuropathic pain |
| EP2523660A4 (de) | 2010-01-14 | 2013-07-10 | Nuvo Res Inc | Bildung fester formen von lokalanästhesieformulierungen zur schmerzbekämpfung |
-
1978
- 1978-11-22 SE SE7812020A patent/SE432192B/sv not_active IP Right Cessation
- 1978-11-28 DE DE19782851369 patent/DE2851369A1/de active Granted
- 1978-11-29 AU AU42028/78A patent/AU524406B2/en not_active Expired
- 1978-11-30 GB GB7846755A patent/GB2008946B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2851369A1 (de) | 1979-06-07 |
| DE2851369C2 (de) | 1988-04-28 |
| GB2008946A (en) | 1979-06-13 |
| AU524406B2 (en) | 1982-09-16 |
| SE7812020L (sv) | 1979-06-02 |
| GB2008946B (en) | 1982-06-30 |
| AU4202878A (en) | 1979-06-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR950014448B1 (ko) | 소양증 치료를 위한 피부과용 약제 조성물 | |
| US6299902B1 (en) | Enhanced transdermal anesthesia of local anesthetic agents | |
| AU2008289109B2 (en) | High concentration local anesthetic formulations | |
| JP6473134B2 (ja) | フルニソリドの局所用組成物および治療方法 | |
| US4794106A (en) | Cream | |
| JP2006522832A (ja) | Ｔｒｐｖ１アゴニストの投与のための方法および組成物 | |
| US20220211730A1 (en) | Treatment of skin conditions using high krafft temperature anionic surfactants | |
| US6495602B1 (en) | Topical pharmaceutical base with anti-pruritic and/or anti-inflammatory drugs | |
| SE432192B (sv) | En lokalanestetisk emulsionsalva for utvertes bruk av typen olja-i-vatten-emulsion | |
| EP0131228A2 (de) | Nicardipinhydrochlorid- bzw. Nifedipinsalben | |
| DE60018707T2 (de) | Anti-androgene und verfahren zur behandlung von krankheiten | |
| JP2010184903A (ja) | 外用医薬組成物 | |
| IE46872B1 (en) | Dithranol composition for the treatment of psoriasis | |
| JP4138910B2 (ja) | 経皮吸収性が良好で且つ皮膚刺激性の少ない塩酸アゼラスチン含有経皮製剤 | |
| US2457188A (en) | Benzocaine solution | |
| JPH07557B2 (ja) | 皮膚炎に対する治療用組成物 | |
| JP6903411B2 (ja) | 外用組成物 | |
| US20110237593A1 (en) | Topical anti-pruritic compositions and methods of action of same | |
| RU2157214C2 (ru) | Противовоспалительное и антимикробное лекарственное средство для местного применения | |
| JPS609486B2 (ja) | ステロイド組成物 | |
| TW202135825A (zh) | 含托法替尼（Ｔｏｆａｃｉｔｉｎｉｂ）之基於彈性體的無水凝膠調配物 | |
| JP2000229884A (ja) | 皮膚外用剤 | |
| JP7299683B2 (ja) | 皮膚外用組成物 | |
| JP2022178158A (ja) | 外用組成物 | |
| JPS6033366B2 (ja) | 安定化されたトルナフテ−ト含有乳剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 7812020-1 Effective date: 19930610 Format of ref document f/p: F |