RU98123607A - Применение топирамата или его производных для получения лекарственного средства для лечения маниакально-депрессивных биполярных расстройств - Google Patents
Применение топирамата или его производных для получения лекарственного средства для лечения маниакально-депрессивных биполярных расстройствInfo
- Publication number
- RU98123607A RU98123607A RU98123607/14A RU98123607A RU98123607A RU 98123607 A RU98123607 A RU 98123607A RU 98123607/14 A RU98123607/14 A RU 98123607/14A RU 98123607 A RU98123607 A RU 98123607A RU 98123607 A RU98123607 A RU 98123607A
- Authority
- RU
- Russia
- Prior art keywords
- maniakal
- topiramat
- medicines
- derivatives
- preparation
- Prior art date
Links
- 206010004938 Bipolar disease Diseases 0.000 title claims 2
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 title claims 2
- 230000003001 depressive Effects 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 206010004939 Bipolar I disease Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- -1 methylenedioxy group Chemical group 0.000 claims 1
- 229960004394 topiramate Drugs 0.000 claims 1
Claims (4)
1. Способ лечения маниакально-депрессивного биполярного расстройства, включающий введение млекопитающему, подверженному такому состоянию, терапевтически эффективного количества для лечения такого состояния соединения формулы I:
где X представляет СН2 или кислород;
R1 представляет водород или алкил;
R2, R3, R4 и R5 независимо представляют водород или низший алкил, когда Х является кислородом, R2 и R3 и/или R4 и R5 вместе могут представлять метилендиоксигруппу следующей формулы II:
где R6 и R7, одинаковые или отличные друг от друга, и представляют водород, низший алкил, или представляют алкил и объединены с образованием циклопентильного или циклогексильного кольца.
где X представляет СН2 или кислород;
R1 представляет водород или алкил;
R2, R3, R4 и R5 независимо представляют водород или низший алкил, когда Х является кислородом, R2 и R3 и/или R4 и R5 вместе могут представлять метилендиоксигруппу следующей формулы II:
где R6 и R7, одинаковые или отличные друг от друга, и представляют водород, низший алкил, или представляют алкил и объединены с образованием циклопентильного или циклогексильного кольца.
2. Способ по п.1, где соединением формулы I является топирамат.
3. Способ по п. 1, где терапевтически эффективное количество составляет 50 - 200 мг.
4. Способ по п. 1, где указанное количество составляет 25 - 100 мг.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2085096P | 1996-06-28 | 1996-06-28 | |
| US60/020,580 | 1996-06-28 | ||
| US08/881,008 US5753693A (en) | 1996-06-28 | 1997-06-23 | Anticonvulsant derivatives useful in treating manic-depressive bipolar disorder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU98123607A true RU98123607A (ru) | 2000-09-27 |
| RU2185824C2 RU2185824C2 (ru) | 2002-07-27 |
Family
ID=26693960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU98123607/14A RU2185824C2 (ru) | 1996-06-28 | 1997-06-24 | Применение топирамата или его производных для получения лекарственного средства для лечения маниакально-депрессивных биполярных расстройств |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5753693A (ru) |
| EP (1) | EP0932398B1 (ru) |
| JP (1) | JP2002515875A (ru) |
| KR (1) | KR20000022233A (ru) |
| CN (1) | CN1224350A (ru) |
| AP (1) | AP1401A (ru) |
| AT (1) | ATE330593T1 (ru) |
| AU (1) | AU739363B2 (ru) |
| BR (1) | BR9712783A (ru) |
| CA (1) | CA2258895C (ru) |
| CZ (1) | CZ297342B6 (ru) |
| DE (1) | DE69736183T2 (ru) |
| ES (1) | ES2267144T3 (ru) |
| HU (1) | HUP0003381A3 (ru) |
| IL (1) | IL127714A (ru) |
| NO (1) | NO317641B1 (ru) |
| NZ (1) | NZ333565A (ru) |
| RU (1) | RU2185824C2 (ru) |
| SK (1) | SK180498A3 (ru) |
| WO (1) | WO1998000123A1 (ru) |
| ZA (1) | ZA975773B (ru) |
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| AU764510B2 (en) * | 1998-11-17 | 2003-08-21 | Ortho-Mcneil Pharmaceutical, Inc. | Anticonvulsant derivatives useful in treating post traumatic stress disorder |
| AU1909700A (en) * | 1998-12-03 | 2000-06-19 | Ortho-Mcneil Pharmaceutical, Inc. | Topiramate and related derivatives for treating Schizophrenia |
| EP1152756B1 (en) | 1999-02-08 | 2005-07-13 | Ortho-McNeil Pharmaceutical, Inc. | Anticonvulsant derivatives useful in treating autism |
