SE411118B - Ett forfarande for framstellning av 2,6-dialkoxibensamider med terapentiska egenskaper - Google Patents
Ett forfarande for framstellning av 2,6-dialkoxibensamider med terapentiska egenskaperInfo
- Publication number
- SE411118B SE411118B SE7803411A SE7803411A SE411118B SE 411118 B SE411118 B SE 411118B SE 7803411 A SE7803411 A SE 7803411A SE 7803411 A SE7803411 A SE 7803411A SE 411118 B SE411118 B SE 411118B
- Authority
- SE
- Sweden
- Prior art keywords
- formula
- compound
- solution
- mol
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (31)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7803411A SE411118B (sv) | 1978-03-23 | 1978-03-23 | Ett forfarande for framstellning av 2,6-dialkoxibensamider med terapentiska egenskaper |
ZA79964A ZA79964B (en) | 1978-03-23 | 1979-02-28 | 2,6-dialkoxybenzamides,intermediates,pharmaceutical compositions and methods for treatment of psychotic disorders |
CA322,555A CA1101873A (en) | 1978-03-23 | 1979-03-01 | 2,6-dialkoxybenzamides, intermediates, pharmaceutical compositions and methods for treatment of psychotic disorders |
DE7979850013T DE2964774D1 (en) | 1978-03-23 | 1979-03-05 | 2,6-dialkoxybenzamides, process for their preparation, compositions and these compounds for use in the treatment of psychotic disordes |
EP79850013A EP0004831B1 (en) | 1978-03-23 | 1979-03-05 | 2,6-dialkoxybenzamides, process for their preparation, compositions and these compounds for use in the treatment of psychotic disordes |
US06/018,784 US4232037A (en) | 1978-03-23 | 1979-03-08 | 2,6-Dialkoxybenzamides, intermediates, pharamaceutical compositions and methods for treatment of psychotic disorders |
FI790922A FI73979C (fi) | 1978-03-23 | 1979-03-19 | Framstaellning av och mellanprodukter till 2,6-dialkoxibensamider. |
AU45219/79A AU525475B2 (en) | 1978-03-23 | 1979-03-19 | 2,6-dialkoxybenzamidomethyl pyrrolidines |
NZ189935A NZ189935A (en) | 1978-03-23 | 1979-03-19 | 2,6-dialkoxybenzamide derivatives and pharmaceutical compositions |
NO790934A NO152414C (no) | 1978-03-23 | 1979-03-20 | Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2,6-dialkoksybenzamider |
SU792739699A SU818481A3 (ru) | 1978-03-23 | 1979-03-22 | Способ получени производных бен-зАМидА или иХ СОлЕй или РАцЕМичЕСКиХСМЕСЕй, или СТЕРЕОизОМЕРОВ |
CS791902A CS226183B2 (en) | 1978-03-23 | 1979-03-22 | Method of preparing n-ethyl-2-(2,6-dialkoxybenzamidomethyl)-pyrrolidine derivatives |
ES478871A ES478871A1 (es) | 1978-03-23 | 1979-03-22 | Un procedimiento de preparacion de 2,6-dialcoxibenzamidas. |
DK117779A DK157844C (da) | 1978-03-23 | 1979-03-22 | Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive n-alkyl-(2,6-dialkoxybenzamidometyl)-pyrrolidiner eller farmaceutisk acceptable salte deraf med syrer samt mellemprodukt til brug i fremgangsmaaden |
HU79AA924A HU177793B (en) | 1978-03-23 | 1979-03-22 | Process for producing 2,6-dialkoxy-benzamides |
DD79211750A DD143605A5 (de) | 1978-03-23 | 1979-03-22 | Verfahren zur herstellung von 2,6-dialkoxybenzamiden |
JP54033429A JPS585910B2 (ja) | 1978-03-23 | 1979-03-23 | 新規なジアルコキシベンズアミド類およびその製法 |
AT0217779A AT374173B (de) | 1978-03-23 | 1979-03-23 | Verfahren zur herstellung neuer 2,6 -dialkoxybenzamide, ihrer salze und stereoisomeren |
IE630/79A IE48491B1 (en) | 1978-03-23 | 1979-08-08 | 2,6-dialkoxybenzamides,process for their preparation,compositions and these compounds for use in the treatment of psychotic disorders |
CA359,745A CA1109484A (en) | 1978-03-23 | 1980-09-04 | 2,6-dialkoxybenzamides, intermediates, pharmaceutical compositions and methods for treatment of psychotic disorders |
AT0253483A AT389994B (de) | 1978-03-23 | 1983-07-11 | Verwendung von neuen 2,6-dialkoxybenzamiden zur herstellung antipsychotischer heilmittel |
