ES2194753T3 - Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. - Google Patents
Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.Info
- Publication number
- ES2194753T3 ES2194753T3 ES00945957T ES00945957T ES2194753T3 ES 2194753 T3 ES2194753 T3 ES 2194753T3 ES 00945957 T ES00945957 T ES 00945957T ES 00945957 T ES00945957 T ES 00945957T ES 2194753 T3 ES2194753 T3 ES 2194753T3
- Authority
- ES
- Spain
- Prior art keywords
- amino
- procedure
- obtaining
- trihydrated
- hydroxibutiliden
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- IZDROVVXIHRYMH-UHFFFAOYSA-N methanesulfonic anhydride Chemical compound CS(=O)(=O)OS(C)(=O)=O IZDROVVXIHRYMH-UHFFFAOYSA-N 0.000 abstract 1
- 238000010979 pH adjustment Methods 0.000 abstract 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Procedimiento para la obtención del ácido 4-amino-1- hidroxibutiliden-1, 1-bisfosfónico y de su sal monosódica trihidratada consistente en hacer reaccionar el ácido 4- aminobutírico con una mezcla de fosfonación e hidrolizar el producto resultante de la reacción para aislar posteriormente, mediante el ajuste de pH adecuado, el ácido libre o la sal monosódica, caracterizado porque la mezcla de fosfonación está formada por ácido fosforoso y anhídrido metansulfónico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009901806A ES2153794B1 (es) | 1999-08-06 | 1999-08-06 | Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2194753T3 true ES2194753T3 (es) | 2003-12-01 |
Family
ID=8309563
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009901806A Expired - Fee Related ES2153794B1 (es) | 1999-08-06 | 1999-08-06 | Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. |
ES00945957T Expired - Lifetime ES2194753T3 (es) | 1999-08-06 | 2000-07-17 | Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009901806A Expired - Fee Related ES2153794B1 (es) | 1999-08-06 | 1999-08-06 | Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. |
Country Status (18)
Country | Link |
---|---|
US (1) | US6573401B1 (es) |
EP (1) | EP1205484B1 (es) |
KR (1) | KR100688287B1 (es) |
AT (1) | ATE238317T1 (es) |
AU (1) | AU5987300A (es) |
BR (1) | BR0013031A (es) |
CA (1) | CA2380841C (es) |
CR (1) | CR6575A (es) |
DE (1) | DE60002347T2 (es) |
DK (1) | DK1205484T3 (es) |
ES (2) | ES2153794B1 (es) |
HU (1) | HUP0202196A3 (es) |
IL (1) | IL148000A (es) |
MX (1) | MXPA02001293A (es) |
PL (1) | PL191733B1 (es) |
PT (1) | PT1205484E (es) |
SI (1) | SI1205484T1 (es) |
WO (1) | WO2001010874A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040052843A1 (en) * | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
WO2003057136A2 (en) * | 2001-12-24 | 2003-07-17 | Teva Pharmaceutical Industries Ltd. | Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it |
ITMI20020908A1 (it) | 2002-04-29 | 2003-10-29 | Chemi Spa | Processo di preparazione di sodio alendronato |
US7038083B2 (en) * | 2002-05-17 | 2006-05-02 | Teva Pharmaceutical Industries, Ltd. | Process for making bisphosphonic acids using diluents other than halogenated hydrocarbons |
HUP0300227A2 (hu) * | 2003-01-28 | 2004-09-28 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására |
WO2005035542A1 (en) * | 2003-10-14 | 2005-04-21 | Pliva-Istrazivanje I Razvoj D.O.O. | Solid-state form of alendronate sodium and preparation thereof |
EP1883644A2 (en) * | 2005-05-06 | 2008-02-06 | Medichem, S.A. | Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof |
WO2006134603A1 (en) | 2005-06-13 | 2006-12-21 | Jubilant Organosys Limited | Process for producing bisphosphonic acids and forms thereof |
US8003820B2 (en) * | 2005-10-20 | 2011-08-23 | Dr. Reddy's Laboratories Limited | Process for preparing bisphosphonic acids |
WO2007083240A2 (en) | 2006-01-20 | 2007-07-26 | Aurobindo Pharma Limited | An improved process for the preparation of bisphosphonic acids |
EP2016084A2 (en) * | 2006-05-11 | 2009-01-21 | Ind-Swift Laboratories Limited | Process for the preparation of pure risedronic acid or salts |
WO2011039378A1 (en) | 2009-10-02 | 2011-04-07 | Straitmark Holding Ag | Method for the manufacture of aminohydroxy diphosphonic acids |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3016289A1 (de) | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
US4639338A (en) * | 1984-08-06 | 1987-01-27 | Ciba-Geigy Corporation | Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate |
DE3434667A1 (de) * | 1984-09-21 | 1986-04-03 | Henkel KGaA, 4000 Düsseldorf | 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung |
IT1196315B (it) | 1984-10-29 | 1988-11-16 | Gentili Ist Spa | Procedimento per la preparazione di acidi difosfonici |
US4922007A (en) * | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
US5019651A (en) | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