| JP2002537326A (ja) * | 1999-02-24 | 2002-11-05 | ユニヴァーシティ・オブ・シンシナティ | 衝動調節障害の治療のためのスルファメート誘導体の使用 |
| US6583172B1 (en) | 1999-04-08 | 2003-06-24 | Richard P. Shank | Anticonvulsant derivatives useful in treating chronic neurodegenerative disorders |
| US6420369B1 (en) | 1999-05-24 | 2002-07-16 | Ortho-Mcneil Pharmaceutical, Inc. | Anticonvulsant derivatives useful in treating dementia |
| US7659256B2 (en) * | 1999-06-14 | 2010-02-09 | Vivus, Inc. | Combination therapy for effecting weight loss and treating obesity |
| US7056890B2 (en) | 1999-06-14 | 2006-06-06 | Vivus, Inc. | Combination therapy for effecting weight loss and treating obesity |
| US20080103179A1 (en) * | 2006-10-27 | 2008-05-01 | Tam Peter Y | Combination Therapy |
| ES2542892T3 (es) | 1999-06-14 | 2015-08-12 | Vivus, Inc. | Terapia de combinación para el tratamiento de hipertensión asociada con la obesidad |
| US7553818B2 (en) * | 1999-06-14 | 2009-06-30 | Vivus, Inc. | Combination therapy for effecting weight loss and treating obesity |
| US7674776B2 (en) | 1999-06-14 | 2010-03-09 | Vivus, Inc. | Combination therapy for effecting weight loss and treating obesity |
| US20080255093A1 (en) * | 1999-06-14 | 2008-10-16 | Tam Peter Y | Compositions and methods for treating obesity and related disorders |
| US6191117B1 (en) * | 2000-07-10 | 2001-02-20 | Walter E. Kozachuk | Methods of producing weight loss and treatment of obesity |
| EP1309325A1 (en) | 2000-08-02 | 2003-05-14 | Ortho-McNeil Pharmaceutical, Inc. | Anticonvulsant derivatives useful for the treatment of depression |
| WO2002043731A2 (en) | 2000-11-30 | 2002-06-06 | University Of Florida | Treatments for neurogenetic disorders, impulse control disorders, and wound healing |
| EP1423127A1 (en) * | 2001-08-30 | 2004-06-02 | Ortho-Mcneil Pharmaceutical, Inc. | Treatment of dementia and memory disorders with anticonvulsants and acetylcholinesterase inhibitors |
| US20040235957A1 (en) * | 2001-10-12 | 2004-11-25 | David Bleakman | Use of sulfonamide derivatives as pharmaceuticals compounds |
| US6559293B1 (en) | 2002-02-15 | 2003-05-06 | Transform Pharmaceuticals, Inc. | Topiramate sodium trihydrate |
| US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| US7790905B2 (en) * | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
| US20100311701A1 (en) * | 2002-02-15 | 2010-12-09 | Transform Pharmaceuticals, Inc | Pharmaceutical Co-Crystal Compositions |
| US20030224006A1 (en) | 2002-03-01 | 2003-12-04 | Zaworotko Michael J. | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
| US20090088443A1 (en) * | 2002-02-15 | 2009-04-02 | Julius Remenar | Novel crystalline forms of conazoles and methods of making and using the same |
| US20070059356A1 (en) * | 2002-05-31 | 2007-03-15 | Almarsson Oern | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| JP2006500377A (ja) * | 2002-06-21 | 2006-01-05 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 改善された溶解性を有する医薬組成物 |
| MXPA05001184A (es) * | 2002-07-29 | 2005-09-12 | Johnson & Johnson | Formulaciones y formas de dosificacion para administracion controlada de topiramato. |
| US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
| WO2005000294A1 (en) * | 2003-06-06 | 2005-01-06 | Pharmacia Corporation | Selective inhibitor and an anticonvulsant agent for the treatment of central nervous system disorders |
| CA2550699A1 (en) * | 2003-12-29 | 2005-07-21 | Alza Corporation, Inc. | Novel drug compositions and dosage forms of topiramate |
| AR049646A1 (es) * | 2004-06-16 | 2006-08-23 | Janssen Pharmaceutica Nv | Derivados de sulfamato y sulfamida utiles para el tratamiento de la epilepsia y trastornos relacionados |
| MY147767A (en) * | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| AU2005277134A1 (en) * | 2004-08-24 | 2006-03-02 | Janssen Pharmaceutica N.V. | Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents |
| EA200702558A1 (ru) * | 2005-05-20 | 2008-06-30 | Янссен Фармацевтика Н. В. | Способ получения производных сульфамида |
| US8497298B2 (en) * | 2005-12-19 | 2013-07-30 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels |
| US8716231B2 (en) * | 2005-12-19 | 2014-05-06 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain |
| US8691867B2 (en) * | 2005-12-19 | 2014-04-08 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction |
| US20070155827A1 (en) * | 2005-12-19 | 2007-07-05 | Smith-Swintosky Virginia L | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression |
| US8492431B2 (en) * | 2005-12-19 | 2013-07-23 | Janssen Pharmaceutica, N.V. | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity |
| US20070155823A1 (en) * | 2005-12-19 | 2007-07-05 | Smith-Swintosky Virginia L | Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents |
| US8937096B2 (en) * | 2005-12-19 | 2015-01-20 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder |
| US20070191450A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Mania and Bipolar Disorder |
| US20070191449A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Depression |
| US20070191474A1 (en) * | 2006-02-15 | 2007-08-16 | Smith-Swintosky Virginia L | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine |
| AU2007253814A1 (en) * | 2006-05-19 | 2007-11-29 | Janssen Pharmaceutica N.V. | Co-therapy for the treatment of epilepsy |
| US9744137B2 (en) * | 2006-08-31 | 2017-08-29 | Supernus Pharmaceuticals, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
| ES2312308T3 (es) | 2006-11-17 | 2013-03-26 | Supernus Pharmaceuticals, Inc. | Formulaciones de liberación sostenida de topiramato |
| CN102114002B (zh) | 2006-12-04 | 2016-05-11 | 苏佩努斯制药公司 | 托吡酯的增强的立即释放制剂 |
| US20090247617A1 (en) * | 2008-03-26 | 2009-10-01 | Abdel-Magid Ahmed F | Process for the preparation of benzo-fused heteroaryl sulfamates |
| US20090247616A1 (en) * | 2008-03-26 | 2009-10-01 | Smith-Swintosky Virginia L | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of anxiety |
| US20090304789A1 (en) | 2008-06-09 | 2009-12-10 | Thomas Najarian | Novel topiramate compositions and an escalating dosing strategy for treating obesity and related disorders |
| US8580298B2 (en) | 2008-06-09 | 2013-11-12 | Vivus, Inc. | Low dose topiramate/phentermine composition and methods of use thereof |
| EA018567B1 (ru) | 2008-06-23 | 2013-08-30 | Янссен Фармацевтика Нв | Кристаллическая форма (2s)-(-)-n-(6-хлор-2,3-дигидробензо[1,4]диоксин-2-илметил)сульфамида |
| US8815939B2 (en) * | 2008-07-22 | 2014-08-26 | Janssen Pharmaceutica Nv | Substituted sulfamide derivatives |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| WO2020104837A1 (en) | 2018-11-21 | 2020-05-28 | Rosemont Pharmaceuticals Limited | Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability |
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| US4513006A (en) * | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| US5384327A (en) * | 1992-12-22 | 1995-01-24 | Mcneilab, Inc. | Anticonvulsant sorbopyranose sulfamates |
-
1997
- 1997-06-23 US US08/881,008 patent/US5753693A/en not_active Expired - Fee Related
- 1997-06-24 HU HU0003381A patent/HUP0003381A3/hu unknown
- 1997-06-24 AT AT97930212T patent/ATE330593T1/de not_active IP Right Cessation
- 1997-06-24 CZ CZ0427798A patent/CZ297342B6/cs not_active IP Right Cessation
- 1997-06-24 DE DE69736183T patent/DE69736183T2/de not_active Expired - Fee Related
- 1997-06-24 ES ES97930212T patent/ES2267144T3/es not_active Expired - Lifetime
- 1997-06-24 EP EP97930212A patent/EP0932398B1/en not_active Expired - Lifetime
- 1997-06-24 RU RU98123607/14A patent/RU2185824C2/ru not_active IP Right Cessation
- 1997-06-24 AU AU34096/97A patent/AU739363B2/en not_active Ceased
- 1997-06-24 NZ NZ333565A patent/NZ333565A/xx unknown
- 1997-06-24 SK SK1804-98A patent/SK180498A3/sk unknown
- 1997-06-24 AP APAP/P/1998/001427A patent/AP1401A/en active
- 1997-06-24 CA CA002258895A patent/CA2258895C/en not_active Expired - Fee Related
- 1997-06-24 KR KR1019980710653A patent/KR20000022233A/ko not_active Application Discontinuation
- 1997-06-24 CN CN97195907A patent/CN1224350A/zh active Pending
- 1997-06-24 IL IL12771497A patent/IL127714A/en not_active IP Right Cessation
- 1997-06-24 JP JP50424298A patent/JP2002515875A/ja not_active Ceased
- 1997-06-24 BR BR9712783-3A patent/BR9712783A/pt not_active Application Discontinuation
- 1997-06-24 WO PCT/US1997/010949 patent/WO1998000123A1/en active IP Right Grant
- 1997-06-27 ZA ZA975773A patent/ZA975773B/xx unknown
-
1998
- 1998-12-22 NO NO19986051A patent/NO317641B1/no unknown
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