CY1111600T1 - Αμορφη ριτοναβιρη - Google Patents

Αμορφη ριτοναβιρη

Info

Publication number
CY1111600T1
CY1111600T1 CY20091100614T CY091100614T CY1111600T1 CY 1111600 T1 CY1111600 T1 CY 1111600T1 CY 20091100614 T CY20091100614 T CY 20091100614T CY 091100614 T CY091100614 T CY 091100614T CY 1111600 T1 CY1111600 T1 CY 1111600T1
Authority
CY
Cyprus
Prior art keywords
amorphous ritonavir
ritonavir
preparation
relates
substantially pure
Prior art date
Application number
CY20091100614T
Other languages
English (en)
Inventor
John F Bauer
Azita Saleki-Gerhardt
Sanjay R Chemburkar
Ketan Patel
Harry O Spiwek
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26817251&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1111600(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of CY1111600T1 publication Critical patent/CY1111600T1/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28Radicals substituted by nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Steroid Compounds (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με την ουσιαστικώς καθαρή άμορφη ριτοναβίρη και με μία διεργασία για την παρασκευή εξ αυτής. Η εφεύρεση σχετίζεται επίσης με μία διεργασία για την παρασκευή του ουσιαστικώς καθαρού κρυσταλλικού πολύμορφου ριτοναβίρης Μορφή I.
CY20091100614T 1998-07-20 2009-06-11 Αμορφη ριτοναβιρη CY1111600T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11934598A 1998-07-20 1998-07-20
US32609399A 1999-06-04 1999-06-04
EP20030029709 EP1418174B1 (en) 1998-07-20 1999-07-19 Amorphous Ritonavir

Publications (1)

Publication Number Publication Date
CY1111600T1 true CY1111600T1 (el) 2015-10-07

Family

ID=26817251

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20091100614T CY1111600T1 (el) 1998-07-20 2009-06-11 Αμορφη ριτοναβιρη
CY20111101205T CY1112139T1 (el) 1998-07-20 2011-12-05 Μια φαρμακευτικη συνθεση περιλαμβανουσα κρυσταλλικη ριτοναβιρη μορφη ιι και ενα παρασκευασμα εξ αυτης

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20111101205T CY1112139T1 (el) 1998-07-20 2011-12-05 Μια φαρμακευτικη συνθεση περιλαμβανουσα κρυσταλλικη ριτοναβιρη μορφη ιι και ενα παρασκευασμα εξ αυτης

Country Status (30)

