MA55429A - Phosphate de calcium amorphe stabilisé dopé par des ions fluorure et procédé permettant de le produire - Google Patents
Phosphate de calcium amorphe stabilisé dopé par des ions fluorure et procédé permettant de le produireInfo
- Publication number
- MA55429A MA55429A MA055429A MA55429A MA55429A MA 55429 A MA55429 A MA 55429A MA 055429 A MA055429 A MA 055429A MA 55429 A MA55429 A MA 55429A MA 55429 A MA55429 A MA 55429A
- Authority
- MA
- Morocco
- Prior art keywords
- nanoparticle
- citrate
- calcium phosphate
- solution
- salt
- Prior art date
Links
- 229910000389 calcium phosphate Inorganic materials 0.000 title abstract 3
- 239000001506 calcium phosphate Substances 0.000 title abstract 3
- 235000011010 calcium phosphates Nutrition 0.000 title abstract 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title abstract 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002105 nanoparticle Substances 0.000 abstract 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 3
- -1 phosphate anion Chemical class 0.000 abstract 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 150000005323 carbonate salts Chemical class 0.000 abstract 1
- 150000001860 citric acid derivatives Chemical class 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
- C01B25/327—After-treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/838—Phosphorus compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/15—Compositions characterised by their physical properties
- A61K6/17—Particle size
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/50—Preparations specially adapted for dental root treatment
- A61K6/54—Filling; Sealing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/864—Phosphate cements
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2002/00—Crystal-structural characteristics
- C01P2002/01—Crystal-structural characteristics depicted by a TEM-image
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2002/00—Crystal-structural characteristics
- C01P2002/02—Amorphous compounds
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/01—Particle morphology depicted by an image
- C01P2004/03—Particle morphology depicted by an image obtained by SEM
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/01—Particle morphology depicted by an image
- C01P2004/04—Particle morphology depicted by an image obtained by TEM, STEM, STM or AFM
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/50—Agglomerated particles
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/60—Particles characterised by their size
- C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/12—Surface area
Landscapes
- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Geology (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Environmental & Geological Engineering (AREA)
- General Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Materials Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Composite Materials (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Manufacturing & Machinery (AREA)
- Dental Preparations (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Glass Compositions (AREA)
- Catalysts (AREA)
- Materials For Medical Uses (AREA)
Abstract
L'invention concerne un procédé de préparation d'une nanoparticule de phosphate de calcium amorphe revêtue de citrate, qui comprend les étapes suivantes : 1) fournir une première solution d'un sel de calcium et d'un sel de citrate, le rapport molaire de l'ion citrate à l'ion calcium se situant dans une plage comprise entre 1 et 2, obtenant ainsi une première solution transparente ; 2) fournir une seconde solution d'un sel capable de donner un anion phosphate et un sel de carbonate ; 3) mélanger la première et la seconde solution à un ph situé dans une plage comprise entre 8 et 11 ; 4) faire précipiter la nanoparticule ; et 5) sécher la nanoparticule obtenue à l'étape 4). De préférence et de manière avantageuse, l'invention concerne l'ajout d'un composé fluorure à l'étape 2) pour obtenir une nanoparticule de phosphate de calcium revêtue de citrate dopée au fluor, ou un agglomérat de nanoparticules. La nanoparticule / l'agglomérat de nanoparticules de l'invention présente une aire de surface et un diamètre spécifiques qui lui permettent d'être utilisé comme biomatériau pour une application de dentisterie.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102018000006753A IT201800006753A1 (it) | 2018-06-28 | 2018-06-28 | Calcio fosfato amorfo stabilizzato dopato con ioni fluoruro e un procedimento per produrlo |
Publications (2)
Publication Number | Publication Date |
---|---|
MA55429A true MA55429A (fr) | 2021-05-05 |
MA55429B1 MA55429B1 (fr) | 2022-02-28 |
Family
ID=63491977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA55429A MA55429B1 (fr) | 2018-06-28 | 2019-06-27 | Phosphate de calcium amorphe stabilisé dopé par des ions fluorure et procédé permettant de le produire |
