SA520420892B1 - فوسفات كالسيوم غير متبلر مستقر مطعم بأيونات فلوريد وعملية لإنتاجها - Google Patents
فوسفات كالسيوم غير متبلر مستقر مطعم بأيونات فلوريد وعملية لإنتاجهاInfo
- Publication number
- SA520420892B1 SA520420892B1 SA520420892A SA520420892A SA520420892B1 SA 520420892 B1 SA520420892 B1 SA 520420892B1 SA 520420892 A SA520420892 A SA 520420892A SA 520420892 A SA520420892 A SA 520420892A SA 520420892 B1 SA520420892 B1 SA 520420892B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- nanoparticle
- solution
- citrate
- calcium phosphate
- salt
- Prior art date
Links
- -1 Fluoride Ions Chemical class 0.000 title abstract 3
- 229910000389 calcium phosphate Inorganic materials 0.000 title abstract 3
- 239000001506 calcium phosphate Substances 0.000 title abstract 3
- 235000011010 calcium phosphates Nutrition 0.000 title abstract 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000002105 nanoparticle Substances 0.000 abstract 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 150000005323 carbonate salts Chemical class 0.000 abstract 1
- 150000001860 citric acid derivatives Chemical class 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
- C01B25/327—After-treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/15—Compositions characterised by their physical properties
- A61K6/17—Particle size
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/50—Preparations specially adapted for dental root treatment
- A61K6/54—Filling; Sealing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/838—Phosphorus compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/864—Phosphate cements
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2002/00—Crystal-structural characteristics
- C01P2002/01—Crystal-structural characteristics depicted by a TEM-image
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2002/00—Crystal-structural characteristics
- C01P2002/02—Amorphous compounds
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/01—Particle morphology depicted by an image
- C01P2004/03—Particle morphology depicted by an image obtained by SEM
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/01—Particle morphology depicted by an image
- C01P2004/04—Particle morphology depicted by an image obtained by TEM, STEM, STM or AFM
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/50—Agglomerated particles
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/60—Particles characterised by their size
- C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/12—Surface area
Landscapes
- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Geology (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Environmental & Geological Engineering (AREA)
- General Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Materials Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Composite Materials (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Manufacturing & Machinery (AREA)
- Dental Preparations (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Glass Compositions (AREA)
- Catalysts (AREA)
- Materials For Medical Uses (AREA)
Abstract
يتعلق الاختراع الحالي بعملية لتحضير جسيم نانوي nanoparticle من فوسفات كالسيوم غير متبلور مطلي بالسيترات citrate-coated amorphous calcium phosphate حيث تشتمل على الخطوات التالية: 1) توفير محلول أول first solution من ملح كالسيوم salt of calcium وملح سيترات citrate salt حيث تكون النسبة الجزيئية لأيون السيترات citrate ion إلى أيون الكالسيوم calcium ion في نطاق يتراوح من 1 إلى 2 مما يؤدي إلى الحصول على محلول صافِ أول clear first solution ؛ 2) توفير محلول ثان second solution من ملح قادر إعطاء أيون فوسفات phosphate anion وملح كربونات carbonate salt ؛ 3) خلط المحلول الأول والثاني معاً عند رقم هيدروجيني في نطاق يتراوح من 8 إلى 11؛ 4) ترسيب الجسيم النانوي nanoparticle ؛ و5) تجفيف الجسيم النانوي الذي تم الحصول عليه من الخطوة 4). يوفر الاختراع على نحو مفضل ومفيد إضافة مركب فلوريد fluoride compound في الخطوة 2) للحصول على جسيم نانوي nanoparticle أو كتلة جسيمات نانوية من فوسفات كالسيوم calcium phosphate nanoparticle مغطى بالسيترات مطعم بالفلوريد fluorine-doped citrate-coated. الجسيم النانوي/كتلة
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102018000006753A IT201800006753A1 (it) | 2018-06-28 | 2018-06-28 | Calcio fosfato amorfo stabilizzato dopato con ioni fluoruro e un procedimento per produrlo |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA520420892B1 true SA520420892B1 (ar) | 2022-09-20 |
Family
ID=63491977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA520420892A SA520420892B1 (ar) | 2018-06-28 | 2020-12-24 | فوسفات كالسيوم غير متبلر مستقر مطعم بأيونات فلوريد وعملية لإنتاجها |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US11377353B2 (ar) |
| EP (1) | EP3813762B1 (ar) |