Country Link
EP (4) EP2017269B1 (el)
JP (4) JP4815050B2 (el)
KR (3) KR100853371B1 (el)
CN (5) CN101259128A (el)
AR (5) AR019431A1 (el)
AT (3) ATE425974T1 (el)
AU (1) AU768207B2 (el)
BG (4) BG65150B1 (el)
BR (1) BR9912010A (el)
CA (3) CA2510949C (el)
CO (1) CO5090830A1 (el)
CY (2) CY1111600T1 (el)
CZ (2) CZ307116B6 (el)
DE (2) DE69915628T2 (el)
DK (3) DK1097148T3 (el)
ES (3) ES2214038T3 (el)
HK (2) HK1037918A1 (el)
HU (3) HU230150B1 (el)
ID (1) ID27996A (el)
IL (4) IL140492A0 (el)
MY (2) MY145265A (el)
NO (2) NO318385B1 (el)
NZ (2) NZ509125A (el)
PL (2) PL213978B1 (el)
PT (3) PT1097148E (el)
SI (3) SI1097148T1 (el)
SK (3) SK286388B6 (el)
TR (1) TR200100171T2 (el)
TW (3) TWI271400B (el)
WO (1) WO2000004016A2 (el)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY145265A (en) * 1998-07-20 2012-01-13 Abbott Lab Amorphous ritonavir
US6894171B1 (en) 1998-07-20 2005-05-17 Abbott Laboratories Polymorph of a pharmaceutical
SI1183026T1 (sl) * 1999-06-04 2006-10-31 Abbott Lab Izboljsane farmacevtske spojine, vsebujoce ritonavir
CA2448438A1 (en) * 2001-05-25 2002-12-05 Abbott Laboratories Soft elastic capsules comprising ritonavir and/or lopinavir
AR037797A1 (es) * 2001-12-12 2004-12-01 Tibotec Pharm Ltd Combinacion de inhibidores de proteasa dependientes del citocromo p450
US7205413B2 (en) 2002-05-03 2007-04-17 Transform Pharmaceuticals, Inc. Solvates and polymorphs of ritonavir and methods of making and using the same
US8377952B2 (en) * 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
BRPI0401742B8 (pt) 2004-05-13 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda composto análogo do ritonavir útil como inibidor de protease retroviral, preparação do composto análogo do ritonavir e composição farmacêutica do composto análogo do ritonavir
EP1891027A1 (en) * 2005-05-30 2008-02-27 Ranbaxy Laboratories Limited Processes for the preparation of stable polymorphic form i of ritonavir
WO2008041176A2 (en) * 2006-10-03 2008-04-10 Ranbaxy Laboratories Limited Process for the preparation of form i and form ii of ritonavir
CN102898398B (zh) * 2011-07-27 2015-01-14 上海迪赛诺药业有限公司 一种制备i型利托那韦多晶型结晶的方法
ES2587559T3 (es) 2012-03-07 2016-10-25 Ratiopharm Gmbh Forma farmacéutica que comprende lopinavir y ritonavir
EP2822553B1 (en) 2012-03-07 2016-05-18 ratiopharm GmbH Dosage form comprising non-crystalline lopinavir and crystalline ritonavir
CA2918707A1 (en) 2013-08-29 2015-03-05 Teva Pharmaceuticals Industries Ltd. Unit dosage form comprising emtricitabine, tenofovir, darunavir and ritonavir and a monolithic tablet comprising darunavir and ritonavir
AU2015245217A1 (en) 2014-04-08 2016-10-13 Teva Pharmaceutical Industries Ltd. Unit dosage form comprising Emtricitabine, Tenofovir, Darunavir and Ritonavir
CN106749085B (zh) * 2016-12-23 2019-05-24 东北制药集团股份有限公司 一种制备利托那韦的方法
EP3569225A1 (en) 2018-05-18 2019-11-20 Pharmaceutical Oriented Services Ltd Solid dispersion containing ritonavir
RU2759544C1 (ru) * 2021-01-29 2021-11-15 Общество с ограниченной ответственностью "АМЕДАРТ" Твёрдая фармацевтическая композиция для изготовления перорального терапевтического средства для профилактики и/или лечения ВИЧ-инфекции

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696270A (en) 1989-05-23 1997-12-09 Abbott Laboratories Intermediate for making retroviral protease inhibiting compounds
US5354866A (en) 1989-05-23 1994-10-11 Abbott Laboratories Retroviral protease inhibiting compounds
ATE143262T1 (de) * 1992-12-29 1996-10-15 Abbott Lab Inhibitoren der retroviralen protease
IL110752A (en) 1993-09-13 2000-07-26 Abbott Lab Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
US5559158A (en) 1993-10-01 1996-09-24 Abbott Laboratories Pharmaceutical composition
US5491253A (en) 1993-10-22 1996-02-13 Abbott Laboratories Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane
IL111991A (en) 1994-01-28 2000-07-26 Abbott Lab Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent
US5567823A (en) * 1995-06-06 1996-10-22 Abbott Laboratories Process for the preparation of an HIV protease inhibiting compound
US6037157A (en) * 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US6160122A (en) 1996-06-28 2000-12-12 Abbott Laboratories Process for the preparation of a disubstituted thiazole
ZA9710071B (en) * 1996-11-21 1998-05-25 Abbott Lab Pharmaceutical composition.
MY145265A (en) * 1998-07-20 2012-01-13 Abbott Lab Amorphous ritonavir
DE19856432A1 (de) * 1998-12-08 2000-06-15 Basf Ag Nanopartikuläre Kern-Schale Systeme sowie deren Verwendung in pharmazeutischen und kosmetischen Zubereitungen
SI1183026T1 (sl) * 1999-06-04 2006-10-31 Abbott Lab Izboljsane farmacevtske spojine, vsebujoce ritonavir

