ES2194753T3 - Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. - Google Patents

Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.

Info

Publication number
ES2194753T3
ES2194753T3 ES00945957T ES00945957T ES2194753T3 ES 2194753 T3 ES2194753 T3 ES 2194753T3 ES 00945957 T ES00945957 T ES 00945957T ES 00945957 T ES00945957 T ES 00945957T ES 2194753 T3 ES2194753 T3 ES 2194753T3
Authority
ES
Spain
Prior art keywords
amino
procedure
obtaining
trihydrated
hydroxibutiliden
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00945957T
Other languages
English (en)
Inventor
I Llado Jordi Bosch
Lista Eugenia Pagans
Miguel M Del Carmen Onrubia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medichem SA
Original Assignee
Medichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem SA filed Critical Medichem SA
Application granted granted Critical
Publication of ES2194753T3 publication Critical patent/ES2194753T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procedimiento para la obtención del ácido 4-amino-1- hidroxibutiliden-1, 1-bisfosfónico y de su sal monosódica trihidratada consistente en hacer reaccionar el ácido 4- aminobutírico con una mezcla de fosfonación e hidrolizar el producto resultante de la reacción para aislar posteriormente, mediante el ajuste de pH adecuado, el ácido libre o la sal monosódica, caracterizado porque la mezcla de fosfonación está formada por ácido fosforoso y anhídrido metansulfónico.
ES00945957T 1999-08-06 2000-07-17 Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. Expired - Lifetime ES2194753T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009901806A ES2153794B1 (es) 1999-08-06 1999-08-06 Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.

Publications (1)

Publication Number Publication Date
ES2194753T3 true ES2194753T3 (es) 2003-12-01

Family

ID=8309563

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009901806A Expired - Fee Related ES2153794B1 (es) 1999-08-06 1999-08-06 Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
ES00945957T Expired - Lifetime ES2194753T3 (es) 1999-08-06 2000-07-17 Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES009901806A Expired - Fee Related ES2153794B1 (es) 1999-08-06 1999-08-06 Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.

Country Status (18)

Country Link
US (1) US6573401B1 (es)
EP (1) EP1205484B1 (es)
KR (1) KR100688287B1 (es)
AT (1) ATE238317T1 (es)
AU (1) AU5987300A (es)
BR (1) BR0013031A (es)
CA (1) CA2380841C (es)
CR (1) CR6575A (es)
DE (1) DE60002347T2 (es)
DK (1) DK1205484T3 (es)
ES (2) ES2153794B1 (es)
HU (1) HUP0202196A3 (es)
IL (1) IL148000A (es)
MX (1) MXPA02001293A (es)
PL (1) PL191733B1 (es)
PT (1) PT1205484E (es)
SI (1) SI1205484T1 (es)
WO (1) WO2001010874A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
WO2003057136A2 (en) * 2001-12-24 2003-07-17 Teva Pharmaceutical Industries Ltd. Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
ITMI20020908A1 (it) 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
US7038083B2 (en) * 2002-05-17 2006-05-02 Teva Pharmaceutical Industries, Ltd. Process for making bisphosphonic acids using diluents other than halogenated hydrocarbons
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
WO2005035542A1 (en) * 2003-10-14 2005-04-21 Pliva-Istrazivanje I Razvoj D.O.O. Solid-state form of alendronate sodium and preparation thereof
EP1883644A2 (en) * 2005-05-06 2008-02-06 Medichem, S.A. Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof
WO2006134603A1 (en) 2005-06-13 2006-12-21 Jubilant Organosys Limited Process for producing bisphosphonic acids and forms thereof
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
EP2016084A2 (en) * 2006-05-11 2009-01-21 Ind-Swift Laboratories Limited Process for the preparation of pure risedronic acid or salts
WO2011039378A1 (en) 2009-10-02 2011-04-07 Straitmark Holding Ag Method for the manufacture of aminohydroxy diphosphonic acids

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016289A1 (de) 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de) * 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
GB2248061A (en) * 1990-09-18 1992-03-25 Merck & Co Inc Amino-hydroxy-alkylidene bis phosphonic acids
US5039819A (en) 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
IT1246992B (it) * 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
US5510517A (en) 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
TW257765B (es) 1993-08-25 1995-09-21 Merck & Co Inc
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
EA003861B1 (ru) * 1999-02-17 2003-10-30 Тева Фармасьютикал Индастриес Лтд. Новый способ получения алендроновой кислоты

Also Published As

Publication number Publication date
CA2380841A1 (en) 2001-02-15
KR20020024320A (ko) 2002-03-29
EP1205484A1 (en) 2002-05-15
EP1205484B1 (en) 2003-04-23
IL148000A0 (en) 2002-09-12
SI1205484T1 (en) 2003-12-31
DE60002347T2 (de) 2004-02-12
MXPA02001293A (es) 2002-07-22
IL148000A (en) 2005-12-18
PL354033A1 (en) 2003-12-15
CR6575A (es) 2002-08-16
WO2001010874A1 (es) 2001-02-15
KR100688287B1 (ko) 2007-02-28
AU5987300A (en) 2001-03-05
HUP0202196A3 (en) 2002-12-28
DK1205484T3 (da) 2003-08-11
ES2153794B1 (es) 2001-10-16
ATE238317T1 (de) 2003-05-15
BR0013031A (pt) 2002-04-16
CA2380841C (en) 2009-09-15
DE60002347D1 (de) 2003-05-28
ES2153794A1 (es) 2001-03-01
US6573401B1 (en) 2003-06-03
PT1205484E (pt) 2003-08-29
HUP0202196A2 (en) 2002-10-28
PL191733B1 (pl) 2006-06-30

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