SA98181116B1 - مثبطات بروتياز protease inhibitors فيروس نقص المناعه البشرية HIV - Google Patents

مثبطات بروتياز protease inhibitors فيروس نقص المناعه البشرية HIV Download PDF

Info

Publication number
SA98181116B1
SA98181116B1 SA98181116A SA98181116A SA98181116B1 SA 98181116 B1 SA98181116 B1 SA 98181116B1 SA 98181116 A SA98181116 A SA 98181116A SA 98181116 A SA98181116 A SA 98181116A SA 98181116 B1 SA98181116 B1 SA 98181116B1
Authority
SA
Saudi Arabia
Prior art keywords
compound
purity
group
alkyl
salt
Prior art date
Application number
SA98181116A
Other languages
Arabic (ar)
English (en)
Inventor
كيم اف . البيزاتي
ميكائيل دي . فامي
سيجفريد ريش
تاكيو كوباياشي
كانوين اي. زهانج
Original Assignee
جابان توباكو، انك.
أجورون فارماسيوتكالز انك
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by جابان توباكو، انك., أجورون فارماسيوتكالز انك filed Critical جابان توباكو، انك.
Publication of SA98181116B1 publication Critical patent/SA98181116B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Plant Substances (AREA)
SA98181116A 1997-03-13 1998-04-21 مثبطات بروتياز protease inhibitors فيروس نقص المناعه البشرية HIV SA98181116B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81595197A 1997-03-13 1997-03-13

Publications (1)

Publication Number Publication Date
SA98181116B1 true SA98181116B1 (ar) 2006-10-04

Family

ID=25219265

Family Applications (1)

Application Number Title Priority Date Filing Date
SA98181116A SA98181116B1 (ar) 1997-03-13 1998-04-21 مثبطات بروتياز protease inhibitors فيروس نقص المناعه البشرية HIV

Country Status (35)

Country Link
EP (1) EP0970055A2 (ko)
JP (1) JP2001516350A (ko)
KR (1) KR100511089B1 (ko)
CN (1) CN1179948C (ko)
AP (1) AP1358A (ko)
AR (1) AR012556A1 (ko)
AU (1) AU743078B2 (ko)
BG (1) BG63540B1 (ko)
BR (1) BR9808867A (ko)
CA (1) CA2284163A1 (ko)
CO (1) CO4940496A1 (ko)
CZ (1) CZ296647B6 (ko)
EA (1) EA002378B1 (ko)
EE (1) EE04114B1 (ko)
GE (1) GEP20022764B (ko)
HR (1) HRP980112A2 (ko)
HU (1) HUP0001380A3 (ko)
IL (2) IL131870A0 (ko)
IS (1) IS5176A (ko)
MX (1) MXPA99008395A (ko)
MY (1) MY117535A (ko)
NO (1) NO315555B1 (ko)
NZ (1) NZ337706A (ko)
OA (1) OA11196A (ko)
PA (1) PA8448801A1 (ko)
PE (1) PE58799A1 (ko)
PL (1) PL192786B1 (ko)
SA (1) SA98181116B1 (ko)
SK (1) SK283636B6 (ko)
SV (1) SV1998000038A (ko)
TR (1) TR199902508T2 (ko)
TW (1) TW200517112A (ko)
UA (1) UA57772C2 (ko)
WO (1) WO1998040357A2 (ko)
ZA (1) ZA982047B (ko)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors

