SE0302487D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
SE0302487D0
SE0302487D0 SE0302487A SE0302487A SE0302487D0 SE 0302487 D0 SE0302487 D0 SE 0302487D0 SE 0302487 A SE0302487 A SE 0302487A SE 0302487 A SE0302487 A SE 0302487A SE 0302487 D0 SE0302487 D0 SE 0302487D0
Authority
SE
Sweden
Prior art keywords
sup
novel compounds
compounds
racemates
tautomers
Prior art date
Application number
SE0302487A
Other languages
English (en)
Swedish (sv)
Inventor
Peter Hansen
Hans Loenn
Antonios Nikitidis
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29212489&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE0302487(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0302487A priority Critical patent/SE0302487D0/xx
Publication of SE0302487D0 publication Critical patent/SE0302487D0/xx
Priority to TW093127678A priority patent/TW200526579A/zh
Priority to US10/572,640 priority patent/US20070043036A1/en
Priority to KR1020067005458A priority patent/KR20060096995A/ko
Priority to BRPI0414570-4A priority patent/BRPI0414570A/pt
Priority to JP2006526856A priority patent/JP2007505902A/ja
Priority to DE602004019110T priority patent/DE602004019110D1/de
Priority to UAA200602252A priority patent/UA84878C2/ru
Priority to CA002538410A priority patent/CA2538410A1/en
Priority to UY28513A priority patent/UY28513A1/es
Priority to RU2006112427/04A priority patent/RU2348617C2/ru
Priority to CNB2004800275174A priority patent/CN100439339C/zh
Priority to PCT/SE2004/001336 priority patent/WO2005026124A1/en
Priority to EP04775439A priority patent/EP1663974B1/en
Priority to MXPA06002723A priority patent/MXPA06002723A/es
Priority to AT04775439T priority patent/ATE420861T1/de
Priority to ES04775439T priority patent/ES2319300T3/es
Priority to HK06109477.7A priority patent/HK1089167B/en
Priority to AU2004272485A priority patent/AU2004272485B2/en
Priority to ARP040103354A priority patent/AR046083A1/es
Priority to SA4250300A priority patent/SA04250300B1/ar
Priority to IL173986A priority patent/IL173986A0/en
Priority to CO06026211A priority patent/CO5670357A2/es
Priority to ZA200602262A priority patent/ZA200602262B/xx
Priority to IS8394A priority patent/IS8394A/is
Priority to NO20061700A priority patent/NO20061700L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
SE0302487A 2003-09-18 2003-09-18 Novel compounds SE0302487D0 (sv)

Priority Applications (26)

