CZ2006533A3 - Amorfní ritonavir, způsoby jeho přípravy, jeho použití a farmaceutická kompozice ho obsahující - Google Patents
Amorfní ritonavir, způsoby jeho přípravy, jeho použití a farmaceutická kompozice ho obsahujícíInfo
- Publication number
- CZ2006533A3 CZ2006533A3 CZ2006533A CZ2006533A CZ2006533A3 CZ 2006533 A3 CZ2006533 A3 CZ 2006533A3 CZ 2006533 A CZ2006533 A CZ 2006533A CZ 2006533 A CZ2006533 A CZ 2006533A CZ 2006533 A3 CZ2006533 A3 CZ 2006533A3
- Authority
- CZ
- Czechia
- Prior art keywords
- preparation
- methods
- pharmaceutical composition
- amorphous ritonavir
- ritonavir
- Prior art date
Links
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 title 1
- 229960000311 ritonavir Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicinal Preparation (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11934598A | 1998-07-20 | 1998-07-20 | |
| US32609399A | 1999-06-04 | 1999-06-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ2006533A3 true CZ2006533A3 (cs) | 2001-05-16 |
| CZ307116B6 CZ307116B6 (cs) | 2018-01-24 |
Family
ID=26817251
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ2006-533A CZ307116B6 (cs) | 1998-07-20 | 1999-07-19 | Amorfní ritonavir, způsoby jeho přípravy, jeho použití a farmaceutická kompozice ho obsahující |
| CZ20010203A CZ298188B6 (cs) | 1998-07-20 | 1999-07-19 | Krystalický polymorf ritonaviru a zpusob jeho prípravy |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20010203A CZ298188B6 (cs) | 1998-07-20 | 1999-07-19 | Krystalický polymorf ritonaviru a zpusob jeho prípravy |
Country Status (29)
| Country | Link |
|---|---|
| EP (4) | EP2298751A3 (cs) |
| JP (4) | JP4815050B2 (cs) |
| KR (3) | KR100740796B1 (cs) |
| CN (5) | CN102153524A (cs) |
| AR (5) | AR019431A1 (cs) |
| AT (3) | ATE425974T1 (cs) |
| AU (1) | AU768207B2 (cs) |
| BG (4) | BG65150B1 (cs) |
| BR (1) | BR9912010A (cs) |
| CA (3) | CA2510949C (cs) |
| CO (1) | CO5090830A1 (cs) |
| CY (2) | CY1111600T1 (cs) |
| CZ (2) | CZ307116B6 (cs) |
| DE (2) | DE69915628T2 (cs) |
| DK (3) | DK1418174T3 (cs) |
| ES (3) | ES2372990T3 (cs) |
| HU (3) | HU227540B1 (cs) |
| ID (1) | ID27996A (cs) |
| IL (4) | IL140492A0 (cs) |
| MY (2) | MY121765A (cs) |
| NO (2) | NO318385B1 (cs) |
| NZ (2) | NZ509125A (cs) |
| PL (2) | PL213978B1 (cs) |
| PT (3) | PT2017269E (cs) |
| SI (3) | SI2017269T1 (cs) |
| SK (3) | SK287381B6 (cs) |
| TR (1) | TR200100171T2 (cs) |
| TW (3) | TWI271400B (cs) |
| WO (1) | WO2000004016A2 (cs) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY121765A (en) * | 1998-07-20 | 2006-02-28 | Abbott Lab | Polymorph of ritonavir |
| US6894171B1 (en) | 1998-07-20 | 2005-05-17 | Abbott Laboratories | Polymorph of a pharmaceutical |
| ATE429224T1 (de) * | 1999-06-04 | 2009-05-15 | Abbott Lab | Arzneizubereitungen enthaltend mindestens einen hiv preoteaseinhibitor |
| MXPA03010771A (es) * | 2001-05-25 | 2004-07-01 | Abbott Lab | Capsulas elasticas blandas que comprenden ritonavir y/o lopinavir. |
| TWI286476B (en) * | 2001-12-12 | 2007-09-11 | Tibotec Pharm Ltd | Combination of cytochrome P450 dependent protease inhibitors |
| US7205413B2 (en) | 2002-05-03 | 2007-04-17 | Transform Pharmaceuticals, Inc. | Solvates and polymorphs of ritonavir and methods of making and using the same |