Also Published As

Publication number Publication date
EA002378B1 (ru) 2002-04-25
CA2284163A1 (en) 1998-09-17
CO4940496A1 (es) 2000-07-24
PA8448801A1 (es) 2000-05-24
NZ337706A (en) 2001-04-27
WO1998040357A3 (en) 1998-11-26
IS5176A (is) 1999-09-10
HRP980112A2 (en) 1998-12-31
TW200517112A (en) 2005-06-01
EP0970055A2 (en) 2000-01-12
NO994415D0 (no) 1999-09-10
SK283636B6 (sk) 2003-11-04
SV1998000038A (es) 1999-02-15
ZA982047B (en) 1998-09-28
NO994415L (no) 1999-11-10
CZ319199A3 (cs) 2000-06-14
UA57772C2 (uk) 2003-07-15
PL335672A1 (en) 2000-05-08
MXPA99008395A (es) 2003-08-12
AP1358A (en) 2004-12-03
IL131870A (en) 2006-04-10
KR100511089B1 (ko) 2005-08-31
GEP20022764B (en) 2002-08-26
MY117535A (en) 2004-07-31
IL131870A0 (en) 2001-03-19
BR9808867A (pt) 2000-07-11
TR199902508T2 (xx) 2000-02-21
EE04114B1 (et) 2003-08-15
CZ296647B6 (cs) 2006-05-17
SK122299A3 (en) 2000-05-16
OA11196A (en) 2003-05-21
KR20000076236A (ko) 2000-12-26
HUP0001380A3 (en) 2001-12-28
AU743078B2 (en) 2002-01-17
EE9900416A (et) 2000-04-17
NO315555B1 (no) 2003-09-22
EA199900823A1 (ru) 2000-04-24
PE58799A1 (es) 1999-07-12
CN1253548A (zh) 2000-05-17
JP2001516350A (ja) 2001-09-25
AP9901648A0 (en) 1999-09-30
BG63540B1 (bg) 2002-04-30
PL192786B1 (pl) 2006-12-29
WO1998040357A2 (en) 1998-09-17
AR012556A1 (es) 2000-11-08
CN1179948C (zh) 2004-12-15
HUP0001380A2 (hu) 2000-09-28
BG103727A (en) 2000-04-28
AU6457598A (en) 1998-09-29

Similar Documents

Publication Publication Date Title
KR100383161B1 (ko) 신규한아미디노나프틸유도체또는이의염
US5728718A (en) 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and anthranilamide subunits and methods of using same
JP3732858B2 (ja) Ｈｉｖプロテアーゼ阻害剤としてのｎ−（３− アミノ−２− ヒドロキシブチル）スルホンアミド誘導体
KR19990022450A (ko) 아릴설포닐아미노벤젠 유도체 및 엑스에이 인자 억제제로서의그 이용 방법
KR0173034B1 (ko) 선택적 트롬빈 억제제
EA002740B1 (ru) Производные гуанидина (варианты), способ их получения (варианты), фармацевтическая композиция для ингибирования протеолиза у млекопитающего, способ лечения, способ ингибирования: протеолиза у млекопитающего, тромбин-индуцированной агрегации тромбоцитов и образования сгустков фибриногена в плазме, тромбина в крови, образования агрегатов тромбоцитов в крови, образования тромбов в крови, устройство для сбора, циркуляции и хранения крови
JPH06234789A (ja) Ａｉｄｓの処置のために有用なｈｉｖ−プロテアーゼ阻害剤
ES2438731T3 (es) Derivados aromáticos como inhibidores de la aspartil proteasa del VIH
HRP20000304A2 (en) Biphenylamidine derivatives
ES2389300T3 (es) Derivados de ácido 3-alcanoilamino-propiónico como inhibidores de la integrina AVSS6
JPH06234728A (ja) Ａｉｄｓの処置のために有用なｈｉｖ−プロテアーゼ阻害剤
Jung et al. New peptidomimetic rhodesain inhibitors with improved selectivity towards human cathepsins
US5763464A (en) Retroviral agents containing anthranilamide, substituted benzamide and other subunits, and methods of using same
SA98181116B1 (ar) مثبطات بروتياز protease inhibitors فيروس نقص المناعه البشرية HIV
US20230099089A1 (en) Antiviral substances with a wide spectrum of activity
US5559150A (en) N,N-disulfonylated aminobenzene carboxlic acids and the use thereof as thrombin inhibitors
US6001851A (en) HIV protease inhibitors
Mundra Insignificant in vitro falcipain‑2 inhibitory activity of novel 2‑(4‑(substituted benzoyl) piperazine‑1‑yl)‑N‑phenylacetamide derivatives
KR19980032448A (ko) 경구투여가 가능한 선택적 트롬빈 억제제