SG518/85A SG51885G (en) | 1978-03-23 | 1985-07-01 | 2,6-dialkoxybenzamides,process for their preparation,compositions and these compounds for use in the treatment of psychotic disorders |
HK770/85A HK77085A (en) | 1978-03-23 | 1985-10-10 | 2,6-dialkoxybenzamides,process for their preparation,compositions and these compounds for use in the treatment of psychotic disorders |
MY407/85A MY8500407A (en) | 1978-03-23 | 1985-12-30 | 2,6-dial koxybenzamides, process for their preparation compositions and these compounds for use in the treatment of psychotic discorders |
AT0104286A AT395147B (de) | 1978-03-23 | 1986-04-21 | Verfahren zur herstellung und zur verwendung von neuen 3-brom-5-chlor-2,6-dialkoxybenzoesaeuren |
AT141289A AT392274B (de) | 1978-03-23 | 1989-06-08 | 2,6-dialkoxybenzamide |
MX9203148A MX9203148A (es) | 1978-03-23 | 1992-06-23 | 2,6-dialcoxipenzamidas y composiciones farmaceuticas que las contienen. |
NL930052C NL930052I2 (nl) | 1978-03-23 | 1993-06-10 | 2,6-Dialkoxybenzamiden, werkwijze ter bereiding ervan, samenstellingen en deze verbindingen voor toepassing bij de behandeling van psychotische afwijkingen. |
LU88308C LU88308I2 (fr) | 1978-03-23 | 1993-06-16 | Remoxipride (Roxiam) |
LV930821A LV5469A3 (lv) | 1978-03-23 | 1993-06-30 | Panemiens benzamida atvasinajumu vai to salu vai racemisko maisijumu vai stereoizomeru iegusanai |
LTRP936A LT2246B (lt) | 1978-03-23 | 1993-09-06 | Benzamido dariniu ar ju drusku ar raceminiu misinuarba stereoizomeru gavimo budas |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7803411A SE411118B (sv) | 1978-03-23 | 1978-03-23 | Ett forfarande for framstellning av 2,6-dialkoxibensamider med terapentiska egenskaper |
Publications (2)
Publication Number | Publication Date |
---|---|
SE7803411L SE7803411L (sv) | 1979-09-24 |
SE411118B true SE411118B (sv) | 1979-12-03 |
Family
ID=20334412
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7803411A SE411118B (sv) | 1978-03-23 | 1978-03-23 | Ett forfarande for framstellning av 2,6-dialkoxibensamider med terapentiska egenskaper |
Country Status (26)
Country | Link |
---|---|
US (1) | US4232037A (ja) |
EP (1) | EP0004831B1 (ja) |
JP (1) | JPS585910B2 (ja) |
AT (1) | AT374173B (ja) |
AU (1) | AU525475B2 (ja) |
CA (1) | CA1101873A (ja) |
CS (1) | CS226183B2 (ja) |
DD (1) | DD143605A5 (ja) |
DE (1) | DE2964774D1 (ja) |
DK (1) | DK157844C (ja) |
ES (1) | ES478871A1 (ja) |
FI (1) | FI73979C (ja) |
HK (1) | HK77085A (ja) |
HU (1) | HU177793B (ja) |
IE (1) | IE48491B1 (ja) |
LT (1) | LT2246B (ja) |
LU (1) | LU88308I2 (ja) |
MX (1) | MX9203148A (ja) |
MY (1) | MY8500407A (ja) |
NL (1) | NL930052I2 (ja) |
NO (1) | NO152414C (ja) |
NZ (1) | NZ189935A (ja) |
SE (1) | SE411118B (ja) |
SG (1) | SG51885G (ja) |
SU (1) | SU818481A3 (ja) |
ZA (1) | ZA79964B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986007591A1 (en) * | 1985-06-19 | 1986-12-31 | Astra Läkemedel Aktiebolag | Catecholcarboxamides, process for their preparation, intermediates and a pharmaceutical preparation |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8101536L (sv) * | 1981-03-11 | 1982-09-12 | Astra Laekemedel Ab | Bensamid-derivat |
US4470977A (en) * | 1981-06-04 | 1984-09-11 | Adria Laboratories, Inc. | Antiemetic and antipsychotic agents |
SE8205135D0 (sv) * | 1982-09-09 | 1982-09-09 | Astra Laekemedel Ab | Benzamido-derivatives |
SE8400478D0 (sv) * | 1984-01-31 | 1984-01-31 | Astra Laekemedel Ab | Oxysalicylamido derivatives |
US5240957A (en) * | 1984-01-31 | 1993-08-31 | Astra Lakemedel Akteibolag | Oxysalicylamido derivatives |
DE3629598A1 (de) * | 1986-08-30 | 1988-03-03 | Boehringer Ingelheim Kg | 3-brom-2,6-dimethoxibenzamide, ihre herstellung und verwendung |