| US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| BRPI0401742B8 (pt) | 2004-05-13 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | composto análogo do ritonavir útil como inibidor de protease retroviral, preparação do composto análogo do ritonavir e composição farmacêutica do composto análogo do ritonavir |
| US20080312300A1 (en) * | 2005-05-30 | 2008-12-18 | Yoginder Pal Sachdeva | Processes for the Preparation of Stable Polymorphic Form I of Ritonavir |
| WO2008041176A2 (en) * | 2006-10-03 | 2008-04-10 | Ranbaxy Laboratories Limited | Process for the preparation of form i and form ii of ritonavir |
| CN102898398B (zh) * | 2011-07-27 | 2015-01-14 | 上海迪赛诺药业有限公司 | 一种制备i型利托那韦多晶型结晶的方法 |
| ES2587559T3 (es) | 2012-03-07 | 2016-10-25 | Ratiopharm Gmbh | Forma farmacéutica que comprende lopinavir y ritonavir |
| ES2586912T3 (es) | 2012-03-07 | 2016-10-19 | Ratiopharm Gmbh | Forma de dosificación que comprende lopinavir no cristalino y ritonavir cristalino |
| HK1220390A1 (zh) | 2013-08-29 | 2017-05-05 | Teva Pharmaceutical Industries Ltd. | 包括恩曲他滨，替诺福韦，达芦那韦和利托那韦的单位剂型以及包含达芦那韦和利托那韦的单体片剂 |
| AU2015245217A1 (en) | 2014-04-08 | 2016-10-13 | Teva Pharmaceutical Industries Ltd. | Unit dosage form comprising Emtricitabine, Tenofovir, Darunavir and Ritonavir |
| CN106749085B (zh) * | 2016-12-23 | 2019-05-24 | 东北制药集团股份有限公司 | 一种制备利托那韦的方法 |
| EP3569225A1 (en) | 2018-05-18 | 2019-11-20 | Pharmaceutical Oriented Services Ltd | Solid dispersion containing ritonavir |
| RU2759544C1 (ru) * | 2021-01-29 | 2021-11-15 | Общество с ограниченной ответственностью "АМЕДАРТ" | Твёрдая фармацевтическая композиция для изготовления перорального терапевтического средства для профилактики и/или лечения ВИЧ-инфекции |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5696270A (en) | 1989-05-23 | 1997-12-09 | Abbott Laboratories | Intermediate for making retroviral protease inhibiting compounds |
| US5354866A (en) | 1989-05-23 | 1994-10-11 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| DE10199053I1 (de) * | 1992-12-29 | 2002-08-29 | Abbott Lab | Inhibitoren der retroviralen Protease |
| IL110752A (en) | 1993-09-13 | 2000-07-26 | Abbott Lab | Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor |
| US5559158A (en) | 1993-10-01 | 1996-09-24 | Abbott Laboratories | Pharmaceutical composition |
| US5491253A (en) | 1993-10-22 | 1996-02-13 | Abbott Laboratories | Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane |
| IL111991A (en) | 1994-01-28 | 2000-07-26 | Abbott Lab | Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent |
| US5567823A (en) * | 1995-06-06 | 1996-10-22 | Abbott Laboratories | Process for the preparation of an HIV protease inhibiting compound |
| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| US6160122A (en) | 1996-06-28 | 2000-12-12 | Abbott Laboratories | Process for the preparation of a disubstituted thiazole |
| ZA9710071B (en) | 1996-11-21 | 1998-05-25 | Abbott Lab | Pharmaceutical composition. |
| MY121765A (en) * | 1998-07-20 | 2006-02-28 | Abbott Lab | Polymorph of ritonavir |