Country Status (34)
Country | Link |
---|---|
US (1) | US11377353B2 (fr) |
EP (1) | EP3813762B1 (fr) |
JP (1) | JP7044906B2 (fr) |
KR (1) | KR20210025624A (fr) |
CN (1) | CN112384187B (fr) |
AR (1) | AR120965A1 (fr) |
AU (1) | AU2019295211B2 (fr) |
BR (1) | BR112020026617B1 (fr) |
CA (1) | CA3103861A1 (fr) |
CY (1) | CY1124996T1 (fr) |
DK (1) | DK3813762T3 (fr) |
EA (1) | EA039099B1 (fr) |
EC (1) | ECSP21001201A (fr) |
ES (1) | ES2906408T3 (fr) |
HR (1) | HRP20220157T1 (fr) |
HU (1) | HUE058215T2 (fr) |
IL (1) | IL279585B2 (fr) |
IT (1) | IT201800006753A1 (fr) |
JO (1) | JOP20200316A1 (fr) |
LT (1) | LT3813762T (fr) |
MA (1) | MA55429B1 (fr) |
MD (1) | MD3813762T2 (fr) |
MX (1) | MX2020013890A (fr) |
PH (1) | PH12020552250A1 (fr) |
PL (1) | PL3813762T3 (fr) |
PT (1) | PT3813762T (fr) |
RS (1) | RS62957B1 (fr) |
SA (1) | SA520420892B1 (fr) |
SG (1) | SG11202012901VA (fr) |
SI (1) | SI3813762T1 (fr) |
TW (1) | TWI819013B (fr) |
UA (1) | UA127460C2 (fr) |
WO (1) | WO2020002517A1 (fr) |
ZA (1) | ZA202100423B (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111362661A (zh) * | 2020-04-17 | 2020-07-03 | 中山职业技术学院 | 一种高密度无定形磷酸钙纳米粉体及其制备方法和应用 |
CN114886782B (zh) * | 2022-05-07 | 2023-06-16 | 深圳市博威凯特科技有限公司 | 一种基于纳米羟基磷灰石的活态钙复合物及其制备方法和应用 |
WO2024134524A1 (fr) | 2022-12-22 | 2024-06-27 | Consiglio Nazionale Delle Ricerche | Matériau composite à base de verre bioactif et de phosphate de calcium amorphe et procédé pour sa production |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7670579B2 (en) * | 2004-04-06 | 2010-03-02 | American Dental Association Foundation | Nanostructured bioactive materials prepared by dual nozzle spray drying techniques |
CN103876945B (zh) * | 2014-04-17 | 2016-08-03 | 厦门大学 | 一种牙本质小管封闭剂及其制备方法 |
ES2557183B1 (es) * | 2014-07-21 | 2016-11-03 | Consejo Superior De Investigaciones Científicas (Csic) | Procedimiento de obtención de nanopartículas de fosfato de calcio amorfo recubiertas de citrato y dopadas con flúor |
EP3236947B1 (fr) * | 2014-12-22 | 2023-06-28 | Consiglio Nazionale Delle Ricerche | Produits pour l'administration de composés thérapeutiques/diagnostiques au coeur |
EP3334685A1 (fr) * | 2015-08-11 | 2018-06-20 | Thomas Bein | Nanoparticules mésoporeuses de phosphate et de citrate de calcium et leurs utilisations |
US10406078B2 (en) * | 2016-11-18 | 2019-09-10 | Pac-Dent International, Inc. | Nano-complexes for enamel remineralization |
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2018
- 2018-06-28 IT IT102018000006753A patent/IT201800006753A1/it unknown
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2019
- 2019-06-27 EP EP19742294.2A patent/EP3813762B1/fr active Active
- 2019-06-27 ES ES19742294T patent/ES2906408T3/es active Active
- 2019-06-27 TW TW108122608A patent/TWI819013B/zh active
- 2019-06-27 AU AU2019295211A patent/AU2019295211B2/en active Active
- 2019-06-27 CN CN201980043839.4A patent/CN112384187B/zh active Active
- 2019-06-27 EA EA202190142A patent/EA039099B1/ru unknown
- 2019-06-27 UA UAA202100287A patent/UA127460C2/uk unknown
- 2019-06-27 JP JP2020572498A patent/JP7044906B2/ja active Active
- 2019-06-27 US US17/255,522 patent/US11377353B2/en active Active
- 2019-06-27 IL IL279585A patent/IL279585B2/en unknown
- 2019-06-27 PT PT197422942T patent/PT3813762T/pt unknown
- 2019-06-27 KR KR1020217002748A patent/KR20210025624A/ko unknown
- 2019-06-27 MA MA55429A patent/MA55429B1/fr unknown
- 2019-06-27 MD MDE20210426T patent/MD3813762T2/ro unknown
- 2019-06-27 DK DK19742294.2T patent/DK3813762T3/da active
- 2019-06-27 WO PCT/EP2019/067188 patent/WO2020002517A1/fr active Application Filing
- 2019-06-27 JO JOP/2020/0316A patent/JOP20200316A1/ar unknown
- 2019-06-27 HU HUE19742294A patent/HUE058215T2/hu unknown
- 2019-06-27 LT LTEPPCT/EP2019/067188T patent/LT3813762T/lt unknown
- 2019-06-27 BR BR112020026617-5A patent/BR112020026617B1/pt active IP Right Grant
- 2019-06-27 SG SG11202012901VA patent/SG11202012901VA/en unknown
- 2019-06-27 HR HRP20220157TT patent/HRP20220157T1/hr unknown
- 2019-06-27 MX MX2020013890A patent/MX2020013890A/es unknown
- 2019-06-27 SI SI201930164T patent/SI3813762T1/sl unknown
- 2019-06-27 PL PL19742294T patent/PL3813762T3/pl unknown
- 2019-06-27 RS RS20220101A patent/RS62957B1/sr unknown
- 2019-06-27 CA CA3103861A patent/CA3103861A1/fr active Pending
- 2019-06-28 AR ARP190101805A patent/AR120965A1/es active IP Right Grant
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2020
- 2020-12-22 PH PH12020552250A patent/PH12020552250A1/en unknown
- 2020-12-24 SA SA520420892A patent/SA520420892B1/ar unknown
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2021
- 2021-01-08 EC ECSENADI20211201A patent/ECSP21001201A/es unknown
- 2021-01-20 ZA ZA2021/00423A patent/ZA202100423B/en unknown
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2022
- 2022-02-15 CY CY20221100130T patent/CY1124996T1/el unknown
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