GB2248061A (en) * | 1990-09-18 | 1992-03-25 | Merck & Co Inc | Amino-hydroxy-alkylidene bis phosphonic acids |
US5039819A (en) | 1990-09-18 | 1991-08-13 | Merck & Co., Inc. | Diphosphonate intermediate for preparing an antihypercalcemic agent |
IT1246992B (it) * | 1991-01-08 | 1994-12-12 | Gentili Ist Spa | Procedimento per la preparazione di acidi difosfonici e loro sali |
US5510517A (en) | 1993-08-25 | 1996-04-23 | Merck & Co., Inc. | Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids |
TW257765B (es) | 1993-08-25 | 1995-09-21 | Merck & Co Inc | |
CA2197267C (en) * | 1997-02-11 | 2000-02-08 | Yong Tao | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
EA003861B1 (ru) * | 1999-02-17 | 2003-10-30 | Тева Фармасьютикал Индастриес Лтд. | Новый способ получения алендроновой кислоты |
-
1999
- 1999-08-06 ES ES009901806A patent/ES2153794B1/es not_active Expired - Fee Related
-
2000
- 2000-07-17 BR BR0013031-1A patent/BR0013031A/pt not_active Application Discontinuation
- 2000-07-17 AT AT00945957T patent/ATE238317T1/de not_active IP Right Cessation
- 2000-07-17 DK DK00945957T patent/DK1205484T3/da active
- 2000-07-17 SI SI200030140T patent/SI1205484T1/xx unknown
- 2000-07-17 AU AU59873/00A patent/AU5987300A/en not_active Abandoned
- 2000-07-17 WO PCT/ES2000/000254 patent/WO2001010874A1/es active IP Right Grant
- 2000-07-17 IL IL14800000A patent/IL148000A/xx not_active IP Right Cessation
- 2000-07-17 MX MXPA02001293A patent/MXPA02001293A/es active IP Right Grant
- 2000-07-17 ES ES00945957T patent/ES2194753T3/es not_active Expired - Lifetime
- 2000-07-17 PL PL354033A patent/PL191733B1/pl not_active IP Right Cessation
- 2000-07-17 DE DE60002347T patent/DE60002347T2/de not_active Expired - Fee Related
- 2000-07-17 CA CA002380841A patent/CA2380841C/en not_active Expired - Fee Related
- 2000-07-17 US US10/048,267 patent/US6573401B1/en not_active Expired - Fee Related
- 2000-07-17 HU HU0202196A patent/HUP0202196A3/hu unknown
- 2000-07-17 EP EP00945957A patent/EP1205484B1/en not_active Expired - Lifetime
- 2000-07-17 KR KR1020027001589A patent/KR100688287B1/ko not_active IP Right Cessation
- 2000-07-17 PT PT00945957T patent/PT1205484E/pt unknown
-
2002
- 2002-01-31 CR CR6575A patent/CR6575A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA2380841A1 (en) | 2001-02-15 |
KR20020024320A (ko) | 2002-03-29 |
EP1205484A1 (en) | 2002-05-15 |
EP1205484B1 (en) | 2003-04-23 |
IL148000A0 (en) | 2002-09-12 |
SI1205484T1 (en) | 2003-12-31 |
DE60002347T2 (de) | 2004-02-12 |
MXPA02001293A (es) | 2002-07-22 |
IL148000A (en) | 2005-12-18 |
PL354033A1 (en) | 2003-12-15 |
CR6575A (es) | 2002-08-16 |
WO2001010874A1 (es) | 2001-02-15 |
KR100688287B1 (ko) | 2007-02-28 |
AU5987300A (en) | 2001-03-05 |
HUP0202196A3 (en) | 2002-12-28 |
DK1205484T3 (da) | 2003-08-11 |
ES2153794B1 (es) | 2001-10-16 |
ATE238317T1 (de) | 2003-05-15 |
BR0013031A (pt) | 2002-04-16 |
CA2380841C (en) | 2009-09-15 |
DE60002347D1 (de) | 2003-05-28 |
ES2153794A1 (es) | 2001-03-01 |
US6573401B1 (en) | 2003-06-03 |
PT1205484E (pt) | 2003-08-29 |
HUP0202196A2 (en) | 2002-10-28 |
PL191733B1 (pl) | 2006-06-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2194753T3 (es) | Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. | |
FI960851A (fi) | Menetelmä N-amino-1-hydroksi-alkylideeni-1,1-bisfosfonihappojen valmistamiseksi | |
ES2193605T3 (es) | Procedimiento para la preparacion de acidos dialquil-fosfinicos. | |
CY1111600T1 (el) | Αμορφη ριτοναβιρη | |
RS53403A (en) | Process for making amlodipine maleate | |
EP1164127A4 (en) | PROCESS FOR PRODUCTION OF ONIUM SALT DERIVATIVE AND NEW ONIUM SALT DERIVATIVE | |
ES2138539B1 (es) | "fabricacion de acido 3-amino-1-hidroxipropano-1,1-difosfonico". | |
DK434989D0 (da) | Fremgangsmaade til kontinuerlig fremstilling af 2-phosphonobutan-1,2,4-tricarboxylsyre eller dennes alkalimetalsalte | |
MA23155A1 (fr) | Procede de production de l'acide aminomethanephosphonique | |
HUP0300227A2 (hu) | Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására | |
BR0015663A (pt) | Processo de preparação de ácido linoléico conjugado | |
AU4048701A (en) | Process for preparing alkylene diamine triacetic acid | |
DE69914493D1 (de) | Verfahren zur herstellung von 2-hydroxy-6-trifluormethylpyridin | |
DE50201297D1 (de) | Verfahren zur herstellung von 1-hydroxy-1, 1-diphosphonsäureverbindungen | |
SE9903345D0 (sv) | Novel process | |
ES2194745T3 (es) | Procedimiento para la obtencion de 4,6-dicloropirimidi-na. | |
FR2795728B1 (fr) | Procede de preparation de l'acide lysergique | |
DE69907961D1 (de) | Verfahren zur herstellung fliessfähiger, konzentrierter betainlösungen | |
DE50202429D1 (de) | Verfahren zur herstellung von peracylierten 1-o-glycosiden |