| DE19856432A1 (de) * | 1998-12-08 | 2000-06-15 | Basf Ag | Nanopartikuläre Kern-Schale Systeme sowie deren Verwendung in pharmazeutischen und kosmetischen Zubereitungen |
| ATE429224T1 (de) * | 1999-06-04 | 2009-05-15 | Abbott Lab | Arzneizubereitungen enthaltend mindestens einen hiv preoteaseinhibitor |
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1999
- 1999-07-16 MY MYPI9903007 patent/MY121765A/en unknown
- 1999-07-16 MY MYPI0402546 patent/MY145265A/en unknown
- 1999-07-16 CO CO99045166A patent/CO5090830A1/es unknown
- 1999-07-19 SK SK5029-2008A patent/SK287381B6/sk not_active IP Right Cessation
- 1999-07-19 WO PCT/US1999/016334 patent/WO2000004016A2/en active Application Filing
- 1999-07-19 CN CN2011100389228A patent/CN102153524A/zh active Pending
- 1999-07-19 CN CN998089273A patent/CN1310715B/zh not_active Expired - Lifetime
- 1999-07-19 ID ID20010165A patent/ID27996A/id unknown
- 1999-07-19 DK DK03029709T patent/DK1418174T3/da active
- 1999-07-19 IL IL14049299A patent/IL140492A0/xx unknown
- 1999-07-19 HU HU0103823A patent/HU227540B1/hu unknown
- 1999-07-19 CA CA 2510949 patent/CA2510949C/en not_active Expired - Lifetime
- 1999-07-19 DE DE1999615628 patent/DE69915628T2/de not_active Expired - Lifetime
- 1999-07-19 PT PT08007622T patent/PT2017269E/pt unknown
- 1999-07-19 PL PL381194A patent/PL213978B1/pl unknown
- 1999-07-19 CZ CZ2006-533A patent/CZ307116B6/cs not_active IP Right Cessation
- 1999-07-19 HU HU0800267A patent/HU229999B1/hu unknown
- 1999-07-19 AT AT03029709T patent/ATE425974T1/de active
- 1999-07-19 ES ES08007622T patent/ES2372990T3/es not_active Expired - Lifetime
- 1999-07-19 DE DE69940616T patent/DE69940616D1/de not_active Expired - Lifetime
- 1999-07-19 PL PL99348033A patent/PL194710B1/pl unknown
- 1999-07-19 SI SI9931066T patent/SI2017269T1/sl unknown
- 1999-07-19 EP EP20100179472 patent/EP2298751A3/en not_active Withdrawn
- 1999-07-19 CA CA 2337846 patent/CA2337846C/en not_active Expired - Lifetime
- 1999-07-19 EP EP20080007622 patent/EP2017269B1/en not_active Expired - Lifetime
- 1999-07-19 HU HU0800266A patent/HU230150B1/hu unknown
- 1999-07-19 NZ NZ50912599A patent/NZ509125A/xx not_active IP Right Cessation
- 1999-07-19 CN CNA2003101181720A patent/CN1502613A/zh active Pending
- 1999-07-19 KR KR1020047011204A patent/KR100740796B1/ko not_active Expired - Lifetime
- 1999-07-19 AT AT08007622T patent/ATE534636T1/de active
- 1999-07-19 ES ES03029709T patent/ES2322759T3/es not_active Expired - Lifetime
- 1999-07-19 EP EP19990934143 patent/EP1097148B1/en not_active Expired - Lifetime
- 1999-07-19 ES ES99934143T patent/ES2214038T3/es not_active Expired - Lifetime
- 1999-07-19 NZ NZ522690A patent/NZ522690A/en not_active IP Right Cessation
- 1999-07-19 PT PT03029709T patent/PT1418174E/pt unknown
- 1999-07-19 CN CN2010101669679A patent/CN101966180A/zh active Pending
- 1999-07-19 SK SK5028-2008A patent/SK287586B6/sk not_active IP Right Cessation
- 1999-07-19 AU AU50037/99A patent/AU768207B2/en not_active Expired
- 1999-07-19 EP EP20030029709 patent/EP1418174B1/en not_active Expired - Lifetime
- 1999-07-19 AT AT99934143T patent/ATE261947T1/de active
- 1999-07-19 DK DK99934143T patent/DK1097148T3/da active
- 1999-07-19 KR KR1020067022587A patent/KR100853371B1/ko not_active Expired - Lifetime