| JP (1) | JP7044906B2 (ar) |
| KR (1) | KR20210025624A (ar) |
| CN (1) | CN112384187B (ar) |
| AR (1) | AR120965A1 (ar) |
| AU (1) | AU2019295211B2 (ar) |
| BR (1) | BR112020026617B1 (ar) |
| CA (1) | CA3103861A1 (ar) |
| CY (1) | CY1124996T1 (ar) |
| DK (1) | DK3813762T3 (ar) |
| EA (1) | EA039099B1 (ar) |
| EC (1) | ECSP21001201A (ar) |
| ES (1) | ES2906408T3 (ar) |
| HR (1) | HRP20220157T1 (ar) |
| HU (1) | HUE058215T2 (ar) |
| IL (1) | IL279585B2 (ar) |
| IT (1) | IT201800006753A1 (ar) |
| JO (1) | JOP20200316A1 (ar) |
| LT (1) | LT3813762T (ar) |
| MA (1) | MA55429B1 (ar) |
| MD (1) | MD3813762T2 (ar) |
| MX (1) | MX2020013890A (ar) |
| NZ (1) | NZ772246A (ar) |
| PH (1) | PH12020552250A1 (ar) |
| PL (1) | PL3813762T3 (ar) |
| PT (1) | PT3813762T (ar) |
| RS (1) | RS62957B1 (ar) |
| SA (1) | SA520420892B1 (ar) |
| SG (1) | SG11202012901VA (ar) |
| SI (1) | SI3813762T1 (ar) |
| TW (1) | TWI819013B (ar) |
| UA (1) | UA127460C2 (ar) |
| WO (1) | WO2020002517A1 (ar) |
| ZA (1) | ZA202100423B (ar) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111362661A (zh) * | 2020-04-17 | 2020-07-03 | 中山职业技术学院 | 一种高密度无定形磷酸钙纳米粉体及其制备方法和应用 |
| CN114886782B (zh) * | 2022-05-07 | 2023-06-16 | 深圳市博威凯特科技有限公司 | 一种基于纳米羟基磷灰石的活态钙复合物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7670579B2 (en) * | 2004-04-06 | 2010-03-02 | American Dental Association Foundation | Nanostructured bioactive materials prepared by dual nozzle spray drying techniques |
| CN103876945B (zh) * | 2014-04-17 | 2016-08-03 | 厦门大学 | 一种牙本质小管封闭剂及其制备方法 |
| ES2557183B1 (es) * | 2014-07-21 | 2016-11-03 | Consejo Superior De Investigaciones Científicas (Csic) | Procedimiento de obtención de nanopartículas de fosfato de calcio amorfo recubiertas de citrato y dopadas con flúor |
| SG11201705128VA (en) * | 2014-12-22 | 2017-07-28 | Consiglio Nazionale Ricerche | Products for the delivery of therapeutic/diagnostic compounds to the heart |
| US10751290B2 (en) * | 2015-08-11 | 2020-08-25 | Ludwig-Maximilians-Universität München | Mesoporous calcium phosphate-citrate nanoparticles and uses thereof |
| US10406078B2 (en) * | 2016-11-18 | 2019-09-10 | Pac-Dent International, Inc. | Nano-complexes for enamel remineralization |
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2018
- 2018-06-28 IT IT102018000006753A patent/IT201800006753A1/it unknown
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2019
- 2019-06-27 IL IL279585A patent/IL279585B2/en unknown
- 2019-06-27 BR BR112020026617-5A patent/BR112020026617B1/pt active IP Right Grant
- 2019-06-27 JO JOP/2020/0316A patent/JOP20200316A1/ar unknown
- 2019-06-27 KR KR1020217002748A patent/KR20210025624A/ko unknown
- 2019-06-27 US US17/255,522 patent/US11377353B2/en active Active
- 2019-06-27 MX MX2020013890A patent/MX2020013890A/es unknown
- 2019-06-27 NZ NZ772246A patent/NZ772246A/en unknown
- 2019-06-27 ES ES19742294T patent/ES2906408T3/es active Active
- 2019-06-27 AU AU2019295211A patent/AU2019295211B2/en active Active
- 2019-06-27 LT LTEPPCT/EP2019/067188T patent/LT3813762T/lt unknown
- 2019-06-27 MA MA55429A patent/MA55429B1/fr unknown
- 2019-06-27 MD MDE20210426T patent/MD3813762T2/ro unknown
- 2019-06-27 PT PT197422942T patent/PT3813762T/pt unknown
- 2019-06-27 WO PCT/EP2019/067188 patent/WO2020002517A1/en unknown
- 2019-06-27 TW TW108122608A patent/TWI819013B/zh active
- 2019-06-27 CA CA3103861A patent/CA3103861A1/en active Pending
- 2019-06-27 HU HUE19742294A patent/HUE058215T2/hu unknown
- 2019-06-27 SI SI201930164T patent/SI3813762T1/sl unknown
- 2019-06-27 UA UAA202100287A patent/UA127460C2/uk unknown
- 2019-06-27 JP JP2020572498A patent/JP7044906B2/ja active Active
- 2019-06-27 RS RS20220101A patent/RS62957B1/sr unknown
- 2019-06-27 DK DK19742294.2T patent/DK3813762T3/da active
- 2019-06-27 CN CN201980043839.4A patent/CN112384187B/zh active Active
- 2019-06-27 PL PL19742294T patent/PL3813762T3/pl unknown
- 2019-06-27 EP EP19742294.2A patent/EP3813762B1/en active Active
- 2019-06-27 HR HRP20220157TT patent/HRP20220157T1/hr unknown
- 2019-06-27 SG SG11202012901VA patent/SG11202012901VA/en unknown
- 2019-06-27 EA EA202190142A patent/EA039099B1/ru unknown
- 2019-06-28 AR ARP190101805A patent/AR120965A1/es active IP Right Grant
-
2020
- 2020-12-22 PH PH12020552250A patent/PH12020552250A1/en unknown
- 2020-12-24 SA SA520420892A patent/SA520420892B1/ar unknown
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2021
- 2021-01-08 EC ECSENADI20211201A patent/ECSP21001201A/es unknown
- 2021-01-20 ZA ZA2021/00423A patent/ZA202100423B/en unknown
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2022
- 2022-02-15 CY CY20221100130T patent/CY1124996T1/el unknown
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