US4772459A (en) * | 1986-09-09 | 1988-09-20 | Erbamont, Inc. | Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein |
US4751236A (en) * | 1987-05-20 | 1988-06-14 | Avihou Mishniot | Method for treating genital herpes |
US5154913A (en) * | 1987-11-19 | 1992-10-13 | Vanderbilt University | Radioiodinated benzamines method of their use as radioimaging agents |
US5231099A (en) * | 1991-04-15 | 1993-07-27 | Du Pont Merck Pharmaceutical Company | Use of sigma receptor antagonists to enhance the effects of antipsychotic drugs |
US5248817A (en) * | 1991-07-15 | 1993-09-28 | Merck & Co., Inc. | Process for aromatic bromination |
WO1993002036A1 (en) * | 1991-07-15 | 1993-02-04 | Merck & Co., Inc. | Novel process for aromatic bromination |
CN104058956A (zh) * | 2014-06-04 | 2014-09-24 | 蚌埠团结日用化学有限公司 | 3-溴-2,6二甲氧基苯甲酸合成的生产工艺 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD67123A (ja) * | ||||
US3342826A (en) * | 1964-01-13 | 1967-09-19 | Ile De France | Heterocyclic aminoalkyl benzamides |
FR5916M (ja) * | 1966-01-21 | 1968-05-06 | ||
BE695272A (ja) * | 1967-03-09 | 1967-09-11 | ||
US3862139A (en) * | 1972-06-23 | 1975-01-21 | Delmar Chem | Heterocyclic benzamide compounds |
IT1070992B (it) * | 1973-12-21 | 1985-04-02 | Italfarmaco Spa | Processo per la preparazione della i etil 2 2 metossi 5 sulfamoil benzamidometil pirrolidina |
CH605793A5 (ja) * | 1974-03-05 | 1978-10-13 | Ile De France | |
FR2294698A1 (fr) * | 1974-12-18 | 1976-07-16 | Synthelabo | Nouveaux derives des methoxy-2 benzamides substitues, leurs sels, leur preparation et les medicaments qui en renferment |
DE2556457C3 (de) * | 1974-12-18 | 1981-02-12 | Synthelabo S.A., Paris | N-(Pyrrolidin-2-yl-methyl)-2-methoxybenzamide, deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
-
1978
- 1978-03-23 SE SE7803411A patent/SE411118B/sv unknown
-
1979
- 1979-02-28 ZA ZA79964A patent/ZA79964B/xx unknown
- 1979-03-01 CA CA322,555A patent/CA1101873A/en not_active Expired
- 1979-03-05 DE DE7979850013T patent/DE2964774D1/de not_active Expired
- 1979-03-05 EP EP79850013A patent/EP0004831B1/en not_active Expired
- 1979-03-08 US US06/018,784 patent/US4232037A/en not_active Expired - Lifetime
- 1979-03-19 FI FI790922A patent/FI73979C/fi not_active IP Right Cessation
- 1979-03-19 NZ NZ189935A patent/NZ189935A/en unknown
- 1979-03-19 AU AU45219/79A patent/AU525475B2/en not_active Ceased
- 1979-03-20 NO NO790934A patent/NO152414C/no unknown
- 1979-03-22 DK DK117779A patent/DK157844C/da not_active IP Right Cessation
- 1979-03-22 ES ES478871A patent/ES478871A1/es not_active Expired
- 1979-03-22 CS CS791902A patent/CS226183B2/cs unknown
- 1979-03-22 HU HU79AA924A patent/HU177793B/hu not_active IP Right Cessation
- 1979-03-22 SU SU792739699A patent/SU818481A3/ru active
- 1979-03-22 DD DD79211750A patent/DD143605A5/de not_active IP Right Cessation
- 1979-03-23 JP JP54033429A patent/JPS585910B2/ja not_active Expired
- 1979-03-23 AT AT0217779A patent/AT374173B/de not_active IP Right Cessation
- 1979-08-08 IE IE630/79A patent/IE48491B1/en not_active IP Right Cessation
-
1985
- 1985-07-01 SG SG518/85A patent/SG51885G/en unknown
- 1985-10-10 HK HK770/85A patent/HK77085A/xx not_active IP Right Cessation
- 1985-12-30 MY MY407/85A patent/MY8500407A/xx unknown
-
1992
- 1992-06-23 MX MX9203148A patent/MX9203148A/es unknown
-
1993
- 1993-06-10 NL NL930052C patent/NL930052I2/nl unknown
- 1993-06-16 LU LU88308C patent/LU88308I2/fr unknown
- 1993-09-06 LT LTRP936A patent/LT2246B/xx unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986007591A1 (en) * | 1985-06-19 | 1986-12-31 | Astra Läkemedel Aktiebolag | Catecholcarboxamides, process for their preparation, intermediates and a pharmaceutical preparation |
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