- 1999-07-19 SK SK92-2001A patent/SK286388B6/sk not_active IP Right Cessation
- 1999-07-19 CA CA 2674800 patent/CA2674800A1/en not_active Abandoned
- 1999-07-19 PT PT99934143T patent/PT1097148E/pt unknown
- 1999-07-19 KR KR1020017000857A patent/KR100793046B1/ko not_active Expired - Lifetime
- 1999-07-19 CZ CZ20010203A patent/CZ298188B6/cs not_active IP Right Cessation
- 1999-07-19 SI SI9931030T patent/SI1418174T1/sl unknown
- 1999-07-19 BR BR9912010A patent/BR9912010A/pt not_active Application Discontinuation
- 1999-07-19 SI SI9930586T patent/SI1097148T1/xx unknown
- 1999-07-19 CN CNA2008100805471A patent/CN101259128A/zh active Pending
- 1999-07-19 JP JP2000560122A patent/JP4815050B2/ja not_active Expired - Lifetime
- 1999-07-19 TR TR200100171T patent/TR200100171T2/xx unknown
- 1999-07-19 DK DK08007622T patent/DK2017269T3/da active
- 1999-07-20 AR ARP990103557 patent/AR019431A1/es active IP Right Grant
- 1999-07-31 TW TW90127014A patent/TWI271400B/zh not_active IP Right Cessation
- 1999-07-31 TW TW95132288A patent/TWI362382B/zh not_active IP Right Cessation
- 1999-07-31 TW TW88112226A patent/TWI227713B/zh not_active IP Right Cessation
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2000
- 2000-12-22 IL IL14049200A patent/IL140492A/en not_active IP Right Cessation
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2001
- 2001-01-18 NO NO20010298A patent/NO318385B1/no not_active IP Right Cessation
- 2001-01-30 BG BG105197A patent/BG65150B1/bg unknown
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2004
- 2004-04-20 AR ARP040101329 patent/AR044029A2/es not_active Application Discontinuation
- 2004-06-09 NO NO20042393A patent/NO327320B1/no not_active IP Right Cessation
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2005
- 2005-06-29 AR ARP050102703 patent/AR049658A2/es not_active Application Discontinuation
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2006
- 2006-09-20 BG BG110080A patent/BG110080A/bg unknown
- 2006-09-20 BG BG109682A patent/BG65963B1/bg unknown
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2007
- 2007-03-06 AR ARP070100929 patent/AR059764A2/es not_active Application Discontinuation
- 2007-03-06 AR ARP070100928 patent/AR059763A2/es unknown
- 2007-11-05 IL IL18718107A patent/IL187181A/en not_active IP Right Cessation
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2008
- 2008-03-12 BG BG10110080A patent/BG66140B1/bg unknown
- 2008-05-20 IL IL191582A patent/IL191582A/en not_active IP Right Cessation
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2009
- 2009-06-11 CY CY20091100614T patent/CY1111600T1/el unknown
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2010
- 2010-07-22 JP JP2010164769A patent/JP5732212B2/ja not_active Expired - Lifetime
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2011
- 2011-12-05 CY CY20111101205T patent/CY1112139T1/el unknown
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2013
- 2013-12-11 JP JP2013255680A patent/JP2014074047A/ja active Pending
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2016
- 2016-10-21 JP JP2016206663A patent/JP2017061475A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4A | Patent expired |
Effective date: 20190719 |