CY1124996T1 - Σταθεροποιημενο αμορφο φωσφορικο ασβεστιο ενισχυμενο με ιοντα φθοριου και μια διαδικασια για την παραγωγη αυτου - Google Patents
Σταθεροποιημενο αμορφο φωσφορικο ασβεστιο ενισχυμενο με ιοντα φθοριου και μια διαδικασια για την παραγωγη αυτουInfo
- Publication number
- CY1124996T1 CY1124996T1 CY20221100130T CY221100130T CY1124996T1 CY 1124996 T1 CY1124996 T1 CY 1124996T1 CY 20221100130 T CY20221100130 T CY 20221100130T CY 221100130 T CY221100130 T CY 221100130T CY 1124996 T1 CY1124996 T1 CY 1124996T1
- Authority
- CY
- Cyprus
- Prior art keywords
- nanoparticle
- solution
- citrate
- calcium phosphate
- amorphous calcium
- Prior art date
Links
- 229910000389 calcium phosphate Inorganic materials 0.000 title abstract 3
- 239000001506 calcium phosphate Substances 0.000 title abstract 3
- 235000011010 calcium phosphates Nutrition 0.000 title abstract 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 title 1
- 239000002105 nanoparticle Substances 0.000 abstract 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 150000005323 carbonate salts Chemical class 0.000 abstract 1
- 150000001860 citric acid derivatives Chemical class 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 150000002222 fluorine compounds Chemical class 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- -1 phosphate anion Chemical class 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
- C01B25/327—After-treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/838—Phosphorus compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/15—Compositions characterised by their physical properties
- A61K6/17—Particle size
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/50—Preparations specially adapted for dental root treatment
- A61K6/54—Filling; Sealing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/864—Phosphate cements
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2002/00—Crystal-structural characteristics
- C01P2002/01—Crystal-structural characteristics depicted by a TEM-image
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2002/00—Crystal-structural characteristics
- C01P2002/02—Amorphous compounds
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/01—Particle morphology depicted by an image
- C01P2004/03—Particle morphology depicted by an image obtained by SEM
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/01—Particle morphology depicted by an image
- C01P2004/04—Particle morphology depicted by an image obtained by TEM, STEM, STM or AFM
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/50—Agglomerated particles
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/60—Particles characterised by their size
- C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/12—Surface area
Landscapes
- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Geology (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Environmental & Geological Engineering (AREA)
- General Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Materials Engineering (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Composite Materials (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Manufacturing & Machinery (AREA)
- Dental Preparations (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Glass Compositions (AREA)
- Catalysts (AREA)
- Materials For Medical Uses (AREA)
Abstract
Η εφεύρεση αφορά μια διαδικασία για την παρασκευή ενός επικαλυμμένου με κιτρικό άλας άμορφου νανοσωματιδίου φωσφορικού ασβεστίου, που περιλαμβάνει τα ακόλουθα βήματα: 1) παροχή ενός πρώτου διαλύματος ενός άλατος ασβεστίου και ενός κιτρικού άλατος, όπου η μοριακή αναλογία κιτρικού ιόντος προς ιόν ασβεστίου είναι εντός του εύρους από 1 έως 2, λαμβάνοντας έτσι ένα καθαρό πρώτο διάλυμα, 2) παροχή ενός δεύτερου διαλύματος ενός άλατος που είναι σε θέση να δώσει φωσφορικό ανιόν και ένα ανθρακικό άλας, 3) ανάμειξη μαζί το διαυγές πρώτο διάλυμα και το δεύτερο διάλυμα σε ένα pΗ εντός του εύρους από 8 έως 11, 4) καθίζηση του νανοσωματιδίου, και 5) ξήρανση του νανοσωματιδίου που λαμβάνεται από το βήμα 4). Κατά προτίμηση και με πλεονεκτικό τρόπο η εφεύρεση προβλέπει την προσθήκη μιας ένωσης φθορίου στο βήμα 2) για τη λήψη ενός επικαλυμμένου με κιτρικό άλας άμορφου νανοσωματιδίου φωσφορικού ασβεστίου ενισχυμένου με φθόριο ή ενός συσσωματώματος νανοσωματιδίων. Το νανοσωματίδιο / συσσωμάτωμα νανοσωματιδίων της εφεύρεσης έχει μια ιδιαίτερη επιφάνεια και μια διάμετρο που επιτρέπει τη χρήση του ως βιοϋλικό για εφαρμογή στην οδοντιατρική.