Application Number Priority Date Filing Date Title
SE0302487A SE0302487D0 (sv) 2003-09-18 2003-09-18 Novel compounds
TW093127678A TW200526579A (en) 2003-09-18 2004-09-13 Novel compounds
HK06109477.7A HK1089167B (en) 2003-09-18 2004-09-15 2-pyridone derivatives as netrophil elastase inhibitors and their use
AU2004272485A AU2004272485B2 (en) 2003-09-18 2004-09-15 2-pyridone derivatives as neutrophil elastase inhibitors and their use
CNB2004800275174A CN100439339C (zh) 2003-09-18 2004-09-15 用作嗜中性白细胞弹性蛋白酶抑制剂的2-吡啶酮衍生物及其用途
EP04775439A EP1663974B1 (en) 2003-09-18 2004-09-15 2-pyridone derivatives as netrophil elastase inhibitors and their use
BRPI0414570-4A BRPI0414570A (pt) 2003-09-18 2004-09-15 derivados de 2-piridona como inibidores de elastase de neutrófilo e seu uso
JP2006526856A JP2007505902A (ja) 2003-09-18 2004-09-15 好中球エラスターゼ阻害剤としての２−ピリドン誘導体およびその使用
DE602004019110T DE602004019110D1 (de) 2003-09-18 2004-09-15 2-pyridonderivate als inhibitoren von neutrophilelastase und deren verwendung
UAA200602252A UA84878C2 (ru) 2003-09-18 2004-09-15 Производные 2-пиридона как ингибиторы нейтрофилов эластазы, фармацевтическая композиция на их основе, способ их получения
CA002538410A CA2538410A1 (en) 2003-09-18 2004-09-15 2-pyridone derivatives as netrophil elastase inhibitors and their use
UY28513A UY28513A1 (es) 2003-09-18 2004-09-15 Nuevos compuestos
RU2006112427/04A RU2348617C2 (ru) 2003-09-18 2004-09-15 Производные 2-пиридона в качестве ингибиторов эластазы нейтрофилов и их применение
US10/572,640 US20070043036A1 (en) 2003-09-18 2004-09-15 2-Pyridone derivatives as neutrophil elastase inhibitors and their use
PCT/SE2004/001336 WO2005026124A1 (en) 2003-09-18 2004-09-15 2-pyridone derivatives as netrophil elastase inhibitors and their use
KR1020067005458A KR20060096995A (ko) 2003-09-18 2004-09-15 중성구 엘라스타제 억제제로서의 2-피리돈 유도체 및 그의용도
MXPA06002723A MXPA06002723A (es) 2003-09-18 2004-09-15 Derivados de 2-piridona como inhibidores de neutrofilo elastasa y su uso.
AT04775439T ATE420861T1 (de) 2003-09-18 2004-09-15 2-pyridonderivate als inhibitoren von neutrophilelastase und deren verwendung
ES04775439T ES2319300T3 (es) 2003-09-18 2004-09-15 Derivados de 2-piridona como inhibidores de elastasa neutrofila y su uso.
ARP040103354A AR046083A1 (es) 2003-09-18 2004-09-17 Derivados de 2 piridona como inhibidores de la elastasa de neutrofilos
SA4250300A SA04250300B1 (ar) 2003-09-18 2004-09-18 مشتقات 2_ بيريدون تعمل كمثبطات لانزيم ايلاستيز النتيروفيل واستخدامها
IL173986A IL173986A0 (en) 2003-09-18 2006-02-27 2-pyridone derivatives as netrophil elastase inhibitors and their use
CO06026211A CO5670357A2 (es) 2003-09-18 2006-03-15 Derivados de 2-piridona como inhibidores de elastasa neutrofila y su uso
ZA200602262A ZA200602262B (en) 2003-09-18 2006-03-17 2-Pyridone derivatives as neutrophil elastase inhibitors and their use
IS8394A IS8394A (is) 2003-09-18 2006-03-31 2-pýridónafleiður sem daukyrningselastasatálmar og notkun þeirra
NO20061700A NO20061700L (no) 2003-09-18 2006-04-18 2-pyridonderivater som neutrofil elastase inhibitorer og deres anvendelse

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0302487A SE0302487D0 (sv) 2003-09-18 2003-09-18 Novel compounds

Publications (1)

Publication Number Publication Date
SE0302487D0 true SE0302487D0 (sv) 2003-09-18

Family

ID=29212489

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0302487A SE0302487D0 (sv) 2003-09-18 2003-09-18 Novel compounds

Country Status (25)