Also Published As

Publication number Publication date
HK1037918A1 (en) 2002-02-22
SI2017269T1 (sl) 2012-02-29
IL187181A0 (en) 2008-02-09
BG109682A (bg) 2007-03-30
AR019431A1 (es) 2002-02-20
NZ522690A (en) 2004-04-30
NO20042393L (no) 2001-01-18
IL140492A0 (en) 2002-02-10
DE69915628T2 (de) 2004-08-12
EP1097148B1 (en) 2004-03-17
KR100740796B1 (ko) 2007-07-20
TR200100171T2 (tr) 2001-05-21
JP5732212B2 (ja) 2015-06-10
AR049658A2 (es) 2006-08-23
AU768207B2 (en) 2003-12-04
ATE261947T1 (de) 2004-04-15
HK1121155A1 (en) 2009-04-17
CN101966180A (zh) 2011-02-09
PT1418174E (pt) 2009-06-08
HU0800266D0 (en) 2008-06-30
SI1418174T1 (sl) 2009-08-31
AU5003799A (en) 2000-02-07
ES2322759T3 (es) 2009-06-26
PT2017269E (pt) 2011-12-20
CY1112139T1 (el) 2015-11-04
IL140492A (en) 2010-12-30
AR044029A2 (es) 2005-08-24
KR20010072003A (ko) 2001-07-31
HUP0103823A2 (hu) 2002-02-28
IL191582A (en) 2016-02-29
HU0800267D0 (en) 2008-06-30
CN1310715B (zh) 2010-11-03
ES2214038T3 (es) 2004-09-01
JP2002520410A (ja) 2002-07-09
EP2298751A2 (en) 2011-03-23
PT1097148E (pt) 2004-05-31
PL213978B1 (pl) 2013-05-31
DK2017269T3 (da) 2012-03-05
EP2017269A2 (en) 2009-01-21
EP1097148A2 (en) 2001-05-09
BG65150B1 (bg) 2007-04-30
CA2337846A1 (en) 2000-01-27
SK922001A3 (en) 2001-07-10
SI1097148T1 (en) 2004-10-31
CO5090830A1 (es) 2001-10-30
TWI227713B (en) 2005-02-11
BR9912010A (pt) 2001-04-10
CN101259128A (zh) 2008-09-10
ES2372990T3 (es) 2012-01-30
BG66140B1 (bg) 2011-07-29
CA2510949C (en) 2009-11-17
CA2674800A1 (en) 2000-01-27
BG110080A (bg) 2008-11-28
AR059763A2 (es) 2008-04-30
KR100853371B1 (ko) 2008-08-22
CN1310715A (zh) 2001-08-29
TW200716550A (en) 2007-05-01
IL191582A0 (en) 2008-12-29
ID27996A (id) 2001-05-03
EP1418174B1 (en) 2009-03-18
HUP0103823A3 (en) 2003-05-28
IL187181A (en) 2009-09-01
BG105197A (en) 2001-10-31
EP1418174A2 (en) 2004-05-12
SK286388B6 (sk) 2008-09-05
JP2014074047A (ja) 2014-04-24
CZ307116B6 (cs) 2018-01-24
EP2017269A8 (en) 2009-09-30
HU230150B1 (hu) 2015-09-28
ATE534636T1 (de) 2011-12-15
CZ2006533A3 (cs) 2001-05-16
EP2298751A3 (en) 2011-08-17
EP1418174A3 (en) 2004-06-23
ATE425974T1 (de) 2009-04-15
KR100793046B1 (ko) 2008-01-10
NO318385B1 (no) 2005-03-14
CZ298188B6 (cs) 2007-07-18
HU229999B1 (en) 2015-04-28
KR20040081137A (ko) 2004-09-20
CN1502613A (zh) 2004-06-09
EP2017269A9 (en) 2009-10-14
EP2017269B1 (en) 2011-11-23
PL348033A1 (en) 2002-05-06
HU227540B1 (en) 2011-08-29
DE69915628D1 (en) 2004-04-22
TWI271400B (en) 2007-01-21
NO20010298D0 (no) 2001-01-18
WO2000004016A3 (en) 2000-03-30
PL194710B1 (pl) 2007-06-29
JP2017061475A (ja) 2017-03-30
NO327320B1 (no) 2009-06-08
SK287586B6 (sk) 2011-03-04
CA2510949A1 (en) 2000-01-27
CN102153524A (zh) 2011-08-17
WO2000004016A2 (en) 2000-01-27
CZ2001203A3 (en) 2001-05-16
JP2010270135A (ja) 2010-12-02
MY121765A (en) 2006-02-28
DE69940616D1 (de) 2009-04-30
TWI362382B (en) 2012-04-21
NZ509125A (en) 2003-02-28
DK1418174T3 (da) 2009-05-18
CA2337846C (en) 2006-02-21
MY145265A (en) 2012-01-13
EP2017269A3 (en) 2009-06-10
AR059764A2 (es) 2008-04-30
NO20010298L (no) 2001-01-18
SK287381B6 (sk) 2010-08-09
BG65963B1 (bg) 2010-07-30
DK1097148T3 (da) 2004-04-26
KR20060118022A (ko) 2006-11-17
JP4815050B2 (ja) 2011-11-16

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