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102018000006753A IT201800006753A1 (it) | 2018-06-28 | 2018-06-28 | Calcio fosfato amorfo stabilizzato dopato con ioni fluoruro e un procedimento per produrlo |
| PCT/EP2019/067188 WO2020002517A1 (en) | 2018-06-28 | 2019-06-27 | Stabilized amorphous calcium phosphate doped with fluoride ions and a process for producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124996T1 true CY1124996T1 (el) | 2023-01-05 |
Family
ID=63491977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20221100130T CY1124996T1 (el) | 2018-06-28 | 2022-02-15 | Σταθεροποιημενο αμορφο φωσφορικο ασβεστιο ενισχυμενο με ιοντα φθοριου και μια διαδικασια για την παραγωγη αυτου |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US11377353B2 (el) |
| EP (1) | EP3813762B1 (el) |
| JP (1) | JP7044906B2 (el) |
| KR (1) | KR20210025624A (el) |
| CN (1) | CN112384187B (el) |
| AR (1) | AR120965A1 (el) |
| AU (1) | AU2019295211B2 (el) |
| BR (1) | BR112020026617B1 (el) |
| CA (1) | CA3103861A1 (el) |
| CY (1) | CY1124996T1 (el) |
| DK (1) | DK3813762T3 (el) |
| EA (1) | EA039099B1 (el) |
| EC (1) | ECSP21001201A (el) |
| ES (1) | ES2906408T3 (el) |
| HR (1) | HRP20220157T1 (el) |
| HU (1) | HUE058215T2 (el) |
| IL (1) | IL279585B2 (el) |
| IT (1) | IT201800006753A1 (el) |
| JO (1) | JOP20200316A1 (el) |
| LT (1) | LT3813762T (el) |
| MA (1) | MA55429B1 (el) |
| MD (1) | MD3813762T2 (el) |
| MX (1) | MX2020013890A (el) |
| PH (1) | PH12020552250A1 (el) |
| PL (1) | PL3813762T3 (el) |
| PT (1) | PT3813762T (el) |
| RS (1) | RS62957B1 (el) |
| SA (1) | SA520420892B1 (el) |
| SG (1) | SG11202012901VA (el) |
| SI (1) | SI3813762T1 (el) |
| TW (1) | TWI819013B (el) |
| UA (1) | UA127460C2 (el) |
| WO (1) | WO2020002517A1 (el) |
| ZA (1) | ZA202100423B (el) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111362661A (zh) * | 2020-04-17 | 2020-07-03 | 中山职业技术学院 | 一种高密度无定形磷酸钙纳米粉体及其制备方法和应用 |
| CN114886782B (zh) * | 2022-05-07 | 2023-06-16 | 深圳市博威凯特科技有限公司 | 一种基于纳米羟基磷灰石的活态钙复合物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7670579B2 (en) * | 2004-04-06 | 2010-03-02 | American Dental Association Foundation | Nanostructured bioactive materials prepared by dual nozzle spray drying techniques |
| CN103876945B (zh) * | 2014-04-17 | 2016-08-03 | 厦门大学 | 一种牙本质小管封闭剂及其制备方法 |
| ES2557183B1 (es) * | 2014-07-21 | 2016-11-03 | Consejo Superior De Investigaciones Científicas (Csic) | Procedimiento de obtención de nanopartículas de fosfato de calcio amorfo recubiertas de citrato y dopadas con flúor |
| AU2015370986B2 (en) * | 2014-12-22 | 2021-02-04 | Consiglio Nazionale Delle Ricerche | Products for the delivery of therapeutic/diagnostic compounds to the heart |
| WO2017025359A1 (en) * | 2015-08-11 | 2017-02-16 | FECKL, Johann | Mesoporous calcium phosphate-citrate nanoparticles and uses thereof |
| US10406078B2 (en) * | 2016-11-18 | 2019-09-10 | Pac-Dent International, Inc. | Nano-complexes for enamel remineralization |
-
2018
- 2018-06-28 IT IT102018000006753A patent/IT201800006753A1/it unknown
-
2019
- 2019-06-27 IL IL279585A patent/IL279585B2/en unknown
- 2019-06-27 HR HRP20220157TT patent/HRP20220157T1/hr unknown
- 2019-06-27 CN CN201980043839.4A patent/CN112384187B/zh active Active
- 2019-06-27 MD MDE20210426T patent/MD3813762T2/ro unknown
- 2019-06-27 TW TW108122608A patent/TWI819013B/zh active
- 2019-06-27 MA MA55429A patent/MA55429B1/fr unknown
- 2019-06-27 SI SI201930164T patent/SI3813762T1/sl unknown
- 2019-06-27 PT PT197422942T patent/PT3813762T/pt unknown
- 2019-06-27 RS RS20220101A patent/RS62957B1/sr unknown
- 2019-06-27 JP JP2020572498A patent/JP7044906B2/ja active Active