Country Link
US (1) US20070043036A1 (ref)
EP (1) EP1663974B1 (ref)
JP (1) JP2007505902A (ref)
KR (1) KR20060096995A (ref)
CN (1) CN100439339C (ref)
AR (1) AR046083A1 (ref)
AT (1) ATE420861T1 (ref)
AU (1) AU2004272485B2 (ref)
BR (1) BRPI0414570A (ref)
CA (1) CA2538410A1 (ref)
CO (1) CO5670357A2 (ref)
DE (1) DE602004019110D1 (ref)
ES (1) ES2319300T3 (ref)
IL (1) IL173986A0 (ref)
IS (1) IS8394A (ref)
MX (1) MXPA06002723A (ref)
NO (1) NO20061700L (ref)
RU (1) RU2348617C2 (ref)
SA (1) SA04250300B1 (ref)
SE (1) SE0302487D0 (ref)
TW (1) TW200526579A (ref)
UA (1) UA84878C2 (ref)
UY (1) UY28513A1 (ref)
WO (1) WO2005026124A1 (ref)
ZA (1) ZA200602262B (ref)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200500341A (en) * 2002-11-12 2005-01-01 Astrazeneca Ab Novel compounds
SE0302486D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US7432373B2 (en) 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US20050288290A1 (en) 2004-06-28 2005-12-29 Borzilleri Robert M Fused heterocyclic kinase inhibitors
TW200700392A (en) * 2005-03-16 2007-01-01 Astrazeneca Ab Novel compounds
MX2007014114A (es) * 2005-05-10 2008-03-14 Intermune Inc Derivados de piridona para modular el sistema de proteina cinasa activada por estres.
GB0516313D0 (en) 2005-08-08 2005-09-14 Argenta Discovery Ltd Azole derivatives and their uses
EP1924553A1 (en) 2005-08-08 2008-05-28 Argenta Discovery Limited Bicyclo[2.2.]hept-7-ylamine derivatives and their uses
CA2623957A1 (en) * 2005-09-29 2007-04-05 University Of Alberta Compositions for and methods of granzyme b inhibition
GB0605469D0 (en) * 2006-03-17 2006-04-26 Argenta Discovery Ltd Multimers of heterocyclic compounds and their use
TW200808763A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
TW200808771A (en) * 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
US8470859B2 (en) 2006-10-23 2013-06-25 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
JP5276005B2 (ja) 2006-11-08 2013-08-28 ブリストル−マイヤーズ スクイブ カンパニー ピリジノン化合物
CA2703996A1 (en) * 2007-11-06 2009-05-14 Astrazeneca Ab Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
NZ585888A (en) 2007-12-14 2012-02-24 Pulmagen Therapeutics Asthma Ltd Indoles and their therapeutic use
SI2235002T1 (sl) 2008-01-23 2013-06-28 Bristol-Myers Squibb Company Spojine 4-piridinona in njihova uporaba za zdravljenje raka
US8481569B2 (en) 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
JP5627574B2 (ja) 2008-06-03 2014-11-19 インターミューン， インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
BRPI1005327A2 (pt) 2009-02-17 2019-09-24 Chiesi Farm Spa derivados de triazolopiridina como inibidores de p38 map quinase
GB0902648D0 (en) 2009-02-17 2009-04-01 Argenta Discovery Ltd Pharmaceutical compounds and compositions
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
RU2012116877A (ru) * 2009-10-02 2013-11-10 Астразенека Аб Соединения 2-пиридона, применяемые в качестве ингибиторов нейтрофильной эластазы
GB0918922D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminopyridine derivatives
GB0918923D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminothiazole derivatives
GB0918924D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Azaindole derivatives
WO2011071730A1 (en) * 2009-12-08 2011-06-16 Boehringer Ingelheim International Gmbh Process for synthesis of intermediates useful for making substituted indazole and azaindazole compounds
GB201009731D0 (en) 2010-06-10 2010-07-21 Pulmagen Therapeutics Inflamma Kinase inhibitors
US9040516B2 (en) 2011-08-01 2015-05-26 Sumitomo Dainippon Pharma Co., Ltd. Uracil derivative and use thereof for medical purposes
KR20140103925A (ko) 2011-12-09 2014-08-27 키에시 파르마슈티시 엣스. 피. 에이. 4-히드록시-1,2,3,4-테트라히드로나프탈렌-1-일 우레아 및 호흡기 질환의 치료에서의 이들의 용도
KR20140105459A (ko) 2011-12-09 2014-09-01 키에시 파르마슈티시 엣스. 피. 에이. 키나아제 억제제
ES2612259T3 (es) 2011-12-09 2017-05-16 Chiesi Farmaceutici S.P.A. Inhibidores de cinasa
US20140057920A1 (en) 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US20140057926A1 (en) 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US9102624B2 (en) 2012-08-23 2015-08-11 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
HK1220459A1 (zh) 2013-06-06 2017-05-05 奇斯药制品公司 激酶抑制剂
US9221807B2 (en) * 2014-02-21 2015-12-29 Boehringer Ingelheim International Gmbh Substituted pyridones and pyrazinones and their use as inhibitors of neutrophil elastase activity
US10233195B2 (en) 2014-04-02 2019-03-19 Intermune, Inc. Anti-fibrotic pyridinones