- 2019-06-27 CA CA3103861A patent/CA3103861A1/en active Pending
- 2019-06-27 WO PCT/EP2019/067188 patent/WO2020002517A1/en unknown
- 2019-06-27 MX MX2020013890A patent/MX2020013890A/es unknown
- 2019-06-27 LT LTEPPCT/EP2019/067188T patent/LT3813762T/lt unknown
- 2019-06-27 UA UAA202100287A patent/UA127460C2/uk unknown
- 2019-06-27 BR BR112020026617-5A patent/BR112020026617B1/pt active IP Right Grant
- 2019-06-27 KR KR1020217002748A patent/KR20210025624A/ko unknown
- 2019-06-27 PL PL19742294T patent/PL3813762T3/pl unknown
- 2019-06-27 DK DK19742294.2T patent/DK3813762T3/da active
- 2019-06-27 US US17/255,522 patent/US11377353B2/en active Active
- 2019-06-27 ES ES19742294T patent/ES2906408T3/es active Active
- 2019-06-27 EP EP19742294.2A patent/EP3813762B1/en active Active
- 2019-06-27 SG SG11202012901VA patent/SG11202012901VA/en unknown
- 2019-06-27 HU HUE19742294A patent/HUE058215T2/hu unknown
- 2019-06-27 JO JOP/2020/0316A patent/JOP20200316A1/ar unknown
- 2019-06-27 AU AU2019295211A patent/AU2019295211B2/en active Active
- 2019-06-27 EA EA202190142A patent/EA039099B1/ru unknown
- 2019-06-28 AR ARP190101805A patent/AR120965A1/es active IP Right Grant
-
2020
- 2020-12-22 PH PH12020552250A patent/PH12020552250A1/en unknown
- 2020-12-24 SA SA520420892A patent/SA520420892B1/ar unknown
-
2021
- 2021-01-08 EC ECSENADI20211201A patent/ECSP21001201A/es unknown
- 2021-01-20 ZA ZA2021/00423A patent/ZA202100423B/en unknown
-
2022
- 2022-02-15 CY CY20221100130T patent/CY1124996T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1124996T1 (el) | Σταθεροποιημενο αμορφο φωσφορικο ασβεστιο ενισχυμενο με ιοντα φθοριου και μια διαδικασια για την παραγωγη αυτου | |
| DK2070991T3 (da) | Fremgangsmåde til frembringelse af overflademodificeret, udfældet calciumcarbonat | |
| CY1126052T1 (el) | 1η-πυρρολο[2,3-c]πυριδιν-7(6η)-ονες και πυραζολο[3,4-c]πυριδιν-7(6η)- ονες ως αναστολεις των bet πρωτεϊνων | |
| BR112017015109A2 (pt) | processo controlado para precipitar carbonato de cálcio | |
| CY1105664T1 (el) | Ομοιογενως επικαλυμμενη διαταξη εχουσα οστεοεπαγωγικες και οστεοαγωγους ιδιοτητες | |
| RU2008102637A (ru) | Ионные комплексы | |
| DE60327251D1 (de) | MIT EINEM LiFePO4 UND WASSERLÖSLICHEN BINDEMITTEL ENTHALTENDEN FILM BESCHICHTETE KATHODE, HERSTELLUNGSVERFAHREN DAFÜR UND ELEKTROCHEMISCHES SYSTEM | |
| EA201792446A1 (ru) | Водная композиция для системы тонирования, комплект компонентов для системы тонирования, тонированные системы покраски и штукатурки, покраска и штукатурка путем нанесения тонированных систем покраски и штукатурки | |
| CY1116044T1 (el) | Μεθοδος για την παρασκευη δισκιων που περιεχουν s-αδενοσυλομεθειονινη | |
| MX2021005060A (es) | Produccion de cemento. | |
| CY1121770T1 (el) | Συνθεσεις για χρηση στην ογκολογια | |
| RU2018115132A (ru) | Производство составов фосфата кальция | |
| RU2017101869A (ru) | Способ получения покрытых цитратом и легированных фторидом наночастиц аморфного фосфата кальция | |
| ATE223919T1 (de) | Ionische flüssigkeiten, ihre herstellung und ihre verwendung | |
| ES2194753T3 (es) | Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. | |
| PH12021050073A1 (en) | Hypochlorous acid disinfectant and its production method | |
| MX2021006228A (es) | Produccion de sales de calcio tratado en superficie por conversion inducida por molienda. | |
| CY1125059T1 (el) | Πολυμορφο νεριδρονικου αλατος νατριου και μεθοδος παρασκευης αυτου | |
| ATE416182T1 (de) | Kristalline form von risedronat-mononatrium | |
| RU2015138950A (ru) | Презерватив | |
| PL424963A1 (pl) | Krystaliczna forma kompleksu dihydrat triakwabis(1,3-dimetyloksantyno)miedź(II) i sposób jej wytwarzania | |
| PL439911A1 (pl) | Krystaliczna forma polimeru koordynacyjnego poli-bis(L-arginina)octaazydotetramiedź(II) hydrat ¼ oraz sposób jej wytwarzania | |
| PL419359A1 (pl) | Sposób modyfikowania grupami bisfosfonowymi i/lub fosfonowymi materiałów węglowych zwłaszcza nanomateriałów | |
| SE1551530A1 (en) | A method of manufacturing a pole | |
| US111602A (en) | Improvement in coating brick, wood, and other surfaces on walls |