UY36875A (es) 2015-09-02 2017-03-31 Glaxosmithkline Intellectual Property (No 2) Ltd Composiciones inhibidoras de bromodominios para el tratamiento de diversas enfermedades
TW201720828A (zh) 2015-11-23 2017-06-16 赫孚孟拉羅股份公司 治療性化合物及組合物以及其使用方法
EP3394060A1 (en) 2015-12-23 2018-10-31 Chiesi Farmaceutici S.p.A. 1-(3-tert-butyl-2h-pyrazol-5-yl or 5-tert-butyl-isoxaol-3-yl)-3-(4-([1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-1,2,3,4-tetrahydro-naphthalenyl) urea derivatives and their use as p38 mapk inhibitors
TW201730189A (zh) 2015-12-23 2017-09-01 吉斯藥品公司 激酶抑制劑
EP3394058B1 (en) 2015-12-23 2020-10-14 Chiesi Farmaceutici S.p.A. N-[3-(3-{4-[[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl} -ureido)-phenyl]-methanesulfonamide derivatives and their use as p38 mapk inhibitors
JP7034942B2 (ja) 2016-05-05 2022-03-14 エフ．ホフマン－ラ ロシュ アーゲー ピラゾール誘導体、その組成物及び治療的使用
KR20190045302A (ko) 2016-09-06 2019-05-02 에프. 호프만-라 로슈 아게 8-(아제티딘-1-일)-[1,2,4]트라이아졸로[1,5-a]피리딘일 화합물 및 이의 조성물 및 사용 방법
AU2017385543A1 (en) 2016-12-29 2019-05-23 F. Hoffmann-La Roche Ag Pyrazolopyrimidine compounds and methods of use thereof
EP3596072B1 (en) 2017-03-14 2022-06-22 F. Hoffmann-La Roche AG Pyrazolochlorophenyl compounds, compositions and methods of use thereof
WO2018215389A1 (en) 2017-05-22 2018-11-29 F. Hoffmann-La Roche Ag Therapeutic compounds and compositions, and methods of use thereof
US20180334465A1 (en) 2017-05-22 2018-11-22 Genentech, Inc. Therapeutic compounds and compositions, and methods of use thereof
US10364245B2 (en) 2017-06-07 2019-07-30 Chiesi Farmaceutici S.P.A. Kinase inhibitors
JP7339263B2 (ja) 2018-01-15 2023-09-05 エフ． ホフマン－ラ ロシュ アーゲー Ｊａｋ阻害剤としてのピラゾロピリミジン化合物
EP3749697A4 (en) 2018-02-05 2021-11-03 Bio-Rad Laboratories, Inc. CHROMATOGRAPHY RESIN WITH LIGAND MIXED MODE ANIONIC / HYDROPHOBIC EXCHANGE
CN110192948B (zh) * 2019-05-28 2022-01-04 河南省超亚医药器械有限公司 一种小儿腹部热敷贴
CN110192947B (zh) * 2019-05-28 2022-01-04 河南省超亚医药器械有限公司 一种小儿肺部热敷贴
MX2021015319A (es) 2019-06-18 2022-04-07 Hoffmann La Roche Inhibidores de jak cinasas basados en pirazolopirimidina sulfona y usos de los mismos.
US20200399274A1 (en) 2019-06-18 2020-12-24 Genentech, Inc. Tetrazole-substituted pyrazolopyrimidine inhibitors of jak kinases and uses thereof
EP3986899A1 (en) 2019-06-18 2022-04-27 F. Hoffmann-La Roche AG Pyrazolopyrimidine aryl ether inhibitors of jak kinases and uses thereof
WO2021053058A1 (en) 2019-09-17 2021-03-25 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
LT4106757T (lt) 2020-04-16 2023-11-10 Mereo Biopharma 4 Limited Neutrofilų elastazės inhibitoriaus alvelestato panaudojimas kvėpavimo sistemos ligų, nulemtų alfa-1 antitripsino nepakankamumo, gydymui
JP2024540952A (ja) 2021-10-20 2024-11-06 メレオ バイオファーマ ４ リミテッド 線維化の治療における使用のための好中球エラスターゼ阻害剤
CN114057630B (zh) * 2021-12-23 2023-06-02 郑州大学 吡非尼酮衍生物及其合成方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521179A (en) * 1991-04-18 1996-05-28 Zeneca Limited Heterocyclic amides
GB9207145D0 (en) * 1991-04-18 1992-05-13 Ici Plc Heterocyclic amides
FR2687674B1 (fr) * 1992-02-07 1995-05-19 Roussel Uclaf Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
ATE263761T1 (de) * 1993-11-19 2004-04-15 Parke Davis & Co 5,6-dihydropyronderivate als proteaseinhibitoren und antiviralmittel
RU2067579C1 (ru) * 1994-10-07 1996-10-10 Пермский фармацевтический институт 3-(2'-нафтоилметилен)-пиперазинон-2 и 1-n-фенил-3-фенацилиденпиперазинон-2, проявляющие противовоспалительную активность
KR100828982B1 (ko) * 2000-12-28 2008-05-14 시오노기세이야쿠가부시키가이샤 칸나비노이드 2형 수용체 친화 작용을 갖는 피리돈 유도체
GB0129260D0 (en) * 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
CA2470813A1 (en) * 2001-12-20 2003-07-03 Bayer Healthcare Ag 1,4-dihydro-1,4-diphenylpyridine derivatives
GB2383326A (en) * 2001-12-20 2003-06-25 Bayer Ag Antiinflammatory dihydropyridines
TW200500341A (en) * 2002-11-12 2005-01-01 Astrazeneca Ab Novel compounds
SE0302486D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds

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ATE420861T1 (de) 2009-01-15
EP1663974A1 (en) 2006-06-07
DE602004019110D1 (de) 2009-03-05
SA04250300B1 (ar) 2008-09-07
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AU2004272485A1 (en) 2005-03-24
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JP2007505902A (ja) 2007-03-15
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AU2004272485B2 (en) 2008-03-13
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